Correlations between mental state and quantitative neuropathology in the Vienna Longitudinal Study on Dementia

European Archives of Psychiatry and Clinical Neuroscience

Volumn 246, Issue 3, 1996, Pages 137-146

  Bancher, C ^a   Jellinger, K ^a   Lassmann, H ^b   Fischer, P ^c   Leblhuber, F ^d  

^a GENERAL HOSPITAL LINZ   (Austria)

^b ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^c University Hospital for Psychiatry   (Austria)

^d KEPLER UNIVERSITY HOSPITAL   (Austria)

Author keywords

Alzheimer's dementia; Apoptosis; Clinicopathological correlations; Neurofibrillary tangles; Pathogenesis; Senile plaques; Synapse Poss

Indexed keywords

AMYLOID BETA PROTEIN; CHROMOGRANIN; CYTOSKELETON PROTEIN; PROTEIN PRECURSOR; SYNAPTOPHYSIN;

AGED; ALZHEIMER DISEASE; CLINICAL ARTICLE; COGNITIVE DEFECT; DEMENTIA; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LONGITUDINAL STUDY; MALE; MENTAL HEALTH; MOLECULAR BIOLOGY; MORPHOLOGY; NEOCORTEX; NERVE CELL DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PATHOGENESIS; PRIORITY JOURNAL; PSYCHOMETRY; REVIEW; SCORING SYSTEM; SENILE PLAQUE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AUSTRIA; DEMENTIA; DNA DAMAGE; FEMALE; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LONGITUDINAL STUDIES; MALE; NERVE DEGENERATION; NEUROFIBRILLARY TANGLES; PROSPECTIVE STUDIES; PSYCHIATRIC STATUS RATING SCALES; PSYCHOMETRICS; SYNAPTOPHYSIN;

EID: 0029877684     PISSN: 09401334     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (81)

1. American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders (DSM-III-R), 3rd edn, revised, American Psychiatric Press, Washington, DC
2. Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42 : 631-639
3. Bancher C, Grundke-Iqbal I, Igbal K, Fried VA, Smith HT, Wisniewski HM (1991) Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease. Brain Res 539 : 11-18
4. Bancher C, Braak H, Fischer P, Jellinger KA (1993) Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patients. Neurosci Lett 162 : 179-182
5. Barcikowska M, Wisniewski HM, Bancher C, Grundke-Iqbal I (1989) About the presence of paired helical filaments in dystrophic neurites participating in the plaque formation. Acta Neuropathol 78 : 225-231
6. Behl C, Davis B, Klier FG, Schubert H (1994) Amyloid β-peptide induces necrosis rather than apoptosis. Brain Res 645 : 253-264
7. Bennet DA, Cochran EJ, Saper CB, Leverenz JB, Gilley DW, Wilson RS (1993) Pathological changes in frontal cortex from biopsy to autopsy in Alzheimer's disease. Neurobiol Aging 14 : 589-596
8. Berg L, McKeel DW Jr, Miller JP, Baty J, Morris JC (1993) Neuropathological indexes of Alzheimer's disease in demented and nondemented persons aged 80 years and older. Arch Neurol 50 : 349-358
9. Bierer LM, Hof PR, Purohit DP, Carlin L, Schmeidler J, Davis KL, Perl DP (1995) Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease. Arch Neurol 52 : 81-88
10. Binder LI, Frankfurter A, Rebhun LI (1985) The distribution of tau in the mammalian central nervous system. J Cell Biol 101 : 1371-1378
11. Blessed G, Tomlinson BE, Roth M (1968) The association between quantitative measures of dementia and of senile change in the cerebral gray matter of elderly subjects. Br J Psychiatry 114 : 797-811
12. Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82 : 239-259
13. Braak H, Duyckaerts C, Braak E, Piette F (1993) Neuropathological staging of Alzheimer-related changes correlates with psychometrically assessed intellectual status. In: Corain B, Iqbal K, Nicolini M, Winblad B, Wisniewski H, Zatta P (eds) Alzheimer's disease: advances in clinical and basic research. Wiley, New York, pp 131-137
14. Buschke H, Fuld PA (1974) Evaluating storage retention and retrieval in disordered memory and learning. Neurology 24 : 1019-1025
15. Crystal H, Dickson D, Fuld P, Masur D, Scott R, Mehler M, Masdeu J, Kawas C, Aronson M, Wolfson L (1988) Clinico-pathological studies in dementia: nondemented subjects with pathologically confirmed Alzheimer's disease. Neurology 38 : 1682-1687
16. DeCarli C, Atack JR, Ball MJ, Kay JA, Grady CL, Fewster P, Pettigrew KD, Rapoport SI, Schapiro MB (1992) Post-mortem regional neurofibrillary tangle densities but not senile plaque densities are related to regional cerebral metabolic rates for glucose during life in Alzheimer's disease patients. Neurodegeneration 1 : 113-121
17. DeKosky ST, Harbaugh RE, Schmitt FA, Bakay RAE, Chui HC, Knopman DS, Reeder TM, Shetter AG, Senter HJ, Markesbery WR, Intraventricular Bethanecol Study Group (1992) Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Ann Neurol 32 : 625-632
18. Delaere P, Duyckaerts C, Brion JP, Poulain V, Hauw JJ (1989) Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer's type. Acta Neuropathol 77 : 645-653
19. DeRenzi E, Vignolo LA (1962) The Token Test. A sensitive test to detect receptive disturbances in aphasics. Brain 85 : 665-678
20. Dickson DW, Crystal HA, Mattiace LA, Masur DM, Blau AD, Davies P, Yen S-H, Aronson MK (1991) Identification of normal and pathologic aging in prospectively studied nondemented elderly humans. Neurobiol Aging 13 : 179-189
21. Dickson DW, Crystal HA, Bevona C, Honer W, Vincent I, Davies P (1995) Correlations of synaptic and pathological markers with cognition of the elderly. Neurobiol Aging 16 : 285-304
22. Duyckaerts C, Delaere P, Poulain V, Brion J-P, Hauw J-J (1988) Does amyloid precede paired helical filaments in the senile plaque? A study of 15 cases with graded intellectual status in aging and Alzheimer disease. Neurosci Lett 91 : 354-359
23. Evans DA, Beckett LA, Albert MS, Hebert LE, Scherr PA, Funkenstein HH, Taylor JO (1993) Level of education and change in cognitive function in a community population of older persons. Ann Epidemiol 3 : 71-77
24. Felsenstein KM, Hunihan LW, Roberts SB (1994) Altered cleavage and secretion of a recombinant β-APP bearing the Swedish familial Alzheimer's disease mutation. Nat Genet 6 : 251-256
25. Fischer P, Lassmann H, Jellinger K, Simanyi M, Bancher C, Travniczek-Marterer A, Gatterer G, Danielczyk W (1991) Die Demenz vom Alzheimer Typ. Eine klinische Längsschnittstudie mit quantitativer Neuropathologie. Wien Med Wochenschr 141 : 455-462
26. Fischer-Colbrie R, Wohlfarter T, Schmid KW, Grino H, Winkler H (1989) Dexamethasone induces an increased biosynthesis of chromogranin A in rat pituitary eland. J Endocrinol 121 : 487-494
27. Folstein MF, Folstein SE, McHugh PR (1975) "Mini Mental State". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12 : 189-198
28. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 119 : 494-501
29. Gold R, Schmied M, Rothe G, Zischler H, Breitschopf H, Wekerle H, Lassmann H (1993) Detections of DNA fragmentation in apoptosis: application of in situ nick translation to cell culture systems and tissue sections. J Histochem Cytochem 41 : 1023-1030
30. Gold R, Schmied M, Giegerich G, Breitschopf H, Hartung HP, Toyka K, Lassmann H (1994) Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques. Lab Invest 71 : 219-225
31. Haass C, Hung AY, Selkoe DJ, Teplow DB (1994) Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid β-protem precursor. J Biol Chem 269 : 17741-17748
32. Huber W, Poeck K, Weiger K, Willmes K (1982) Der Aachener Aphasietest, Hogrefe, Göttingen
33. Hyman BT, Van Hoesen GW, Kromer LJ, Damasio AR (1986) Perforant pathway changes and the memory impairment of Alzheimer's disease. Ann Neurol 20 : 472-481
34. Iseki S (1986) DNA strand breaks in rat tissue as detected by in situ nick translation. Exp Cell Res 167 : 311-326
35. Jellinger KA, Bancher C (1994) Classification of dementias based on functional morphology. In: Jellinger KA, Ladurner G, Windisch E (eds) New trends in the diagnosis and treatment of Alzheimer's disease. Springer, Berlin Heidelbers New York, pp 9-39
36. Jellinger K, Bancher C, Fischer P, Lassmann H (1992) Quantitative histopathologic validation of senile dementia of the Alzheimer type. Eur J Gerontol 3 : 146-156
37. Jellinger KA, Bancher C, Fischer P, Lassmann H (1994) Staging of degenerative dementia. Neurol Croat 43 (Suppl 2) : 39-58
38. Katzman R, Terry R, DeTeresa R, Brown T, Davies P, Fuld P, Renbing X, Peck A (1988) Clinical pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol 23 : 138-144
39. Kazee AM, Eskin TA, Lapham LW, Gabriel KR, McDaniel KD, Hamill RW (1993) Clinicopathologic correlates in Alzheimer disease: assessment of clinical and pathologic diagnostic criteria. Alz Dis Assoc Disord 7 : 152-164
40. Khachaturian ZS (1985) Diagnosis of Alzheimer's disease. Arch Neurol 42 : 1097-1105
41. Kim KS, Miller DL, Sapienza VJ, Chen CM, Bai C, Grundke-Iqbal I, Currie JR, Wisniewski HM (1988) Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci Res Commun 2 : 121-130
42. Lassmann H, Weiler R, Fischer P, Bancher C, Jellinger K, Floor E, Danielczyk W, Seitelberger F, Winkler H (1992) Synaptic pathology in Alzheimer's disease: immunological data for markers of synaptic and large dense-core vesicles. Neuroscience 46 : 1-8
43. Lassmann H, Bancher C, Breitschopf H, Wegiel J, Bobinski M, Jellinger K, Wisniewski HM (1995) Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ. Acta Neuropathol 89 : 35-41
44. Mann DMA, Yates PO, Marcyniuk B, Ravindra CR (1986) The topography of plaques and tangles in Down's syndrome patients of different ages. Neuropathol Appl Neurobiol 12 : 447-457
45. Mann DMA, Marcyniuk B, Yates PO, Neary D, Snowden JS (1988) The progression of the pathological changes of Alzheimer's disease in frontal and temporal neocortex examined both at biopsy and at autopsy. Neuropathol Appl Neurobiol 14 : 177-195
46. Mann DMA, Esiri M (1989) The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Downs's syndrome. J Neurol Sci 89 : 169-179
47. McKhann G, Drachman D, Folstein M, Katzmann R, Price D, Stadlan E (1994) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34 : 939-944
48. Markowitsch HJ (1994) Anatomical basis of memory disorders. In: Gazzaniga MS (ed) The cognitive neurosciences. MIT Press, Cambridge, Mass, pp 765-781
49. Masliah E (1995) Mechanisms of synaptic dysfunction in Alzheimer's disease. Histol Histopathol 10 : 509-519
50. Masliah E, Terry RD, Mallory M, Alford M, Hansen LA (1990) Diffuse plaques do not accentuate synapse loss in Alzheimer's disease. Am J Pathol 137 : 1293-1297
51. McKee AC, Kosik KS, Kowall NW (1991) Neuritic pathology and dementia in Alzheimer disease. Ann Neurol 30 : 156-165
52. Mirra SS, Hart MN, Terry RD (1993) Making the diagnosis of Alzheimer's disease. A primer for practicina patholosists. Arch Pathol Lab Med 117 : 132-144
53. Morris JC, McKeel DW Jr, Storandt M, Rubin EH, Price JL, Grant EA, Ball MJ, Berg L (1991) Very mild Alzheimer's disease: informant-based clinical, psychometric, and pathologic distinction from normal aging. Neurology 41 : 469-478
54. Nagy Z, Esiri MM, Jobst KA, Morris JH, King EM-F, McDonald B, Litchfield S, Smith A, Barnetson L, Smith AD (1995) Relative roles of plaques and tangles in the dementia of Alzheimer's disease: correlations using three sets of neuropathological criteria Dementia 6 : 21-31
55. Nie NH, Hull CH, Jenkins JG, Steinbrenner K, Bent DH (1975) SPSS Statistical Package for the Social Sciences. McGraw-Hill, New York
56. Ohm TG, Müller H, Braak H, Bohl J (1995) Close-meshed prevalence rates of different stages as a tool to uncover the rate of Alzheimer's disease-related neurofibrillary changes. Neuroscience 64 : 209-217
57. Orgass B (1982) Token-Test (TT) von Ennio De Renzi und Luigi A. Vignolo. Deutsche Bearbeitung. Weinheim, Beltz
58. Price JL, Davis PB, Morris JC, White DL (1991) The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease. Neurobiol Aging 12 : 295-312
59. Reusche E (1991) Silver staining of senile plaques and neurofibrillary tangles in paraffin sections. A simple and effective method. Path Res Pract 187 : 1045-1049
60. Rumble B, Retallack R, Hilbich C, Simms G, Multhaup G, Martins R, Hockey A, Montgomery P, Beyreuther K, Masters CL (1989) Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease. N Engl J Med 320 : 1446-1452
61. Samuel W, Masliah E, Hill LR, Butters N, Terry R (1994 a) Hippocampal connectivity and Alzheimer's dementia; effects of synapse loss and tangles frequency in a two-component model. Neurology 44 : 2081-2088
62. Samuel W, Terry RD, DeTeresa R, Butters N, Masliah E (1994 b) Clinical correlates of cortical and nucleus basalis pathology in Alzheimer dementia. Arch Neurol 51 : 772-778
63. Schubert W, Prior R, Weidemann A, Dircksen H, Multhaup G, Masters CL, Beyreuther K (1991) Localization of Alzheimer βA4 precursor at central and peripheral synaptic sites. Brain Res 563 : 184-194
64. Selkoe DJ (1994) Alzheimer's disease: a central role for amyloid. J Neuropathol Exp Neurol 53 : 438-447
65. Shimokawa M, Yanagisawa K, Nishiye H, Miyatake T (1993) Identification of amyloid precursor protein in synaptic plasma membrane. Biochem Biophys Res Commun 196 : 240-244
66. Shin R-W, Ogomori K, Kitamoto T, Tateishi J (1989) Increased iau accumulation in senile plaques as a hallmark in Alzheimer's disease. Am J Pathol 134 : 1365-1371
67. Stern Y, Gurland B, Tatemichi TK, Ming Xin Tang, Wilder D, Mayeux R (1994) Influence of education and occupation on the incidence of Alzheimer's disease. J Am Med Assoc 271 : 1004-1010
68. Terry RD, Masliah E (1994) Synaptic pathology in the pathogenesis of Alzheimer dementia. In: Jellinger KA, Ladurner G, Windisch M (eds) New trends in the diagnosis and therapy of Alzheimer's disease. Springer. Berlin Heidelberg New York, pp 1-8
69. Terry RD, Masliah E, Salmon DP (1991) Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30 : 572-580
70. Terry RD, Masliah E, Hansen LA (1994) Structural basis of cognitive alterations in Alzheimer disease. In: Terry RD, Katzmann R, Bick KL (eds) Alzheimer disease. Raven Press, New York, pp 179-196
71. Tierney MC, Fisher RH, Lewis AJ, Zorzitto ML, Snow WG, Reid DW, Nieuwstraten P (1988) The NINCDS-ADRDA Work Group criteria for the clinical diagnosis of possible Alzheimer's disease: a clinicopathologic study of 57 cases. Neurology 38 : 359-364
72. Tomlinson BE, Henderson G (1976) Some quantitative cerebral findings in normal and demented old people. In: Terry RD, Gershon S (eds) Neurobiology of aging. Raven Press, New York, pp 183-204
73. Trojanowski JQ, Shin R-W, Schmidt ML, Lee VM-Y (1995) Relationship between plaques, tangles, and dystrophic processes in Alzheimer's disease. Neurobiol Aging 16 : 335-345
74. Wang GP, Grundke-Iqbal I, Kascak RJ, Iqbal K, Wisniewski HM (1984) Alzheimer neurofibrillary tangles: monoclonal antibodies to inherent antigens Acta Neuropathol 62 : 268-275
75. Weiler R, Feichtinger H, Schmid KW, Fischer-Colbrie R, Grimelius L, Cedermark B, Papotti M, Bussolati G, Winkler H (1987) Chromogranin A and B and Secretogranin II in bronchial and intestinal carcinomas. Virchows Arch A 412 : 103-109
76. Wettstein A, Lang W (1990) Correlation of cognitive skills in nursing home patients with histologic Alzheimer changes in specific brain areas. Dementia 1 : 278-285
77. Wilcock GK, Esiri MM (1982) Plaques, tangles and dementia. A quantitative study. J Neurol Sci 56 : 343-356
78. Wisniewski K, Jervis GA, Moretz RC, Wisniewski HM (1979) Alzheimer neurofibrillary tangles in disease other than senile and presenile dementia. Ann Neurol 5 : 288-294
79. Yamamoto T, Hirano A (1986) A comparative study of modified Bielschowsky, Bodian and thioflavin S stain on Alzheimer's neurofibrillary tangles. Neuropathol Appl Neurobiol 12 : 3-9
80. Yankner BA, Duffy LK, Kirschner DA (1990) Neurotrophic and neurotoxic effects of amyloid β-protein: reversal by tachykinin neuropeptides. Science 250 : 279-282
81. Yankner BA, Mesulam MM (1991) Beta amyloid and the pathogenesis of Alzheimer's disease. N Engl J Med 325 : 1849-1857