Proline ameliorates arginine deficiency during enteral but not parenteral feeding in neonatal piglets

American Journal of Physiology - Endocrinology and Metabolism

Volumn 277, Issue 2 40-2, 1999, Pages

  Brunton, Janet A ^a   Bertolo, Robert F P ^b   Pencharz, Paul B ^a,b,c   Ball, Ronald O ^a,b,c  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF GUELPH   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Hyperammonemia; Newborn; Total parenteral nutrition; Urea cycle

Indexed keywords

AMMONIA; ARGININE; PROLINE;

AMINO ACID DEFICIENCY; AMINO ACID SYNTHESIS; AMMONIA BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENTERIC FEEDING; MALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SWINE; TOTAL PARENTERAL NUTRITION; UREA CYCLE;

EID: 0032847848     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.277.2.e223     Document Type: Article

References (31)

1. Alverdy, J. C. Amino acids to support gut function and morphology. In: Amino Acid Metabolism and Therapy in Health and Nutritional Disease, edited by L. A. Cynober. New York: CRC, 1995, p. 435-440.
2. Batshaw, M. L., R. C. Wachtel, G. H. Thomas, A. Starrett, and S. W. Brusilow. Arginine-responsive asymptomatic hyperammonemia in the premature infant. J. Pediatr. 105: 86-90, 1984.
3. Bertolo, R. F. P., P. B. Pencharz, and R. O. Ball. A comparison of parenteral and enteral feeding in neonatal piglets including assessment of the utilization of a glutamine-rich pediatric elemental diet. J. Parent. Enteral Nutr. In press.
4. Bidlingmeyer, B. A., S. A. Cohen, and T. L. Tarvin. Rapid analysis of amino acids using pre-column derivation. J. Chromatogr. 336: 93-104, 1984.
5. Blachier, F., H. M'Rabet-Touil, L. Posho, B. Darcy-Vrillon, and P. H. Duee. Intestinal arginine metabolism during development. Evidence for de novo synthesis of L-arginine in newborn pig enterocytes. Eur. J. Biochem. 216: 109-117, 1993.
6. Castillo, L., T. DeRojas-Walker, Y. M. Yu, M. Sanchez, T. E. Chapman, D. Shannon, S. Tannenbaum, J. F. Burke, and V. R. Young. Whole body arginine metabolism and nitric oxide synthesis in newborns with persistent pulmonary hypertension. Pediatr. Res. 38: 17-24, 1995.
7. Davis, T. A., H. V. Nguyen, R. Garcia-Bravo, M. L. Fiorotto, E. M. Jackson, D. S. Lewis, D. R. Lee, and P. J. Reeds. Amino acid composition of human milk is not unique. J. Nutr. 124: 1126-1132, 1994.
8. Dhanakoti, S. N., J. T. Brosnan, G. R. Hertzberg, and M. E. Brosnan. Renal arginine synthesis: studies in vitro and in vivo. Am. J. Physiol. 259 (Endocrinol. Metab. 22): E437-E442, 1990.
9. Di Lorenzo, M., J. Bass, and A. Krantis. Use of L-arginine in the treatment of experimental necrotizing enterocolitis. J. Pediatr. Surg. 30: 235-241, 1995.
10. Flynn, N. E., and G. Wu. An important role for endogenous synthesis of arginine in maintaining arginine homeostasis in neonatal pigs. Am. J. Physiol. 271 (Regulatory Integrative Comp. Physiol. 40): R1149-R1155, 1996.
11. Heird, W. C., J. F. Nicholson, J. M. Driscoll, J. N. Schullinger, and R. W. Winters. Hyperammonemia resulting from intravenous alimentation using a mixture of synthetic L-amino acids: a preliminary report. J. Pediatr. 81: 162-165, 1972.
12. 14C]phenylalanine. Am. J. Clin. Nutr. 67: 67-73, 1998.
13. Jones, M. E. Conversion of glutamate to ornithine and proline: pyrroline-5-carboxylate, a possible modulator of arginine requirements. J. Nutr. 115: 509-515, 1985.
14. Miller, R. G., T. H. Keshen, F. Jahoor, S. B. Shew, and T. Jaksic. Compartmentation of endogenously synthesized amino acids in neonates. J. Surg. Res. 63: 199-203, 1996.
15. Murch, S. J., R. L. Wilson, J. M. Murphy, and R. O. Ball. Proline is synthesized from intravenously infused arginine by piglets consuming low proline diets. Can. J. Anim. Sci. 76: 435-441, 1996.
16. Murphy, J. M., S. J. Murch, and R. O. Ball. Proline is synthesized from glutamate during intragastric infusion but not during intravenous infusion in neonatal piglets. J. Nutr. 126: 878-886, 1996.
17. Prior, R. L., and K. L. Gross. Dietary arginine deficiency and gut ammonium infusion alter flux of urea cycle intermediates across the portal-drained viscera of pigs. J. Nutr. 125: 251-263, 1995.
18. Samuels, S. E., H. L. M. Aarts, and R. O. Ball. Effect of dietary proline on proline metabolism in the neonatal pig. J. Nutr. 119: 1900-1906, 1989.
19. Seashore, J. H., M. R. Seashore, and C. Riely. Hyperammonemia during total parenteral nutrition in children. J. Parent. Enteral Nutr. 6: 114-118, 1982.
20. Shohat, M., E. Wielundky, and S. H. Reisner. Plasma ammonia levels in preterm infants receiving parenteral nutrition with crystalline L-amino acids. J. Parent. Enteral Nutr. 8: 178-180, 1984.
21. Southern, L. L., and D. H. Baker. Arginine requirement of the young pig. J. Anim. Sci. 57: 402-412, 1983.
22. Stoll, B., J. Henry, P. J. Reeds, H. Yu, F. Jahoor, and D. G. Burrin. Catabolism dominates the first-pass intestinal metabolism of dietary essential amino acids in milk protein-fed piglets. J. Nutr. 128: 606-614, 1998.
23. Thomas, D. W., F. R. Sinatra, S. L. Hack, T. M. Smith, A. C. G. Platzker, and R. J. Merritt. Hyperammonemia in neonates receiving intravenous nutrition. J. Parent. Enteral Nutr. 6: 503-506, 1982.
24. Vosatka, R. J., S. Kashyap, and R. R. Trifiletti. Arginine deficiency accompanies persistent pulmonary hypertension of the newborn. Biol. Neonate 66: 65-70, 1994.
25. Windmueller, H. G., and A. E. Spaeth. Intestinal metabolism of glutamine and glutamate from the lumen as compared to glutamine from blood. Arch. Biochem. Biophys. 171: 662-672, 1975.
26. Wu, G. Synthesis of citrulline and arginine from proline in enterocytes of postnatal pigs. Am. J. Physiol. 272 (Gastrointest. Liver Physiol. 35): G1382-G1390, 1997.
27. Wu, G., A. G. Borbolla, and D. A. Knabe. The uptake of glutamine and release of arginine, citrulline and proline by the small intestine of developing pigs. J. Nutr. 124: 2437-2444, 1994.
28. Wu, G., and D. A. Knabe. Arginine synthesis in enterocytes of neonatal pigs. Am. J. Physiol. 269 (Regulatory Integrative Comp. Physiol. 38): R621-R629, 1995.
29. Wu, G., D. A. Knabe, and N. E. Flynn. Synthesis of citrulline from glutamine in pig enterocytes. Biochem. J. 299: 114-121, 1994.
30. Wykes, L. J., R. O. Ball, and P. B. Pencharz. Development and validation of a total parenteral nutrition model in the neonatal piglet. J. Nutr. 123: 1248-1259, 1993.
31. Wykes, L. J., J. D. House, R. O. Ball, and P. B. Pencharz. Amino acid profile and aromatic amino acid concentration in total parenteral nutrition: effect on growth, protein metabolism and aromatic amino acid metabolism in the neonatal piglet. Clin. Sci. (Colch.) 87: 75-84, 1994.