Molecular characterization of the substance P·Neurokinin-1 receptor complex. Development of an experimentally based model

Journal of Biological Chemistry

Volumn 276, Issue 25, 2001, Pages 22862-22867

  Pellegrini, Maria ^a   Bremer, Andrew A ^b   Ulfers, Amy L ^a   Boyd, Norman D ^b   Mierke, Dale F ^a  

^a BROWN UNIVERSITY   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; COMPUTER SIMULATION; MOLECULAR DYNAMICS; NEUROLOGY; PROTEINS; SOLVENTS; TOPOLOGY;

LIGAND BINDING;

BIOCHEMISTRY;

G PROTEIN COUPLED RECEPTOR; NEUROKININ 1 RECEPTOR; SUBSTANCE P; SUBSTANCE P [3 (4 BENZOYLPHENYLALANINE)]; SUBSTANCE P [4 (4 BENZOYLPHENYLALANINE)]; SUBSTANCE P [8 (4 BENZOYLPHENYLALANINE)]; SUBSTANCE P DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID COMPOSITION; ARTICLE; HORMONE PROTEIN COMPLEX; HORMONE RECEPTOR INTERACTION; MOLECULAR DYNAMICS; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; PHOTOAFFINITY LABELING; PROTEIN CONFORMATION;

HUMANS; MODELS, MOLECULAR; PHOTOAFFINITY LABELS; PROTEIN CONFORMATION; RECEPTORS, NEUROKININ-1; SUBSTANCE P;

EID: 0035933818     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M101057200     Document Type: Article

References (42)

1. Fong, T. M., Cascieri, M. A., Yu, H., Bansal, A., Swain, C., and Strader, C. D. (1993) Nature 362, 350-353
2. Fong, T. M., Yu, H., Cascieri, M. A., Underwood, D., Swain, C. J., and Strader, C. D. (1994) J. Biol. Chem. 269, 2728-2732
3. Strader, C. D., Fong, T. M., Tota, M. R., Unredwood, D., and Dixon, R. A. F. (1994) Annu. Rev. Biochem. 63, 101-132
4. Turcatti, G., Zoffmann, S., Lowe, J. A. III, Drozda, S. E., Chassaing, G., Schwartz, T. W., and Chollet, A. (1997) J. Biol. Chem. 272, 21167-21175
5. Elling, C. E., and Schwartz, T. W. (1996) EMBO J. 15, 6213-6219
6. Elling, C. E., Thirstrup, K., Nielsen, S. M., Hjorth, S. A., and Schwartz, T. W. (1997) Ann. N. Y. Acad. Sci. 814, 142-151
7. Holst, B., Zoffmann, S., Elling, C. E., Hjorth, S. A., and Schwartz, T. W. (1998) Mol. Pharmacol. 53, 166-175
8. Takeuchi, Y., Shands, E. F., Beusen, D. D., and Marshall, G. R. (1998) J. Med. Chem. 41, 3609-3623
9. Vedani, A., Briem, H., Dobler, M., Dollinger, H., and McMasters, D. R. (2000) J. Med. Chem. 43, 4416-4427
10. Fong, T. M., Yu, H., Huang, R. R., and Strader, C. D. (1992) Biochemistry 31, 11806-11811
11. Fong, T. M., Yu, H., and Strader, C. D. (1992) Biophys. J. 62, 59-60
12. Huang, R. R., Huang, D., Strader, C. D., and Fong, T. M. (1995) Biochemistry 34, 16467-16472
13. MacDonald, D., Mierke, D. F., Li, H., Pellegrini, M., Sachais, B., Krause, J. E., Leeman, S. E., and Boyd, N. D. (2001) Biochemistry 40, 2530-2539
14. Boyd, N. D., Kage, R., Dumas, J. J., Krause, J. E., and Leeman, S. E. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 433-437
15. Kage, R., Leeman, S. E., Krause, J. E., Costello, C. E., and Boyd, N. D. (1996) J. Biol. Chem. 271, 25797-25800
16. Li, H., Macdonald, D. M., Hronowski, X., Costello, C. E., Leeman, S. E., and Boyd, N. D. (2001) J. Biol. Chem. 276, 10589-10593
17. Bremer, A. A., Leeman, S. E., and Boyd, N. D. (2001) J. Biol. Chem. 276, 22857-22861
18. Unger, V. M., Hargrave, P. A., Baldwin, J. M., and Schertler, G. F. (1997) Nature 389, 203-206
19. Baldwin, J. M., Schertler, G. F., and Unger, V. M. (1997) J. Mol. Biol. 272, 144-164
20. Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Le Trong, I., Teller, D. C., Okada, T., Stenkamp, R. E., Yamamoto, M., and Miyano, M. (2000) Science 289, 739-745
21. Prado, G. N., Mierke, D. F., Pellegrini, M., Taylor, L., and Polgar, P. (1998) J. Biol. Chem. 273, 33548-33555
22. Roelz, C., Pellegrini, M., and Mierke, D. F. (1999) Biochemistry 38, 6397-6405
23. Altschul, S. F., Madden, T. L., Schaffer, A. A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D. J. (1997) Nucleic Acids Res. 25, 3389-3402
24. Paterlini, G., Portoghese, P. S., and Ferguson, D. M. (1997) J. Med. Chem. 40, 3254-3262
25. Woolley, G. A., and Deber, C. M. (1987) Biopolymers 26, suppl., S109-S121
26. Tallon, M., Ron, D., Halle, D., Amodeo, P., Saviano, G., Temussi, P. A., Zelinger, Z., Naider, F., and Chorev, M. (1993) Biopolymers 33, 915-926
27. Seelig, A., Alt, T., Lotz, S., and Holzemann, G. (1996) Biochemistry 35, 4365-4374
28. Whitehead, T. L., McNair, S. D., Hadden, C. E., Young, J. K., and Hicks, R. P. (1998) J. Med. Chem. 41, 1497-1506
29. Auge, S., Bersch, B., Tropis, M., and Milon, A. (2000) Biopolymers 54, 297-306
30. Berendsen, H. J. C., van der Spoel, D., and van Buuren, R. (1995) Comp. Phys. Commun. 95, 43-56
31. van Buuren, A. R., Marrink, S., and Berendsen, H. J. C. (1993) J. Phys. Chem. 97, 9206-9216
32. Elling, C. E., Nielsen, S. M., and Schwartz, T. W. (1995) Nature 374, 74-77
33. Holst, B., Elling, C. E., and Schwartz, T. W. (2000) Mol. Pharmacol. 58, 263-270
34. Winnik, M. A. (1981) Chem. Rev. 81, 491-534
35. Elling, C. E., Raffetseder, U., Nielsen, S. M., and Schwartz, T. W. (2000) Biochemistry 39, 667-675
36. Fong, T. M., Huang, R. R., Yu, H., and Strader, C. D. (1993) Regul. Pept. 46, 43-48
37. Fong, T. M., Huang, R. C., Yu, H., Swain, C. J., Underwood, D., Cascieri, M. A., and Strader, C. D. (1995) Can. J. Physiol. Pharmacol. 73, 860-865
38. Kage, R., Hershey, A. D., Krause, J. E., Boyd, N. D., and Leeman, S. E. (1995) J. Neurochem. 64, 316-321
39. Rens-Domiano, S., and Reisine, T. (1991) J. Biol. Chem. 266, 20094-20102
40. Hastrup, H., and Schwartz, T. W. (1996) FEBS Lett. 399, 264-266
41. Sagan, S., Beaujouan, J. C., Torrens, Y., Saffroy, M., Chassaing, G., Glowinski, J., and Lavielle, S. (1997) Mol. Pharmacol. 52, 120-127
42. Bremer, A. A., Leeman, S. E., and Boyd, N. D. (2000) FEBS Lett. 486, 43-48