Drug resistance conferred by MDR1 expression in spheroids formed by glioblastoma cell lines

Anticancer Research

Volumn 17, Issue 5 A, 1997, Pages 3321-3327

  Kolchinsky, A ^a   Roninson, I B ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Cell cycle; Glioblastoma; Multiple drug resistance; Spheroids; Vinblastine

Indexed keywords

AGAROSE; FLUORESCENT DYE; GLYCOPROTEIN P; VINBLASTINE;

ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GLIOBLASTOMA; HUMAN; HUMAN CELL; ISOTOPE LABELING; MONOLAYER CULTURE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR SPHEROID;

CELL CYCLE; CELL DIVISION; DRUG RESISTANCE, MULTIPLE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOBLASTOMA; HUMANS; ORGANOIDS; P-GLYCOPROTEIN; RNA, MESSENGER; TUMOR CELLS, CULTURED; VINBLASTINE;

EID: 0030815278     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Teicher BA, Herman TS, Holden SA, Wang YY et al: Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo. Science 247: 1457-1461, 1990.
2. Kobayashi H, Man S, Graham CH et al: Multicellular-mediated resistance to alkylating agents in cancer. Proc Nat Acad Sci USA 90: 3294-3298, 1993.
3. Bjerkvig R, ed. Spheroid Culture in Cancer Research. Roca Baton, FL, CRC Press, 1992.
4. Sutherland RM: Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 240: 177-184, 1988.
5. Roninson IB, ed. Molecular and Cellular Biology of Multidrug resistance in tumor cells. NY, Plenum Press, 1991.
6. Bradley G, Ling V: P-glycoprotein, multidrug resistance and tumor progression. Cancer and Metastasis Rev 13: 223-233, 1994.
7. Becker I, Becker KF, Meyermann R, Hollt: The multidrug-resistance gene MDR1 is expressed in human glial tumors. Acta Neuropathol 82: 516-519, 1991.
8. Dietzmann K, Bossanyi PV, Franke DS: Expression of P-glycoprotein as a multidrug resistance gene product in human reactive astrocytes and astrocytoma. Zentralbl Pathol 140: 149-153, 1994.
9. Kiwit JC, Hertel A, Matuschek AE: Reversal of chemoresistance in malignant gliomas by calcium antagonists: correlation with the expression of multidrug-resistant p-glycoprotein. J Neurosurg 81: 587-594, 1994.
10. Krishnan A: Rapid flow cytometric analysis of mammalian cell cycle by propidium iodine staining. J Cell Biol 66: 188-193, 1975.
11. de Graaf D, Sharma R, Mechetner EM, Schimke R, Roninson IB: P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake. Proc Natl Acad Sci USA 93: 1238-1242, 1996.
12. Pear WS, Scott ML and Nolan GP (1996). Generation of high-titer helper-free retroviruses by transient transfection. In: Methods in Molecular Medicine, Vol. 7: Gene Therapy Protocols, P. Robbins, ed., Humana Press, pp. 30-37. Totowa, NJ.
13. Ponte P, Ng SY, Engel J, Cunning P, Kedes L: Evolutionary conservation in the untranslated regions of actin mRNA: DNA sequence of a human beta-actin cDNA. Nucl Acids Res 12: 1687-1696, 1984.
14. Mechetner EB, Roninson IB: Efficient inhibition of P-glycoprotein mediated drug resistance with a monoclonal antibody. Proc Natl Acad Sci USA 89: 5824-5828, 1992.
15. Chaudhary PM, Roninson IB: Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 66: 85-94, 1991.
16. Carlsson J, Nederman T: Tumor spheroids as a model in studies of drug effects. In: Bjerkvig R, ed. Spheroid Culture in Cancer Research. Roca Baton, FL, CRC Press, 1992, pp. 199-216.
17. Olive PL, Durand RE: Drug and radiation resistance in spheroids - cell contact and kinetics. Cancer Metastasis Rev 13: 121-138, 1994.
18. Nederman T: Effects of vinblastine and 5-fluorouracil on human glioma and thyroid cancer cell monolayers and spheroids. Cancer Res 44: 254-258, 1984.
19. Tonn JC, Haugland HK, Saraste J, Roosen, K. Laerum, OD: Differential effects of vincristine and phenytoin on the proliferation, migration and invasion of human glioblastoma cell lines. J Neurosurgery 82: 1035-1043, 1995.
20. Madoc-Jones H, Mauro F: Interphase action of vinblastine and vincristine: differences in their lethal action through the mitotic cycle of cultured mammalian cells. J Cell Physiol 72: 185-196, 1968.
21. Wibe E: Resistance to vincristine of human cells grown as multicellular spheroids. Br J Cancer 42: 937-941, 1980.
22. Erlichman C, Wu A: Resistance of MGH-U1 bladder cancer spheroids to vincristine. Anticancer Res 12: 1233-1236, 1992.
23. Thomas DGT, Salcman, M: in vivo estimates of kinetic parameters. In: Neurobiology of brain tumors (Salcman, M, ed). Baltimore, Williams and Wilkins, 1991, pp. 259-273.
24. Nederman T, Carlsson J: Penetration and binding of vinblastine and 5-fluorouracil in cellular spheroids. Cancer Chemother Pharmacol 13: 131-135, 1984.
25. Nederman T, Carlsson J, Malmquist M: Penetration of substances into tumor tissue. A methodological study on cellular spheroids. In vitro 17: 290-298, 1981.