New hope for Alzheimer disease vaccine

Nature Medicine

Volumn 8, Issue 11, 2002, Pages 1195-1196

  Haass, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN;

ALZHEIMER DISEASE; ANTIBODY TITER; ASEPTIC MENINGITIS; DRUG EFFECT; ENCEPHALITIS; HUMAN; IMMUNOTHERAPY; MENINGOENCEPHALITIS; MOUSE; NONHUMAN; POSTVACCINAL ENCEPHALITIS; PRIORITY JOURNAL; SHORT SURVEY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; ALZHEIMER VACCINES; AMYLOID BETA-PROTEIN; ANIMALS; CLINICAL TRIALS; HUMANS; MICE;

MUS MUSCULUS;

EID: 0036851865     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1102-1195     Document Type: Short Survey

References (15)

1. Hock, C. et al. Generation of anti-amyloid antibodies by vaccination of patients with Alzheimer's disease. Nature Med. 8, 1270-1275 (2002).
2. McLaurin, J.A. et al. Therapeutically effective anti-Aβ antibodies target Aβ residues 4-10 and inhibit cytotoxicity and fibrillogenesis. Nature Med. 8, 1263-1269 (2002).
3. Check, E. Nerve inflammation halts trial for Alzheimer's drug. Nature 415, 462 (2002).
4. Haass, C. & Steiner, H. Alzheimer's disease γ-secretase, a multicomponent complex involving presenilin proteases of the GxGD type. Trends Cell Biol. (in the press).
5. Walsh, D.M. et al. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535-539 (2002).
6. Weihofen, A., Binns, K., Lemberg, M.K., Ashman, K. & Martoglio, B. Identification of signal peptide peptidase, a presenilin-type aspartic protease. Science 296, 2215-2218 (2002).
7. Cai, H. et al. BACE1 is the major β-secretase for generation of Aβ peptides by neurons. Nature Neurosci. 4, 233-234 (2001).
8. Luo, Y. et al. Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation. Nature Neurosci. 4, 231-232 (2001).
9. Schenk, D. et al. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173-177 (1999).
10. Bard, F. et al. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nature Med. 6, 916-919 (2000).
11. DeMattos, R.B. et al. Peripheral anti-Aβ antibody alters CNS and plasma A β clearance and decreases brain A β burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 98, 8850-8855 (2001).
12. Solomon, B., Koppel, R., Frankel, D. & Hanan-Aharon, E. Disaggregation of Alzheimer β-amyloid by site-directed mAb. Proc. Natl. Acad. Sci. USA 94, 4109-4112 (1997).
13. Morgan, D. et al. A β peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408, 982-985 (2000).
14. Janus, C. et al. A β peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 408, 979-982 (2000).
15. Smith, M.A., Atwood, C.S., Joseph, J.A. & Perry, G. Predicting the failure of amyloid-β vaccine. Lancet 359, 1864-1865 (2002).