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Volumn 11, Issue 11, 2002, Pages 1575-1585

Developing strategies for liver fibrosis treatment

Author keywords

Antifibrotic therapy; Hepatic stellate cell; Liver fibrosis

Indexed keywords

ACETYLCYSTEINE; ALPHA INTERFERON; ALPHA TOCOPHEROL; AMILORIDE; ANTIFIBROTIC AGENT; ANTIOXIDANT; AZATHIOPRINE; CARBON TETRACHLORIDE; COLCHICINE; CORTICOSTEROID; DILTIAZEM; DIMETHYLNITROSAMINE; FIBRILLAR COLLAGEN; GLYCYRRHIZIC ACID; INFLIXIMAB; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; MATRIX METALLOPROTEINASE; METHIONINE; NIFEDIPINE; PHOSPHATIDYLCHOLINE; RESVERATROL; RETINOL PALMITATE; RIBAVIRIN; S ADENOSYLMETHIONINE; SILYMARIN; THALIDOMIDE; TISSUE INHIBITOR OF METALLOPROTEINASE; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

EID: 0036849481     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.11.11.1575     Document Type: Review
Times cited : (21)

References (109)
  • 1
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • FRIEDMAN SL: Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. (2000) 275:2247-2250.
    • (2000) J. Biol. Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 2
    • 0032146551 scopus 로고    scopus 로고
    • Mechanisms of spontaneous resolution of rat liver fibrosis: Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
    • IREDALE JP, BENYON RC, PICKERING J et al.: Mechanisms of spontaneous resolution of rat liver fibrosis: hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J. Clin. Invest. (1998) 102:538-549.
    • (1998) J. Clin. Invest , vol.102 , pp. 538-549
    • Iredale, J.P.1    Benyon, R.C.2    Pickering, J.3
  • 3
    • 0035083958 scopus 로고    scopus 로고
    • Apoptosis of hepatic stellate cells: Involvement in resolution of biliary fibrosis and regulation by soluble growth factors
    • ISSA R, WILLIAMS E, TRIM N et al.: Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors. Gut (2001) 48:548-557.
    • (2001) Gut , vol.48 , pp. 548-557
    • Issa, R.1    Williams, E.2    Trim, N.3
  • 4
    • 0034040935 scopus 로고    scopus 로고
    • Lamivudine for hepatitis B in clinical practice
    • SCHIFF ER: Lamivudine for hepatitis B in clinical practice. J. Med. Virol. (2000) 61(3):386.
    • (2000) J. Med. Virol , vol.61 , Issue.3 , pp. 386
    • Schiff, E.R.1
  • 5
    • 0032547944 scopus 로고    scopus 로고
    • Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C
    • International Hepatitis Interventional Therapy Group
    • DAVIS GL, ESTEBAN-MUR R, RUSTGI V et al.: Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. International Hepatitis Interventional Therapy Group. N. Engl. J. Med (1998) 339:1493-1499.
    • (1998) N. Engl. J. Med , vol.339 , pp. 1493-1499
    • Davis, G.L.1    Esteban-Mur, R.2    Rustgi, V.3
  • 6
    • 0031054425 scopus 로고    scopus 로고
    • Hepatic stellate cell activation in genetic haemochromatosis-Lobular distribution, effect of increasing hepatic iron and response to phlebotomy
    • RAMM CA, CRAWFORD DHG, POWELL LW, WALKER NI, FLETCHER LM, HALLIDAY JW. Hepatic stellate cell activation in genetic haemochromatosis-Lobular distribution, effect of increasing hepatic iron and response to phlebotomy. J. Hepatol. (1997) 26:584-592.
    • (1997) J. Hepatol , vol.26 , pp. 584-592
    • Ramm, C.A.1    Crawford, D.H.G.2    Powell, L.W.3    Walker, N.I.4    Fletcher, L.M.5    Halliday, J.W.6
  • 8
    • 17144455384 scopus 로고    scopus 로고
    • Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy
    • SHIRATORI Y, IMAZEKI F, MORIYAMA M et al.: Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy. Ann. Intern. Med. (2000) 132:517-524.
    • (2000) Ann. Intern. Med , vol.132 , pp. 517-524
    • Shiratori, Y.1    Imazeki, F.2    Moriyama, M.3
  • 9
    • 0030692704 scopus 로고    scopus 로고
    • Reversibility of hepatic fibrosis in autoimmune hepatitis
    • DUFOUR JF, DELELLIS R, KAPLAN MM: Reversibility of hepatic fibrosis in autoimmune hepatitis. Ann. Int. Med. (1997) 127:981-985.
    • (1997) Ann. Int. Med , vol.127 , pp. 981-985
    • Dufour, J.F.1    Delellis, R.2    Kaplan, M.M.3
  • 10
    • 0024395234 scopus 로고
    • Active and latent collagenase activity during reversal of hepatic fibrosis in murine schistosomiasis
    • EMONARD H, GRIMAUD JA: Active and latent collagenase activity during reversal of hepatic fibrosis in murine schistosomiasis. Hepatology (1989) 10:77-83.
    • (1989) Hepatology , vol.10 , pp. 77-83
    • Emonard, H.1    Grimaud, J.A.2
  • 11
    • 0035825721 scopus 로고    scopus 로고
    • Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct
    • HAMMEL P, COUVELARD A, O'TOOLE D et al.: Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct. N. Engl. J. Med. (2001) 344:418-423.
    • (2001) N. Engl. J. Med , vol.344 , pp. 418-423
    • Hammel, P.1    Couvelard, A.2    O'Toole, D.3
  • 12
    • 0033766167 scopus 로고    scopus 로고
    • Impact of interferon alfa-2b and ribavirin on progression of liver fibrosis in patients with chronic hepatitis C
    • POYNARD T, MCHUTCHISON J, DAVIS GL et al.: Impact of interferon alfa-2b and ribavirin on progression of liver fibrosis in patients with chronic hepatitis C. Hepatology (2000) 32:1131-1137.
    • (2000) Hepatology , vol.32 , pp. 1131-1137
    • Poynard, T.1    Mchutchison, J.2    Davis, G.L.3
  • 13
    • 0030933395 scopus 로고    scopus 로고
    • Natural history of liver fibrosis progression in patients with chronic hepatitis C
    • The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups
    • POYNARD T, BEDOSSA P, OPOLON P: Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet (1997) 349:825-832.
    • (1997) Lancet , vol.349 , pp. 825-832
    • Poynard, T.1    Bedossa, P.2    Opolon, P.3
  • 14
    • 0034074276 scopus 로고    scopus 로고
    • Molecular pathogenesis of liver disease: An approach to hepatic inflammation, cirrhosis and liver transplant tolerance
    • MCCAUGHAN GW. GORRELL MD, BISHOP GA et al.: Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance. Immunol. Rev. (2000) 174:172-191.
    • (2000) Immunol. Rev , vol.174 , pp. 172-191
    • Mccaughan, G.W.1    Gorrell, M.D.2    Bishop, G.A.3
  • 15
    • 12644298684 scopus 로고    scopus 로고
    • Neutrophil-derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells: Role of nitric oxide
    • CASINI A, CENI E, SALZANO R et al.: Neutrophil-derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells: role of nitric oxide. Hepatology (1997) 25:361-367.
    • (1997) Hepatology , vol.25 , pp. 361-367
    • Casini, A.1    Ceni, E.2    Salzano, R.3
  • 16
    • 0029893937 scopus 로고    scopus 로고
    • Dexamethasone alters messenger rna levels but not synthesis of collagens, fibronectin, or laminin by cultured rat fat-storing cells
    • NIKI T, SCHUPPAN D, DEBLESER PJ et al.: Dexamethasone alters messenger rna levels but not synthesis of collagens, fibronectin, or laminin by cultured rat fat-storing cells. Hepatology (1996) 23:1673-1681.
    • (1996) Hepatology , vol.23 , pp. 1673-1681
    • Niki, T.1    Schuppan, D.2    Debleser, P.J.3
  • 17
    • 0029941556 scopus 로고    scopus 로고
    • Survival and prognostic factors in patients with severe alcoholic hepatitis treated with prednisolone
    • MATHURIN P, DUCHATELLE V, RAMOND MJ et al.: Survival and prognostic factors in patients with severe alcoholic hepatitis treated with prednisolone. Gastroenterology (1996) 110:1847-1853.
    • (1996) Gastroenterology , vol.110 , pp. 1847-1853
    • Mathurin, P.1    Duchatelle, V.2    Ramond, M.J.3
  • 21
    • 10344254306 scopus 로고    scopus 로고
    • A randomized trial comparing colchicine and ursodeoxycholic acid combination to ursodeoxycholic acid in primary biliary cirrhosis
    • UDCA-PBC Study Group
    • POUPON RE, HUET PM, POUPON R, BONNAND AM, NHIEU JT, ZAFRANI ES: A randomized trial comparing colchicine and ursodeoxycholic acid combination to ursodeoxycholic acid in primary biliary cirrhosis. UDCA-PBC Study Group. Hepatology (1996) 24:1098-1103.
    • (1996) Hepatology , vol.24 , pp. 1098-1103
    • Poupon, R.E.1    Huet, P.M.2    Poupon, R.3    Bonnand, A.M.4    Nhieu, J.T.5    Zafrani, E.S.6
  • 22
    • 0033529049 scopus 로고    scopus 로고
    • Infliximab for the treatment of fistulas in patients with Crohn's disease
    • PRESENT DH, RUTGEERTS P, TARGAN S et al.: Infliximab for the treatment of fistulas in patients with Crohn's disease. N. Engl. J. Med. (1999) 340:1398-1405.
    • (1999) N. Engl. J. Med , vol.340 , pp. 1398-1405
    • Present, D.H.1    Rutgeerts, P.2    Targan, S.3
  • 23
    • 0000974324 scopus 로고    scopus 로고
    • Clinical and cytokine response to anti-TNF antibody therapy in severe alcoholic hepatitis
    • (4, Pt 2)
    • JALAN R, WILLIAMS R, KASER A et al.: Clinical and cytokine response to anti-TNF antibody therapy in severe alcoholic hepatitis. Hepatology (2001) 34(4, Pt 2):A1077.
    • (2001) Hepatology , vol.34
    • Jalan, R.1    Williams, R.2    Kaser, A.3
  • 24
    • 4243295790 scopus 로고    scopus 로고
    • Thalidomide partially prevents CCL4-induced liver cirrhosis
    • MURIEL P, PONCE S, GARCIA J: Thalidomide partially prevents CCL4-induced liver cirrhosis. Hepatology (2001) 34 (4, Pt. 2):A1378.
    • (2001) Hepatology , vol.34 , Issue.4 PART 2
    • Muriel, P.1    Ponce, S.2    Garcia, J.3
  • 25
    • 0031049463 scopus 로고    scopus 로고
    • Analysis of Arg-Gly-Asp mimetics and soluble receptor of tumour necrosis factor as therapeutic modalities for concanavalin A induced hepatitis in mice
    • BRUCK R, SHIRIN H, HERSHKOVIZ R et al.: Analysis of Arg-Gly-Asp mimetics and soluble receptor of tumour necrosis factor as therapeutic modalities for concanavalin A induced hepatitis in mice. Gut (1997) 40:133-138.
    • (1997) Gut , vol.40 , pp. 133-138
    • Bruck, R.1    Shirin, H.2    Hershkoviz, R.3
  • 26
    • 0028209921 scopus 로고
    • An interleukin-1 receptor antagonist decreases fibrosis induced by dimethylnitrosamine in rat liver
    • MANCINI R, BENEDETTI A, JEZEQUEL AM: An interleukin-1 receptor antagonist decreases fibrosis induced by dimethylnitrosamine in rat liver. Virchows Arch. (1994) 424:25-31.
    • (1994) Virchows Arch , vol.424 , pp. 25-31
    • Mancini, R.1    Benedetti, A.2    Jezequel, A.M.3
  • 27
    • 17344371807 scopus 로고    scopus 로고
    • Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice
    • LOUIS H, VAN LAETHEM JL, WU W et al.: Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice. Hepatology (1998) 28:1607-1615.
    • (1998) Hepatology , vol.28 , pp. 1607-1615
    • Louis, H.1    Van Laethem, J.L.2    Wu, W.3
  • 28
    • 0034022483 scopus 로고    scopus 로고
    • Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: A pilot trial of interferon nonresponders
    • NELSON DR, LAUWERS GY, LAU JY, DAVIS GL: Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonresponders. Gastroenterology (2000) 118:655-660.
    • (2000) Gastroenterology , vol.118 , pp. 655-660
    • Nelson, D.R.1    Lauwers, G.Y.2    Lau, J.Y.3    Davis, G.L.4
  • 29
    • 0024852111 scopus 로고
    • Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet derived growth factor receptors
    • FRIEDMAN SL, ARTHUR MJP: Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet derived growth factor receptors. J. Clin. Invest. (1989) 84:1780-1785.
    • (1989) J. Clin. Invest , vol.84 , pp. 1780-1785
    • Friedman, S.L.1    Arthur, M.J.P.2
  • 30
    • 0033028453 scopus 로고    scopus 로고
    • Leukocytes as modulators of stellate cell activation
    • MAHER JJ: Leukocytes as modulators of stellate cell activation. Alcohol. Clin. Exp. Res. (1999) 23:917-921.
    • (1999) Alcohol. Clin. Exp. Res , vol.23 , pp. 917-921
    • Maher, J.J.1
  • 31
    • 0028876152 scopus 로고
    • Molecular dissection of the mitogenic effect of hepatocytes on cultured hepatic stellate cells
    • GRESSNER AM, LAHME B, BRENZEL A: Molecular dissection of the mitogenic effect of hepatocytes on cultured hepatic stellate cells. Hepatology (1995) 22:1507-1518.
    • (1995) Hepatology , vol.22 , pp. 1507-1518
    • Gressner, A.M.1    Lahme, B.2    Brenzel, A.3
  • 32
    • 0031058607 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 induces activation of Ras, Raf- 1, MEK and MAPK in rat hepatic stellate cells
    • REIMANN T, HEMPEL U, KRAUTWALD S et al.: Transforming growth factor-beta 1 induces activation of Ras, Raf- 1, MEK and MAPK in rat hepatic stellate cells. FEBS Lett. (1997) 403:57-60.
    • (1997) FEBS Lett , vol.403 , pp. 57-60
    • Reimann, T.1    Hempel, U.2    Krautwald, S.3
  • 33
    • 0031930768 scopus 로고    scopus 로고
    • Signal transduction in hepatic stellate cells
    • PINZANI M, MARRA F, CARLONI V: Signal transduction in hepatic stellate cells. Liver (1998) 18:2-13.
    • (1998) Liver , vol.18 , pp. 2-13
    • Pinzani, M.1    Marra, F.2    Carloni, V.3
  • 34
    • 0032862560 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat
    • MARRA F, ARRIGHI MC, FAZI M et al.: Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat. Hepatology (1999) 30:951-958.
    • (1999) Hepatology , vol.30 , pp. 951-958
    • Marra, F.1    Arrighi, M.C.2    Fazi, M.3
  • 35
    • 0033055983 scopus 로고    scopus 로고
    • A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture
    • NIKI T, ROMBOUTS K, DE BLESER P et al.: A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. Hepatology (1999) 29:858-867.
    • (1999) Hepatology , vol.29 , pp. 858-867
    • Niki, T.1    Rombouts, K.2    De Bleser, P.3
  • 36
    • 0034680787 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and hepatic stellate cell activation
    • MIYAHARA T, SCHRUM L, RIPPE R et al.: Peroxisome proliferator-activated receptors and hepatic stellate cell activation. J. Biol. Chem. (2000) 275:35715-35722.
    • (2000) J. Biol. Chem , vol.275 , pp. 35715-35722
    • Miyahara, T.1    Schrum, L.2    Rippe, R.3
  • 37
    • 0033855572 scopus 로고    scopus 로고
    • Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells
    • MARRA F, EFSEN E, ROMANELLI RG et al.: Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells. Gastroenterology (2002) 119:466-478.
    • (2002) Gastroenterology , vol.119 , pp. 466-478
    • Marra, F.1    Efsen, E.2    Romanelli, R.G.3
  • 38
    • 0028289518 scopus 로고
    • Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo
    • FRIEDMAN SL, YAMASAKI G, WONG L: Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo. J. Biol. Chem. (1994) 269:10551-10558.
    • (1994) J. Biol. Chem , vol.269 , pp. 10551-10558
    • Friedman, S.L.1    Yamasaki, G.2    Wong, L.3
  • 39
    • 0032412030 scopus 로고    scopus 로고
    • Induction of cellular processes containing collagenase and retinoid by integrin-binding to interstitial collagen in hepatic stellate cell culture
    • SATO M, KOJIMA N, MIURA M, IMAI K, SENOO H: Induction of cellular processes containing collagenase and retinoid by integrin-binding to interstitial collagen in hepatic stellate cell culture. Cell Biol. Int. (1998) 22:115-125.
    • (1998) Cell Biol. Int , vol.22 , pp. 115-125
    • Sato, M.1    Kojima, N.2    Miura, M.3    Imai, K.4    Senoo, H.5
  • 40
    • 0037192866 scopus 로고    scopus 로고
    • Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: Implications for reversibility of liver fibrosis
    • MURPHY FR, ISSA R, ZHOU X et al: Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: Implications for reversibility of liver fibrosis. J. Biol. Chem. (2002) 277:11069-11076.
    • (2002) J. Biol. Chem , vol.277 , pp. 11069-11076
    • Murphy, F.R.1    Issa, R.2    Zhou, X.3
  • 41
    • 0028855914 scopus 로고
    • The mitogenic effect of platelet-derived growth factor in human hepatic stellate cells requires calcium influx
    • FAILLI P, RUOCCO C, DE FRANCO R et al.: The mitogenic effect of platelet-derived growth factor in human hepatic stellate cells requires calcium influx. Am. J. Physiol. (1995) 269:C1133-C1139.
    • (1995) Am. J. Physiol , vol.269
    • Failli, P.1    Ruocco, C.2    De Franco, R.3
  • 42
    • 0032946712 scopus 로고    scopus 로고
    • Intracellular pathways mediating Na+/H+ exchange activation by platelet-derived growth factor in rat hepatic stellate cells
    • DI SARIO A, BENDIA E, SVEGLIATI BG et al.: Intracellular pathways mediating Na+/H+ exchange activation by platelet-derived growth factor in rat hepatic stellate cells. Gastroenterology (1999) 116:1155-1166.
    • (1999) Gastroenterology , vol.116 , pp. 1155-1166
    • Di Sario, A.1    Bendia, E.2    Svegliati, B.G.3
  • 43
    • 0026670128 scopus 로고
    • Vitamin E dietary Suppl.ementation protects against carbon tetrachloride-induced chronic liver damage and cirrhosis
    • PAROLA M, LEONARDUZZI G, BIASI F et al.: Vitamin E dietary Suppl.ementation protects against carbon tetrachloride-induced chronic liver damage and cirrhosis. Hepatology (1992) 16:1014-1021.
    • (1992) Hepatology , vol.16 , pp. 1014-1021
    • Parola, M.1    Leonarduzzi, G.2    Biasi, F.3
  • 44
    • 0028916565 scopus 로고
    • Effects of long-term vitamin E supplementation in alcoholic cirrhotics
    • DE LA MAZA MP, PETERMANN M, BUNOUT D, HIRSCH S: Effects of long-term vitamin E supplementation in alcoholic cirrhotics. J. Am. Coll. Nutr. (1995) 14:192-196.
    • (1995) J. Am. Coll. Nutr , vol.14 , pp. 192-196
    • De La Maza, M.P.1    Petermann, M.2    Bunout, D.3    Hirsch, S.4
  • 45
    • 0030958298 scopus 로고    scopus 로고
    • Antifibrotic effects of a polysaccharide extracted from Ganoderma lucidum, glycyrrhizin, and pentoxifylline in rats with cirrhosis induced by biliary obstruction
    • PARK EJ, KO G, KIM J, SOHN DH: Antifibrotic effects of a polysaccharide extracted from Ganoderma lucidum, glycyrrhizin, and pentoxifylline in rats with cirrhosis induced by biliary obstruction. Biol. Pharm. Bull. (1997) 20:417-420.
    • (1997) Biol. Pharm. Bull , vol.20 , pp. 417-420
    • Park, E.J.1    Ko, G.2    Kim, J.3    Sohn, D.H.4
  • 46
    • 0034065342 scopus 로고    scopus 로고
    • Deactivation of cultured human liver myofibroblasts by trans- resveratrol, a grapevine-derived polyphenol
    • GODICHAUD S, KRISA S, COURONNE B et al.: Deactivation of cultured human liver myofibroblasts by trans- resveratrol, a grapevine-derived polyphenol. Hepatology (2000) 31:922-931.
    • (2000) Hepatology , vol.31 , pp. 922-931
    • Godichaud, S.1    Krisa, S.2    Couronne, B.3
  • 47
    • 0030767712 scopus 로고    scopus 로고
    • Polyenylphosphatidylcholine prevents carbon tetrachloride-induced lipid peroxidation while it attenuates liver fibrosis
    • ALEYNIK SI, LEO MA, MA X, ALEYNIK MK, LIEBER CS: Polyenylphosphatidylcholine prevents carbon tetrachloride-induced lipid peroxidation while it attenuates liver fibrosis. J. Hepatol. (1997) 27:554-561.
    • (1997) J. Hepatol , vol.27 , pp. 554-561
    • Aleynik, S.I.1    Leo, M.A.2    Ma, X.3    Aleynik, M.K.4    Lieber, C.S.5
  • 48
    • 0030014283 scopus 로고    scopus 로고
    • Polyenylphosphatidylcholine attenuates non-alcoholic hepatic fibrosis and accelerates its regression
    • MA X, ZHAO J, LIEBER CS: Polyenylphosphatidylcholine attenuates non-alcoholic hepatic fibrosis and accelerates its regression. J. Hepatol. (1996) 24:604-613.
    • (1996) J. Hepatol , vol.24 , pp. 604-613
    • Ma, X.1    Zhao, J.2    Lieber, C.S.3
  • 49
    • 0033117629 scopus 로고    scopus 로고
    • Dilinoleoylphosphatidylcholine decreases hepatic stellate cell activation
    • PONIACHIK J, BARAONA E, ZHAO J, LIEBER CS: Dilinoleoylphosphatidylcholine decreases hepatic stellate cell activation. J. Lab. Clin. Med (1999) 133:342-348.
    • (1999) J. Lab. Clin. Med , vol.133 , pp. 342-348
    • Poniachik, J.1    Baraona, E.2    Zhao, J.3    Lieber, C.S.4
  • 50
    • 0032404112 scopus 로고    scopus 로고
    • Retinyl palmitate reduces hepatic fibrosis in rats induced by dimethylnitrosamine or pig serum
    • MIZOBUCHI Y, SHIMIZU I, YASUDA M, HORI H, SHONO M, ITO S: Retinyl palmitate reduces hepatic fibrosis in rats induced by dimethylnitrosamine or pig serum. J. Hepatol. (1998) 29:933-943.
    • (1998) J. Hepatol , vol.29 , pp. 933-943
    • Mizobuchi, Y.1    Shimizu, I.2    Yasuda, M.3    Hori, H.4    Shono, M.5    Ito, S.6
  • 51
    • 0344867846 scopus 로고    scopus 로고
    • S-adenosylmethionine in alcoholic liver cirrhosis: A randomized, placebo-controlled, double-blind, multicenter clinical trial
    • MATO JM, CAMARA J, FERNANDEZ DP et al.: S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J. Hepatol. (1999) 30:1081-1089.
    • (1999) J. Hepatol , vol.30 , pp. 1081-1089
    • Mato, J.M.1    Camara, J.2    Fernandez, D.P.3
  • 52
    • 0030915582 scopus 로고    scopus 로고
    • Steatosis and collagen content in experimental liver cirrhosis are affected by dietary monounsaturated and polyunsaturated fatty acids
    • FERNANDEZ MI, TORRES MI, GIL A, RIOS A: Steatosis and collagen content in experimental liver cirrhosis are affected by dietary monounsaturated and polyunsaturated fatty acids. Scand. J. Gastroenterol. (1997) 32-350-356.
    • (1997) Scand. J. Gastroenterol , vol.32 , pp. 350-356
    • Fernandez, M.I.1    Torres, M.I.2    Gil, A.3    Rios, A.4
  • 53
    • 0030665615 scopus 로고    scopus 로고
    • Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the rat
    • NANJI AA, ZAKIM D, RAHEMTULLA A et al.: Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the rat. Hepatology (1997) 26:1538-1545.
    • (1997) Hepatology , vol.26 , pp. 1538-1545
    • Nanji, A.A.1    Zakim, D.2    Rahemtulla, A.3
  • 54
    • 0030796417 scopus 로고    scopus 로고
    • Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats
    • BOIGK G, STROEDTER L, HERBST H, WALDSCHMIDT J, RIECKEN EO, SCHUPPAN D: Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats. Hepatology (1997) 26:643-649.
    • (1997) Hepatology , vol.26 , pp. 643-649
    • Boigk, G.1    Stroedter, L.2    Herbst, H.3    Waldschmidt, J.4    Riecken, E.O.5    Schuppan, D.6
  • 55
    • 0031960861 scopus 로고    scopus 로고
    • Effects of silymarin in alcoholic patients with cirrhosis of the liver: Results of a controlled, double-blind, randomized and multicenter trial
    • PARES A, PLANAS R, TORRES M et al.: Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial. J. Hepatol. (1998) 28:615-621.
    • (1998) J. Hepatol , vol.28 , pp. 615-621
    • Pares, A.1    Planas, R.2    Torres, M.3
  • 56
    • 0031037877 scopus 로고    scopus 로고
    • Inhibition of PDGF-mediated proliferation of vascular smooth muscle cells by calcium antagonists
    • KATAOKA S, ALAM R, DASH PK, YATSU FM: Inhibition of PDGF-mediated proliferation of vascular smooth muscle cells by calcium antagonists. Stroke (1997) 28:364-369.
    • (1997) Stroke , vol.28 , pp. 364-369
    • Kataoka, S.1    Alam, R.2    Dash, P.K.3    Yatsu, F.M.4
  • 57
    • 0032738763 scopus 로고    scopus 로고
    • Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis
    • ZHU J, WU J, FRIZELL E et al.: Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis. Gastroenterology (1999) 117:1198-1204.
    • (1999) Gastroenterology , vol.117 , pp. 1198-1204
    • Zhu, J.1    Wu, J.2    Frizell, E.3
  • 58
    • 0029098308 scopus 로고
    • Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: Potential role in liver injury
    • MARRA F, GRANDALIANO G, VALENTE AJ, ABBOUD HE: Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: potential role in liver injury. Hepatology (1995) 22:780-787.
    • (1995) Hepatology , vol.22 , pp. 780-787
    • Marra, F.1    Grandaliano, G.2    Valente, A.J.3    Abboud, H.E.4
  • 59
    • 0034120267 scopus 로고    scopus 로고
    • Angiotensin II induces contraction and proliferation of human hepatic stellate cells
    • BATALLER R, GINES P, NICOLAS JM et al.: Angiotensin II induces contraction and proliferation of human hepatic stellate cells. Gastroenterology (2000) 118:1149-1156.
    • (2000) Gastroenterology , vol.118 , pp. 1149-1156
    • Bataller, R.1    Gines, P.2    Nicolas, J.M.3
  • 60
    • 0034961836 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibition attenuates the progression of rat hepatic fibrosis
    • JONSSON JR, CLOUSTON AD, ANDO Y et al: Angiotensin-converting enzyme inhibition attenuates the progression of rat hepatic fibrosis. Gastroenterology (2001) 121:148-155.
    • (2001) Gastroenterology , vol.121 , pp. 148-155
    • Jonsson, J.R.1    Clouston, A.D.2    Ando, Y.3
  • 61
    • 0033868025 scopus 로고    scopus 로고
    • Nitrovasodilators inhibit platelet-derived growth factor-induced proliferation and migration of activated human hepatic stellate cells
    • FAILLI P, DEFRANCO RM, CALIGIURI A et al.: Nitrovasodilators inhibit platelet-derived growth factor-induced proliferation and migration of activated human hepatic stellate cells. Gastroenterology (2000) 119:479-492.
    • (2000) Gastroenterology , vol.119 , pp. 479-492
    • Failli, P.1    Defranco, R.M.2    Caligiuri, A.3
  • 62
    • 0032903634 scopus 로고    scopus 로고
    • Hepatocyte growth factor gene therapy of liver cirrhosis in rats
    • UEKI T, KANEDA Y, TSUTSUI H et al: Hepatocyte growth factor gene therapy of liver cirrhosis in rats. Nat. Med. (1999) 5:226-230.
    • (1999) Nat. Med , vol.5 , pp. 226-230
    • Ueki, T.1    Kaneda, Y.2    Tsutsui, H.3
  • 63
    • 0030858931 scopus 로고    scopus 로고
    • Pharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis
    • WINDMEIER C, GRESSNER AM: Pharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis. Gen. Pharmacol. (1997) 29:181-196.
    • (1997) Gen. Pharmacol , vol.29 , pp. 181-196
    • Windmeier, C.1    Gressner, A.M.2
  • 64
    • 0032731750 scopus 로고    scopus 로고
    • The Ras antagonist, farnesylthiosalicylic acid (FTS), inhibits experimentally-induced liver cirrhosis in rats
    • REIF S, WEIS B, AEED H et al: The Ras antagonist, farnesylthiosalicylic acid (FTS), inhibits experimentally-induced liver cirrhosis in rats.J Hepatol. (1999) 31:1053-1061.
    • (1999) J. Hepatol , vol.31 , pp. 1053-1061
    • Reif, S.1    Weis, B.2    Aeed, H.3
  • 65
    • 0033765497 scopus 로고    scopus 로고
    • Inhibition of hepatic stellate cell proliferation and activation by the semisynthetic analogue of fumagillin TNP-470 in rats
    • WANG YQ, IKEDA K, IKEBE T et al: Inhibition of hepatic stellate cell proliferation and activation by the semisynthetic analogue of fumagillin TNP-470 in rats. Hepatology (2000) 32:980-989.
    • (2000) Hepatology , vol.32 , pp. 980-989
    • Wang, Y.Q.1    Ikeda, K.2    Ikebe, T.3
  • 66
    • 18744431251 scopus 로고    scopus 로고
    • Inhibition of experimentally-induced liver cirrhosis in rats by a nonpeptidic mimetic of the extracellular matrix-associated Arg-Gly-Asp epitope
    • BRUCK R, HERSHKOVIZ R, LIDER O et al.: Inhibition of experimentally-induced liver cirrhosis in rats by a nonpeptidic mimetic of the extracellular matrix-associated Arg-Gly-Asp epitope. J. Hepatol. (1996) 24:731-738.
    • (1996) J. Hepatol , vol.24 , pp. 731-738
    • Bruck, R.1    Hershkoviz, R.2    Lider, O.3
  • 67
    • 0033623899 scopus 로고    scopus 로고
    • Nuclear factor κB in proliferation, activation, and apoptosis in rat hepatic stellate cells
    • LANG A, SCHOONHOVEN R, TUVIA S, BRENNER DA, RIPPE RA: Nuclear factor κB in proliferation, activation, and apoptosis in rat hepatic stellate cells. J. Hepatol. (2000) 33:49-58.
    • (2000) J. Hepatol , vol.33 , pp. 49-58
    • Lang, A.1    Schoonhoven, R.2    Tuvia, S.3    Brenner, D.A.4    Rippe, R.A.5
  • 68
    • 0034830886 scopus 로고    scopus 로고
    • Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats
    • WRIGHT MC, ISSA R, SMART DE et al.: Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats. Gastroenterology (2001) 121:685-698.
    • (2001) Gastroenterology , vol.121 , pp. 685-698
    • Wright, M.C.1    Issa, R.2    Smart, D.E.3
  • 70
    • 0033847886 scopus 로고    scopus 로고
    • Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation
    • TRIM N, MORGAN S, EVANS M et al.: Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation. Am. J. Pathol. (2000) 156:1235-1243.
    • (2000) Am. J. Pathol , vol.156 , pp. 1235-1243
    • Trim, N.1    Morgan, S.2    Evans, M.3
  • 71
    • 0035851123 scopus 로고    scopus 로고
    • 15-deoxy-Delta 12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors
    • LI L, TAO J, DAVAILLE J et al: 15-deoxy-Delta 12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors. J. Biol. Chem. (2001) 276:38152-38158.
    • (2001) J. Biol. Chem , vol.276 , pp. 38152-38158
    • Li, L.1    Tao, J.2    Davaille, J.3
  • 72
    • 0035087890 scopus 로고    scopus 로고
    • Expression of the peripheral-type benzodiazepine receptor and apoptosis induction in hepatic stellate cells
    • FISCHER R, SCHMITT M, BODE JG, HAUSSINGER D: Expression of the peripheral-type benzodiazepine receptor and apoptosis induction in hepatic stellate cells. Gastroenterology (2001) 120:1212-1226.
    • (2001) Gastroenterology , vol.120 , pp. 1212-1226
    • Fischer, R.1    Schmitt, M.2    Bode, J.G.3    Haussinger, D.4
  • 73
    • 0032810213 scopus 로고    scopus 로고
    • Prolyl 4-hydroxylase inhibitor (HOE 077) prevents TIMP-1 gene expression in rat liver fibrosis
    • SAKAIDA I, UCHIDA K, HIRONAKA K, OKITA K: Prolyl 4-hydroxylase inhibitor (HOE 077) prevents TIMP-1 gene expression in rat liver fibrosis. J Gastroenterol. (1999) 34:376-377.
    • (1999) J Gastroenterol , vol.34 , pp. 376-377
    • Sakaida, I.1    Uchida, K.2    Hironaka, K.3    Okita, K.4
  • 74
    • 0031975486 scopus 로고    scopus 로고
    • Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: Differential effects in males and females
    • WANG YJ, WANG SS, BICKEL M, GUENZLER V, GERL M, BISSELL DM: Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females. Am. J. Pathol. (1998) 152:279-287.
    • (1998) Am. J. Pathol , vol.152 , pp. 279-287
    • Wang, Y.J.1    Wang, S.S.2    Bickel, M.3    Guenzler, V.4    Gerl, M.5    Bissell, D.M.6
  • 75
    • 0029923670 scopus 로고    scopus 로고
    • The prolyl 4-hydroxylase inhibitor hoe 077 prevents activation of ito cells, reducing procollagen gene expression in rat liver fibrosis induced by choline-deficient l-amino acid-defined diet
    • SAKAIDA I, MATSUMURA Y, KUBOTA M, KAYANO K, TAKENAKA K, OKITA K: The prolyl 4-hydroxylase inhibitor hoe 077 prevents activation of ito cells, reducing procollagen gene expression in rat liver fibrosis induced by choline-deficient l-amino acid-defined diet. Hepatology (1996) 23:755-763.
    • (1996) Hepatology , vol.23 , pp. 755-763
    • Sakaida, I.1    Matsumura, Y.2    Kubota, M.3    Kayano, K.4    Takenaka, K.5    Okita, K.6
  • 76
    • 0030806437 scopus 로고    scopus 로고
    • Prolyl 4-hydroxylase inhibitor (HOE 077) inhibits pig serum-induced rat liver fibrosis by preventing stellate cell activation
    • MATSUMURA Y, SAKAIDA I, UCHIDA K, KIMURA T, ISHIHARA T, OKITA K: Prolyl 4-hydroxylase inhibitor (HOE 077) inhibits pig serum-induced rat liver fibrosis by preventing stellate cell activation. J. Hepatol, (1997) 27:185-192.
    • (1997) J. Hepatol , vol.27 , pp. 185-192
    • Matsumura, Y.1    Sakaida, I.2    Uchida, K.3    Kimura, T.4    Ishihara, T.5    Okita, K.6
  • 77
    • 17344372001 scopus 로고    scopus 로고
    • Selective inhibition of hepatic collagen accumulation in experimental liver fibrosis in rats by a new prolyl 4-hydroxylase inhibitor
    • BICKEL M, BARINGHAUS KH, GERL M et al: Selective inhibition of hepatic collagen accumulation in experimental liver fibrosis in rats by a new prolyl 4-hydroxylase inhibitor. Hepatology (1998) 28:404-411.
    • (1998) Hepatology , vol.28 , pp. 404-411
    • Bickel, M.1    Baringhaus, K.H.2    Gerl, M.3
  • 78
    • 0032745497 scopus 로고    scopus 로고
    • Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice
    • MATSUSAKA T, KATORI H, INAGAMI T, FOGO A, ICHIKAWA I: Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice. J. Clin. Invest. (1999) 103:1451-1458.
    • (1999) J. Clin. Invest , vol.103 , pp. 1451-1458
    • Matsusaka, T.1    Katori, H.2    Inagami, T.3    Fogo, A.4    Ichikawa, I.5
  • 79
    • 0034119307 scopus 로고    scopus 로고
    • The role of vasoactive compounds, growth factors and cytokines in the progression of renal disease
    • KLAHR S, MORRISSEY JJ: The role of vasoactive compounds, growth factors and cytokines in the progression of renal disease. Kidney Int. Suppl. (2000) 75:S7-S14.
    • (2000) Kidney Int. Suppl , vol.75
    • Klahr, S.1    Morrissey, J.J.2
  • 81
    • 0030059990 scopus 로고    scopus 로고
    • Endothelin-1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells
    • PINZANI M, MILANI S, DEFRANCO R et al.: Endothelin-1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells. Gastroenterology (1996) 110:534-548.
    • (1996) Gastroenterology , vol.110 , pp. 534-548
    • Pinzani, M.1    Milani, S.2    Defranco, R.3
  • 82
    • 0034120477 scopus 로고    scopus 로고
    • An oral endothelin-A receptor antagonist blocks collagen synthesis and deposition in advanced rat liver fibrosis
    • CHO JJ, HOCHER B, HERBST H et al.: An oral endothelin-A receptor antagonist blocks collagen synthesis and deposition in advanced rat liver fibrosis. Gastroenterology (2000) 118:1169-1178.
    • (2000) Gastroenterology , vol.118 , pp. 1169-1178
    • Cho, J.J.1    Hocher, B.2    Herbst, H.3
  • 83
    • 0030759740 scopus 로고    scopus 로고
    • Halofuginone, a specific inhibitor of collagen Type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis
    • PINES M, KNOPOV V, GENINA O, LAVELIN I, NAGLER A: Halofuginone, a specific inhibitor of collagen Type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis. J. Hepatol. (1997) 27:391-398.
    • (1997) J. Hepatol , vol.27 , pp. 391-398
    • Pines, M.1    Knopov, V.2    Genina, O.3    Lavelin, I.4    Nagler, A.5
  • 85
    • 0029887586 scopus 로고    scopus 로고
    • Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis
    • BARONI GS, D'AMBROSIO L, CURTO P et al.: Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis. Hepatology (1996) 23:1189-1199.
    • (1996) Hepatology , vol.23 , pp. 1189-1199
    • Baroni, G.S.1    D'Ambrosio, L.2    Curto, P.3
  • 86
    • 0028941524 scopus 로고
    • Interferon alfa and gamma inhibit proliferation and collagen synthesis of human ito cells in culture
    • MALLAT A, PREAUX AM, BLAZEJEWSKI S, ROSENBAUM J, DHUMEAUX D, MAVIER P: Interferon alfa and gamma inhibit proliferation and collagen synthesis of human ito cells in culture. Hepatology (1995) 21:1003-1010.
    • (1995) Hepatology , vol.21 , pp. 1003-1010
    • Mallat, A.1    Preaux, A.M.2    Blazejewski, S.3    Rosenbaum, J.4    Dhumeaux, D.5    Mavier, P.6
  • 87
    • 0030885185 scopus 로고    scopus 로고
    • Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses
    • SHI Z, WAKIL AE, ROCKEY DC: Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses. Proc. Natl. Acad. Sci. USA (1997) 94:10663-10668.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10663-10668
    • Shi, Z.1    Wakil, A.E.2    Rockey, D.C.3
  • 88
    • 4243398779 scopus 로고
    • Characterisation of TGF-beta receptors in cultured rat lipocytes; enhanced receptor expression accompanies cellular activation
    • FRIEDMAN SL, YAMASAKI G: Characterisation of TGF-beta receptors in cultured rat lipocytes; enhanced receptor expression accompanies cellular activation. Hepatology (1991) 14:113A.
    • (1991) Hepatology , vol.14
    • Friedman, S.L.1    Yamasaki, G.2
  • 89
    • 0031438047 scopus 로고    scopus 로고
    • TGF-beta signalling from cell membrane to nucleus through SMAD proteins
    • HELDIN CH, MIYAZONO K, TEN DIJKE P: TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature (1997) 390:465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    Ten Dijke, P.3
  • 90
    • 0028349374 scopus 로고
    • Transforming Growth Factor beta 1 Regulates Tissue Inhibitor of Metalloproteinases-1 Expression in Differentiated Human Articular Chondrocytes
    • GUNTHER M, HAUBECK HD, VANDELEUR E et al.: Transforming Growth Factor beta 1 Regulates Tissue Inhibitor of Metalloproteinases-1 Expression in Differentiated Human Articular Chondrocytes. Arthritis Rheum. (1994) 37:395-405.
    • (1994) Arthritis Rheum , vol.37 , pp. 395-405
    • Gunther, M.1    Haubeck, H.D.2    Vandeleur, E.3
  • 91
    • 0031741016 scopus 로고    scopus 로고
    • Protease inhibitors suppress TGF-beta generation by hepatic stellate cells
    • OKUNO M, MORIWAKI H, MUTO Y, KOJIMA S: Protease inhibitors suppress TGF-beta generation by hepatic stellate cells. J. Hepatol. (1998) 29:1031-1032.
    • (1998) J. Hepatol , vol.29 , pp. 1031-1032
    • Okuno, M.1    Moriwaki, H.2    Muto, Y.3    Kojima, S.4
  • 92
    • 0000338177 scopus 로고    scopus 로고
    • Inhibition of rat hepatic fibrogenesis by a soluble TGF beta Type II receptor
    • GEORGE J, ROULOT D, KOTELIANSKY VE, BISSELL MD: Inhibition of rat hepatic fibrogenesis by a soluble TGF beta Type II receptor. Hepatology (1998) 28:312A.
    • (1998) Hepatology , vol.28
    • George, J.1    Roulot, D.2    Koteliansky, V.E.3    Bissell, M.D.4
  • 93
    • 0033515099 scopus 로고    scopus 로고
    • Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat
    • QI Z, ATSUCHI N, OOSHIMA A, TAKESHITA A, UENO H: Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat. Proc. Natl. Acad. Sci. USA (1999) 96:2345-2349.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2345-2349
    • Qi, Z.1    Atsuchi, N.2    Ooshima, A.3    Takeshita, A.4    Ueno, H.5
  • 94
    • 0034650610 scopus 로고    scopus 로고
    • The 5' stem-loop regulates expression of collagen alphal (I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix
    • STEFANOVIC B, LINDQUIST J, BRENNER DA: The 5' stem-loop regulates expression of collagen alphal (I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. NucleicAcids. Res. (2000) 28: 641-647.
    • (2000) NucleicAcids. Res , vol.28 , pp. 641-647
    • Stefanovic, B.1    Lindquist, J.2    Brenner, D.A.3
  • 96
    • 0034567343 scopus 로고    scopus 로고
    • Liver cirrhosis is reverted by urokinase-type plasminogen activator gene therapy
    • SALGADO S, GARCIA J, VERA J et al.: Liver cirrhosis is reverted by urokinase-type plasminogen activator gene therapy. Mol. Ther. (2000) 2:545-551.
    • (2000) Mol. Ther , vol.2 , pp. 545-551
    • Salgado, S.1    Garcia, J.2    Vera, J.3
  • 97
    • 4243282268 scopus 로고    scopus 로고
    • Overexpression of matrix metalloproteinase-1 in the rat liver for modulation of hepatic extracellular matrix
    • NISHIO T, IIMURO Y. SHINKURA N et al.: Overexpression of matrix metalloproteinase-1 in the rat liver for modulation of hepatic extracellular matrix. Hepatology (1998) 28-A1426.
    • (1998) Hepatology , vol.28
    • Nishio, T.1    Iimuro, Y.2    Shinkura, N.3
  • 98
    • 0034949533 scopus 로고    scopus 로고
    • Inhibiting effect of antisense oligonucleotides phosphorthinate on gene expression of TIMP-1 in rat liver fibrosis
    • NIE QH, CHENG YQ, XIE YM, ZHOU YX, CAO YZ: Inhibiting effect of antisense oligonucleotides phosphorthinate on gene expression of TIMP-1 in rat liver fibrosis. World J. Gastroenterol. (2001) 7:363-369.
    • (2001) World J. Gastroenterol , vol.7 , pp. 363-369
    • Nie, Q.H.1    Cheng, Y.Q.2    Xie, Y.M.3    Zhou, Y.X.4    Cao, Y.Z.5
  • 99
    • 4243326255 scopus 로고    scopus 로고
    • Effects of antisense tissue inhibitor of metalloproteinase-1 expressing plasmid on pig serum induced rat liver fibrosis
    • WANG J, JIANG W, YANG C, WANG Y, HE B: Effects of antisense tissue inhibitor of metalloproteinase-1 expressing plasmid on pig serum induced rat liver fibrosis. Gastroenerology (2002):M839.
    • (2002) Gastroenerology
    • Wang, J.1    Jiang, W.2    Yang, C.3    Wang, Y.4    He, B.5
  • 100
    • 0026733683 scopus 로고
    • Influence of dietary zinc on hepatic collagen and prolyl hydroxylase activity in alcoholic rats
    • GIMENEZ A, CABALLERIA J, PARES A et al.: Influence of dietary zinc on hepatic collagen and prolyl hydroxylase activity in alcoholic rats. Hepatology (1992) 16:815-819.
    • (1992) Hepatology , vol.16 , pp. 815-819
    • Gimenez, A.1    Caballeria, J.2    Pares, A.3
  • 101
    • 0028087959 scopus 로고
    • Fibrogenic and collagenolytic activity in carbon- Tetrachloride- Injured rats: Beneficial effects of zinc administration
    • GIMENEZ A, PARES A, ALIE S et al.: Fibrogenic and collagenolytic activity in carbon- tetrachloride- injured rats: Beneficial effects of zinc administration. J. Hepatol. (1994) 21:292-298.
    • (1994) J. Hepatol , vol.21 , pp. 292-298
    • Gimenez, A.1    Pares, A.2    Alie, S.3
  • 102
    • 0032899156 scopus 로고    scopus 로고
    • Albumin modified with mannose 6-phosphate: A potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells
    • BELJAARS L, MOLEMA G, WEERT B et al.: Albumin modified with mannose 6-phosphate: A potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells. Hepatology (1999) 29:1486-1493.
    • (1999) Hepatology , vol.29 , pp. 1486-1493
    • Beljaars, L.1    Molema, G.2    Weert, B.3
  • 103
    • 0034724911 scopus 로고    scopus 로고
    • Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen Type VI receptor
    • BELJAARS L, MOLEMA G, SCHUPPAN D et al.: Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen Type VI receptor. J. Biol. Chem. (2000) 275:12743-12751.
    • (2000) J. Biol. Chem , vol.275 , pp. 12743-12751
    • Beljaars, L.1    Molema, G.2    Schuppan, D.3
  • 104
    • 0029000625 scopus 로고
    • Serum hyaluronan as a marker of liver fibrosis
    • GUECHOT J, POUPON RE, POUPON R: Serum hyaluronan as a marker of liver fibrosis. J. Hepatol. (1995) 22:103-106.
    • (1995) J. Hepatol , vol.22 , pp. 103-106
    • Guechot, J.1    Poupon, R.E.2    Poupon, R.3
  • 105
    • 0029145767 scopus 로고
    • Long-term decrease in serum N-terminal propetide of Type III procollagen in patients with chronic hepatitis C treated with interferon alfa
    • SUOU T, HOSHO K, KISHIMOTO Y, HORIE Y, KAWASAKI H: Long-term decrease in serum N-terminal propetide of Type III procollagen in patients with chronic hepatitis C treated with interferon alfa. Hepatology (1995) 22:426-431.
    • (1995) Hepatology , vol.22 , pp. 426-431
    • Suou, T.1    Hosho, K.2    Kishimoto, Y.3    Horie, Y.4    Kawasaki, H.5
  • 106
    • 0031048395 scopus 로고    scopus 로고
    • Circulating matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 as serum markers of fibrosis in patients with chronic hepatitis C - Relationship to interferon response
    • KASAHARA A, HAYASHI N, MOCHIZUKI K et al : Circulating matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 as serum markers of fibrosis in patients with chronic hepatitis C - Relationship to interferon response. J. Hepatol. (1997) 26:574-583.
    • (1997) J. Hepatol , vol.26 , pp. 574-583
    • Kasahara, A.1    Hayashi, N.2    Mochizuki, K.3
  • 107
    • 0030023829 scopus 로고    scopus 로고
    • Significance of serum tissue inhibitor of metalloproteinases-1 in various liver diseases
    • UENO T, TAMAKI S, SUGAWARA H et al.: Significance of serum tissue inhibitor of metalloproteinases-1 in various liver diseases. J. Hepatol. (1996) 24:177-184.
    • (1996) J. Hepatol , vol.24 , pp. 177-184
    • Ueno, T.1    Tamaki, S.2    Sugawara, H.3
  • 108
    • 0030480386 scopus 로고    scopus 로고
    • Serum markers for hepatic fibrosis in alcoholic liver disease: Which is the best marker, Type III procollagen, Type IV collagen, laminin, tissue inhibitor of metalloproteinase, or prolyl hydroxylase?
    • TSUTSUMI M, TAKASE S, URASHIMA S, UESHIMA Y, KAWAHARA H, TAKADA A. Serum markers for hepatic fibrosis in alcoholic liver disease: Which is the best marker, Type III procollagen, Type IV collagen, laminin, tissue inhibitor of metalloproteinase, or prolyl hydroxylase? Alcohol. Clin. Exp. Res. (1996) 20:1512-1517.
    • (1996) Alcohol. Clin. Exp. Res , vol.20 , pp. 1512-1517
    • Tsutsumi, M.1    Takase, S.2    Urashima, S.3    Ueshima, Y.4    Kawahara, H.5    Takada, A.6
  • 109
    • 0001090295 scopus 로고    scopus 로고
    • Automated assays of serum markers of liver fibrosis predict histological hepatic fibrosis
    • ROSENBERG WM, BURT A, BECKA M et al.: Automated assays of serum markers of liver fibrosis predict histological hepatic fibrosis. Hepatology (2000) 32:A84.
    • (2000) Hepatology , vol.32
    • Rosenberg, W.M.1    Burt, A.2    Becka, M.3


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