Mutations in the extracellular amino-terminal domain of the NK2 neurokinin receptor abolish cAMP signaling but preserve intracellular calcium responses

Journal of Biological Chemistry

Volumn 277, Issue 44, 2002, Pages 42034-42048

  Lecat, Sandra ^a   Bucher, Bernard ^a   Mely, Yves ^a   Galzi, Jean Luc ^a,b  

^a CNRS   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CONFORMATIONS; ENERGY TRANSFER; FLUORESCENCE; NEUROLOGY; POLYPEPTIDES; RESONANCE;

KINETIC MODELING;

BIOCHEMISTRY;

CALCIUM; CYCLIC AMP; NEUROKININ 2 RECEPTOR; NEUROKININ A; NEUROPEPTIDE; TACHYKININ RECEPTOR;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EMBRYO; ENERGY TRANSFER; ENZYME ACTIVE SITE; EXTRACELLULAR SPACE; FLUORESCENCE; GENE MUTATION; HUMAN; HUMAN CELL; KINETICS; LIGAND BINDING; MOLECULAR MODEL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; RECEPTOR BINDING;

CALCIUM; CYCLIC AMP; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; KINETICS; MODELS, THEORETICAL; MUTATION; NEUROKININ A; PROTEIN CONFORMATION; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTANCE P;

EID: 0036830604     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M203606200     Document Type: Article

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