Definition and characterization of relative hypo- and hyperleptinemia in a large Caucasian population

Journal of Endocrinology

Volumn 175, Issue 3, 2002, Pages 745-756

  Buettner, R ^a   Bollheimer, L C ^a   Zietz, B ^a   Drobnik, W ^a   Lackner, K ^a   Schmitz, G ^a   Scholmerich J ^a   Palitzsch, K D ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; CHOLESTEROL; FERRITIN; GLUCOSE; INSULIN; IRON; LEPTIN; LIPID; TESTOSTERONE;

ADRENAL FUNCTION; ADULT; ANTHROPOMETRY; ARTICLE; BODY MASS; CAUCASIAN; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; FERRITIN BLOOD LEVEL; GERMANY; GLUCOSE METABOLISM; HUMAN; INSULIN BLOOD LEVEL; IRON METABOLISM; KIDNEY FUNCTION; MALE; METABOLIC PARAMETERS; POPULATION RESEARCH; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REPRODUCTION; RISK ASSESSMENT; TESTOSTERONE BLOOD LEVEL;

ADULT; BLOOD GLUCOSE; BODY MASS INDEX; C-PEPTIDE; CHOLESTEROL; COHORT STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FERRITINS; GERMANY; HUMANS; INSULIN; IRON; LEPTIN; LINEAR MODELS; LIPIDS; MALE; RISK; STATISTICS, NONPARAMETRIC; TESTOSTERONE;

EID: 0036936487     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1750745     Document Type: Article

References (69)

1. Asakawa H, Tokunaga K & Kawakami F 2001 Relationship of leptin level with metabolic disorders and hypertension in Japanese type 2 diabetes mellitus patients. Journal of Diabetes and its Complications 15 57-62.
2. Behre HM, Simoni M & Nieschlag E 1997 Strong association between serum levels of leptin and testosterone in men. Clinical Endocrinology 47 237-240.
3. Ben Ari Z, Schafer Z, Sulkes J, Manhaim V, Tur-Kaspa R & Fainaru M 2002 Alterations in serum leptin in chronic liver disease. Digestive Diseases Science 47 183-189.
4. Bernard A & Lauwerys R 1984 Turbidimetric latex immunoassay for serum ferritin. Journal of Immunological Methods 71 141-147.
5. Brabant G, Horn R, von zur Muhlen A, Mayr B, Wurster U, Heidenreich F, Schnabel D, Gruters-Kieslich A, Zimmermann-Belsing T & Feldt-Rasmussen U 2000 Free and protein bound leptin are distinct and independently controlled factors in energy regulation. Diabetologia 43 438-442.
6. Campillo B, Sherman E, Richardet JP & Bories PN 2001 Serum leptin levels in alcoholic liver cirrhosis: relationship with gender, nutritional status, liver function and energy metabolism. European Journal of Clinical Nutrition 55 980-988.
7. Caprio M, Fabbrini E, Isidori AM, Aversa A & Fabbri A 2001 Leptin in reproduction. Trends in Endocrinology and Metabolism 12 65-72.
8. Carter P 1971 Spectrophotometric determination of serum iron at the submicrogram level with a new reagent (ferrozine). Analytical Biochemistry 40 450-458.
9. Casaril M, Stanzial AM, Tognella P, Pantalena M, Capra F, Colombari R & Corrocher R 2000 Role of iron load on fibrogenesis in chronic hepatitis C. Hepatogastroenterology 47 220-225.
10. Ceddia RB, Lopes G, Souza HM, Borba-Murad GR, William WN Jr, Bazotte RB & Curi R 1999 Acute effects of leptin on glucose metabolism of in situ rat perfused livers and isolated hepatocytes. International Journal of Obesity and Related Metabolic Disorders 23 1207-1212.
11. Chen G, Koyama K, Yuan X, Lee Y, Zhou YT, O'Doherty R, Newgard CB & Unger RH 1996 Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. PNAS 93 14795-14799.
12. Chu NF, Spiegelman D, Yu J, Rifai N, Hotamisligil GS & Rimm EB 2001 Plasma leptin concentrations and four-year weight gain among US men. International Journal of Obesity and Related Metabolic Disorders 25 346-353.
13. Ciccone M, Vettor R, Pannacciulli N, Minenna A, Bellacicco M, Rizzon P, Giorgino R & De Pergola G 2001 Plasma leptin is independently associated with the intima-media thickness of the common carotid artery. International Journal of Obesity and Related Metabolic Disorders 25 805-810.
14. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL et al. 1996 Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine 334 292-295.
15. Dua A, Hennes MI, Hoffmann RG, Maas DL, Krakower GR, Sonnenberg GE & Kissebah AH 1996 Leptin: a significant indicator of total body fat but not of visceral fat and insulin insensitivity in African-American women. Diabetes 45 1635-1637.
16. Esler M, Rumantir M, Wiesner G, Kaye D, Hastings J & Lambert G 2001 Sympathetic nervous system and insulin resistance: from obesity to diabetes. American Journal of Hypertension 14 304S-309S.
17. Fantuzzi G & Faggioni R 2000 Leptin in the regulation of immunity, inflammation, and hematopoiesis. Journal of Leukocyte Biology 68 437-446.
18. Farooqi IS, Keogh JM, Kamath S, Jones S, Gibson WT, Trussell R, Jebb SA, Lip GY & O'Rahilly S 2001 Partial leptin deficiency and human adiposity. Nature 414 34-35.
19. Friedman JM 2000 Obesity in the new millennium. Nature 404 632-634.
20. Glasow A & Bornstein SR 2000 Leptin and the adrenal gland. European Journal of Clinical Investigation 30 (Suppl 3) 39-45.
21. Greco AV, Mingrone G, Favuzzi A, Capristo E, Gniuli D, Addolorato G, Brunani A, Cavagnin F & Gasbarrini G 2000 Serum leptin levels in post-hepatitis liver cirrhosis. Journal of Hepatology 33 38-42.
22. Grinspoon S, Gulick T, Askari H, Landt M, Lee K, Anderson E, Ma Z, Vignati L, Bowsher R, Herzog D & Klibanski A 1996 Serum leptin levels in women with anorexia nervosa. Journal of Clinical Endocrinology and Metabolism 81 3861-3863.
23. Haffner SM, Mykkanen L, Rainwater DL, Karhapaa P & Laakso M 1999 Is leptin concentration associated with the insulin resistance syndrome in nondiabetic men? Obesity Research 7 164-169.
24. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK & Friedman JM 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269 543-546.
25. Hardwick JC, Van Den Brink GR, Offerhaus GJ, Van Deventer SJ & Peppelenbosch MP 2001 Leptin is a growth factor for colonic epithelial cells. Gastroenterology 121 79-90.
26. Haynes WG 2000 Interaction between leptin and sympathetic nervous system in hypertension. Current Hypertension Reports 2 311-318.
27. Henriksen JH, Holst JJ, Moller S, Brinch K & Bendtsen F 1999 Increased circulating leptin in alcoholic cirrhosis: relation to release and disposal. Hepatology 29 1818-1824.
28. Hsing AW, Chua S Jr, Gao YT, Gentzschein E, Chang L, Deng J & Stanczyk FZ 2001 Prostate cancer risk and serum levels of insulin and leptin: a population-based study. Journal of the National Cancer Institute 93 783-789.
29. Ikejima K, Honda H, Yoshikawa M, Hirose M, Kitamura T, Takei Y & Sato N 2001 Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals. Hepatology 34 288-297.
30. Kazumi T, Kawaguchi A, Katoh J, Iwahashi M & Yoshino G 1999 Fasting insulin and leptin serum levels are associated with systolic blood pressure independent of percentage body fat and body mass index. Journal of Hypertension 17 1451-1455.
31. Kieffer TJ, Heller RS, Leech CA, Holz GG & Habener JF 1997 Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes 46 1087-1093.
32. Langendonk JG, Pijl H, Toornvliet AC, Burggraaf J, Frolich M, Schoemaker RC, Doornbos J, Cohen AF & Meinders AE 1998 Circadian rhythm of plasma leptin levels in upper and lower body obese women: influence of body fat distribution and weight loss. Journal of Clinical Endocrinology and Metabolism 83 1706-1712.
33. Leroy P, Dessolin S, Villageois P, Moon BC, Friedman JM, Ailhaud G & Dani C 1996 Expression of ob gene in adipose cells. Regulation by insulin. Journal of Biological Chemistry 271 2365-2368.
34. Liu Z, Uesaka T, Watanabe H & Kato N 2001 High fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin. International Journal of Oncology 19 1009-1014.
35. Luukkaa V, Pesonen U, Huhtaniemi I, Lehtonen A, Tilvis R, Tuomilehto J, Koulu M & Huupponen R 1998 Inverse correlation between serum testosterone and leptin in men. Journal of Clinical Endocrinology and Metabolism 83 3243-3246.
36. Mackintosh RM & Hirsch J 2001 The effects of leptin administration in non-obese human subjects. Obesity Research 9 462-469.
37. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S et al. 1995 Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Medicine 1 1155-1161.
38. Martini G, Valenti R, Giovani S, Campagna S, Franci B & Nuti R 2001 Leptin and body composition in healthy postmenopausal women. Panminerva Medicine 43 149-154.
39. Matsubara M, Chiba H, Maruoka S & Katayose S 2000 Elevated serum leptin concentrations in women with components of multiple risk factor clustering syndrome. Journal of Atherosclerosis and Thrombosis 7 231-237.
40. Mendler MH, Turlin B, Moirand R, Jouanolle AM, Sapey T, Guyader D, Le Gall JY, Brissot P, David V & Deugnier Y 1999 Insulin resistance-associated hepatic iron overload. Gastroenterology 117 1155-1163.
41. Mohamed-Ali V, Pinkney JH, Panahloo A, Goodrick S, Coppack SW & Yudkin JS 1997 Relationships between plasma leptin and insulin concentrations, but not insulin resistance, in non-insulin-dependent (type 2) diabetes mellitus. Diabetic Medicine 14 376-380.
42. Moirand R, Mendler MH, Guillygomarc'h A, Brissot P & Deugmer Y 2000 Non-alcoholic steatohepatitis with iron: part of insulin resistance-associated hepatic iron overload? Journal of Hepatology 33 1024-1026.
43. Nakamuta M, Tada S, Uchimura K, Enjoji M, Kinukawa N, Iwamoto H, Sugimoto R, Shimada M, Ohashi M, Sugimachi K & Nawata H 2001 Serum leptin levels in patients with nonalcoholic chronic liver disease. Hepatogastroenterology 48 527-532.
44. Narkiewicz K, Kato M, Phillips BG, Pesek CA, Choe I, Winnicki M, Palatini P, Sivitz WI & Somers VK 2001 Leptin interacts with heart rate but not sympathetic nerve traffic in healthy male subjects. Journal of Hypertension 19 1089-1094.
45. Nemecz M, Preininger K, Englisch R, Furnsinn C, Schneider B, Waldhausl W & Roden M 1999 Acute effect of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver. Hepatology 29 166-172.
46. Nicolas JM, Fernandez-Sola J, Fatjo F, Casamitjana R, Bataller R, Sacanella E, Tobias E, Badia E & Estruch R 2001 Increased circulating leptin levels in chronic alcoholism. Alcoholism, Clinical and Experimental Research 25 83-88.
47. Palitzsch KD, Nusser J, Arndt H, Enger I, Zietz B, Hügl S, Cuk A, Schäffler A, Büttner R, Frick E, Rath H & Schölmerich J 2000 Die Pä valenz des Diabetes mellitus wird in Deutschland deutlich unterschä tzt - eine bundesweite epidemiologische Studie auf der Basis einer HbA1c-Analyse. Diabetes und Stoffwechsel 8, 189-200.
48. Parhami F, Tintut Y, Ballard A, Fogelman AM & Demer LL 2001 Leptin enhances the calcification of vascular cells: artery wall as a target of leptin. Circulation Research 88 954-960.
49. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T & Collins F 1995 Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269 540-543.
50. Pietrangelo A 1998 Iron, oxidative stress and liver fibrogenesis. Journal of Hepatology 28 (Suppl 1) 8-13.
51. Rentsch J & Chiesi M 1996 Regulation of ob gene mRNA levels in cultured adipocytes. FEBS Letters 379 55-59.
52. Rossetti L, Massillon D, Barzilai N, Vuguin P, Chen W, Hawkins M, Wu J & Wang J 1997 Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. Journal of Biological Chemistry 272 27758-27763.
53. Ruige JB, Dekker JM, Blum WF, Stehouwer CD, Nijpels G, Mooy J, Kostense PJ, Bouter LM & Heine RJ 1999 Leptin and variables of body adiposity, energy balance, and insulin resistance in a population-based study. The Hoorn Study. Diabetes Care 22 1097-1104.
54. Segal KR, Landt M & Klein S 1996 Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men. Diabetes 45 988-991.
55. Simon C, Gronfier C, Schlienger JL & Brandenberger G 1998 Circadian and ultradian variations of leptin in normal man under continuous enteral nutrition: relationship to sleep and body temperature. Journal of Clinical Endocrinology and Metabolism 83 1893-1899.
56. Sinha MK, Sturis J, Ohannesian J, Magosin S, Stephens T, Heiman ML, Polonsky KS & Caro JF 1996 Ultradian oscillations of leptin secretion in humans. Biochemical and Biophysical Research Communications 228 733-738.
57. Soderberg S, Ahren B, Stegmayr B, Johnson O, Wiklund PG, Weinehall L, Hallmans G & Olsson T 1999 Leptin is a risk marker for first-ever hemorrhagic stroke in a population-based cohort. Stroke 30 328-337.
58. Stan S, Levy E, Bendayan M, Zoltowska M, Lambert M, Michaud J, Asselin C & Delvin EE 2001 Effect of human recombinant leptin on lipid handling by fully differentiated Caco-2 cells. FEBS Letters 508 80-84.
59. Stattin P, Soderberg S, Hallmans G, Bylund A, Kaaks R, Stenman UH, Bergh A & Olsson T 2001 Leptin is associated with increased prostate cancer risk: a nested case-referent study. Journal of Clinical Endocrinology and Metabolism 86 1341-1345.
60. Tessitore L, Vizio B, Jenkins O, De SI, Ritossa C, Argiles JM, Benedetto C & Mussa A 2000 Leptin expression in colorectal and breast cancer patients. International Journal of Molecular Medicine 5 421-426.
61. VanPatten S, Ranginani N, Shefer S, Nguyen LB, Rossetti L & Cohen DE 2001 Impaired biliary lipid secretion in obese Zucker rats: leptin promotes hepatic cholesterol clearance. American Journal of Physiology 281 G393-G404.
62. Verdich C, Toubro S, Buemann B, Holst JJ, Bulow J, Simonsen L, Sondergaard SB, Christensen NJ & Astrup A 2001 Leptin levels are associated with fat oxidation and dietary-induced weight loss in obesity. Obesity Research 9 452-461.
63. Wauters M, Considine RV & Van Gaal LF 2000 Human leptin: from an adipocyte hormone to an endocrine mediator. European Journal of Endocrinology 143 293-311.
64. Weigle DS, Bukowski TR, Foster DC, Holderman S, Kramer JM, Lasser G, Lofton-Day CE, Prunkard DE, Raymond C & Kuijper JL 1995 Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. Journal of Clinical Investigation 96 2065-2070.
65. Weigle DS, Duell PB, Connor WE, Steiner RA, Soules MR & Kuijper JL 1997 Effect of fasting, refeeding, and dietary fat restriction on plasma leptin levels. Journal of Clinical Endocrinology and Metabolism 82 561-565.
66. Westerterp-Plantenga MS, Saris WH, Hukshorn CJ & Campfield LA 2001 Effects of weekly administration of pegylated recombinant human OB protein on appetite profile and energy metabolism in obese men. American Journal of Clinical Nutrition 74 426-434.
67. Widjaja A, Kielstein JT, Horn R, von zur Muhlen A, Kliem V & Brabant G 2000 Free serum leptin but not bound leptin concentrations are elevated in patients with end-stage renal disease. Nephrology, Dialysis, Transplantation 15 846-850.
68. Yamagishi SI, Edelstein D, Do XL, Kaneda Y, Guzman M & Brownlee M 2001 Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. Journal of Biological Chemistry 276 25096-25100.
69. Yiannakouris N, Yannakoulia M, Melistas L, Chan JL, Klimis-Zacas D & Mantzoros CS 2001 The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. Journal of Clinical Endocrinology and Metabolism 86