Defective HDL particle uptake in ob/ob hepatocytes causes decreased recycling, degradation, and selective lipid uptake

Journal of Clinical Investigation

Volumn 105, Issue 2, 2000, Pages 151-159

  Silver, David L ^a   Wang, Nan ^a   Tall, Alan R ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; TRANSFERRIN;

ANIMAL CELL; ARTICLE; ENDOSOME; FEMALE; HUMAN; LIPID METABOLISM; LIPID TRANSPORT; LIPOPROTEIN BLOOD LEVEL; LIVER CELL; LIVER METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN INTERACTION;

EID: 0033972321     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI8087     Document Type: Article

References (28)

1. Glass, C.K., Pittman, R.C., Keller, G.A., and Steinberg, D. 1983. Tissue sites of degradation of apoprotein A-I in the rat. J. Biol. Chem. 258:7161-7167.
2. Brinton, E.A., Eisenberg, S., and Breslow, J.L. 1994. Human HDL cholesterol levels are determined by apoA-I fractional catabolic rate, which correlates inversely with estimates of HDL particle size. Effects of gender, hepatic and lipoprotein lipases, triglyceride and insulin levels, and body fat distribution. Arterioscler. Thromb. 14:707-720.
3. Fidge, N., Nestel, P., Ishikawa, T., Reardon, M., and Billington, T. 1980. Turnover of apoproteins A-I and A-II of high density lipoprotein and the relationship to other lipoproteins in normal and hyperlipidemic individuals. Metabolism. 29:643-653.
4. Mehrabian,M., et al. 1993. Influence of the apoA-II gene locus on HDL levels and fatty streak development in mice [erratum 1993, 13:466]. Arterioscler. Thromb. 13:1-10.
5. Goldstein, J.L., and Brown, M.S. 1992. Lipoprotein receptors and the control of plasma LDL cholesterol levels. Eur. Heart J. 13(Suppl. B):34-36.
6. Mukherjee, S., Ghosh, R.N., and Maxfield, F.R. 1997. Endocytosis. Physiol. Rev. 77:759-803.
7. Rigotti, A., et al. 1997. Scavenger receptor BI: a cell surface receptor for high density lipoprotein. Curr. Opin. Lipidol. 8:181-188.
8. Rigotti, A., et al. 1997. A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. Proc. Natl. Acad. Sci. USA. 94:12610-12615.
9. Varban, M.L., et al. 1998. Targeted mutation reveals a central role for SR-BI in hepatic selective uptake of high density lipoprotein cholesterol. Proc. Natl. Acad. Sci. USA. 95:4619-4624.
10. Fidge, N.H. 1999. High density lipoprotein receptors, binding proteins, and ligands. J. Lipid Res. 40:187-201.
11. Silver, D.L., Jiang, X.C., and Tall, A.R. 1999. Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnover. J. Biol. Chem. 274:4140-4146.
12. Honkakoski, P., and Negishi, M. 1998. Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes. Biochem. J. 330:889-895.
13. Hammad, S.M., et al. 1999. Cubilin, the endocytic receptor for intrinsic factor-vitamin B(12) complex, mediates high-density lipoprotein holoparticle endocytosis. Proc. Natl. Acad. Sci. USA. 96:10158-10163.
14. Mukherjee, S., Zha, X., Tabas, I., and Maxfield, F.R. 1998. Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog. Biophys. J. 75:1915-1925.
15. Subtil, A., et al. 1999. Acute cholesterol depletion inhibits clathrin-coated pit budding. Proc. Natl. Acad. Sci. USA. 96:6775-6780.
16. Weng, W., et al. 1999. ApoA-II maintains HDL levels in part by inhibition of hepatic lipase. Studies in apoA-II and hepatic lipase double knockout mice. J. Lipid Res. 40:1064-1070.
17. Cohen, J.C., Vega, G.L., and Grundy, S.M. 1999. Hepatic lipase: new insights from genetic and metabolic studies. Curr. Opin. Lipidol. 10:259-267.
18. DeLamatre, J.G., Sarphie, T.G., Archibold, R.C., and Hornick, C.A. 1990. Metabolism of apoE-free high density lipoproteins in rat hepatoma cells: evidence for a retroendocytic pathway. J. Lipid Res. 31:191-202.
19. Takata, K., Horiuchi, S. , Rahim, A.T., and Morino, Y. 1988. Receptor-mediated internalization of high density lipoprotein by rat sinusoidal liver cells: identification of a nonlysosomal endocytic pathway by fluorescence-labeled ligand. J. Lipid Res. 29:1117-1126.
20. Kambouris, A.M., Roach, P.D., Calvert, G.D., and Nestel, P.J. 1990. Retroendocytosis of high density lipoproteins by the human hepatoma cell line, HepG2. Arteriosclerosis. 10:582-590.
21. Hemery, I., Durand-Schneider, A.M., Feldmann, G., Vaerman, J.P, and Maurice, M. 1996. The transcytotic pathway of an apical plasma membrane protein (B10) in hepatocytes is similar to that of IgA and occurs via a tubular pericentriolar compartment. J. Cell. Sci. 109:1215-1227.
22. Duan, H., Lin, C.Y., and Mazzone, T. 1997. Degradation of macrophage ApoE in a nonlysosomal compartment. Regulation by sterols. J. Biol. Chem. 272:31156-31162.
23. Rivett, A.J. 1989. The multicatalytic proteinase. Multiple proteolytic activities. J. Biol. Chem. 264:12215-12219.
24. Feingold, K.R., Lear, S.R., and Moser, A.H. 1984. De novo cholesterol synthesis in three different animal models of diabetes. Diabetologia. 26:234-239.
25. Neufeld, E.B., et al. 1996. Intracellular trafficking of cholesterol monitored with a cyclodextrin. J. Biol. Chem. 271:21604-21613.
26. Mayor, S., Sabharanjak, S., and Maxfield, F.R. 1998. Cholesterol-dependent retention of GPI-anchored proteins in endosomes. EMBO J. 17:4626-4638.
27. Rodal, S.K., et al. 1999. Extraction of cholesterol with methyl beta-cyclodextrin perturbs formation of clathrin-coated endocyric vesicles. Mol. Biol. Cell. 10:961-974.
28. Shimomura, I., Bashmakov, Y., and Horton, J.D. 1999. Increased levels of nuciear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J. Biol. Chem. 274:30028-30032.