Comparison of pig, human and rat hepatocytes as a source of liver specific metabolic functions in culture systems - Implications for use in bioartificial liver devices

International Journal of Artificial Organs

Volumn 24, Issue 6, 2001, Pages 392-396

  Vilei, M T ^a   Granato, A ^a   Ferraresso, C ^a   Neri, D ^a   Carraro, P ^a   Gerunda, G ^a   Muraca, M ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Bioartificial liver; Hepatocyte; Species differences

Indexed keywords

CELLS; CYTOLOGY; METABOLISM; RATS; UREA;

ANIMAL CELLS; BIOARTIFICIAL LIVER; BIOARTIFICIAL LIVER DEVICES; CULTURE SYSTEMS; HEPATOCYTES; HUMAN HEPATOCYTES; METABOLIC ACTIVITY; METABOLIC FUNCTION; RAT HEPATOCYTES; SPECIES DIFFERENCE;

ARTIFICIAL ORGANS;

BILIRUBIN; DIAZEPAM; UREA;

ANIMAL CELL; ARTICLE; ARTIFICIAL LIVER; BILIRUBIN BINDING; CELL CULTURE; CELL ISOLATION; COMPARATIVE STUDY; DRUG METABOLISM; HUMAN; HUMAN CELL; LIVER CELL; LIVER METABOLISM; NONHUMAN; RAT; SWINE;

EID: 0034878090     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139880102400609     Document Type: Article

References (29)

1. Review of support systems used in the management of fulminant hepatic failure
2. Hepatic support strategies
3. Hybrid liver support
4. Clinical experience with a bioartificial liver in the treatment of severe liver failure. A phase I clinical trial
5. Hepatocyte liver assist system - A clinical update
6. Artificial liver
7. Artificial liver: The biological core
8. Automated liver cell processing facilitates large scale isolation and purification of porcine hepatocytes
9. Characterization of drug metabolizing activities in pig hepatocytes for use in bioartificial liver devices: Comparison with other hepatic cellular models
10. Hepatocyte culture between woven capillary networks: A microscopy study
11. Which hepatocyte will it be? Hepatocyte choice for bioartificial liver support systems
12. Xenobiotic induction of P-450 PB-40 (IIB1) and P-450c (IA1) and associated monooxygenase activities in primary cultures of adult rat hepatocytes
13. Pharmacokinetic analysis verifies P450 function during in vitro and in vivo application of a bioartificial liver
14. Primary or established liver cells for a hybrid liver? Comparison of metabolic features
15. Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver
16. Preparation of isolated rat liver cells
17. Connective tissue biomatrix: Its isolation and utilization for long-term cultures of normal rat hepatocytes
18. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
19. Identification and measurement by high-performance liquid chromatography of mono- and diester conjugates of bilirubin in human serum of healthy adults
20. Comparison in different species of bilirubin IXa conjugates with the activities of hepatic and renal bilirubin IXa uridine diphosphate glycosyltransferase
21. Functional activity of isolated pig hepatocytes in a bioartificial liver
22. Infection of human cells by an endogenous retrovirus of pigs
23. Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice
24. Evidence of absence of porcine endogenous retrovirus (PERV) infection in patients treated with bioartificial liver support system
25. Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue
26. A hybrid artificial liver system. Function of cultured monolyer pig hepatocytes in plasma from hepatic failure patients
27. Ammonia: A key factor in the pathogenesis of hepatic encephalopathy
28. Biochemical alterations in neonatal hyperbilirubinemia and bilirubin encephalopathy: A review
29. Acute renal failure treated by hemofiltration: Factors affecting outcome