Inhibitors of apoptosis proteins in injury and disease

IUBMB Life

Volumn 54, Issue 5, 2002, Pages 231-240

  Lotocki, George ^a   Keane, Robert W ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Cancer; Caspases; Excitotoxic injury; Inhibitors of apoptosis; Neurodegeneration; Review; Spinal cord injury; Transforming growth factor beta signaling; Traumatic brain injury; Tumor necrosis factor signaling

Indexed keywords

BINDING PROTEIN; CASPASE; CASPASE 3; CASPASE 7; CASPASE 9; CELL SURFACE RECEPTOR; CYTOKINE RECEPTOR; INHIBITOR OF APOPTOSIS PROTEIN; SURVIVIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR RECEPTOR;

APOPTOSIS; BRAIN INJURY; CANCER; CELL DEATH; DEGENERATIVE DISEASE; DNA DAMAGE; GENETIC TRANSCRIPTION; HUMAN; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; MULTIGENE FAMILY; NERVE CELL LESION; NERVOUS SYSTEM INJURY; NEUROLOGIC DISEASE; NONHUMAN; REVIEW; RNA TRANSLATION; SIGNAL TRANSDUCTION; SPINAL CORD INJURY; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, BIOLOGICAL; MULTIGENE FAMILY; NEOPLASM PROTEINS; NEOPLASMS; NERVE TISSUE PROTEINS; NEURONAL APOPTOSIS-INHIBITORY PROTEIN; NEURONS; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, TERTIARY; PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

INTRACISTERNAL A-PARTICLES;

EID: 0036878240     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216540215675     Document Type: Review

References (66)

1. Holcik, M., Gibson, H., and Kornluk, R. G. (2001) XIAP: apoptotic brake and promising therapeutic target. Apoptosis 6, 253-261.
2. Salvesen, G. S., and Duckett, C. S. (2002) IAP proteins: blocking the road to death's door. Nat. Mol. Cell Biol. 3, 401-410.
3. Stennicke, H. R., Ryan, C. A., and Salvesen, G. S. (2002) Reprieval from execution: the molecular basis of caspase inhibition. Trends Biochem. Sci. 27, 94-101.
4. Verhagen, A. M., Coulson, E. J., and Vaux, D. L. (2001) Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs. Genome Biol. 2(7), 3009.1-3009.10.
5. Li, X., Yang, Y., and Ashwell, J. D. (2002) TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature 416(6878), 345-347.
6. Rothe, M., Pan, M. G., Henzel, W. J., Ayres, T. M., and Goeddel, D. V. (1995) The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 83(7), 1243-1252.
7. Uren, A. G., Pakusch, M., Hawkins, C. J., Puls, K. L., and Vaux, D. L. (1996) Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. Proc. Natl. Acad. Sci. U.S.A. 93(10), 4974-4878.
8. Keane, R. W., Kraydieh, S., Lotocki, G., Alonso. O. F., Aldana, P., and Dietrich, W. D. (2001) Apoptotic and antiapoptotic mechanisms after traumatic brain injury. J. Cereb. Blood Flow Metab. 21(10), 1189-1198.
9. Keane, R. W., Kraydieh, S., Lotocki, G., Bethea, J. R., Krajewski, S., Reed, J. C., and Dietrich, W. D. (2001) Apoptotic and anti-apoptotic mechanisms following spinal cord injury. J. Neuropathol. Exp. Neurol. 60(5), 422-429.
10. Chen, Z., Naito, M., Hori, S., Mashima, T., Yamori, T., and Tsuruo, T. (1999) A human IAP-family gene, apollon, expressed in human brain cancer cells. Biochem. Biophys. Res. Commun. 264(3), 847-854.
11. Jordan, B. W., Dinev, D., LeMellay, V., Troppmair, J., Gotz, R., Wixler, L., Sendtner, M., Ludwig, S., and Rapp, U. R. (2001) Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death. J. Biol. Chem. 276, 39985-39989.
12. Yamaguchi, K., Nagai, S., Ninomiya-Tsuji, J., Nishita, M., Tamai, K., Irie, K., Ueno, N., Nishida, E., Shibuya, H., and Matsumoto, K. (1999) XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. EMBO J. 18(1), 179-187.
13. Birkey Reffey, S., Wurthner, J. U., Parks, W. T., Roberts, A. B., and Duckett, C. S. (2001) X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling. J. Biol. Chem. 276(28), 26542-26549.
14. Sarma, M. G., da Silva Correia, J., Ducrey, O., Lee, J., Nomoto, K., Schrantz, N., Deveraux, Q. L., and Ulevitch, R. J. (2002) IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition. Mol. Cell Biol. 22(6), 1754-1766.
15. Tang, G., Minemoto, Y., Dibling, B., Purcell, N. H., Li, Z., Karin, M., and Lin, A. (2001) Inhibition of JNK activation through NF-κB target genes. Nature 414, 313-317.
16. Shin, S., Sung, B. J., Cho, Y. S., Kim, H. J., Ha, N. C., Hwang, J. I., Chung, C. W., Jung, Y. K., and Oh, B. H. (2001) An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. Biochemistry 40(4), 1117-1123.
17. Chu, Z. L., McKinsey, T. A., Liu, L., Gentry, J. J., Malim, M. H., and Ballard, D. W. (1997) Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control. Proc. Natl. Acad. Sci. U.S.A. 94(19), 10057-10062.
18. Mattson, M. P., Culmsee, C., Yu. Z., and Camandola, S. (2000) Roles of nuclear factor-κB in neuronal survival and plasticity. J. Neurochem. 74, 443-456.
19. Stehlik, C., de Martin, R., Kumabashiri, I., Schmid, J. A., Binder, B. R., and Lipp, J. (1998) Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis. J. Exp. Med. 188(1), 211-216.
20. Simic, G., Seso-Simic, D., Lucassen, P. J., Islam, A., Krsnik, Z., Cviko, A., Jelasic, D., Barisic, N., Winblad, B., Kostovic, I., and Kruslin, B. (2000) Ultrastructural analysis and TUNEL demonstrate motor neuron apoptosis in Werdnig -Hoffmann disease. J. Neuropathol. Exp. Neurol. 59(5), 398-407.
21. McEleny, K. R., Watson, R. W., Coffey, R. N., O'Neill, A. J., and Fitzpatrick, J. M. (2002) Inhibitors of apoptosis proteins in prostate cancer cell lines. Prostate 51(2), 133-140.
22. Messineo, C., Jamerson, M. H., Hunter, E., Braziel, R., Bagg, A., Irving, S. G., and Cossman, J. (1998) Gene expression by single Reed-Sternberg cells: pathways of apoptosis and activation. Blood 91(7), 2443-2451.
23. Pryhuber, G. S., Huyck, H. L., Staversky, R. J., Finkelstein, J. N., and O'Reilly, M. A. (2000) Tumor necrosis factor-alpha-induced lung cell expression of antiapoptotic genes TRAF1 and cIAP2. Am. J. Respir. Cell Mol. Biol. 22(2), 150-156.
24. Imoto, I., Yang, Z. Q., Pimkhaokham, A., Tsuda, H., Shimada, Y., Imamura, M., Ohki, M., and Inazawa, J. (2001) Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas. Cancer Res. 61(18), 6629-6634.
25. Fang, G., Kim, C. N., Perkins, C. L., Ramadevi, N., Winton, E., Wittmann, S., and Bhalla, K. N. (2000) CGP57148B (STI-571) induces differentiation and apoptosis and sensitizes Bcr-Abl-positive human leukemia cells to apoptosis due to antileukemic drugs. Blood 96(6), 2246-2253.
26. Tamm, I., Kornblau, S. M., Segall, H., Krajewski, S., Welsh, K., Kitada, S., Scudiero, D. A., Tudor, G., Qui, Y. H., Monks, A., Andreeff, M., and Reed, J. C. (2000) Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin. Cancer Res. 6(5), 1796-1803.
27. Tamm, I., Wang, Y., Sausville, E., Scudiero, D. A., Vigna, N., Oltersdorf, T., and Reed, J. C. (1998) IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 58(23), 5315-5320.
28. Sawaya, M. E., Blume-Peytavi, U., Mullins, D. L., Nusbaum, B. P., Whiting, D., Nicholson, D. W., Lotocki, G., and Keane, R. W. (2002) Effects of finasteride on apoptosis and regulation of the human hair cycle. J. Cutan. Med. Surg. 6(1), 1-9.
29. Xu, D. G., Crocker, S. J., Doucet, J. P., St-Jean, M., Tamai, K., Hakim, A. M., Ikeda, J. E., Liston, P., Thompson, C. S., Kornluk, R. G., MacKenzie, A., and Robertson, G. S. (1997) Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus. Nat. Med. 3(9), 997-1004.
30. Xu, D., Bureau, Y., McIntyre, D. C., Nicholson, D. W., Liston, P., Zhu, Y., Fong, W. G., Crocker, S. J., Kornluk, R. G., and Robertson, G. S. (1999) Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus. J. Neurosci. 19(12), 5026-5033.
31. Perrelet, D., Ferri, A., MacKenzie, A. E., Smith, G. M., Kornluk, R. G., Liston, P., Sagot, Y., Terrado, J., Monnier, D., and Kato, A. C. (2000) IAP family proteins delay motor neuron cell death in vivo. Eur. J. Neurosci. 12(6), 2059-2067.
32. Belluardo, N., Korhonen, L., Mudo, G., and Lindholm, D. (2002) Neuronal expression and regulation of rat inhibitor of apoptosis protein-2 by kainic acid in the rat brain. Eur J. Neurosci. 15(1), 87-100.
33. Korhonen, L., Belluardo, N., and Lindholm, D. (2001) Regulation of X-chromosome-linked inhibitor of apoptosis protein in kainic acid-induced neuronal death in the rat hippocampus. Mol. Cell Neurosci. 17(2), 364-372.
34. Simons, M., Beinroth, S., Gleichmann, M., Liston, P., Kornluk, R. G., MacKenzie, A. E., Bahr, M., Klockgether, T., Robertson, G. S., Weller, M., and Schulz, J. B. (1999) Adenovirus-mediated gene transfer of inhibitors of apoptosis protein delays apoptosis in cerebellar granule neurons. J. Neurochem. 72(1), 292-301.
35. Kim, G. M., Xu, J., Xu, J., Song, S. K., Yan, P., Ku, G., Xu, X. M., and Hsu, C. Y. (2001) Tumor necrosis factor receptor deletion reduces nuclear factor-kappaB activation, cellular inhibitor of apoptosis protein 2 expression, and functional recovery after traumatic spinal cord injury. J. Neurosci. 21(17), 6617-6625.
36. Johnson, D. E., Gastman, B. R., Wieckowski, E., Wang, G. Q., Amoscato, A., Delach, S. M., and Rabinowich, H. (2000) Inhibitor of apoptosis protein hILP undergoes caspase-mediated cleavage during T lymphocyte apoptosis. Cancer Res. 60(7), 1818-1823.
37. Clem, R. J., Sheu, T. T., Richter, B. W., He, W. W., Thornberry, N. A., Duckett, C. S., and Hardwick, J. M. (2001) c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment. J. Biol. Chem. 276(10), 7602-7608.
38. Herrera, B., Fernandez, M., Benito, M., and Fabregat, I. (2002) cIAP-1, but not XIAP, is cleaved by caspases during the apoptosis induced by TGF-beta in fetal rat hepatocytes. FEBS Lett. 520(1-3), 93-96.
39. Katz, L. M., Lotocki, G., Wang, Y., Kraydieh, S., Dietrich, W. D., and Keane, R. W. (2001) Regulation of caspases and XIAP in the brain after asphyxial cardiac arrest in rats. Neuroreport 12(17), 3751-3754.
40. Dong, Z., Nishiyama, J., Yi, X., Venkatachalam, M. A., Denton, M., Gu, S., Li, S., and Qiang, M. (2002) Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia. Biochem J. 364(2), 413-421.
41. Dong, Z., Venkatachalam, M. A., Wang, J., Patel, Y., Saikumar, P., Semenza, G. L., Force, T., and Nishiyama, J. (2001) Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms. J. Biol. Chem. 276(22), 18702-18709.
42. Mercer, E. A., Korhonen, L., Skoglosa, Y., Olsson, P. A., Kukkonen, J. P., and Lindholm, D. (2000) NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways. EMBO J. 19(14), 3597-3607.
43. Perrelet, D., Ferri, A., Liston, P., Muzzin, P., Kornluk, R. G., and Kato, A. C. (2002) IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo. Nat. Cell Biol. 4(2), 175-179.
44. Diez, E., Yaraghi, Z., MacKenzie, A., and Gros, P. (2000) The neuronal apoptosis inhibitory protein (Naip) is expressed in macrophages and is modulated after phagocytosis and during intracellular infection with Legionella pneumophila. J. Immunol. 164(3), 1470-1477.
45. Seidl, R., Bajo, M., Bohm, K., LaCasse, E. C., MacKenzie, A. E., Cairns, N., and Lubec, G. (1999) Neuronal apoptosis inhibitory protein (NAIP)-like immunoreactivity in brains of adult patients with Down syndrome. J. Neural Transm. Suppl. 57, 283-291.
46. Lu, C. D., Altieri, D. C., and Tanigawa, N. (1988) Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas. Cancer Res. 58(9), 1808-1812.
47. Ikehara, M., Oshita, F., Kameda, Y., Ito, H., Ohgane, N., Suzuki, R., Saito, H., Yamada, K., Noda, K., and Mitsuda, A. (2002) Expression of survivin correlated with vessel invasion is a marker of poor prognosis in small adenocarcinoma of the lung. Oncol. Rep. 9(4), 835-838.
48. Ikeguchi, M., Ueda, T., Sakatani, T., Hirooka, Y., and Kaibara, N. (2002) Expression of survivin messenger RNA correlates with poor prognosis in patients with hepatocellular carcinoma. Diagn. Mol. Pahol. 11(1), 33-40.
49. Ito, T., Shiraki, K., Sugimoto, K., Yamanaka, T., Fujikawa, K., Ito, M., Takase, K., Moriyama, M., Kawano, H., Hayashida, M., Nakano, T., and Suzuki, A. (2000) Survivin promotes cell proliferation in human hepatocellular carcinoma. Hepatology 31(5), 1080-1085.
50. Adida, C., Haioun, C., Gaulard, P., Lepage, E., Morel, P., Briere, J., Dombret, H., Reyes, F., Diebold, J., Gisselbrecht, C., Salles, G., Altieri, D. C., and Molina, T. J. (2000) Prognostic significance of survivin expression in diffuse large B-cell lymphomas. Blood 96(5), 1921-1925.
51. Grossman, D., Kim, P. J., Schechner, J. S., and Altieri, D. C. (2001) Inhibition of melanoma tumor growth in vivo by survivin targeting. Proc. Natl. Acad. Sci. U.S.A. 98(2), 635-640.
52. Kato, J., Kuwabara, Y., Mitani, M., Shinoda, N., Sato, A., Toyama, T., Mitsui, A., Nishiwaki, T., Moriyama, S., Kudo, J., and Fujii, Y. (2001) Expression of survivin in esophageal cancer: correlation with the prognosis and response to chemotherapy. Int. J. Cancer 95(2), 92-95.
53. Sarela, A. I., Verbeke, C. S., Ramsdale, J., Davies, C. L., Markham, A. F., and Guillou, P. J. (2002) Expression of survivin, a novel inhibitor of apoptosis and cell cycle regulatory protein, in pancreatic adenocarcinoma. Br. J. Cancer 86(6), 886-892.
54. Satoh, K., Kaneko, K., Hirota, M., Masamune, A., Satoh, A., and Shimosegawa, T. (2001) Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors. Cancer 92(2), 271-278.
55. Lo Muzio, L., Staibano, S., Pannone, G., Mignogna, M. D., Mariggio, A., Salvatore, G., Chieffi, P., Tramontano, D., De Rosa, G., and Altieri, D. C. (2001) Expression of the apoptosis inhibitor survivin in aggressive squamous cell carcinoma. Exp. Mol. Pathol. 70(3), 249-254.
56. Mori, A., Wada, H., Nishimura, Y., Okamoto, T., Takemoto, Y., and Kakishita, E. (2002) Expression of the antiapoptosis gene survivin in human leukemia. Int. J. Hematol. 75(2), 161-165.
57. Kim, H. S., Shiraki, K., and Park, S. H. (2002) Expression of survivin in CIN and invasive squamous cell carcinoma of uterine cervix. Anticancer Res. 22(2A), 805-808.
58. Doyle, B. T., O'Neill, A. J., Newsholme, P., Fitzpatrick, J. M., and Watson, R. W. (2002) The loss of IAP expression during HL-60 cell differentiation is caspase-independent. J. Leukoc. Biol. 71(2), 247-254.
59. Gotz, R., Karch, C., Digby, M. R., Troppmair, J., Rapp, U. R., and Sendtner, M. (2000) The neuronal apoptosis inhibitory protein suppresses neuronal differentiation and apoptosis in PC12 cells. Hum. Mol. Genet. 9(17), 2479-2489.
60. Manderscheid, M., Messmer, U. K., Franzen, R., and Pfeilschifter, J. (2001) Regulation of inhibitor of apoptosis expression by nitric oxide and cytokines: relation to apoptosis induction in rat mesangial cells and raw 264.7 macrophages. J. Am. Soc. Nephrol. 12(6), 1151-1163.
61. Cui, X., Imaizumi, T., Yoshida, H., Tanji, K., Matsumiya, T., and Satoh, K. (2000) Lipopolysaccharide induces the expression of cellular inhibitor of apoptosis protein-2 in human macrophages. Biochim. Biophys. Acta 1524(2-3), 178-182.
62. Shankar, S. L., Mani, S., O'Guin, K. N., Kandimalla, E. R., Agrawal, S., and Shafit-Zagardo, B. (2001) Survivin inhibition induces human neural tumor cell death through caspase-independent and -dependent pathways. J. Neurochem. 79(2), 426-436.
63. Zhu, L., Fukuda, S., Cordis, G., Das, D. K., and Maulik, N. (2001) Antiapoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning. FEBS Lett. 508(3), 369-374.
64. Hutchison, J. S., Derrane, R. E., Johnston, D. L., Gendron, N., Barnes, D., Fliss, H., King, W. J., Rasquinha, I., MacManus, J., Robertson, G. S., and MacKenzie, A. E. (2001) Neuronal apoptosis inhibitory protein expression after traumatic brain injury in the mouse. J. Neurotrauma 18(12), 1333-1347.
65. Robertson, G. S., Crocker, S. J., Nicholson. D. W., and Schulz, J. B. (2000) Neuroprotection by the inhibition of apoptosis. Brain Pathol. 10(2), 283-292.
66. Crocker, S. J., Wigle, N., Liston, P., Thompson, C. S., Lee, C. J., Xu, D., Roy, S., Nicholson, D. W., Park, D. S., MacKenzie, A., Kornluk, R. G., and Robertson, G. S. (2001) NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease. Eur. J. Neurosci. 14(2), 391-400.