메뉴 건너뛰기




Volumn 93, Issue 12, 2002, Pages 1317-1326

Differential mechanisms of constitutive Akt/PKB activation and its influence on gene expression in pancreatic cancer cells

Author keywords

Akt protein kinase B; Constitutive activation; K ras; Pancreatic cancer; PTEN

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; COMPLEMENTARY DNA; GENISTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE INHIBITOR; RAS PROTEIN; SYNAPTOPHYSIN;

EID: 0036949812     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2002.tb01240.x     Document Type: Review
Times cited : (18)

References (61)
  • 1
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y. and Greenberg, M. E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 91, 231-241 (1997).
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 2
    • 0033517190 scopus 로고    scopus 로고
    • NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
    • Romashkova, J. A. and Makarov, S. S. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature, 401, 86-90 (1999).
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 5
    • 0030860466 scopus 로고    scopus 로고
    • Transforming activity and mitosis-related expression of the AKT2 oncogene: Evidence suggesting a link between cell cycle regulation and oncogenesis
    • Cheng, J. Q., Altomare, D. A., Klein, M. A., Lee, W. C., Kruh, G. D., Lissy, N. A. and Testa, J. R. Transforming activity and mitosis-related expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis. Oncogene, 14, 2793-2801 (1997).
    • (1997) Oncogene , vol.14 , pp. 2793-2801
    • Cheng, J.Q.1    Altomare, D.A.2    Klein, M.A.3    Lee, W.C.4    Kruh, G.D.5    Lissy, N.A.6    Testa, J.R.7
  • 6
    • 0034643331 scopus 로고    scopus 로고
    • AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    • Medema, R. H., Kops, G. J., Bos, J. L. and Burgering, B. M. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature, 404, 782-787 (2000).
    • (2000) Nature , vol.404 , pp. 782-787
    • Medema, R.H.1    Kops, G.J.2    Bos, J.L.3    Burgering, B.M.4
  • 7
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong, H., Chiles, K., Feldser, D., Laughner, E., Hanrahan, C., Georgescu, M. M., Simons, J. W. and Semenza, G. L. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res., 60, 1541-1545 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu M., M.6    Simons, J.W.7    Semenza, G.L.8
  • 12
    • 0032558822 scopus 로고    scopus 로고
    • Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
    • Haas-Kogan, D., Shalev, N., Wong, M., Mills, G., Yount, G. and Stokoe, D. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. Curr. Biol., 8, 1195-1198 (1998).
    • (1998) Curr. Biol. , vol.8 , pp. 1195-1198
    • Haas-Kogan, D.1    Shalev, N.2    Wong, M.3    Mills, G.4    Yount, G.5    Stokoe, D.6
  • 13
    • 0034618439 scopus 로고    scopus 로고
    • Detection of PTEN nonsense mutation and psiPTEN expression in central nervous system high-grade astrocytic tumors by a yeast-based stop codon assay
    • Zhang, C. L., Tada, M., Kobayashi, H., Nozaki, M., Moriuchi, T. and Abe, H. Detection of PTEN nonsense mutation and psiPTEN expression in central nervous system high-grade astrocytic tumors by a yeast-based stop codon assay. Oncogene, 19, 4346-4353 (2000).
    • (2000) Oncogene , vol.19 , pp. 4346-4353
    • Zhang, C.L.1    Tada, M.2    Kobayashi, H.3    Nozaki, M.4    Moriuchi, T.5    Abe, H.6
  • 14
    • 0030761409 scopus 로고    scopus 로고
    • Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
    • Tashiro, H., Blazes, M. S., Wu, R., Cho, K. R., Bose, S., Wang, S. I., Li, J., Parsons, R. and Ellenson, L. H. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res., 57, 3935-3940 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 3935-3940
    • Tashiro, H.1    Blazes M., S.2    Wu, R.3    Cho K., R.4    Bose, S.5    Wang S., I.6    Li, J.7    Parsons, R.8    Ellenson L., H.9
  • 15
    • 0034085811 scopus 로고    scopus 로고
    • Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines
    • Tsao, H., Zhang, X., Fowlkes, K. and Haluska, F. G. Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. Cancer Res., 60, 1800-1804 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 1800-1804
    • Tsao, H.1    Zhang, X.2    Fowlkes, K.3    Haluska, F.G.4
  • 17
    • 0031936947 scopus 로고    scopus 로고
    • Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas
    • Ruggeri, B. A., Huang, L., Wood, M., Cheng, J. Q. and Testa, J. R. Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas. Mol. Carcinog., 21, 81-86 (1998).
    • (1998) Mol. Carcinog. , vol.21 , pp. 81-86
    • Ruggeri, B.A.1    Huang, L.2    Wood, M.3    Cheng, J.Q.4    Testa, J.R.5
  • 18
    • 0028918408 scopus 로고
    • Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase
    • Hu, Q., Klippel, A., Muslin, A. J., Fanti, W. J. and Williams, L. T. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science, 268, 100-102 (1995).
    • (1995) Science , vol.268 , pp. 100-102
    • Hu, Q.1    Klippel, A.2    Muslin, A.J.3    Fanti, W.J.4    Williams, L.T.5
  • 19
    • 0031038131 scopus 로고    scopus 로고
    • R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways
    • Marte, B. M., Rodriguez-Viciana, P., Wennstrom, S., Warne, P. H. and Downward, J. R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways. Curr. Biol., 7, 63-70 (1997).
    • (1997) Curr. Biol. , vol.7 , pp. 63-70
    • Marte, B.M.1    Rodriguez-Viciana, P.2    Wennstrom, S.3    Warne, P.H.4    Downward, J.5
  • 20
    • 0029023942 scopus 로고
    • Rho family GTPases bind to phosphoinositide kinases
    • Tolias, K. F., Cantley, L. C. and Carpenter, C. L. Rho family GTPases bind to phosphoinositide kinases. J. Biol. Chem., 270, 17656-17659 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 17656-17659
    • Tolias, K.F.1    Cantley, L.C.2    Carpenter, C.L.3
  • 21
    • 0034682469 scopus 로고    scopus 로고
    • Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53
    • Lee, S. W., Fang, L., Igarashi, M., Ouchi, T., Lu, K. P. and Aaronson, S. A. Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53. Proc. Natl. Acad. Sci. USA, 97, 8302-8305 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 8302-8305
    • Lee, S.W.1    Fang, L.2    Igarashi, M.3    Ouchi, T.4    Lu, K.P.5    Aaronson, S.A.6
  • 22
    • 0035901496 scopus 로고    scopus 로고
    • p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and P13K/Akt signaling cascades
    • Fang, L., Li, G., Liu, G., Lee, S. W. and Aaronson, S. A. p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and P13K/Akt signaling cascades. EMBO J., 20, 1931-1939 (2001).
    • (2001) EMBO J. , vol.20 , pp. 1931-1939
    • Fang, L.1    Li, G.2    Liu, G.3    Lee, S.W.4    Aaronson, S.A.5
  • 24
    • 0030694492 scopus 로고    scopus 로고
    • High frequency of p53 mutations in human oral epithelial dysplasia and primary squamous cell carcinoma detected by yeast functional assay
    • Kashiwazaki, H., Tonoki, H., Tada, M., Chiba, I., Shindoh, M., Totsuka, Y., Iggo, R. and Moriuchi, T. High frequency of p53 mutations in human oral epithelial dysplasia and primary squamous cell carcinoma detected by yeast functional assay. Oncogene, 15, 2667-2674 (1997).
    • (1997) Oncogene , vol.15 , pp. 2667-2674
    • Kashiwazaki, H.1    Tonoki, H.2    Tada, M.3    Chiba, I.4    Shindoh, M.5    Totsuka, Y.6    Iggo, R.7    Moriuchi, T.8
  • 25
    • 0001457668 scopus 로고    scopus 로고
    • Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
    • Cheng, J. Q., Ruggeri, B., Klein, W. M., Sonoda, G., Altomare, D. A., Watson, D. K. and Testa, J. R. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc. Natl. Acad. Sci. USA, 93, 3636-3641 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3636-3641
    • Cheng, J.Q.1    Ruggeri, B.2    Klein, W.M.3    Sonoda, G.4    Altomare, D.A.5    Watson, D.K.6    Testa, J.R.7
  • 26
    • 0034604041 scopus 로고    scopus 로고
    • PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS
    • Gire, V., Marshall, C. and Wynford-Thomas, D. PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS. Oncogene, 19, 2269-2276 (2000).
    • (2000) Oncogene , vol.19 , pp. 2269-2276
    • Gire, V.1    Marshall, C.2    Wynford-Thomas, D.3
  • 27
    • 0028096233 scopus 로고
    • The 3Rs of life: Ras, Raf and growth regulation
    • Moodie, S. A. and Wolfman, A. The 3Rs of life: Ras, Raf and growth regulation. Trends Genet., 10, 44-48 (1994).
    • (1994) Trends Genet. , vol.10 , pp. 44-48
    • Moodie, S.A.1    Wolfman, A.2
  • 28
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos, C. J., Matter, W. F., Hui, K. Y. and Brown, R. F. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem., 269, 5241-5248 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 30
    • 0026020115 scopus 로고
    • Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer
    • Barton, C. M., Hall, P. A., Hughes, C. M., Gullick, W. J. and Lemoine, N. R. Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer. J. Pathol., 163, 111-116 (1991).
    • (1991) J. Pathol. , vol.163 , pp. 111-116
    • Barton, C.M.1    Hall, P.A.2    Hughes, C.M.3    Gullick, W.J.4    Lemoine, N.R.5
  • 34
    • 0034813635 scopus 로고    scopus 로고
    • Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2
    • Yip-Schneider, M. T., Lin, A. and Marshall, M. S. Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2. Biochem. Biophys. Res. Commun., 280, 992-997 (2001).
    • (2001) Biochem. Biophys. Res. Commun. , vol.280 , pp. 992-997
    • Yip-Schneider, M.T.1    Lin, A.2    Marshall, M.S.3
  • 35
    • 0034020459 scopus 로고    scopus 로고
    • Combined activation of ras and akt in neural progenitors induces glioblastoma formation in mice
    • Holland, E. C., Celestino, J., Dai, C., Schaefer, L., Sawaya, R. E. and Fuller, G. N. Combined activation of ras and akt in neural progenitors induces glioblastoma formation in mice. Nat. Genet., 25, 55-57 (2000).
    • (2000) Nat. Genet. , vol.25 , pp. 55-57
    • Holland, E.C.1    Celestino, J.2    Dai, C.3    Schaefer, L.4    Sawaya, R.E.5    Fuller, G.N.6
  • 36
    • 0034598796 scopus 로고    scopus 로고
    • Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene
    • Tolkacheva, T. and Chan, A. M. Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene. Oncogene, 19, 680-689 (2000).
    • (2000) Oncogene , vol.19 , pp. 680-689
    • Tolkacheva, T.1    Chan, A.M.2
  • 37
    • 0032508517 scopus 로고    scopus 로고
    • Ras isoforms vary in their ability to activate Raf-1 and phosphonoisitide 3-kinase
    • Yan, J., Roy, S., Apolloni, A., Lane, A. and Hancock, J. F. Ras isoforms vary in their ability to activate Raf-1 and phosphonoisitide 3-kinase. J. Biol. Chem., 273, 24052-24056 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 24052-24056
    • Yan, J.1    Roy, S.2    Apolloni, A.3    Lane, A.4    Hancock, J.F.5
  • 38
    • 0024376173 scopus 로고
    • ras oncogenes in human cancer: A review
    • Bos, J. L. ras oncogenes in human cancer: a review. Cancer Res., 49, 4682-4689 (1989).
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 39
    • 0033848574 scopus 로고    scopus 로고
    • H-RAS, K-RAS, and N-RAS gene activation in human bladder cancers
    • Przybojewska, B., Jagiello, A. and Jalmuzna, P. H-RAS, K-RAS, and N-RAS gene activation in human bladder cancers. Cancer Genet. Cytogenet., 121, 73-77 (2000).
    • (2000) Cancer Genet. Cytogenet. , vol.121 , pp. 73-77
    • Przybojewska, B.1    Jagiello, A.2    Jalmuzna, P.3
  • 40
    • 0034626695 scopus 로고    scopus 로고
    • Differential requirements of the MAP kinase and P13 kinase signaling pathways in Src- versus insulin and IGF-1 receptors-induced growth and transformation of rat intestinal epithelial cells
    • Nguyen, K. T., Wang, W. J., Chan, J. L. and Wang, L. H. Differential requirements of the MAP kinase and P13 kinase signaling pathways in Src- versus insulin and IGF-1 receptors-induced growth and transformation of rat intestinal epithelial cells. Oncogene, 19, 5385-5397 (2000).
    • (2000) Oncogene , vol.19 , pp. 5385-5397
    • Nguyen, K.T.1    Wang, W.J.2    Chan, J.L.3    Wang, L.H.4
  • 41
    • 0032978365 scopus 로고    scopus 로고
    • Transformation by v-Src: Ras-MAPK and P13K-mTOR mediate parallel pathways
    • Penuel, E. and Martin, G. S. Transformation by v-Src: Ras-MAPK and P13K-mTOR mediate parallel pathways. Mol. Biol. Cell, 10, 1693-1703 (1999).
    • (1999) Mol. Biol. Cell , vol.10 , pp. 1693-1703
    • Penuel, E.1    Martin, G.S.2
  • 42
    • 0033607633 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Raf by Akt (protein kinase B)
    • Zimmermann, S. and Moelling, K. Phosphorylation and regulation of Raf by Akt (protein kinase B). Science, 286, 1741-1744 (1999).
    • (1999) Science , vol.286 , pp. 1741-1744
    • Zimmermann, S.1    Moelling, K.2
  • 44
    • 0034704141 scopus 로고    scopus 로고
    • Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1
    • Wick, M. J., Dong, L. Q., Riojas, R. A., Ramos, F. J. and Liu, F. Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1. J. Biol. Chem., 275, 40400-40406 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 40400-40406
    • Wick, M.J.1    Dong, L.Q.2    Riojas, R.A.3    Ramos, F.J.4    Liu, F.5
  • 45
    • 0036606010 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors modulate K-Ras-mediated transformation of intestinal epithelial cells
    • Shao, J., Sheng, H. and DuBois, R. N. Peroxisome proliferator-activated receptors modulate K-Ras-mediated transformation of intestinal epithelial cells. Cancer Res., 62, 3282-3288 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 3282-3288
    • Shao, J.1    Sheng, H.2    DuBois, R.N.3
  • 47
    • 0030888163 scopus 로고    scopus 로고
    • The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation
    • Clark, G. J., Kinch, M. S., Rogers-Graham, K., Sebti, S. M., Hamilton, A. D. and Der, C. J. The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation. J. Biol. Chem., 272, 10608-10615 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 10608-10615
    • Clark, G.J.1    Kinch, M.S.2    Rogers-Graham, K.3    Sebti, S.M.4    Hamilton, A.D.5    Der, C.J.6
  • 48
    • 0032484019 scopus 로고    scopus 로고
    • CREB is a regulatory target for the protein kinase Akt/PKB
    • Du, K. and Montminy, M. CREB is a regulatory target for the protein kinase Akt/PKB. J. Biol. Chem., 273, 32377-32379 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 32377-32379
    • Du, K.1    Montminy, M.2
  • 49
    • 0032939723 scopus 로고    scopus 로고
    • Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: Expression patterns and effects on in vitro invasive behavior
    • Miknyoczki, S. J., Lang, D., Huang, L., Klein-Szanto, A. J., Dionne, C. A. and Ruggeri, B. A. Neurotrophins and Trk receptors in human pancreatic ductal adenocarcinoma: expression patterns and effects on in vitro invasive behavior. Int. J. Cancer, 81, 417-427 (1999).
    • (1999) Int. J. Cancer , vol.81 , pp. 417-427
    • Miknyoczki, S.J.1    Lang, D.2    Huang, L.3    Klein-Szanto, A.J.4    Dionne, C.A.5    Ruggeri, B.A.6
  • 50
    • 0034651705 scopus 로고    scopus 로고
    • The Sos1 and Sos2 Ras-specific exchange factors: Differences in placental expression and signaling properties
    • Qian, X., Esteban, L., Vass, W. C., Upadhyaya, C., Papageorge, A. G., Yienger, K., Ward, J. M., Lowy, D. R. and Santos, E. The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties. EMBO J., 19, 642-654 (2000).
    • (2000) EMBO J. , vol.19 , pp. 642-654
    • Qian, X.1    Esteban, L.2    Vass, W.C.3    Upadhyaya, C.4    Papageorge, A.G.5    Yienger, K.6    Ward, J.M.7    Lowy, D.R.8    Santos, E.9
  • 51
    • 0024410958 scopus 로고
    • Enhanced plasminogen activator production of Syrian hamster embryo cells transformed by chemicals or the c-Ha-ras oncogene: Type of plasminogen activators involved and their contribution to the transformed phenotype
    • de Kok, A. J., Sips, H., Chang, G. T. and Verheijen, J. H. Enhanced plasminogen activator production of Syrian hamster embryo cells transformed by chemicals or the c-Ha-ras oncogene: type of plasminogen activators involved and their contribution to the transformed phenotype. Carcinogenesis, 10, 1155-1161 (1989).
    • (1989) Carcinogenesis , vol.10 , pp. 1155-1161
    • de Kok, A.J.1    Sips, H.2    Chang, G.T.3    Verheijen, J.H.4
  • 52
    • 0025837237 scopus 로고
    • Protein kinase C-independent expression of stromelysin by platelet-derived growth factor, ras oncogene, and phosphatidylcholine-hydrolyzing phospholipase C
    • Diaz-Meco, M. T., Quinones, S., Municio, M. M., Sanz, L., Bernal, D., Cabrero, E., Saus, J. and Moscat, J. Protein kinase C-independent expression of stromelysin by platelet-derived growth factor, ras oncogene, and phosphatidylcholine-hydrolyzing phospholipase C. J. Biol. Chem., 266, 22597-22602 (1991).
    • (1991) J. Biol. Chem. , vol.266 , pp. 22597-22602
    • Diaz-Meco, M.T.1    Quinones, S.2    Municio, M.M.3    Sanz, L.4    Bernal, D.5    Cabrero, E.6    Saus, J.7    Moscat, J.8
  • 53
    • 0029926229 scopus 로고    scopus 로고
    • Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences
    • Gum, R., Lengyel, E., Juarez, J., Chen, J. H., Sato, H., Seiki, M. and Boyd, D. Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences. J. Biol. Chem., 271, 10672-10680 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 10672-10680
    • Gum, R.1    Lengyel, E.2    Juarez, J.3    Chen, J.H.4    Sato, H.5    Seiki, M.6    Boyd, D.7
  • 54
    • 0028158351 scopus 로고
    • Alterations in the cyclic AMP signal transduction pathway regulating ribonucleotide reductase gene expression in malignant H-ras transformed cell lines
    • Hurta, R. A. and Wright, J. A. Alterations in the cyclic AMP signal transduction pathway regulating ribonucleotide reductase gene expression in malignant H-ras transformed cell lines. J. Cell. Physiol., 158, 187-197 (1994).
    • (1994) J. Cell. Physiol. , vol.158 , pp. 187-197
    • Hurta, R.A.1    Wright, J.A.2
  • 56
    • 0033559953 scopus 로고    scopus 로고
    • The FHIT gene is expressed in pancreatic ductular cells and is altered in pancreatic cancers
    • Sorio, C., Baron, A., Orlandini, S., Zamboni, G., Pederzoli, P., Huebner, K. and Scarpa, A. The FHIT gene is expressed in pancreatic ductular cells and is altered in pancreatic cancers. Cancer Res., 59, 1308-1314 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 1308-1314
    • Sorio, C.1    Baron, A.2    Orlandini, S.3    Zamboni, G.4    Pederzoli, P.5    Huebner, K.6    Scarpa, A.7
  • 58
    • 0031056833 scopus 로고    scopus 로고
    • Overexpression of intercellular adhesion molecule-1 (ICAM-1) in pancreatic adenocarcinoma in comparison with normal pancreas
    • Shimoyama, S., Gansauge, F., Gansauge, S., Widmaier, U., Oohara, T. and Beger, H. G. Overexpression of intercellular adhesion molecule-1 (ICAM-1) in pancreatic adenocarcinoma in comparison with normal pancreas. Pancreas, 14, 181-186 (1997).
    • (1997) Pancreas , vol.14 , pp. 181-186
    • Shimoyama, S.1    Gansauge, F.2    Gansauge, S.3    Widmaier, U.4    Oohara, T.5    Beger, H.G.6
  • 61
    • 0023032789 scopus 로고
    • Functional studies on the EGF receptor with an antibody that recognizes the intracellular portion of the receptor
    • Beguinot, L., Werth, D., Ito, S., Richert, N., Willingham, M. C. and Pastan, I. Functional studies on the EGF receptor with an antibody that recognizes the intracellular portion of the receptor. J. Biol. Chem., 261, 1801-1807 (1986).
    • (1986) J. Biol. Chem. , vol.261 , pp. 1801-1807
    • Beguinot, L.1    Werth, D.2    Ito, S.3    Richert, N.4    Willingham, M.C.5    Pastan, I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.