Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 282, Issue 2 45-2, 2002, Pages

  Mistry, Sanjay K ^a   Burwell, Tim J ^b   Chambers, Rebecca M ^b   Rudolph Owen, Laura ^b   Spaltmann, Frank ^c   Jim Cook, W ^b   Morris Jr , Sidney M ^a,d  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

^c BAYER CORPORATION   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Arginase superfamily; Brain; Kidney; Putrescine

Indexed keywords

AGMATINASE; AGMATINE; COMPLEMENTARY DNA; ENZYME; ORNITHINE DECARBOXYLASE; POLYAMINE; PUTRESCINE; UNCLASSIFIED DRUG; UREA;

AMINO TERMINAL SEQUENCE; ARTICLE; BRAIN; CHROMOSOME 1; CONTROLLED STUDY; ENZYME ACTIVE SITE; GENE LOCATION; GENETIC COMPLEMENTATION; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; KIDNEY; LIVER; PATHOPHYSIOLOGY; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; RNA ANALYSIS; SKELETAL MUSCLE;

EID: 0036087418     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00386.2001     Document Type: Article

References (42)

1. Agmatine suppresses nitric oxide production in microglia
2. Basic local alignment search tool
3. Hepatitis B virus X protein transactivates the inducible nitric oxide synthase promoter
4. Arginase: A binuclear manganese metalloenzyme
5. Selective inhibition of inducible nitric oxide synthase by agmatine
6. Expression of the cloned genes encoding the putrescine biosynthetic enzymes and methionine adenosyltransferase of Escherichia coli (speA, speB, spec and metK)
7. Transport and metabolism of agmatine in rat hepatocyte cultures
8. Manganese is essential for catalytic activity of Escherichia coli agmatinase
9. Evidence that histidine-163 is critical for catalytic activity, but not for substrate binding to Escherichia coli agmatinase
10. Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme
11. A computer program for aligning a cDNA sequence with a genomic DNA sequence
12. Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine
13. D,L-α-difluoromethylornithine inhibits human cytomegalovirus replication
14. Improved method for high efficiency transformation of intact yeast cells
15. Reconstitution of a bacterial/plant polyamine biosynthesis pathway in Saccharomyces cerevisiae
16. Agmatine: An endogenous clonidine-displacing substance in the brain
17. Agmatine is synthesized by a mitochondrial arginine decarboxylase in rat brain
18. Agmatine, a bioactive metabolite of arginine. Production, degradation, and functional effects in the kidney of the rat
19. Inducible nitric oxide synthase expression in chronic viral hepatitis. Evidence for a virus-induced gene upregulation
20. Human type II arginase: Sequence analysis and tissue-specific expression
21. Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells
22. Regulation of mRNA levels for five urea cycle enzymes in rat liver by diet, cyclic AMP, and glucocorticoids
23. Agmatine activation of nitric oxide synthase in endothelial cells
24. Regulation of messenger ribonucleic acid levels for five urea cycle enzymes in cultured rat hepatocytes. Requirements for cyclic adenosine monophosphate, glucocorticoids, and ongoing protein synthesis
25. Roles of conserved residues in the arginase family
26. Modulation of MAO activity by imidazoline and guanidine derivatives
27. Roles of polyamines in replication of animal viruses
28. Anti-proliferative and anti-inflammatory actions of imidazoline agents. Are imidazoline receptors involved?
29. Characterization of arginine decarboxylase in rat brain and liver: Distinction from ornithine decarboxylase
30. Imidazoline receptors and agmatine in blood vessels: A novel system inhibiting vascular smooth muscle proliferation
31. Agmatine: A novel neurotransmitter?
32. Is agmatine a novel neurotransmitter in brain?
33. Metabolism of agmatine in macrophages: Modulation by lipopolysaccharide and inhibitory cytokines
34. Agmatinase activity in rat brain: A metabolic pathway for the degradation of agmatine
35. Agmatine suppresses proliferation by frameshift induction of antizyme and attenuation of cellular polyamine levels
36. Agmatine affects glomerular filtration via a nitric oxide synthase-dependent mechanism
37. Phylogeny of related functions: The case of polyamine biosynthetic enzymes
38. Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA
39. Polyamines
40. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
41. A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 toward the Fus3 MAP kinase