Autoimmune T cells retard the loss of function in injured rat optic nerves

Journal of Neuroimmunology

Volumn 106, Issue 1-2, 2000, Pages 189-197

  Moalem, Gila ^a   Yoles, Eti ^a   Leibowitz Amit, Raya ^a   Muller Gilor, Shir ^a   Mor, Felix ^a   Cohen, Irun R ^a   Schwartz, Michal ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Autoimmunity; CNS; Injury

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; EVOKED VISUAL RESPONSE; FEMALE; NERVE CONDUCTION; NERVE DEGENERATION; NERVE FIBER TRANSECTION; NEUROPROTECTION; NONHUMAN; OPTIC NERVE LESION; PHOTOSTIMULATION; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL; T LYMPHOCYTE;

ANIMALS; AUTOIMMUNITY; AXONS; CELL LINE; CELL SURVIVAL; EVOKED POTENTIALS, VISUAL; FEMALE; MYELIN BASIC PROTEINS; NEURAL CONDUCTION; OPTIC NERVE INJURIES; RATS; RATS, INBRED LEW; RETINAL GANGLION CELLS; T-LYMPHOCYTES;

EID: 0034237630     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(00)00240-X     Document Type: Article

References (33)

1. Ben Nun A., Cohen I.R. Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells. J. Immunol. 129:1982;303-308.
2. Ben Nun A., Wekerle H., Cohen I.R. The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur. J. Immunol. 11:1981;195-199.
3. Burns J., Rosenzweig A., Zweiman B., Lisak R.P. Isolation of myelin basic protein-reactive T-cell lines from normal human blood. Cell. Immunol. 81:1983;435-440.
4. Cohen I.R. The cognitive paradigm and the immunological homunculus. Immunol. Today. 13:1992;490-494.
5. Dorfman L.J., Gaynon M., Ceranski J., Louis A.A., Howard J.E. Visual electrical evoked potentials: evaluation of ocular injuries. Neurology. 37:1987;123-128.
6. Duvdevani R., Rosner M., Belkin M., Sautter J., Sabel B.A., Schwartz M. Graded crush of the rat optic nerve as a brain injury model: combining electrophysiological, histological and behavioral outcome. Restor. Neurol. Neurosci. 2:1990;31-38.
7. Elias D., Reshef T., Birk O.S., van der Zee R., Walker M.D., Cohen I.R. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc. Natl. Acad. Sci. USA. 88:1991;3088-3091.
8. Faden A.I. Experimental neurobiology of central nervous system trauma. Crit. Rev. Neurobiol. 7:1993;175-186.
9. Faden A.I., Salzman S. Pharmacological strategies in CNS trauma. Trends Pharmacol. Sci. 13:1992;29-35.
10. Gold R., Hartung H.P., Lassmann H. T-cell apoptosis in autoimmune diseases: termination of inflammation in the nervous system and other sites with specialized immune-defense mechanisms. Trends Neurosci. 20:1997;399-404.
11. Hickey W.F., Hsu B.L., Kimura H. T-lymphocyte entry into the central nervous system. J. Neurosci. Res. 28:1991;254-260.
12. Hirschberg D.L., Moalem G., He J., Mor F., Cohen I.R., Schwartz M. Accumulation of passively transferred primed T cells independently of their antigen specificity following central nervous system trauma. J. Neuroimmunol. 89:1998;88-96.
13. Hirshfeld H., Teitelbaum D., Arnon R., Sela M. Basic encephalitogenic protein: a simplified purification on sulfoethyl-Sephadex. FEBS Lett. 7:1970;317.
14. Hovda D.A., Yoshino A., Kawamata T., Katayama Y., Becker D.P. Diffuse prolonged depression of cerebral oxidative metabolism following concussive brain injury in the rat: a cytochrome oxidase histochemistry study. Brain Res. 567:1991;1-10.
15. Liu D., Yang R., Yan X., McAdoo D.J. Hydroxyl radicals generated in vivo kill neurons in the rat spinal cord: electrophysiological, histological, and neurochemical results. J. Neurochem. 62:1994;37-44.
16. Lynch D.R., Dawson T.M. Secondary mechanisms in neuronal trauma. Curr. Opin. Neurol. 7:1994;510-516.
17. Martin R., Jaraquemada D., Flerlage M., Richert J., Whitaker J., Long E.O., et al. Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals. J. Immunol. 145:1990;540-548.
18. McIntosh T.K. Novel pharmacologic therapies in the treatment of experimental traumatic brain injury: a review. J. Neurotrauma. 10:1993;215-261.
19. Moalem G., Leibowitz-Amit R., Yoles E., Mor F., Cohen I.R., Schwartz M. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat. Med. 5:1999;49-55.
20. Moalem G., Monsonego A., Shani Y., Cohen I.R., Schwartz M. Differential T cell response in central and peripheral nerve injury: Connection with immune privilege. FASEB J. 13:1999;46-59.
21. Pette M., Fujita K., Wilkinson D., Altmann D.M., Trowsdale J., Giegerich G., et al. Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors. Proc. Natl. Acad. Sci. USA. 87:1990;7968-7972.
22. Popovich P.G., Stokes B.T., Whitacre C.C. Concept of autoimmunity following spinal cord injury: possible roles for T lymphocytes in the traumatized central nervous system. J. Neurosci. Res. 45:1996;349-363.
23. Ramon y Cajal S. May R.M. Degeneration and Regeneration of the Nervous System, 1959;Hafner, New-York.
24. Schluesener H.J., Wekerle H. Autoaggressive T lymphocyte lines recognizing the encephalitogenic region of myelin basic protein: in vitro selection from unprimed rat T lymphocyte populations. J. Immunol. 135:1985;3128-3133.
25. Smith D.H., Casey K., McIntosh T.K. Pharmacologic therapy for traumatic brain injury: experimental approaches. New Horiz. 3:1995;562-572.
26. Spekreijse H., Apkarian P. The use of a system analysis approach to electrodiagnostic (ERG and VEP) assessment. Vision Res. 26:1986;195-219.
27. Streilein J.W. Unraveling immune privilege. Science. 270:1995;1158-1159.
28. Stys P.K., Ransom B.R., Waxman S.G. Compound action potential of nerve recorded by suction electrode: a theoretical and experimental analysis. Brain Res. 546:1991;18-32.
29. Van Parijs L., Abbas A.K. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science. 280:1998;243-248.
30. Yoles E., Belkin M., Schwartz M. HU-211, a nonpsychotropic cannabinoid, produces short- and long-term neuroprotection after optic nerve axotomy. J. Neurotrauma. 13:1996;49-57.
31. Yoles E., Schwartz M. Degeneration of spared axons following partial white matter lesion: Implications for optic nerve neuropathies. Exp. Neurol. 153:1998;1-7.
32. Yoles E., Zalish M., Lavie V., Duvdevani R., Ben Bassat S., Schwartz M. GM1 reduces injury-induced metabolic deficits and degeneration in the rat optic nerve. Invest. Ophthalmol. Vis. Sci. 33:1992;3586-3591.
33. Yoshino A., Hovda D.A., Kawamata T., Katayama Y., Becker D.P. Dynamic changes in local cerebral glucose utilization following cerebral concussion in rats: evidence of a hyper- and subsequent hypometabolic state. Brain Res. 561:1991;106-119.