Expression of hypothalamic peptides in mice lacking neuronal nitric oxide synthase: Reduced β-END immunoreactivity in the arcuate nucleus

Neuroendocrinology

Volumn 68, Issue 6, 1998, Pages 403-411

  Bernstein, Hans Gert ^a   Keilhoff, Gerburg ^a   Seidel, Bertolt ^a   Stanarius, Andreas ^a   Huang, Paul L ^b   Fishman, Mark C ^b   Reiser, Michael ^a   Bogerts, Bernhard ^a   Wolf, Gerald ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

endorphin; Corticotropin releasing hormone; Immunocytochemistry; In situ hybridization; Molecular neuroendocrinology; Mouse; Neurophysin; Nitric oxide synthase; Pro opiomelanocortin

Indexed keywords

ALPHA INTERMEDIN; BETA ENDORPHIN; CITRULLINE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; NEUROPHYSIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROOPIOMELANOCORTIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ANIMAL CELL; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; ENZYME DEFICIENCY; HORMONE RELEASE; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THALAMUS MIDLINE NUCLEUS;

ANIMALS; ARCUATE NUCLEUS; BETA-ENDORPHIN; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICE, KNOCKOUT; MUTATION; NERVE TISSUE PROTEINS; NEUROPEPTIDES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; PRO-OPIOMELANOCORTIN; RNA, MESSENGER;

EID: 0032406323     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000054390     Document Type: Article

References (37)

1. Pu S, Horvath TL, Diano S, Naftolin F, Kalra PS, Kalra SP: Evidence showing that β-endorphin regulates cyclic guanosine 3′,5′-monophosphate (cGMP) efflux: Anatomical and functional support for an interaction between opiates and nitric oxide. Endocrinology 1997; 138:1537-1543.
2. G-nitro-arginine autoradiography. Neuroscience 1996;75:881-890.
3. Bhat G, Mahesh VB, Aguan K, Brann DW: Evidence that brain nitric oxide synthase is the major nitric oxide synthase isoform in the hypothalamus of the adult female rat and that nitric oxide potently regulates hypothalamic cGMP levels. Neuroendocrinology 1996;64: 93-102.
4. Garthwaite J, Boulton CL: Nitric oxide signaling in the central nervous system. Annu Rev Physiol 1995;57:683-706.
5. Brenman JE, Yia H, Chao DS, Black SM, Bredt DS: Regulation of neuronal nitric oxide synthase through alternative transcripts. Dev Neurosci 1997;19:224-231.
6. McCann SM: The role of nitric oxide at hypothalamic and pituitary levels to alter the release of pituitary hormones. Eur J Endocrinol 1996; 135:533-534.
7. Blanco E, Jirikowski GF, Riesco JM, Juanes JA, Vazquez R: Coexistence of NADPH-diaphorase with tyrosine hydroxylase in hypothalamic magnocellular neurons of the rat. Neuropeptides 1997;31:227-230.
8. Prast H, Lamberti C, Fischer H, Philippu A: Modulation of histamine release in the hypothalamus by nitric oxide. Inflamm Res 1997; 46(suppl 1):41-42.
9. Kaehler ST, Philippu A, Singewald N: Modulation by nitirc oxide of hapothalamic GABA and serotonin release - Implications for central blood-pressure regulation. Naunyn Schmiedebergs Arch Pharmacol 1997;356(suppl 1):158.
10. Hatakeyama S, Kawai Y, Ueyama T, Senba E: Nitric oxide synthase-containing magnocellular neurons of the rat hypothalamus synthesize oxytocin and vasopressin and express fos following stress stimuli. J Chem Neuroanat 1996; 11:243-256.
11. Ceccatelli S: Expression and plasticity of NO synthase in the neuroendocrine system. Brain Res Bull 1997;44:533-538.
12. Crack PJ, Autelitano DJ, Smith AI: The involvement of nitric oxide secretion of β-endorphin from the pituitary intermediate lobe of the rat. Brain Res 1997;761:113-120.
13. Bonavera JJ, Sahu A, Kalra PS, Kalra SP: Evidence that nitric oxide may mediate the ovarian steroid-induced luteinizing hormone surge: Involvement of excitatory amino acids. Endocrinology 1993;133:2481-2487.
14. Bonavera JJ, Sahu A, Kalra PS, Kalra SP: Evidence in support of nitric oxide involvement in the cyclic release of prolactin and LH surge. Brain Res 1994;660:175-179.
15. Kato M: Involvement of nitric oxide in growth hormone (GH)-releasing hormone induced GH secretion in rat pituitary cell. Endocrinology 1993;131:2133-2138.
16. Moretto M, Lopez FJ, Negro-Vilar A: Nitric oxide regulates luteinizing hormone-releasing hormone secretion. Endocrinology 1993;133: 2399-2402.
17. Calka J, Wolf G, Brosz M: Ultrastructural demonstration of NADPH-diaphorase histochemical activity in the supraoptic nucleus of normal and dehydrated rats. Brain Res Bull 1994;34: 301-308.
18. Chatterjee S, Collins TJ, Yallamalli C: Inhibition of nitric oxide facilitates LH release from rat pituitaries. Life Sci 1997;61:45-50.
19. Costa A, Trainer P, Besser M, Grossmann A: Nitric oxide modulates the release of corticotropin-releasing hormone from rat hypothalamus in vitro. Brain Res 1993;605:187-192.
20. Rivier C, Shen GH: In the rat, endogenous nitric oxide modulates the response of the hypothalamo-pituitary-adrenal axis to interleukin-1β, vasopressin, and oxytocin. J Neurosci 1994;14:1985-1993.
21. Huang PL, Dawson TM Bredt DS, Snyder SH, Fishman MC: Targeted disruption of the neuronal nitric oxide synthase gene. Cell 1993;75: 1273-1286.
22. Sternberger LA: Immunocytochemistry. New York, Wiley, 1979.
23. Stanarius A, Töpel I, Schulz S, Noack H, Wolf G: Immunocytochemistry of endothelial nitric oxide synthase in the rat brain: A light and electron microscopical study using the tyramide signal amplification technique. Acta Histochem 1997;99:411-429.
24. Aoki E, Takeuchi I: Immunohistochemical localization of arginine and citrulline in rat renal tissue. J Histochem Cytochem 1997;45:875-881.
25. Wolf G, Würdig S, Henschke G: Nitric oxide synthase in the brain: Light and electron microscopical findings based on the NADPH-diaphorase reaction. J Neural Transm 1994;43: 105-112.
26. Day R, Schafer MKH, Watson SJ, Chrétien M, Seidah NG: Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary. Mol Endocrinol 1992;6:485-497.
27. Coggeshall RE, Lekan HA: Methods for determining numbers of cells and synapses. A case for more uniform standards of review. J Comp Neurol 1996;364:6-15.
28. Bahr M: How should brain nuclei be delineated? Consequences for developmental mechanisms and for correlation of area size, neuron numbers and function of brain nuclei. Trends Neurosci 1997;20:58-62.
29. Jamali AK, Tramu G: Daily cycle of fos expression within hypothalamic POMC neurons of the male rat. Brain Res 1997;771:45-54.
30. Weibel ER, Elias H: Introduction into stereological principles; in Weibel ER, Elias H (eds): Quantitative Methods in Morphology. Berlin, Springer, 1967, pp 8-15.
31. Bernstein H-G, Stanarius A, Baumann B, Henning H, Krell D, Danos P, Falkai P, Bogerts B: Nitric oxide synthase-containing neurons in the human hypothalamus: Reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics. Neuroscience 1998;83:867-875.
32. Eliasson MJL, Blackshaw S, Schell MJ, Snyder SH: Neuronal nitric oxide synthase alternatively spliced forms: Prominent functional localizations in the brain. Proc Natl Acad Sci USA 1997;94:3396-3401.
33. Amir S: Nitric oxide signaling in the hypothalamus; in Vincent SR (ed): Nitric Oxide in the Nervous System. San Diego, Academic Press, 1995, pp 151-162.
34. Purba JS, Hoogendijk WJG, Hofmann MA, Swaab DF: Increased number of vasopressin-and oxytocin-expressing neurons in the paraventricular nucleus of the human hypothalamus in depression. Arch Gen Psychiatry 1996; 53:137-143.
35. Raadsheer FC, Hoogendijk WJG, Stam FC, Tilders FC, Swaab DF: Increased number of corticotropin-releasing hormone neurons in the hypothalamic paraventricular nuclei of depressed patients. Neuroendocrinology 1994;60: 436-444.
36. Kalra SP: Mandatory neuropeptide-steroid signaling for the preovulatory luteinizing hormone-discharge. Endocr Rev 1993;14:507-538.
37. Bernstein HG, Henning H, Seliger N, Baumann B, Bogerts B: Remarkable beta-endorphinergic innervation of human cerebral cortex as revealed by immunohistochemistry. Neurosci Lett 1996;215:33-36.