The combination of HSV-tk and endostatin gene therapy eradicates orthotopic human renal cell carcinomas in nude mice

Cancer Gene Therapy

Volumn 9, Issue 11, 2002, Pages 908-916

  Pulkkanen, Kalevi Juhani ^a,b   Laukkanen, Johanna M ^a   Fuxe, Jonas ^c   Rehn, Marko ^d   Kannatso, Jani M ^a   Parkkinen, Jyrki J ^a   Kauppinen, Risto A ^a   Pettersson, Ralf F ^c   Yla Herttuala, Seppo ^b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY OF OULU   (Finland)

Author keywords

Adenovirus; Endostatin; Gene therapy; HSV tk; Kidney carcinoma

Indexed keywords

ADENOVIRUS VECTOR; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; ENDOSTATIN; GREEN FLUORESCENT PROTEIN; THYMIDINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER MODEL; CANCER SURVIVAL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMAGE ANALYSIS; KIDNEY CARCINOMA; MORPHOMETRICS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUDE MOUSE; PRIORITY JOURNAL; VIRAL GENE DELIVERY SYSTEM; XENOGRAFT;

AMINO ACID SEQUENCE; ANIMALS; CARCINOMA, RENAL CELL; COLLAGEN; DISEASE-FREE SURVIVAL; ENDOSTATINS; GENE THERAPY; GLIOMA; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY NEOPLASMS; LUMINESCENT PROTEINS; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; RECOMBINANT FUSION PROTEINS; SIMPLEXVIRUS; THYMIDINE KINASE; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

ADENOVIRIDAE; ANIMALIA; MUS MUSCULUS; SIMPLEXVIRUS;

EID: 0036840878     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700519     Document Type: Article

References (44)

1. Ljungberg B, Alamdari FI, Rasmuson T, Roos G. Follow-up guidelines for nonmetastatic renal cell carcinoma based on the occurrence of metastases after radical nephrectomy. BJU Int. 1999;84:405-411.
2. Belldegrun A, deKernion JB. Renal tumors. In: Campell's Urology. Philadelphia, PA: Saunders;1998:2292-2318.
3. Fleming S, O'Donnell M. Surgical pathology of renal epithelial neoplasms: Recent advances and current status. Histopathology. 2000;36:195-202.
4. Ljungberg B, Landberg G, Alamdari FI. Factors of importance for prediction of survival in patients with metastatic renal cell carcinoma, treated with or without nephrectomy. Scand J Urol Nephrol. 2000;34:246-251.
5. Shirakawa T, Gardner TA, Ko SC, et al. Cytotoxicity of adenoviral-mediated cytosine deaminase plus 5-fluorocytosine gene therapy is superior to thymidine kinase plus acyclovir in a human renal cell carcinoma model. J Urol. 1999;162:949-954.
6. Godley PA, Taylor M. Renal cell carcinoma. Curr Opin Oncol. 2001;13:199-203.
7. Uckert W, Kammertons T, Haack K, et al. Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo. Hum Gene Ther. 1998;9:855-865.
8. Sandmair AM, Turunen M, Tyynela K, et al. Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: Effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions. Cancer Gene Ther. 2000;7:413-421.
9. Vile RG. Gene therapy. Curr Biol. 1998;8:R73-R75.
10. O'Reilly MS, Boehm T, Shing Y, et al. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth. Cell. 1997;88:277-285.
11. Risau W. Mechanisms of angiogenesis. Nature. 1997;386:671-674.
12. Folkman J. New perspectives in clinical oncology from angiogenesis research. Eur J Cancer. 1996;32A:2534-2539.
13. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1995;1:27-31.
14. Moolten FL. Drug sensitivity ("suicide") genes for selective cancer chemotherapy. Cancer Gene Ther. 1994;1:279-287.
15. Korpelainen EI, Alitalo K. Signaling angiogenesis and lymphangiogenesis. Curr Opin Cell Biol. 1998;10:159-164.
16. Rehn M, Veikkola T, Kukk-Valdre E, et al. Interaction of endostatin with integrins implicated in angiogenesis. Proc Natl Acad Sci USA. 2001;98:1024-1029.
17. Pulkkanen KJ, Parkkinen JJ, Kettunen MI, et al. Characterization of a new animal model for human renal cell carcinoma. In Vivo. 2000;14:393-400.
18. Pulkkanen KJ, Parkkinen JJ, Laukkanen JM, et al. HSV-tk gene therapy for human renal cell carcinoma in nude mice. Cancer Gene Ther. 2001;8:529-536.
19. Sandmair AM, Loimas S, Puranen P, et al. Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses. Hum Gene Ther. 2000;11:2197-2205.
20. Rehn M, Pihlajaniemi T. Identification of three N-terminal ends of type XVIII collagen chains and tissue-specific differences in the expression of the corresponding transcripts. The longest form contains a novel motif homologous to rat and Drosophila frizzled proteins. J Biol Chem. 1995;270:4705-4711.
21. Fuxe J, Akusjarvi G, Goike HM, Roos G, Collins VP, Pettersson RF. Adenovirus-mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4A. Cell Growth Differ. 2000;11:373-384.
22. Evan GI, Lewis GK, Ramsay G, Bishop JM. Isolation of monoclonal antibodies specific for human c-myc protooncogene product. Mol Cell Biol. 1985;5:3610-3616.
23. Ylä-Herttuala S, Rosenfeld ME, Parthasarathy S, et al. Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions. Proc Natl Acad Sci USA. 1990;87:6959-6963.
24. Ylä-Herttuala S, Luoma J, Viita H, Hiltunen T, Sisto T, Nikkari T. Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein. J Clin Invest. 1995;95:2692-2698.
25. Gundersen HJ, Bendtsen TF, Korbo L, et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS, Acta Pathol Microbiol Immunol Scand. 1988;96:379-394.
26. Zar JH. Biostatistical Analysis, 4th Ed. New Jersey: Prentice-Hall; 1999:226.
27. Fuhrman SA, Lasky LC, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol. 1982;6:655-663.
28. Fogh J, Fogh JM, Orfeo T. One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J Natl Cancer Inst. 1977;59:221-226.
29. Vrionis FD, Wu JK, Qi P, Waltzman M, Cherington V, Spray DC. The bystander effect exerted by tumor cells expressing the herpes simplex virus thymidine kinase (HSVtk) gene is dependent on connexin expression and cell communication via gap junctions. Gene Ther. 1997;4:577-585.
30. Ramesh R, Marrogi AJ, Freeman SM. Tumor killing using the HSV-tk suicide gene. In: Gene Therapy and Molecular Biology. Palo Alto, CA: Gene Therapy Press; 1998:253-263.
31. Thust R, Tomicic M, Klocking R, Wutzler P, Kaina BB. Cytogenetic genotoxicity of anti-herpes purine nucleoside analogues in CHO cells expressing the thymidine kinase gene of herpes simplex virus type 1: Comparison of ganciclovir, penciclovir and aciclovir. Mutagenesis. 2000;15:177-184.
32. Blezinger P, Wang J, Gondo M, et al. Systemic inhibition of tumor growth and tumor metastases by intramuscular administration of the endostatin gene. Nat Biotechnol. 1999;17:343-348.
33. Szary J, Szala S. Intra-tumoral administration of naked plasmid DNA encoding mouse endostatin inhibits renal carcinoma growth. Int J Cancer. 2001;91:835-839.
34. Pawliuk R, Bachelot T, Zurkiya O, Eriksson A, Cao Y, Leboulch P. Continuous intravascular secretion of endostatin in mice from transduced hematopoietic stem cells. Mol Ther. 2002;5:345-351.
35. Eisterer W, Jiang X, Bachelot T, et al. Unfulfilled promise of endostatin in a gene therapy - Xenotransplant model of human acute lymphocytic leukemia. Mol Ther. 2002;5:352-359.
36. Kremer EJ, Perricaudet M. Adenovirus and adeno-associated virus mediated gene transfer. Br Med Bull. 1995;51:31-44.
37. Bergers G, Javaherian K, Lo KM, Folkman J, Hanahan D. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science. 1999;284:808-812.
38. Kuo CJ, Famebo F, Yu EY, et al. Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer. Proc Natl Acad Sci USA. 2001;98:4605-4610.
39. Feldman AL, Restifo NP, Alexander HR, et al. Antiangiogenic gene therapy of cancer utilizing a recombinant adenovirus to elevate systemic endostatin levels in mice. Cancer Res. 2000;60:1503-1506.
40. Rygaard J, Povlsen C. Athymic (nude) mouse. In: The Mouse in Biomedical Research. London: Academic Press; 1982;51-64.
41. Dhanabal M, Ramchandran R, Waterman MJ, et al. Endostatin induces endothelial cell apoptosis. J Biol Chem. 1999;274:11721-11726.
42. Pulkkanen KJ, Laukkanen MO, Naarala J, Yla-Herttuala S. False-positive apoptosis signal in mouse kidney and liver detected with TUNEL assay. Apoptosis. 2000;5:329-333.
43. Liu HS, Jan MS, Chou CK, Chen PH, Ke NJ. Is green fluorescent protein toxic to the living cells? Biochem Biophys Res Commun. 1999;260:712-717.
44. Martinez-Serrano A, Villa A, Navarro B, Rubio FJ, Bueno C. Human neural progenitor cells: Better blue than green? Nat Med. 2000;6:483-484.