Leptin levels are associated with fat oxidation and dietary-induced weight loss in obesity

Obesity Research

Volumn 9, Issue 8, 2001, Pages 452-461

  Verdich, Camilla ^a   Toubro, Søren ^a   Buemann, Benjamin ^a   Holst, Jens Juul ^b   Bülow, Jens ^c   Simonsen, Lene ^c   Søndergaard, Susanne Bonnichsen ^d   Christensen, Niels Juel ^d   Astrup, Arne ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c BISPEBJERG HOSPITAL   (Denmark)

^d NONE

Author keywords

Energy expenditure; Spontaneous physical activity; Sympathetic nervous system

Indexed keywords

LEPTIN;

ADIPOSE TISSUE; ADOLESCENT; ADULT; ARTICLE; BLOOD; BODY COMPOSITION; CALORIMETRY; CASE CONTROL STUDY; DIET THERAPY; ENERGY METABOLISM; HUMAN; LIPID METABOLISM; LOW CALORY DIET; MALE; METABOLISM; MIDDLE AGED; OBESITY; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PHYSIOLOGY; RADIODENSITOMETRY; WEIGHT REDUCTION;

ADIPOSE TISSUE; ADOLESCENT; ADULT; BODY COMPOSITION; CALORIMETRY, INDIRECT; CASE-CONTROL STUDIES; DENSITOMETRY, X-RAY; DIET, REDUCING; ENERGY METABOLISM; HUMANS; LEPTIN; LIPID METABOLISM; MALE; MIDDLE AGED; OBESITY; OXIDATION-REDUCTION; WEIGHT LOSS;

EID: 0035430301     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2001.59     Document Type: Article

References (55)

1. Coleman DL. Effects of parabiosus of obese with diabetes and normal mice. Diabetologia. 1973;9:294-8.
2. Zhang Y, Proenca R, Maffaei M, Barone M, Leopold L, Friedmann JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-32.
3. Lee GH, Proenca R, Montez JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature. 1996;379:632-5.
4. Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 1997;387:903-8.
5. Clément K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 1998;392:398-401.
6. Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292-5.
7. Havel PJ, Kasim-Karakas S, Mueller W, Johnson PR, Gingerich RL, Stern JS. Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss. J Clin Endocrinol Metab. 1996;81:4406-13.
8. Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porter D. Cerebrospinal fluid leptin levels: relationship to plasma levels and to plasma levels and to adiposity in humans. Nat Med. 1996;2:589-93.
9. Mistry AM, Swick AG, Romsos DR. Leptin rapidly lowers food intake and elevates metabolic rate in lean and ob/ob mice. J Nutr. 1997;127:2065-72.
10. Pelleymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995;269:540-3.
11. Scarpace PJ, Matheny M, Pollock BH, Turner N. Leptin increases uncoupling protein expression and energy expenditure. Am J Physiol. 1997;273:E226-E30.
12. Schwartz MW, Woods SC, Porter D, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature. 2000;404:661-71.
13. Tang-Christensen M, Havel PJ, Jacobs RR, Larsen PJ, Cameron JL. Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques. J Clin Endocrinol Metab. 1999;84:711-7.
14. Collins S, Kuhn CM, Petro AE, Swick AG, Chrunyk BA, Surwit RS. Role of leptin in fat regulation. Nature. 1996; 380:667.
15. Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI. Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest. 1997;100:270-8.
16. Carulli L, Ferrari S, Bertolini M, Tagliafico E, Del Rio G. Regulation of ob gene expression: evidence for epinephrine-induced suppression in human obesity. J Clin Endocinol Metab. 1999;84:3309-12.
17. Salbe AD, Nicolson M, Ravussin E. Total energy expenditure and the level of physical activity correlated with plasma leptin concentrations in five-year-old children. J Clin Invest. 1997;99:592-5.
18. Nicklas BJ, Toth MJ, Poehlman ET. Daily energy expenditure is related to plasma leptin concentrations in older African-American women but not men. Diabetes. 1997;46: 1389-92.
19. Martin LJ, Jones PJH, Considine RV, Boyd NF, Caro JF. Serum leptin levels and energy expenditure in normal weight women. Can J Physiol Pharmacol. 1998;76:237-41.
20. Tuominen JA, Ebeling P, Heiman ML, Stephens T, Koivisto VA. Leptin and thermogenesis in humans. Acta Physiol Scand. 1997;160:83-7.
21. Jorgensen JOL, Vahl N, Dall R, Christiansen JS. Resting metabolic rate in healthy adults: relation to growth hormone status and leptin levels. Metabolism. 1998;47:1134-9.
22. Levine JA, Eberhardt NL, Jensen MD. Leptin responses to overfeeding: Relationship with body fat and nonexercise activity thermogenesis. J Clin Endocrinol Metab. 1999;84:2751-4.
23. Kennedy A, Gettys TW, Watson P, et al. The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure. J Clin Endocrinol Metab. 1997;82:1293-300.
24. Rosenbaum M, Nicolson M, Hirsch J, Murphy E, Chu F, Liebel RL. Effects of weight change on plasma leptin concentration and energy expenditure. J Clin Endocrinol Metab. 1997;82:3647-54.
25. Campostano A, Grillo G, Bessarione D, De Grandi R, Adamin GF. Relationship of serum leptin to body composition and resting energy expenditure. Horm Metab Res. 1998; 30:646-7.
26. Niskanen L, Haffner S, Karhunen LJ, Turoeinen AK, Miettinen AK, Uusitupa MU. Serum leptin in relation to resting energy expenditure and fuel metabolism in obese subjects. Int J Obes Relat Metab Disord. 1997;21:309-13.
27. Bobbioni-Harsch E, Assimacopoulos F, Lehmann T, Münger R, Allaz A-F, Golay A. Leptin plasma levels as a marker of sparing energy mechanisms in obese women. Int J Obes Relat Metab Disord. 1999;23:470-5.
28. Liuzzu A, Savia G, Tagliaferri M, et al. Serum leptin concentration in moderate and severe obesity: relationship with clinical, anthropometric and metabolic factors. Int J Obes Relat Metab Disord. 1999;23:1066-73.
29. World Health Organization. Obesity: Preventing and Managing the Global Epidemic - Report of WHO Consultation on Obesity. Geneva, Switzerland: World Health Organization Publications; 1997.
30. Verdich C, Lysgård Madsen J, Toubro S, et al. Effects of obesity and major weight reduction on gastric emptying. Int J Obes Relat Metab Disord. 2000;24:899-905.
31. Klausen B, Toubro S, Astrup A. Age and sex effects on energy expenditure. Am J Clin Nutr. 1997;65:895-907.
32. Heitmann BL. Evaluation of body fat estimated from body mass index, skinfolds and impedance: a comparative study. Eur J Clin Nutr. 1990;44:831-7.
33. Astrup A, Thorbek G, Lind J, Isakson B. Prediction of 24-hour energy expenditure and its components from physical characteristics and body composition in normal-weight humans. Am J Clin Nutr. 1990;52:777-83.
34. Toubro S, Christensen NJ, Astrup A. Reproducibility of 24-hour energy expenditure, substrate utilization and spontaneous physical activity in obese measured in a respiration chamber. Int J Obes Relat Metab Disord. 1995;19:544-9.
35. Søndergaard SB, Verdich C, Astrup A, Bratholm P, Christensen NJ. Obese male subjects show increased resting forearm venous plasma noradrenaline concentration but decreased 24-hour sympathetic activity as evaluated by thrombocyte norandrenaline measurements. Int J Obes Relat Metab Disord. 1999;23:810-5.
36. Suzuki R, Watanabe S, Hirai Y, et al. Abdominal wall fat index, estimated by ultrasonography, for assessment of the ratio of visceral fat to subcutaneous fat in the abdomen. Am J Med. 1993;95:309-14.
37. Haffner SM, Gingerich RL, Miettinen H, Stern MP. Leptin concentration in relation to overall adiposity and regional body fat distribution in Mexican Americans. Int J Obes Relat Metab Disord. 1996;20:904-8.
38. Osterlund RE, Yang JW, Klein S, Gingerich R. Relationship between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J Clin Endocrinol. 1996;81:3909-13.
39. Bennett FI, McFarlane-Anderson N, Wilks R, Luke A, Cooper RS, Forrester TE. Leptin concentration in women is influenced by regional distribution of adipose tissue. Am J Clin Nutr. 1997;66:1340-4.
40. Rissanen P, Mäkimattila S, Vehmas T, Taavitsainen M, Rissanen A. Effect of weight loss and regional fat distribution on plasma leptin concentration in obese women. Int J Obes Relat Metab Disord. 1999;23:645-9.
41. Wadden TA, Considine RV, Foster GD, Anderson DA, Sarwer DB, Caro JS. Short- and long-term changes in serum leptin in dieting obese women: effects of caloric restriction and weight loss. J Clin Endocrinol Metab. 1998;83:214-8.
42. Torgerson JS, Carlsson B, Stenlöf K, Carlsson LM, Bringman E, Sjöström L. A low serum leptin level at baseline and a large early decline in leptin predict a large 1-year weight reduction in energy-restricted obese. J Clin Endocrinol Metab. 1999;84:4197-203.
43. Boden G, Chen X, Mozzoli M, Ryan I. Effect of fasting an serum leptin in normal human subjects. J Clin Endocrinol Metab. 1996;81:3419-23.
44. Russell CD, Petersen RN, Rao SP, et al. Leptin expression in adipose tissue from obese humans: depot-specific regulation by insulin and dexamethasone. Am J Physiol. 1998;275: E507-E15.
45. Doucet E, St. Pierre S, Alméras N, Maurigège P, Richard D, Tremblay A. Changes in energy expenditure and substrate oxidation resulting from weight loss in obese men and women: is there an important contribution of leptin? J Clin Endocrinol Metab. 2000;85:1550-6.
46. van Aggel-Leijssen DPC, van Baak MA, Tenenbaum R, Campfield LA, Saris WHM. Regulation of average 24-hour human plasma leptin level: the influence of exercise and physical changes in energy balance. Int J Obes Relat Metab Disord. 1999;23:151-8.
47. Sinha MK, Ohannesian JP, Heiman ML, et al. Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. J Clin Invest. 1996;97:1344-7.
48. Raben A, Astrup A. Leptin is influenced both by predisposition to obesity and diet composition. Int J Obes Relat Metab Disord. 2000;24:450-9.
49. Havel PJ, Townsend R, Chaump L, Teff K. High-fat meals reduce 24-hour circulating leptin concentrations in women. Diabetes. 1999;48:334-41.
50. Matkovic V, Ilich JZ, Badenhop NE, et al. Gain in body fat is inversely related to the nocturnal rise in serum leptin level in young females. J Clin Endocrinol Metab. 1997;82: 1368-72.
51. Siegrist-Kaiser C, Pauli V, Juge-Aubry C, et al. Direct effects of leptin on brown and white adipose tissue. J Clin Invest. 1997;100:2858-64.
52. Astrup A, Bülow J, Madsen J Christensen NJ. Contribution of BAT and skeletal muscle to thermogenesis induced by ephedrine in man. Am J Physiol. 1985;248: E507-E15.
53. Ramsey JJ, Kemnitz JW, Colman RJ, Cunnungham D, Swick AG. Different central and peripheral responses to leptin in rhesus monkeys: brain transport may be limited. J Clin Endocrinol Metab. 1998;83:3230-5.
54. Ravussin E, Pratley RE, Maffei M, et al. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med. 1997;3:238-40.
55. 2. Metabolism. 1991;40:990-6.