The etiological and pathogenetic heterogeneity of Alzheimer's disease;Zur ätiologischen und pathogenetischen heterogenität der Alzheimer-krankheit

Nervenarzt

Volumn 73, Issue 5, 2002, Pages 422-427

  Frolich L ^a   Hoyer, S ^b  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Aging brain; Alzheimer's disease; Amyloid cascade hypothesis; Cholesterol; Etiology; Familial form; Insulin; Oxidative stress; Pathogenesis; Sporadic form

Indexed keywords

ACETYLCHOLINE; AMYLOID; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E4; INSULIN RECEPTOR;

ALZHEIMER DISEASE; ARTICLE; BRAIN METABOLISM; CHROMOSOME 1; CHROMOSOME 14; CHROMOSOME 21; GENE MUTATION; HEREDITY; PATHOGENESIS; PROTEIN METABOLISM;

EID: 0036934451     PISSN: 00282804     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001150101120     Document Type: Article

References (52)

1. Arendt Th (1999) Pathologische Anatomie der Alzheimer-Krankheit. In: Förstl H, Bickel H, Kurz A (Hrsg) Alzheimer Demenz. Grundlagen, Klinik und Therapie. Springer, Berlin Heidelberg Tokyo New York, pp 87-106
2. Bancher C, Jellinger K, Lassmann, H Fischer P (1996) Correlations between mental state and quantitative neuropathology in the Vienna Longitudinal study on dementia. Eur Arch Psychiatry Clin Neurosci 246: 137-146
3. Buttgereit F, Brand MD (1995) A hierarchy of ATP-consuming processes in mammalian cells. Biochem J 312: 163-167.
4. Corder EH, Saunders AM, Strittmatter WJ et al. (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261: 921-923
5. Davis DG, Schmitt FA, Wekstein DR, Markesberry WR (1999) Alzheimer neuropathologic alterations in aged cognitively normal subjects. J Neuropath Exp Neurol 58: 376-388
6. Delaère P, He Y, Fayet G, Duyckaerte C, Hauw JJ (1993) βA4 deposits are constant in the brain of the oldest old: an immunocytochemical study of 20 French centenarians. Neurobiol Aging 14:191-194
7. Dutschke K, Nitsch R, Hoyer S (1994) Short-term mental activation accelerates the age-related decline of high-energy phosphates in rat cerebral cortex. Arch Gerontol Geriatr 19: 43-51
8. Edvinsson L, Mackenzie ET, McCulloch J, Uddmann R (1987) Perivascular innervation and receptor mechanisms in cerebrovascular bed. In: Wood JH (ed) Cerbral blood flow. Physiological and clinical aspects. McGraw-Hill, New York, pp 145-172
9. Frölich L, Blum-Degen D, Bernstein HG et al. (1998) Insulin and insulin receptors in the brain in aging and in sporadic Alzheimer's disease. J NeuralTransm 105: 423-438
10. Frölich L, Pieschl D, Maurer K (1997) Die historische Entwicklung des Krankheitskonzeptes'Demenz vom Alzheimer Typ'-Implikationen für Praxis und Forschung. Nervenheilkunde 16: 19-24
11. Frölich L, Riederer P (1995) Free radical mechanisms in dementia of Alzheimer type and the potential of antioxidative treatment. Arzneimittel Forsch/Drug Res 45: 443-446
12. Frölich L, Riederer P (1996) Stoffwechselhypothesen der Demenz vom Alzheimer Typ-Was gibt es neben dem Amyloid? Neuropsychiatrie 10: 59-66
13. Frölich L, Weinmüller M, Barth N et al. (in press) (r)-, but not (s)-alpha lipoic acid stimulates deficient brain pyruvate dehydrogenase complex in vascular dementia, but not in Alzheimer dementia. Arch Gerontol Geriatr
14. Gabuzda D, Brusciglio J, Chen LB, Matsudaira P, Yankner BA (1994) Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem 269: 13623-13628
15. Ginsberg L, Atack JR, Rapoport SI, Gershfeld NL (1993) Regional specificity of membrane instability in Alzheimer's disease brain. Brain Res 615: 355-357
16. Glabe C (2000) Does Alzheimer disease tilt the scales of amyloid degradation versus accumulation? Nature Med 6: 133-134
17. Gomez-Isla T, Hollister R, West H et al. (1997) Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol 41: 17-24
18. Harik SI, McCracken KA (1986) Age-related increase in presynaptic noradrenergic markers of the rat cerebral cortex. Brain Res 381: 125-30
19. Haass C, de Strooper B (1999) The presenilins in Alzheimer's disease-proteolysis holds the key. Science 286: 916-919
20. Haxby JV, Grady CL, Koss E et al. (1990) Longitudinal study of cerebral metabolic asymmetries and associated neuropsychological patterns in early dementia of the Alzheimer type. Arch Neurol 47: 753-60
21. Hoyer S (1995) Age-related changes in cerebral oxidative metabolism. Implications for drug therapy. Drugs Aging 6: 210-218
22. Hoyer S (1996) Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease. Acta Neurol Scand [Suppl] 165: 18-24
23. Hoyer S (2000) Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update. Exp Gerontol 35: 1363-1372
24. Hoyer S, Frölich L, Sandbrink R (1999) Molekulare Medizin der Alzheimer-Krankheit. In: Ganten D, Ruckpaul K (Hrsg) Handbuch der molekularen Medizin, Bd 5: Erkrankungen des Zentralnervensystems. Springer, Berlin Heidelberg Tokyo New York, pp 195-236
25. Hyman BT, Gomez-Isla T, Briggs M, Chung H, Nichols S, Kohout F, Wallace R (1996) Apolipoprotein E and cognitive change in an elderly population. Ann Neurol 40: 55-66
26. Ikeda K, Akiyama H, Arai T et al. (1999) Clinical aspects of 'senile dementia of the tangle type'-a subset of dementia in the senium separable from late-onset Alzheimer's disease. Dement Geriat Cogn Disord 10: 6-11
27. Iwata N, Tsubuki S, Takaki Y et al. (2000) Identification of the major Ab 1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nature Med 6: 143-150
28. Klein J (2000) Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids. J Neural Transm 107: 1027-1063
29. Mason PR, Shoemaker WJ, Shajenko L, Chambers TE, Herbette LG (1992) Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterol. Neurobiol Aging 13: 413-419
30. Michikawa M, Yanagisawa K (1999) Inhibition of cholesterol production but not of nonsterol isoperiod products induces neuronal cell death. J Neurochem 72: 2278-2285
31. Münch G, Thome J, Foley P, Schinzel R, Riederer P (1997) Advanced glycation end products in ageing and Alzheimer's disease. Brain Res Rev 23: 134-143
32. Naslund J, Haroutunian V, Mohs R, Davis KL, Davies P, Greengard P, Buxbaum JD (2000) Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA 283: 1571-1577
33. Nitsch RM, Blusztayn JK, Pittas AG, Slack BE, Growdon JH, Wurtman RJ (1992) Evidence for a membrane defect in Alzheimer disease brain. Proc Natl Acad Sci USA 89: 1671-1675
34. Reiman EM, Caselli RJ, Yun LS et al. (1996) Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med 334: 752-758
35. Sato A, Sato Y (1995) Cholinergic neural regulation of regional cerebral blood flow. Alzheimer Dis Assoc Disord 9: 28-38
36. Salehi A, Bakker JM, Mulder M, Swaab DF (1998) Limited effects of neuritic plaques on neuronal density on the hippocampal CA1 area of Alzheimer patients. Alz Dis Assoc Dis 12: 77-82
37. Salehi M, Hodgkins MA, Merry BJ, Goyns MH (1996) Age-related changes in gene expression in the rat brain revealed by differential display. Experienta 52: 888-891
38. Sandbrink R, Hartmann T, Masters CL, Beyreuther K (1996) Genes contributing to Alzheimer's disease. Mol Psychiatry 1: 27-40
39. Selkoe DJ (1999) Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399 [Suppl]: A23-31
40. Sims NR, Bowen DM, Allen SJ, Smith CCT, Neary D, Thomas DJ, Davison AN (1983) Presynaptic cholinergic dysfunction in patients with dementia. J Neurochem 40: 503-509
41. 14C) glucose in vitro in human neocortex. J Neurochem 41: 1329-1334
42. Sisodia SS, Kim SH, Thinakaran G (1999) Function and dysfunction of the presenilins. Am J Hum Genet 65: 7-12
43. Söderberg M, Edlund C, Kristensson K, Dallner G (1991) Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease. Lipids 26: 412-425
44. Spector AA, Yorek MA (1985) Membrane lipid composition and cellular function. J Lipid Res 26: 1015-1035
45. St. George-Hyslop P (2000) Molecular genetics of Alzheimer's disease. Biol Psychiatry 47: 183-199
46. Swaab DF, Raadsheer FC, Endert EF, Hofmann MA, Kamphorst W, Racid R (1994) Increases in cortisol levels in aging and Alzheimer's disease in postmortem cerebrospinal fluid. J Neuroendocrinol 6: 681-687
47. Terry RD, Masliah E, Salmon DP et al. (1991) Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann Neurol 30: 572-580
48. Vaucher E, Hamel E (1995) Cholinergic basal forebrain neurons project to cortical microvessels in the rat: electron microscopic study with anterogradely transported Phaseolus vulgaris leucoagglutinin and choline acetyltransferase immunocytochemistry. J Neurosci 15: 7427-41
49. Vekrellis K, Ye Z, Qiu WQ et al. (2000) Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci 20: 1657-65
50. Webster MT, Pearce BR, Bowen DM, Francis PT (1998) The effects of perturbed energy metabolism on the processing of amyloid precursor protein in PC 12 cells. J Neural Transm 105: 839-853
51. Wu HC, Lee EHY (1997) Identification of a rat brain gene associated with aging by PCR differential display method. J Mol Neurosci 7: 13-18
52. Wurtman RJ (1992) Choline metabolism as a basis for the selective vulnerability of cholinergic neurons. Trends Neurosci 15: 117-122