Point mutation increases a form of the NK1 receptor with high affinity for neurokinin A and B and septide

British Journal of Pharmacology

Volumn 125, Issue 2, 1998, Pages 393-401

  Ciucci, Alessandra ^a   Palma, Carla ^a   Manzini, Stefano ^a   Werge, Thomas M ^b  

^a Menarini Ricerche SpA   (Italy)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

High affinity tachykinin binding; Law of mass action; Multiple binding sites; Multiple radioligands; Neurokinins; NK1 receptor; Point mutation; Septide; Two site analysis

Indexed keywords

MUTANT PROTEIN; N BENZYL N2 [4 HYDROXY 1 [(1 METHYL 1H INDOL 3 YL)CARBONYL]PROLYL] N METHYL 3 (2 NAPHTHYL)ALANINAMIDE; NEUROKININ 1 RECEPTOR; NEUROKININ A; NEUROKININ B; NOLPITANTIUM; SEPTIDE; SUBSTANCE P; SUBSTANCE P [6-11]; SUBSTANCE P METHYL ESTER;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHO CELL; CONTROLLED STUDY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RADIOASSAY; RECEPTOR AFFINITY;

ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; NEUROKININ A; NEUROKININ B; PEPTIDE FRAGMENTS; POINT MUTATION; PYRROLIDONECARBOXYLIC ACID; RADIOLIGAND ASSAY; RECEPTORS, NEUROKININ-1; RECOMBINANT PROTEINS; SUBSTANCE P;

EID: 0031689404     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702070     Document Type: Article

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