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Volumn 88, Issue 12, 1999, Pages 1340-1347

In vitro transepithelial drug transport by on-line measurement: Cellular control of paracellular and transcellular transport

Author keywords

[No Author keywords available]

Indexed keywords

CALCEIN; DAUNORUBICIN; DIGITONIN; DILTIAZEM; FLUORESCEIN ISOTHIOCYANATE; FLUORESCENT DYE; IDARUBICIN; VALSPODAR; VERAPAMIL;

EID: 0032748841     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js980497z     Document Type: Article
Times cited : (12)

References (39)
  • 1
    • 0344731684 scopus 로고    scopus 로고
    • Barriers to delivery of macromolecules
    • Topp E. M. Barriers to delivery of macromolecules. Med. Chem. Res. 1997, 7, 493-508.
    • (1997) Med. Chem. Res. , vol.7 , pp. 493-508
    • Topp, E.M.1
  • 2
    • 0031563891 scopus 로고    scopus 로고
    • Transcellular and paracellular contribution to transport processes in the colorectal route
    • Hayashi M.; Tomita M.; Awazu S. Transcellular and paracellular contribution to transport processes in the colorectal route. Adv. Drug Deliv. Rev. 1997, 28, 191-204.
    • (1997) Adv. Drug Deliv. Rev. , vol.28 , pp. 191-204
    • Hayashi, M.1    Tomita, M.2    Awazu, S.3
  • 3
    • 0031925268 scopus 로고    scopus 로고
    • Human intestinal permeability
    • Lennernas H. Human intestinal permeability. J. Pharm. Sci. 1998, 87, 403-410.
    • (1998) J. Pharm. Sci. , vol.87 , pp. 403-410
    • Lennernas, H.1
  • 4
    • 0030273255 scopus 로고    scopus 로고
    • Cell adhesion, cell junctions and the blood-brain barrier
    • Staddon J. M.; Rubin L. L. Cell adhesion, cell junctions and the blood-brain barrier. Curr. Opin. Neurobiol. 1996, 6, 622-627.
    • (1996) Curr. Opin. Neurobiol. , vol.6 , pp. 622-627
    • Staddon, J.M.1    Rubin, L.L.2
  • 5
    • 0031918158 scopus 로고    scopus 로고
    • Role of tight junctions in establishing and maintaining cell polarity
    • Cereijido M.; Valdes J.; Shoshani L.; Contreras R. G. Role of tight junctions in establishing and maintaining cell polarity. Annu. Rev. Physiol. 1998, 60, 161-177.
    • (1998) Annu. Rev. Physiol. , vol.60 , pp. 161-177
    • Cereijido, M.1    Valdes, J.2    Shoshani, L.3    Contreras, R.G.4
  • 6
    • 0031944250 scopus 로고    scopus 로고
    • Molecular architecture of tight junctions
    • Mitic L. L.; Anderson J. M. Molecular architecture of tight junctions. Annu. Rev. Physiol. 1998, 60, 121-142.
    • (1998) Annu. Rev. Physiol. , vol.60 , pp. 121-142
    • Mitic, L.L.1    Anderson, J.M.2
  • 7
    • 0031944543 scopus 로고    scopus 로고
    • Routes and mechanism of fluid transport by epithelia
    • Spring K. R. Routes and mechanism of fluid transport by epithelia. Annu. Rev. Physiol. 1998, 60, 105-119.
    • (1998) Annu. Rev. Physiol. , vol.60 , pp. 105-119
    • Spring, K.R.1
  • 8
    • 0031893146 scopus 로고    scopus 로고
    • Organic cation transporters in intestine, kidney, liver, and brain
    • Koepsell H. Organic cation transporters in intestine, kidney, liver, and brain. Annu. Rev. Physiol. 1998, 60, 243-266.
    • (1998) Annu. Rev. Physiol. , vol.60 , pp. 243-266
    • Koepsell, H.1
  • 10
    • 0029954843 scopus 로고    scopus 로고
    • P-glycoprotein - A mediator of multidrug resistance in tumour cells
    • Germann U. A. P-glycoprotein - A mediator of multidrug resistance in tumour cells. Eur. J. Cancer 1996, 32A, 927-944.
    • (1996) Eur. J. Cancer , vol.32 A , pp. 927-944
    • Germann, U.A.1
  • 11
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
    • Juliano R. L.; Ling V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim. Biophys. Acta 1976, 455, 152-162.
    • (1976) Biochim. Biophys. Acta , vol.455 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 12
    • 0029939665 scopus 로고    scopus 로고
    • Experimental reversal of P-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisers
    • Ford J. M. Experimental reversal of P-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisers. Eur. J. Cancer 1996, 32A, 991-1001.
    • (1996) Eur. J. Cancer , vol.32 A , pp. 991-1001
    • Ford, J.M.1
  • 14
    • 0030975889 scopus 로고    scopus 로고
    • Genetic dissection of the function of mammalian P-glycoproteins
    • Borst P.; Schinkel A. H. Genetic dissection of the function of mammalian P-glycoproteins. Trends Genet. 1997, 13, 217-222.
    • (1997) Trends Genet. , vol.13 , pp. 217-222
    • Borst, P.1    Schinkel, A.H.2
  • 15
    • 0031158805 scopus 로고    scopus 로고
    • The physiological function of drug-transporting P-glycoproteins
    • Schinkel A. H. The physiological function of drug-transporting P-glycoproteins. Semin. Cancer. Biol. 1997, 8, 161-170.
    • (1997) Semin. Cancer. Biol. , vol.8 , pp. 161-170
    • Schinkel, A.H.1
  • 17
    • 0029102179 scopus 로고
    • Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: Uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers
    • Adson A.; Burton P. S.; Raub T. J.; Barsuhn C. L.; Audus K. L.; Ho N. F. H. Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: Uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers. J. Pharm. Sci. 1995, 84, 1197-1204.
    • (1995) J. Pharm. Sci. , vol.84 , pp. 1197-1204
    • Adson, A.1    Burton, P.S.2    Raub, T.J.3    Barsuhn, C.L.4    Audus, K.L.5    Ho, N.F.H.6
  • 19
    • 0031943571 scopus 로고    scopus 로고
    • Regulation of the movement of solutes across tight junctions
    • Madara J. L. Regulation of the movement of solutes across tight junctions. Annu. Rev. Physiol. 1998, 60, 143-159.
    • (1998) Annu. Rev. Physiol. , vol.60 , pp. 143-159
    • Madara, J.L.1
  • 20
    • 0030601332 scopus 로고    scopus 로고
    • Chronic exposure of LLC-PK1 epithelia to the phorbol ester TPA produces polyp-like foci with leaky tight junctions and altered protein kinase C-alpha expression and localization
    • Mullin J. M.; Soler A. P.; Laughlin K. V.; Kampherstein J. A.; Russo L. M.; Saladik D. T.; George K.; Shurina R. D.; O'Brien T. G. Chronic exposure of LLC-PK1 epithelia to the phorbol ester TPA produces polyp-like foci with leaky tight junctions and altered protein kinase C-alpha expression and localization. Exp. Cell Res. 1996, 227, 12-22.
    • (1996) Exp. Cell Res. , vol.227 , pp. 12-22
    • Mullin, J.M.1    Soler, A.P.2    Laughlin, K.V.3    Kampherstein, J.A.4    Russo, L.M.5    Saladik, D.T.6    George, K.7    Shurina, R.D.8    O'Brien, T.G.9
  • 21
    • 0030774488 scopus 로고    scopus 로고
    • P-glycoprotein-independent decrease in drug accumulation by phorbol ester treatment of tumor cells
    • Wielinga P. R.; Heijn M.; Broxterman H. J.; Lankelma J. P-glycoprotein-independent decrease in drug accumulation by phorbol ester treatment of tumor cells. Biochem. Pharmacol. 1997, 54, 791-799.
    • (1997) Biochem. Pharmacol. , vol.54 , pp. 791-799
    • Wielinga, P.R.1    Heijn, M.2    Broxterman, H.J.3    Lankelma, J.4
  • 22
    • 0025604425 scopus 로고
    • Evidence for daunomycin efflux from multidrug-resistant 2780AD human ovarian carcinoma cells against a concentration gradient
    • Lankelma J.; Spoelstra E. C.; Dekker H.; Broxterman H. J. Evidence for daunomycin efflux from multidrug-resistant 2780AD human ovarian carcinoma cells against a concentration gradient. Biochim. Biophys. Acta 1990, 1055, 217-222.
    • (1990) Biochim. Biophys. Acta , vol.1055 , pp. 217-222
    • Lankelma, J.1    Spoelstra, E.C.2    Dekker, H.3    Broxterman, H.J.4
  • 23
    • 0032532385 scopus 로고    scopus 로고
    • A method for studying plasma membrane transport with intact cells using computerized fluorometry
    • Wielinga, P. R.; Heijn, M.; Westerhoff, H. V.; Lankelma, J. A method for studying plasma membrane transport with intact cells using computerized fluorometry. Anal. Biochem. 1998, 263, 221-231.
    • (1998) Anal. Biochem. , vol.263 , pp. 221-231
    • Wielinga, P.R.1    Heijn, M.2    Westerhoff, H.V.3    Lankelma, J.4
  • 24
    • 0020426961 scopus 로고
    • A flow-through tissue culture system with fast dynamic response
    • Lankelma J.; Laurensse E.; Pinedo H. M. A flow-through tissue culture system with fast dynamic response. Anal. Biochem. 1982, 127, 340-345.
    • (1982) Anal. Biochem. , vol.127 , pp. 340-345
    • Lankelma, J.1    Laurensse, E.2    Pinedo, H.M.3
  • 26
    • 0028080058 scopus 로고
    • Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayers
    • Adson A.; Raub T. J.; Burton P. S.; Barsuhn C. L.; Hilgers A. R.; Audus K. L.; Ho N. F. H. Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayers. J. Pharm. Sci. 1994, 83, 1529-1536.
    • (1994) J. Pharm. Sci. , vol.83 , pp. 1529-1536
    • Adson, A.1    Raub, T.J.2    Burton, P.S.3    Barsuhn, C.L.4    Hilgers, A.R.5    Audus, K.L.6    Ho, N.F.H.7
  • 27
    • 0029041046 scopus 로고
    • Regulated assembly of tight junctions by protein kinase C
    • Stuart R. O.; Nigam S. K. Regulated assembly of tight junctions by protein kinase C. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 6072-6076.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 6072-6076
    • Stuart, R.O.1    Nigam, S.K.2
  • 30
    • 0029971199 scopus 로고    scopus 로고
    • Absorption-enhancing mechanism of EDTA, caprate, and decanoylcarnitine in Caco-2 cells
    • Tomita M.; Hayashi M.; Awazu S. Absorption-enhancing mechanism of EDTA, caprate, and decanoylcarnitine in Caco-2 cells. J. Pharm. Sci. 1996, 85, 608-611.
    • (1996) J. Pharm. Sci. , vol.85 , pp. 608-611
    • Tomita, M.1    Hayashi, M.2    Awazu, S.3
  • 32
    • 0028261021 scopus 로고
    • Paracellular barrier and junctional protein distribution depend on basolateral extracellular Ca2+ in cultured epithelia
    • Collaresbuzato C. B.; Mcewan G. T. A.; Jepson M. A.; Simmons N. L.; Hirst B. H. Paracellular barrier and junctional protein distribution depend on basolateral extracellular Ca2+ in cultured epithelia. Biochim. Biophys. Acta 1994, 1222, 147-158.
    • (1994) Biochim. Biophys. Acta , vol.1222 , pp. 147-158
    • Collaresbuzato, C.B.1    Mcewan, G.T.A.2    Jepson, M.A.3    Simmons, N.L.4    Hirst, B.H.5
  • 33
    • 0028926288 scopus 로고
    • Basolateral but not apical application of protease results in a rapid rise of transepithelial electrical resistance and formation of aberrant tight junction strands in MDCK cells
    • Lynch R. D.; Tkachukross L. J.; Mccormack J. M.; Mccarthy K. M.; Rogers R. A.; Schneeberger E. E. Basolateral but not apical application of protease results in a rapid rise of transepithelial electrical resistance and formation of aberrant tight junction strands in MDCK cells. Eur. J. Cell. Biol. 1995, 66, 257-267.
    • (1995) Eur. J. Cell. Biol. , vol.66 , pp. 257-267
    • Lynch, R.D.1    Tkachukross, L.J.2    Mccormack, J.M.3    Mccarthy, K.M.4    Rogers, R.A.5    Schneeberger, E.E.6
  • 34
    • 0029122307 scopus 로고
    • Phosphorylation of the tight junction protein cingulin and the effects of protein kinase inhibitors and activators in MDCK epithelial cells
    • Citi S.; Denisenko N. Phosphorylation of the tight junction protein cingulin and the effects of protein kinase inhibitors and activators in MDCK epithelial cells. J. Cell. Sci. 1995, 108, 2917-2926.
    • (1995) J. Cell. Sci. , vol.108 , pp. 2917-2926
    • Citi, S.1    Denisenko, N.2
  • 35
    • 0031809132 scopus 로고    scopus 로고
    • Increased tyrosine phosphorylation causes redistribution of adherens junction and tight junction proteins and perturbs paracellular barrier function in MDCK epithelia
    • Collaresbuzato C. B.; Jepson M. A.; Simmons N. L.; Hirst B. H. Increased tyrosine phosphorylation causes redistribution of adherens junction and tight junction proteins and perturbs paracellular barrier function in MDCK epithelia. Eur. J. Cell. Biol. 1998, 76, 85-92.
    • (1998) Eur. J. Cell. Biol. , vol.76 , pp. 85-92
    • Collaresbuzato, C.B.1    Jepson, M.A.2    Simmons, N.L.3    Hirst, B.H.4
  • 36
    • 0030982357 scopus 로고    scopus 로고
    • Possible involvement of phosphorylation of occludin in tight junction formation
    • Sakakibara A.; Furuse M.; Saitou M.; AndoAkatsuka Y.; Tsukita S. Possible involvement of phosphorylation of occludin in tight junction formation. J. Cell. Biol. 1997, 137, 1393-1401.
    • (1997) J. Cell. Biol. , vol.137 , pp. 1393-1401
    • Sakakibara, A.1    Furuse, M.2    Saitou, M.3    Andoakatsuka, Y.4    Tsukita, S.5
  • 37
    • 0028063302 scopus 로고
    • Drug excretion mediated by a new prototype of polyspecific transporter
    • Grundemann D.; Gorboulev V.; Gambaryan S.; Veyhl M.; Koepsell H. Drug excretion mediated by a new prototype of polyspecific transporter. Nature 1994, 372, 549-552.
    • (1994) Nature , vol.372 , pp. 549-552
    • Grundemann, D.1    Gorboulev, V.2    Gambaryan, S.3    Veyhl, M.4    Koepsell, H.5
  • 38
    • 0020356720 scopus 로고
    • Membrane transport of anthracyclines
    • Skovsgaard T.; Nissen N. I. Membrane transport of anthracyclines. Pharm. Ther. 1982, 18, 293-311.
    • (1982) Pharm. Ther. , vol.18 , pp. 293-311
    • Skovsgaard, T.1    Nissen, N.I.2
  • 39
    • 0031869860 scopus 로고    scopus 로고
    • Heterologous expression of various P-glycoproteins in polarized epithelial cells induces directional transport of small (type 1) and bulky (type 2) cationic drugs
    • Smit J. W.; Weert B.; Schinkel A. H.; Meijer D. K. F. Heterologous expression of various P-glycoproteins in polarized epithelial cells induces directional transport of small (type 1) and bulky (type 2) cationic drugs. J. Pharmacol. Exp. Ther. 1998, 286, 321-327.
    • (1998) J. Pharmacol. Exp. Ther. , vol.286 , pp. 321-327
    • Smit, J.W.1    Weert, B.2    Schinkel, A.H.3    Meijer, D.K.F.4


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