Fasting insulin and leptin serum levels are associated with systolic blood pressure independent of percentage body fat and body mass index

Journal of Hypertension

Volumn 17, Issue 10, 1999, Pages 1451-1455

  Kazumi, Tsutomu ^a,c   Kawaguchi, Akira ^a   Katoh, Jun Ichi ^a   Iwahashi, Masanori ^a   Yoshino, Gen ^b  

^a KOBE UNIVERSITY OF MERCANTILE MARINE   (Japan)

^b TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Hyogo Rehabilitation Center Hospital   (Japan)

Author keywords

Blood pressure; Insulin; Leptin

Indexed keywords

CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; LIPOPROTEIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY FAT; BODY MASS; CHOLESTEROL BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0032708396     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199917100-00013     Document Type: Article

References (29)

1. Ferrannini E, Buzzigoli R, Bonadona R, Giorico MA, Olegigini M, Graziadei L, et al. Insulin resistance in essential hypertension. N Eng J Med 1987; 317:350-357.
2. Shen D-C, Shei S-M, Fuh M-T, Wu D-A, Chen Y-DI, Reaven GM. Resistance to insulin stimulated glucose uptake in patients with hypertension. J Clin Endocrinol Metabol 1988; 66:580-583.
3. Grunfeld B, Balzaretti M, Romo M, Gimonez M, Gutman R: Hyperinsulinemia in normotensive offspring of hypertensive parents. Hypertension 1994; 23 (suppl 1)112-1-15.
4. Beatty OL, Harper R, Sheridan B, Atkinson AB, Bell PM. Insulin resistance in offspring of hypertensive parents. BMJ 1993; 307:92-96.
5. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L. Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372:425-432.
6. Hopkins PN, Hum SC, Wu LL, Williams GH, Williams RR. Hypertension, dyslipidemia, and insulin resistance: links in a chain or spokes on a wheel? Curr Opin Lipidol 1996, 7:241-253.
7. Reaven GM, Lithell H, Landsberg L. Hypertension and associated metabolic abnormalities: the rote of insulin resistance and the sympathoadrenal system. N Eng J Med 1996; 334:374-381.
8. Modan M, Halkin H. Hyperinsulinemia or increased sympathetic drive as links for obesity and hypertension. Diabetes Care 1996; 14:470-487.
9. Kazumi T, Kawaguchi A, Hozumi T, Ishida Y, Yoshino G. Serum HDL cholesterol values are associated with apoB-containing lipoprotein metabolism and triglycerido-body fat interrelation in young Japanese men. Atherosclerosis 1997; 130:93-100.
10. Kazumi T, Kawaguchi A, Hozumi T, Nagao M, Iwahashi M, Hayakawa M, et al. Low density lipoprotein diameter in young, nonobese, normolipidemic Japanese men. Atherosclerosis 1999; 142:113-119.
11. Guidlines Subcommittee 1999. World Health Organization-International Society of Hypertension guidelines for the management of hypertension. J Hypertens 1989; 17; 151-183.
12. 2+ precipitation procedure for quantitation of high density lipoprorein cholesterol. Clin Chem 1982; 28:1379-1388.
13. Richmond W. Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin Chem 1973; 19:1350-1356.
14. Sulivan DR, Kruijswijk Z, West CE, Kohlmeier M, Katan MB. Determination of serum triglyceride by an accurate enzymatic method not affected by free glycerol. Clin Chem 1985; 31:1227-1228.
15. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18:499-502.
16. Caro JF. Insulin resistance in obese and nonobese man. J Clin Endocrinol Metabol 1997; 73:691-695.
17. Bray GA. Complications of obesity. Ann Intern Med 1985; 103:1052-1062.
18. The Expert Committee on the Diagnosis and Classification of Diabetes Mallitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1988; 21 (suppl):S5-S19.
19. National Cholesterol Education Program (NCEP) Expert Panel. Summary of the second report of the NCEP expert panel on detection, evaluation, and treatment of high blood cholesterol (Adult Treatment Panel II), JAMA 1993; 209:3015-3023.
20. Haynes WG, Sivitz WI, Morgan DA, Walsh SA, Mark AL. Sympathetic and cardiorenal actions of leptin. Hypertension 1997; 30:619-623.
21. Scherrer U, Sartori C. Insulin as a vascular and sympathoexcitatory hormone. Implications for blood pressure regulation, insulin sensitivity, and cardiovascular morbidity. Circulation 1997; 96:4104-4113.
22. Haffner SM, Miitteren H, Gaskill SP, Stern MOP. Metabolic precursors of hypertension. The San Antonio Heart Study. Arch Intern Med 1996; 156:1994-2000.
23. Auwerx J, Staels B. Leptin. Lancet 1998; 351:737-742.
24. Duntar JC, Hu Y, Lu H. Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes 1997; 46:2040-2043.
25. Zipes DP. The long QT interval syndrome. A rossetta stone for sympathetic related ventricular tachyarrhythmias. Circulation 1992; 84:1414-1419.
26. Agata J, Masuda A, Takada M, Higashiura K, Murakami H, Miyazaki Y, et al. High plasma immunoreactive leptin level in essential hypertension. Am J Hypertens 1997; 10:1171-1174.
27. de Courten M, Zimmet P, Hodge A, Collins V, Nicolson M, Staten M, et al. Hyperteptinemia: the missing link in the metabolic syndrome? Diabetic Med 1996; 14:200-208.
28. Leyva F, Godsland IF, Ghatei M, Proudler AJ, Aldis S, Walton C, et al. Hyporleptinemia as a component of a metabolic syndrome of cardiovascular risk. Arterioscler Thromb Vasc Biol 1998; 18:928-933.
29. Kim-Motoyama H, Yamaguchi T, Katakura T, Miura M, Ohashi Y, Yazaki Y, et al. Serum leptin levels are associated with hyperinsulinemia independent of body mass index but not with visceral obesity. Biochem Biophys Res Commun 1997; 239:340-344.