Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 277, Issue 6 21-6, 1999, Pages

  De Sanctis, G T ^a   Singer, J B ^b   Jiao, A ^a   Yandava, C N ^a   Lee, Y H ^a   Haynes, T C ^c   Lander, E S ^b,d   Beier, D R ^a   Drazen, J M ^a,e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c JACKSON LABORATORY   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

A J mice; Asthma; C3H HeJ mice; Methacholine

Indexed keywords

METHACHOLINE;

ANIMAL EXPERIMENT; ARTICLE; ASTHMA; CHROMOSOME 6; CHROMOSOME 7; CONTROLLED STUDY; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; GENOTYPE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

EID: 0033400312     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1999.277.6.l1118     Document Type: Article

References (22)

1. Anonymous. Guidelines for the diagnosis and management of asthma. National Heart, Lung, and Blood Institute. National Asthma Education Program. Expert Panel Report. J. Allergy Clin. Immunol. 88: 425-534, 1991.
2. Christiansen, S. C., D. Proud, R. B. Sarnoff, U. Juergens, C. G. Cochrane, and B. L. Zuraw. Elevation of tissue kallikrein and kinin in the airways of asthmatic subjects after endobronchial allergen challenge. Am. Rev. Respir. Dis. 145: 900-905, 1992.
3. De Sanctis, G. T., A. Itoh, F. H. Green, S. Qin, T. Kimura, J. K. Grobholz, T. R. Martin, T. Maki, and J. M. Drazen. T-lymphocytes regulate genetically determined airway hyperresponsiveness in mice. Nat. Med. 3: 460-462, 1997.
4. De Sanctis, G. T., M. Merchant, D. R. Beier, R. D. Dredge, J. K. Grobholz, T. R. Martin, E. S. Lander, and J. M. Drazen. Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat. Genet. 11: 150-154, 1995.
5. Dietrich, W. F., J. C. Miller, R. G. Steen, M. Merchant, D. Damron, R. Nahf, A. Gross, D. C. Joyce, M. Wessel, R. D. Dredge, A. Marquis, L. D. Stein, N. Goodman, D. C. Page, and E. S. Lander. A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nat. Genet. 7: 220-245, 1994.
6. Duncan, P. G., and J. S. Douglas. Influences of gender and maturation on responses of guinea-pig airway tissues to LTD4. Eur. J. Pharmacol. 112: 423-427, 1985.
7. Evans, D. M., D. M. Jones, G. R. Pitt, D. Ashworth, F. De Clerck, F. Verheyen, and M. Szelke. Synthetic inhibitors of human tissue kallikrein. Immunopharmacology 32: 117-118, 1996.
8. Ewart, S. L., W. Mitzner, D. A. DiSilvestre, D. A. Meyers, and R. C. Levitt. Airway hyperresponsiveness to acetylcholine: segregation analysis and evidence for linkage to murine chromosome 6. Am. J. Respir. Cell Mol. Biol. 14: 487-495, 1996.
9. Lander, E. S., and D. Botstein. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121: 185-199, 1989.
10. Lander, E. S., and N. J. Schork. Genetic dissection of complex traits. Science 265: 2037-2048, 1994.
11. Levitt, R. C., and W. Mitzner. Expression of airway hyperreactivity to acetylcholine as a simple autosomal recessive trait in mice. FASEB J. 2: 2605-2608, 1988.
12. Levitt, R. C., and W. Mitzner. Autosomal recessive inheritance of airway hyperreactivity to 5-hydroxytryptamine. J. Appl. Physiol. 67: 1125-1132, 1989.
13. Longphre, M., and S. R. Kleeberger. Susceptibility to platelet-activating factor-induced airway hyperreactivity and hyperpermeability: interstrain variation and genetic control. Am. J. Respir. Cell Mol. Biol. 13: 586-594, 1995.
14. Martin, T. R., N. P. Gerard, S. J. Galli, and J. M. Drazen. Pulmonary responses to bronchoconstrictor agonists in the mouse. J. Appl. Physiol. 64: 2318-2323, 1988.
15. O'Connor, G. T., D. Sparrow, and S. T. Weiss. A prospective longitudinal study of methacholine airway responsiveness as a predictor of pulmonary-function decline: the Normative Aging Study. Am. J. Respir. Crit. Care Med. 152: 87-92, 1995.
16. Pauwels, R. A., P. R. Germonpre, J. C. Kips, and G. F. Joos. Genetic control of indirect airway responsiveness in the rat. Clin. Exp. Allergy 25, Suppl. 2: 55-60, 1995.
17. Postma, D. S., E. R. Bleecker, P. J. Amelung, K. J. Holroyd, J. Xu, C. I. Panhuysen, D. A. Meyers, and R. C. Levitt. Genetic susceptibility to asthma - bronchial hyperresponsiveness coinherited with a major gene for atopy. N. Engl. J. Med. 333: 894-900, 1995.
18. Robinson, P. J., R. G. Hegele, and R. R. Schellenberg. Increased airway reactivity in human RSV bronchiolitis in the guinea pig is not due to increased wall thickness. Pediatr. Pulmonol. 22: 248-254, 1996.
19. Sparrow, D., G. O'Connor, T. Colton, C. L. Barry, and S. T. Weiss. The relationship of nonspecific bronchial responsiveness to the occurrence of respiratory symptoms and decreased levels of pulmonary function. The Normative Aging Study. Am. Rev. Respir. Dis. 135: 1255-1260, 1987.
20. Woolcock, A. J., and C. R. Jenkins. Assessment of bronchial responsiveness as a guide to prognosis and therapy in asthma. Med. Clin. North Am. 74: 753-765, 1990.
21. Yarkony, K. A., and K. M. Wills. The effects of aging on airway hyperreactivity in inbred strains of mice (Abstract). Am. Rev. Respir. Dis. 147, 1993.
22. Zamel, N., P. A. McClean, P. R. Sandell, K. A. Siminovitch, and A. S. Slutsky. Asthma on Tristan da Cunha: looking for the genetic link. The University of Toronto Genetics of Asthma Research Group. Am. J. Respir. Crit. Care Med. 153: 1902-1906, 1996.