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Volumn 11, Issue 10, 2002, Pages 1365-1374

The therapeutic potential of the cannabinoids in neuroprotection

Author keywords

Cannabinoid; Cerebral ischaemia; Huntington's disease; Multiple sclerosis; Nuerodegeneration; Parkinson's disease; Traumatic brain injury

Indexed keywords

1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 2 ARICHIDONYL GLYCEROL; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ANANDAMIDE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; BAY 38 7271; CANNABIDIOL; CANNABINOID DERIVATIVE; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; CANNABIS DERIVATIVE; CYTOKINE; DELTA8 TETRAHYDROCANNABINOL; DEXANABINOL; DRONABINOL; GLYCEROL DERIVATIVE; LEVODOPA; METHANANDAMIDE; N (4 HYDROXYPHENYL)ARACHIDONAMIDE; NABILONE; PALMIDROL; PRS 211092; PRS 211095; RIMONABANT; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 0036798247     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.11.10.1365     Document Type: Review
Times cited : (72)

References (101)
  • 1
    • 0000506578 scopus 로고
    • Marihuana
    • ADAMS R. Marihuana. Harvey Lectures (1942) 37:168-197.
    • (1942) Harvey Lectures , vol.37 , pp. 168-197
    • Adams, R.1
  • 2
    • 33947489961 scopus 로고
    • Isolation, structure and partial synthesis of an active constituent of hashish
    • GAONI Y, MECHOULAM R: Isolation, structure and partial synthesis of an active constituent of hashish. J. Am. Chem. Soc. (1964) 86:1646-1647.
    • (1964) J. Am. Chem. Soc , vol.86 , pp. 1646-1647
    • Gaoni, Y.1    Mechoulam, R.2
  • 3
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • MATSUDA LA, LOLAIT SJ, BROWNSTEIN MJ, YOUNG AC, BONNER TI: Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature (1990) 346:561-564.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 4
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • MUNRO S, THOMAS KL, ABU-SHAAR M: Molecular characterization of a peripheral receptor for cannabinoids. Nature (1993) 365:61-65.
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-shaar, M.3
  • 6
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • DEVANE WA, HANUS L, BREUER A et al.: Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science (1992) 258:1946-1949.
    • (1992) Science , vol.258 , pp. 1946-1949
    • Devane, W.A.1    Hanus, L.2    Breuer, A.3
  • 7
    • 0036260823 scopus 로고    scopus 로고
    • Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor
    • PORTER AC, SAUER JM, KNIERMAN MD et al.: Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor. J. Pharmacol. Exp. Ther. (2002) 301:1020-1024.
    • (2002) J. Pharmacol. Exp. Ther , vol.301 , pp. 1020-1024
    • Porter, A.C.1    Sauer, J.M.2    Knierman, M.D.3
  • 8
    • 0032751632 scopus 로고    scopus 로고
    • Cannabis and cannabinoids: Pharmacology and rationale for clinical use
    • PERTWEE RG: Cannabis and cannabinoids: pharmacology and rationale for clinical use. Forsch Komplmentarmed. (1999) 6(Suppl. 3):12-15.
    • (1999) Forsch. Komplmentarmed , vol.6 , Issue.SUPPL. 3 , pp. 12-15
    • Pertwee, R.G.1
  • 9
    • 0033921628 scopus 로고    scopus 로고
    • Cannabinoid receptor ligands: Clinical and neuropharmacological considerations, relevant to future drug discovery and development
    • PERTWEE RG: Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development. Expert. Opin. Investig. Drugs (2000) 9:1553-1571.
    • (2000) Expert. Opin. Investig. Drugs , vol.9 , pp. 1553-1571
    • Pertwee, R.G.1
  • 11
    • 0025954862 scopus 로고
    • Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study
    • HERKENHAM M, LYNN AB, JOHNSON MR, MELVIN LS, DE COSTA BR, RICE KC: Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J. Neurosci. (1991) 11:563-583.
    • (1991) J. Neurosci , vol.11 , pp. 563-583
    • Herkenham, M.1    Lynn, A.B.2    Johnson, M.R.3    Melvin, L.S.4    De Costa, B.R.5    Rice, K.C.6
  • 12
    • 0025802871 scopus 로고
    • Neuronal localization of cannabinoid receptors in the basal ganglia of the rat
    • HERKENHAM M, LYNN AB, DE COSTA BR, RICHFIELD EK: Neuronal localization of cannabinoid receptors in the basal ganglia of the rat. Brain Res. (1991) 547:267-274.
    • (1991) Brain Res , vol.547 , pp. 267-274
    • Herkenham, M.1    Lynn, A.B.2    De Costa, B.R.3    Richfield, E.K.4
  • 13
    • 0031929438 scopus 로고    scopus 로고
    • Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
    • TSOU K, BROWN S, SANUDO-PENA MC, MACKIE K, WALKER JM: Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience (1998) 83:393-411.
    • (1998) Neuroscience , vol.83 , pp. 393-411
    • Tsou, K.1    Brown, S.2    Sanudo-pena, M.C.3    Mackie, K.4    Walker, J.M.5
  • 15
    • 0031736065 scopus 로고    scopus 로고
    • In vitro functional evidence of neuronal cannabinoid CB1 receptors in human ileum
    • CROCI T, MANARA L, AUREGGI G et al.: In vitro functional evidence of neuronal cannabinoid CB1 receptors in human ileum. Br. J. Pharmacol. (1998) 125:1393-1395.
    • (1998) Br. J. Pharmacol , vol.125 , pp. 1393-1395
    • Croci, T.1    Manara, L.2    Aureggi, G.3
  • 16
    • 0029094470 scopus 로고
    • Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
    • GALIEGUE S, MARY S, MARCHAND J et al.: Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur. J. Biochem. (1995) 232:54-61.
    • (1995) Eur. J. Biochem , vol.232 , pp. 54-61
    • Galiegue, S.1    Mary, S.2    Marchand, J.3
  • 17
    • 0025878961 scopus 로고
    • Molecular cloning of a human cannabinoid receptor which is also expressed in testis
    • GERARD CM, MOLLEREAU C, VASSART G, PARMENTIER M: Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem. J. (1991) 279:129-134.
    • (1991) Biochem. J , vol.279 , pp. 129-134
    • Gerard, C.M.1    Mollereau, C.2    Vassart, G.3    Parmentier, M.4
  • 18
    • 0022559942 scopus 로고
    • Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs
    • HOWLETT AC, QUALY JM, KHACHATRIAN LL: Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs. Mol. Pharmacol. (1986) 29:307-313.
    • (1986) Mol. Pharmacol , vol.29 , pp. 307-313
    • Howlett, A.C.1    Qualy, J.M.2    Khachatrian, L.L.3
  • 19
    • 0029586743 scopus 로고
    • Activation of mitogenactivated protein kinases by stimulation of the central cannabinoid receptor CB1
    • BOUABOULA M, POINOT-CHAZEL C, BOURRIE, B et al.: Activation of mitogenactivated protein kinases by stimulation of the central cannabinoid receptor CB1. Biochem. J. (1995) 312:637-641.
    • (1995) Biochem. J , vol.312 , pp. 637-641
    • Bouaboula, M.1    Poinot-chazel, C.2    Bourrie, B.3
  • 20
    • 0033806918 scopus 로고    scopus 로고
    • The CB(1) cannabinoid receptor is coupled to the activation of c-Jun N-terminal kinase
    • RUEDA D, GALVE-ROPERH I, HARO A, GUZMAN M: The CB(1) cannabinoid receptor is coupled to the activation of c-Jun N-terminal kinase. Mol. Pharmacol. (2000) 58:814-820.
    • (2000) Mol. Pharmacol , vol.58 , pp. 814-820
    • Rueda, D.1    Galve-roperh, I.2    Haro, A.3    Guzman, M.4
  • 21
    • 0028823316 scopus 로고
    • Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor
    • MACKIE K, LAI Y, WESTENBROEK R, MITCHELL R: Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor. J. Neurosci. (1995) 15:6552-6561.
    • (1995) J. Neurosci , vol.15 , pp. 6552-6561
    • Mackie, K.1    Lai, Y.2    Westenbroek, R.3    Mitchell, R.4
  • 22
    • 0029071194 scopus 로고
    • Cannabinoids modulate voltage sensitive potassium A-current in hippocampal neurons via a cAMP-dependent process
    • 2073
    • DEADWYLER SA, HAMPSON RE, MU J, WHYTE A, CHILDERS S: Cannabinoids modulate voltage sensitive potassium A-current in hippocampal neurons via a cAMP-dependent process. J. Pharmacol. Exp. Ther. (1995) 2073:734-743.
    • (1995) J. Pharmacol. Exp. Ther , pp. 734-743
    • Deadwyler, S.A.1    Hampson, R.E.2    Mu, J.3    Whyte, A.4    Childers, S.5
  • 23
    • 0026603679 scopus 로고
    • Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells
    • MACKIE K, HILLE B: Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells. Proc. Natl. Acad. Sci. USA (1992) 89:3825-3829.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 3825-3829
    • Mackie, K.1    Hille, B.2
  • 24
    • 0033002210 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current
    • GEBREMEDHIN D, LANGE AR, CAMPBELL WB, HILLARD CJ, HARDER DR: Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current. Am. J. Physiol. (1999) 276:H2085-H2093
    • (1999) Am. J. Physiol , vol.276
    • Gebremedhin, D.1    Lange, A.R.2    Campbell, W.B.3    Hillard, C.J.4    Harder, D.R.5
  • 25
    • 0035176184 scopus 로고    scopus 로고
    • CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum
    • GERDEMAN G, LOVINGER DM: CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum. J. Neurophysiol. (2001) 85:468-471.
    • (2001) J. Neurophysiol , vol.85 , pp. 468-471
    • Gerdeman, G.1    Lovinger, D.M.2
  • 26
    • 0034117096 scopus 로고    scopus 로고
    • Cannabinoids inhibit excitatory neurotransmission in the substantia nigra pars reticulata
    • SZABO B, WALLMICHRATH I, MATHONIA P, PFREUNDTNER C: Cannabinoids inhibit excitatory neurotransmission in the substantia nigra pars reticulata. Neuroscience (2000) 97:89-97.
    • (2000) Neuroscience , vol.97 , pp. 89-97
    • Szabo, B.1    Wallmichrath, I.2    Mathonia, P.3    Pfreundtner, C.4
  • 27
    • 0034044078 scopus 로고    scopus 로고
    • Cannabinoids modulate synaptic strength and plasticity at glutamatergic synapses of rat prefrontal cortex pyramidal neurons
    • AUCLAIR N, OTANI S, SOUBRIE P, CREPEL F: Cannabinoids modulate synaptic strength and plasticity at glutamatergic synapses of rat prefrontal cortex pyramidal neurons. J. Neurophysiol. (2000) 83:3287-3293.
    • (2000) J. Neurophysiol , vol.83 , pp. 3287-3293
    • Auclair, N.1    Otani, S.2    Soubrie, P.3    Crepel, F.4
  • 28
    • 0030795910 scopus 로고    scopus 로고
    • Anandamide suppresses nitric oxide and TNF-alpha responses to Theiler's virus or endotoxin in astrocytes
    • MOLINA-HOLGADO F, LLEDO A, GUAZA C: Anandamide suppresses nitric oxide and TNF-alpha responses to Theiler's virus or endotoxin in astrocytes. Neuroreport (1997) 8:1929-1933.
    • (1997) Neuroreport , vol.8 , pp. 1929-1933
    • Molina-holgado, F.1    Lledo, A.2    Guaza, C.3
  • 29
    • 0032982520 scopus 로고    scopus 로고
    • The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells
    • WAKSMAN Y, OLSON JM, CARLISLE SJ, CABRAL GA: The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells. J. Pharmacol. Exp. Ther. (1999) 288:1357-1366.
    • (1999) J. Pharmacol. Exp. Ther , vol.288 , pp. 1357-1366
    • Waksman, Y.1    Olson, J.M.2    Carlisle, S.J.3    Cabral, G.A.4
  • 30
    • 0032830327 scopus 로고    scopus 로고
    • Effects of CB(1) cannabinoid receptor activation on cerebellar granule cell nitric oxide synthase activity
    • HILLARD CJ, MUTHIAN S, KEARN CS: Effects of CB(1) cannabinoid receptor activation on cerebellar granule cell nitric oxide synthase activity. FEBS Lett. (1999) 459, 277-281.
    • (1999) FEBS Lett , vol.459 , pp. 277-281
    • Hillard, C.J.1    Muthian, S.2    Kearn, C.S.3
  • 33
    • 0034069673 scopus 로고    scopus 로고
    • Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice
    • SMITH SR, TERMINELLI C, DENHARDT G: Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice. J. Pharmacol. Exp. Ther. (2000) 293:136-150.
    • (2000) J. Pharmacol. Exp. Ther , vol.293 , pp. 136-150
    • Smith, S.R.1    Terminelli, C.2    Denhardt, G.3
  • 35
    • 0033986604 scopus 로고    scopus 로고
    • Cannabinoids inhibit LPS-inducible cytokine mRNA expression in rat microglial cells
    • PUFFENBARGER RA, BOOTHE AC, CABRAL GA. Cannabinoids inhibit LPS-inducible cytokine mRNA expression in rat microglial cells. Glia (2000) 29:58-69.
    • (2000) Glia , vol.29 , pp. 58-69
    • Puffenbarger, R.A.1    Boothe, A.C.2    Cabral, G.A.3
  • 36
    • 0032949907 scopus 로고    scopus 로고
    • Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60
    • JBILO O, DEROCQ JM, SEGUI M, LE FUR G, CASELLAS P: Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60. FEBS Lett. (1999) 448:273-277.
    • (1999) FEBS Lett , vol.448 , pp. 273-277
    • Jbilo, O.1    Derocq, J.M.2    Segui, M.3    Le Fur, G.4    Casellas, P.5
  • 37
    • 0034703186 scopus 로고    scopus 로고
    • In vivo and in vitro treatment with the synthetic cannabinoid CP55, 940 decreases the in vitro migration of macrophages in the rat: Involvement of both CB1 and CB2 receptors
    • SACERDOTE P, MASSI P, PANERAI AE, PAROLARO D: In vivo and in vitro treatment with the synthetic cannabinoid CP55, 940 decreases the in vitro migration of macrophages in the rat: involvement of both CB1 and CB2 receptors. J. Neuroimmunol. (2000) 109:155-163.
    • (2000) J. Neuroimmunol , vol.109 , pp. 155-163
    • Sacerdote, P.1    Massi, P.2    Panerai, A.E.3    Parolaro, D.4
  • 38
    • 0031822204 scopus 로고    scopus 로고
    • The role of macrophages in THC-induced alteration of the cytokine network
    • NEWTON C, KLEIN T, FRIEDMAN H: The role of macrophages in THC-induced alteration of the cytokine network. Adv. Exp. Med. Biol. (1998) 437:207-214.
    • (1998) Adv. Exp. Med. Biol , vol.437 , pp. 207-214
    • Newton, C.1    Klein, T.2    Friedman, H.3
  • 39
    • 0031418498 scopus 로고    scopus 로고
    • Neurodegenerative disorders in humans: The role of glutathione in oxidative stress-mediated neuronal death
    • BAINS JS, SHAW CA: Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death. Brain Res. Brain Res. Rev. (1997) 25:335-358.
    • (1997) Brain Res. Brain Res. Rev , vol.25 , pp. 335-358
    • Bains, J.S.1    Shaw, C.A.2
  • 40
    • 0029165097 scopus 로고
    • Neuroprotective and antioxidant activities of HU-211, a novel NMDA receptor antagonist
    • ESHHAR N, STRIEM S, KOHEN R, TIROSH O, BIEGON A: Neuroprotective and antioxidant activities of HU-211, a novel NMDA receptor antagonist. Eur. J. Pharmacol. (1995) 283:19-29.
    • (1995) Eur. J. Pharmacol , vol.283 , pp. 19-29
    • Eshhar, N.1    Striem, S.2    Kohen, R.3    Tirosh, O.4    Biegon, A.5
  • 41
    • 0032493197 scopus 로고    scopus 로고
    • Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants
    • HAMPSON AJ, GRIMALDI M, AXELROD J, WINK D: Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc. Natl. Acad. Sci. USA (1998) 95:8268-8273.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8268-8273
    • Hampson, A.J.1    Grimaldi, M.2    Axelrod, J.3    Wink, D.4
  • 42
    • 0036488182 scopus 로고    scopus 로고
    • Neuroprotective properties of cannabinoids against oxidative stress: Role of the cannabinoid receptor CB1
    • MARSICANO G, MOOSMANN B, HERMANN H, LUTZ B, BEHLT C: Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1. J. Neurochem. (2002) 80:448-456.
    • (2002) J. Neurochem , vol.80 , pp. 448-456
    • Marsicano, G.1    Moosmann, B.2    Hermann, H.3    Lutz, B.4    Behlt, C.5
  • 43
    • 0032967382 scopus 로고    scopus 로고
    • The role of excitotoxicity in neurodegenerative disease: Implications for therapy
    • DOBLE A: The role of excitotoxicity in neurodegenerative disease: implications for therapy. Pharmacol. Ther. (1999) 81:163-221.
    • (1999) Pharmacol. Ther , vol.81 , pp. 163-221
    • Doble, A.1
  • 44
    • 0027788085 scopus 로고
    • HU-211, a non-psychotropic cannabinoid, rescues cortical neurones from excitatory amino acid toxicity in culture
    • ESHHAR N, STRIEM S, BIEGON A: HU-211, a non-psychotropic cannabinoid, rescues cortical neurones from excitatory amino acid toxicity in culture. Neuroreport (1993) 5:237-240.
    • (1993) Neuroreport , vol.5 , pp. 237-240
    • Eshhar, N.1    Striem, S.2    Biegon, A.3
  • 45
    • 0027381303 scopus 로고
    • The non-psychotropic cannabinoid (+)-(3S,4S)-7-hydroxy-delta 6-tetrahydrocannabinol 1,1-dimethylheptyl (HU-211) attenuates N-methyl-D-aspartate receptor-mediated neurotoxicity in primary cultures of rat forebrain
    • NADLER V, MECHOULAM R, SOKOLOVSKY M: The non-psychotropic cannabinoid (+)-(3S,4S)-7-hydroxy-delta 6-tetrahydrocannabinol 1,1-dimethylheptyl (HU-211) attenuates N-methyl-D-aspartate receptor-mediated neurotoxicity in primary cultures of rat forebrain. Nturosci. Lett. (1993) 162:43-45.
    • (1993) Nturosci. Lett , vol.162 , pp. 43-45
    • Nadler, V.1    Mechoulam, R.2    Sokolovsky, M.3
  • 46
    • 0029870716 scopus 로고    scopus 로고
    • The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons
    • SKAPER SD, BURIANI A, DAL TOSO R et al.: The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. Proc. Natl. Acad. Sci. USA (1996) 93:3984-3989.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3984-3989
    • Skaper, S.D.1    Buriani, A.2    Dal Toso, R.3
  • 47
    • 0031706164 scopus 로고    scopus 로고
    • Cannabinoid receptor agonists protect cultured rat hippocampal neurons from excitotoxicity
    • SHEN M, THAYER SA: Cannabinoid receptor agonists protect cultured rat hippocampal neurons from excitotoxicity, Mol. Pharmacol. (1998) 54:459-462.
    • (1998) Mol. Pharmacol , vol.54 , pp. 459-462
    • Shen, M.1    Thayer, S.A.2
  • 48
    • 0035979606 scopus 로고    scopus 로고
    • Activation of the CB1 cannabinoid receptor protects cultured mouse spinal neurons against excitotoxicity
    • ABOOD ME, RIZVI G, SALLAPUDI N, MCALLISTER SD: Activation of the CB1 cannabinoid receptor protects cultured mouse spinal neurons against excitotoxicity. Neurosci. Lett. (2001) 309:197-201.
    • (2001) Neurosci. Lett , vol.309 , pp. 197-201
    • Abood, M.E.1    Rizvi, G.2    Sallapudi, N.3    Mcallister, S.D.4
  • 49
    • 0034801539 scopus 로고    scopus 로고
    • Anandamide, but not 2-arachidonoylglycerol, accumulates during in vivo neurodegeneration
    • HANSEN HH, SCHMID PC, BITTIGAU P et al.: Anandamide, but not 2-arachidonoylglycerol, accumulates during in vivo neurodegeneration. J. Neurochem. (2001) 78:1415-1427.
    • (2001) J. Neurochem , vol.78 , pp. 1415-1427
    • Hansen, H.H.1    Schmid, P.C.2    Bittigau, P.3
  • 50
    • 0035437865 scopus 로고    scopus 로고
    • Neuroprotection by Delta9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity
    • VAN DER STELT M, VELDHUIS WB, BAR PR, VELDINK GA, VLIEGENTHART JF, NICOLAY K: Neuroprotection by Delta9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity. J. Neurosci. (2001) 21:6475-6479.
    • (2001) J. Neurosci , vol.21 , pp. 6475-6479
    • Van Der Stelt, M.1    Veldhuis, W.B.2    Bar, P.R.3    Veldink, G.A.4    Vliegenthart, J.F.5    Nicolay, K.6
  • 51
    • 0035890082 scopus 로고    scopus 로고
    • Exogenous anandamide protects rat brain against acute neuronal injury in vivo
    • VAN DER STELT M, VELDHUIS WB, VAN HAAFTEN GW et al.: Exogenous anandamide protects rat brain against acute neuronal injury in vivo. J. Neurosci. (2001) 21:8765-8771.
    • (2001) J. Neurosci , vol.21 , pp. 8765-8771
    • Van Der Stelt, M.1    Veldhuis, W.B.2    Van Haaften, G.W.3
  • 52
    • 0033561159 scopus 로고    scopus 로고
    • Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures
    • NAGAYAMA T, SINOR AD, SIMON RP et al.: Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures. J. Neurosci. (1999) 19:2987-2995.
    • (1999) J. Neurosci , vol.19 , pp. 2987-2995
    • Nagayama, T.1    Sinor, A.D.2    Simon, R.P.3
  • 53
    • 0033988703 scopus 로고    scopus 로고
    • Endocannabinoids protect cerebral cortical neurons from in vitro ischemia in rats
    • SINOR AD, IRVIN SM, GREENBERG DA: Endocannabinoids protect cerebral cortical neurons from in vitro ischemia in rats. Neurosci. Lett. (2000) 278:157-160.
    • (2000) Neurosci. Lett , vol.278 , pp. 157-160
    • Sinor, A.D.1    Irvin, S.M.2    Greenberg, D.A.3
  • 55
    • 0028564867 scopus 로고
    • Neuroprotective activity of HU-211, a novel NMDA antagonist, in global ischemia in gerbils
    • BAR-JOSEPH A, BERKOVITCH Y, ADAMCHIK J, BIEGON A: Neuroprotective activity of HU-211, a novel NMDA antagonist, in global ischemia in gerbils. Mol. Chem. Neuropathol. (1994) 23:125-135.
    • (1994) Mol. Chem. Neuropathol , vol.23 , pp. 125-135
    • Bar-joseph, A.1    Berkovitch, Y.2    Adamchik, J.3    Biegon, A.4
  • 56
    • 0028884634 scopus 로고
    • HU-211, a novel noncompetitive N-methyl-D-aspartate antagonist, improves neurological deficit and reduces infarct volume after reversible focal cerebral ischemia in the rat
    • BELAYEV L, BUSTO R, ZHAO W, GINSBERG MD: HU-211, a novel noncompetitive N-methyl-D-aspartate antagonist, improves neurological deficit and reduces infarct volume after reversible focal cerebral ischemia in the rat. Stroke (1995) 26:2313-2319.
    • (1995) Stroke , vol.26 , pp. 2313-2319
    • Belayev, L.1    Busto, R.2    Zhao, W.3    Ginsberg, M.D.4
  • 57
    • 0029074225 scopus 로고
    • HU-211, a nonpsychotropic cannabinoid, improves neurological signs and reduces brain damage after severe forebrain ischemia in rats
    • BELAYEV L, BAR-JOSEPH A, ADAMCHIK J, BIEGON A: HU-211, a nonpsychotropic cannabinoid, improves neurological signs and reduces brain damage after severe forebrain ischemia in rats. Mol. Chem. Neuropathol. (1995) 25:19-33.
    • (1995) Mol. Chem. Neuropathol , vol.25 , pp. 19-33
    • Belayev, L.1    Bar-Joseph, A.2    Adamchik, J.3    Biegon, A.4
  • 58
    • 0033556581 scopus 로고    scopus 로고
    • Dexanabinol; a novel neuroprotective drug in experimental focal cerebral ischemia
    • LEKER RR, SHOHAMI E, ABRAMSKY O, OVADIA H: Dexanabinol; a novel neuroprotective drug in experimental focal cerebral ischemia. J. Neurol. Sci. (1999) 162:114-119.
    • (1999) J. Neurol. Sci , vol.162 , pp. 114-119
    • Leker, R.R.1    Shohami, E.2    Abramsky, O.3    Ovadia, H.4
  • 59
    • 0033969895 scopus 로고    scopus 로고
    • The effect of delta-9-tetrahydrocannabinol on forebrain ischemia in rat
    • LOUW DF, YANG FW, SUTHERLAND GR: The effect of delta-9-tetrahydrocannabinol on forebrain ischemia in rat. Brain Res. (2000) 857:183-187.
    • (2000) Brain Res , vol.857 , pp. 183-187
    • Louw, D.F.1    Yang, F.W.2    Sutherland, G.R.3
  • 60
    • 0036082491 scopus 로고    scopus 로고
    • Characterization of the diarylether sulfonylester (-)-(R)-3-(2-Hydroxymethylindanyl-4-oxy)phenyl-4,4,4- trifluoro-l-sulfonate (BAY 38-7271) as a potent cannabinoid receptor agonist with neuroprotective properties
    • MAULER F, MITTENDORF J, HORVATH E, DE VRY J: Characterization of the diarylether sulfonylester (-)-(R)-3-(2-Hydroxymethylindanyl -4-oxy)phenyl-4,4,4-trifluoro- l-sulfonate (BAY 38-7271) as a potent cannabinoid receptor agonist with neuroprotective properties. J. Pharmacol. Exp. Ther. (2002) 302:359-368.
    • (2002) J. Pharmacol. Exp. Ther , vol.302 , pp. 359-368
    • Mauler, F.1    Mittendorf, J.2    Horvath, E.3    De Vry, J.4
  • 61
  • 62
    • 0027250138 scopus 로고
    • A nonpsychotropic cannabinoid, HU-211, has cerebroprotective effects after closed head injury in the rat
    • SHOHAMI E, NOVIKOV M, MECHOULAM R. A nonpsychotropic cannabinoid, HU-211, has cerebroprotective effects after closed head injury in the rat. J. Neurotrauma (1993) 10:109-119.
    • (1993) J. Neurotrauma , vol.10 , pp. 109-119
    • Shohami, E.1    Novikov, M.2    Mechoulam, R.3
  • 63
    • 0031047431 scopus 로고    scopus 로고
    • Cytokine production in the brain following closed head injury-dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant
    • SHOHAMI E, GALLILY R, MECHOULAM R, BASS R, BEN-HUR T: Cytokine production in the brain following closed head injury-dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant. J. Neuroimmunol. (1997) 72:169-177.
    • (1997) J. Neuroimmunol , vol.72 , pp. 169-177
    • Shohami, E.1    Gallily, R.2    Mechoulam, R.3    Bass, R.4    Ben-hur, T.5
  • 64
    • 0028981424 scopus 로고
    • 45Ca accumulation in rat brain after closed head injury; attenuation by the novel neuroprotective agent HU-211
    • NADLER V, BIEGON A, BEIT-YANNAI E, ADAMCHIK J, SHOHAMI E: 45Ca accumulation in rat brain after closed head injury; attenuation by the novel neuroprotective agent HU-211. Brain Res. (1995) 685:1-11.
    • (1995) Brain Res , vol.685 , pp. 1-11
    • Nadler, V.1    Biegon, A.2    Beit-yannai, E.3    Adamchik, J.4    Shohami, E.5
  • 65
    • 0035807380 scopus 로고    scopus 로고
    • An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
    • PANIKASHVILI D, SIMEONIDOU C, BEN-SHABAT S et al.: An endogenous cannabinoid (2-AG) is neuroprotective after brain injury. Nature (2001) 413:527-531.
    • (2001) Nature , vol.413 , pp. 527-531
    • Panikashvili, D.1    Simeonidou, C.2    Ben-Shabat, S.3
  • 66
    • 0019604277 scopus 로고
    • Treatment of human spasticity with delta 9-tetrahydrocannabinol
    • PETRO DJ, ELLENBERGER CJ: Treatment of human spasticity with delta 9-tetrahydrocannabinol J. Clin. Pharmacol. (1981) 21:413S-416S.
    • (1981) J. Clin. Pharmacol , vol.21
    • Petro, D.J.1    Ellenberger, C.J.2
  • 67
    • 0020536571 scopus 로고
    • Tetrahydrocannabinol for tremor in multiple sclerosis
    • CLIFFORD DB: Tetrahydrocannabinol for tremor in multiple sclerosis. Ann. Neurol. (1983) 13:669-671.
    • (1983) Ann. Neurol , vol.13 , pp. 669-671
    • Clifford, D.B.1
  • 68
    • 0028950529 scopus 로고
    • Nabilone in the treatment of multiple sclerosis
    • MARTYN CN, ILLIS LS, THOM J: Nabilone in the treatment of multiple sclerosis. Lancet (1995) 345:579.
    • (1995) Lancet , vol.345 , pp. 579
    • Martyn, C.N.1    Illis, L.S.2    Thom, J.3
  • 69
    • 0031866598 scopus 로고    scopus 로고
    • The endogenous cannabinoid anandamide potentiates interleukin-6 production by astrocytes infected with Theiler's murine encephalomyelitis virus by a receptor-mediated pathway
    • MOLINA-HOLGADO F, MOLINA-HOLGADO E, GUAZA C: The endogenous cannabinoid anandamide potentiates interleukin-6 production by astrocytes infected with Theiler's murine encephalomyelitis virus by a receptor-mediated pathway. FEBS Lett. (1998) 433:139-142.
    • (1998) FEBS Lett , vol.433 , pp. 139-142
    • Molina-holgado, F.1    Molina-holgado, E.2    Guaza, C.3
  • 71
    • 0024596492 scopus 로고
    • Delta 9-tetrahydrocannabinol: A novel treatment for experimental autoimmune encephalomyelitis
    • LYMAN WD, SONETT JR, BROSNAN CF, ELKIN R, BORNSTEIN MB: Delta 9-tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis. J Neuroimmunol. (1989) 23:73-81.
    • (1989) J. Neuroimmunol , vol.23 , pp. 73-81
    • Lyman, W.D.1    Sonett, J.R.2    Brosnan, C.F.3    Elkin, R.4    Bornstein, M.B.5
  • 72
    • 0033992335 scopus 로고    scopus 로고
    • Dexanabinol (HU-211) effect on experimental autoimmune encephalomyelitis: Implications for the treatment of acute relapses of multiple sclerosis
    • ACHIRON A, MIRON S, LAVIE V, MARGALIT R, BIEGON A: Dexanabinol (HU-211) effect on experimental autoimmune encephalomyelitis: implications for the treatment of acute relapses of multiple sclerosis. J. Neuroimmunol. (2000) 102:26-31.
    • (2000) J. Neuroimmunol , vol.102 , pp. 26-31
    • Achiron, A.1    Miron, S.2    Lavie, V.3    Margalit, R.4    Biegon, A.5
  • 73
    • 0034594905 scopus 로고    scopus 로고
    • Cannabinoids control spasticity and tremor in a multiple sclerosis model
    • BAKER D, PRYCE G, CROXFORD JL et al.: Cannabinoids control spasticity and tremor in a multiple sclerosis model. Nature (2000) 404:84-87.
    • (2000) Nature , vol.404 , pp. 84-87
    • Baker, D.1    Pryce, G.2    Croxford, J.L.3
  • 74
    • 0035256557 scopus 로고    scopus 로고
    • Endocannabinoids control spasticity in a multiple sclerosis model
    • BAKER D, PRYCE G, CROXFORD JL et al.: Endocannabinoids control spasticity in a multiple sclerosis model. FASEB J. (2001) 15:300-302.
    • (2001) FASEB J , vol.15 , pp. 300-302
    • Baker, D.1    Pryce, G.2    Croxford, J.L.3
  • 75
    • 0030843886 scopus 로고    scopus 로고
    • Influence of cannabinoids on electrically evoked dopamine release and cyclic AMP generation in the rat striatum
    • CADOGAN AK, ALEXANDER SP, BOYD EA, KENDALL DA: Influence of cannabinoids on electrically evoked dopamine release and cyclic AMP generation in the rat striatum. J. Neurochem. (1997) 69:1131-1137.
    • (1997) J. Neurochem , vol.69 , pp. 1131-1137
    • Cadogan, A.K.1    Alexander, S.P.2    Boyd, E.A.3    Kendall, D.A.4
  • 76
    • 0034942985 scopus 로고    scopus 로고
    • Cannabinoid receptor agonist and antagonist effects on motor function in normal antl 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-treated non-human primates
    • MESCHLER JP, HOWLETT AC, MADRAS BK: Cannabinoid receptor agonist and antagonist effects on motor function in normal antl 1-methyl-4-phenyl-1, 2,5,6-tetrahydropyridine (MPTP)-treated non-human primates. Pychopharmacology (Berl) (2001) 156:79-85.
    • (2001) Pychopharmacology (Berl) , vol.156 , pp. 79-85
    • Meschler, J.P.1    Howlett, A.C.2    Madras, B.K.3
  • 77
    • 0034982493 scopus 로고    scopus 로고
    • Striatal cannabirmid CB1 receptor mRNA expression is decreased in the reserpine-treated rat model of Parkinson's disease
    • SILVERDALE MA, MCGUIRE S, MCINNES A, CROSSMAN AR, BROTCHIE JM: Striatal cannabirmid CB1 receptor mRNA expression is decreased in the reserpine-treated rat model of Parkinson's disease. Exp. Neurol. (2001) 169:400-406.
    • (2001) Exp. Neurol , vol.169 , pp. 400-406
    • Silverdale, M.A.1    Mcguire, S.2    Mcinnes, A.3    Crossman, A.R.4    Brotchie, J.M.5
  • 78
    • 0035545362 scopus 로고    scopus 로고
    • Increased cannabinoid CB1 receptor binding and activation of GTP-binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP-treated marmosets
    • LASTRES-BECKER I, CEBEIRA M, DE CEBALLOS ML et al.: Increased cannabinoid CB1 receptor binding and activation of GTP-binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP-treated marmosets. Eur. J. Neurosci. (2001) 14:1827-1832.
    • (2001) Eur. J. Neurosci , vol.14 , pp. 1827-1832
    • Lastres-becker, I.1    Cebeira, M.2    De Ceballos, M.L.3
  • 79
    • 0033936028 scopus 로고    scopus 로고
    • Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease
    • DI MARZO V, HILL MP, BISOGNO T, CROSSMAN AR, BROTCHIE JM: Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease. FASEB J. (2000) 14:1432-1438.
    • (2000) FASEB J , vol.14 , pp. 1432-1438
    • Di Marzo, V.1    Hill, M.P.2    Bisogno, T.3    Crossman, A.R.4    Brotchie, J.M.5
  • 80
    • 0035846577 scopus 로고    scopus 로고
    • Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: A pilot study
    • SIERADZAN KA, FOX SH, HILL M, DICK JP, CROSSMAN AR, BROTCHIE JM: Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study. Neurology (2001) 57:2108-2111.
    • (2001) Neurology , vol.57 , pp. 2108-2111
    • Sieradzan, K.A.1    Fox, S.H.2    Hill, M.3    Dick, J.P.4    Crossman, A.R.5    Brotchie, J.M.6
  • 81
    • 0035035365 scopus 로고    scopus 로고
    • The role of cannabinoids in neurodegenerative diseases
    • GLASS M: The role of cannabinoids in neurodegenerative diseases. Prog. Neuropsychopharmacol. Biol. Psychiatry (2001) 25:743-765.
    • (2001) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.25 , pp. 743-765
    • Glass, M.1
  • 82
    • 0028071467 scopus 로고
    • Selective vulnerability in Huntington's disease: Preferential loss of cannabinoid receptors in lateral globus pallidus
    • RICHFIELD EK, HERKENHAM M: Selective vulnerability in Huntington's disease: preferential loss of cannabinoid receptors in lateral globus pallidus. Ann. Neurol. (1994) 36:577-584.
    • (1994) Ann. Neurol , vol.36 , pp. 577-584
    • Richfield, E.K.1    Herkenham, M.2
  • 83
    • 0034081681 scopus 로고    scopus 로고
    • The pattern of neurodegeneration in Huntington's disease: A comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease
    • CLASS M, DRAGUNOW M, FAULL RL: The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease. Neuroscience (2000) 97:505-519.
    • (2000) Neuroscience , vol.97 , pp. 505-519
    • Class, M.1    Dragunow, M.2    Faull, R.L.3
  • 84
    • 0034047444 scopus 로고    scopus 로고
    • Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington's disease mice
    • DENOVAN-WRIGHT EM, ROBERTSON HA: Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington's disease mice. Neuroscience (2000) 98:705-713.
    • (2000) Neuroscience , vol.98 , pp. 705-713
    • Denovan-wright, E.M.1    Robertson, H.A.2
  • 85
    • 0037040530 scopus 로고    scopus 로고
    • Loss of mRNA levels, binding and activation of GTP-binding proteins for cannabinoid CB(1) receptors in the basal ganglia of a transgenic model of Huntington's disease
    • LASTRES-BECKER I, BERRENDERO F, LUCAS JJ et al.: Loss of mRNA levels, binding and activation of GTP-binding proteins for cannabinoid CB(1) receptors in the basal ganglia of a transgenic model of Huntington's disease. Brain Res. (2002) 929:236-242.
    • (2002) Brain Res , vol.929 , pp. 236-242
    • Lastres-Becker, I.1    Berrendero, F.2    Lucas, J.J.3
  • 86
    • 0033973053 scopus 로고    scopus 로고
    • Effects of systemic 3-nitropropionic acid-induced lesions of the dorsal striatum on cannabinoid and muopioid receptor binding in the basal ganglia
    • PAGE KJ, BESRET L, JAIN M, MONAGHAN EM, DUNNETT SB, EVERITT BJ: Effects of systemic 3-nitropropionic acid-induced lesions of the dorsal striatum on cannabinoid and muopioid receptor binding in the basal ganglia. Exp. Brain Res. (2000) 130:142-150.
    • (2000) Exp. Brain Res , vol.130 , pp. 142-150
    • Page, K.J.1    Besret, L.2    Jain, M.3    Monaghan, E.M.4    Dunnett, S.B.5    Everitt, B.J.6
  • 87
    • 0035919840 scopus 로고    scopus 로고
    • Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington's disease
    • LASTRES-BECKER I, FEZZA F, CEBEIRA M et al.: Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington's disease. Neuroreport (2001) 12:2125-2129.
    • (2001) Neuroreport , vol.12 , pp. 2125-2129
    • Lastres-Becker, I.1    Fezza, F.2    Cebeira, M.3
  • 88
    • 0036179873 scopus 로고    scopus 로고
    • Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease
    • LASTRES-BECKER I, HANSEN HH, BERRENDERO F: Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease. Synapse (2002) 44:23-35.
    • (2002) Synapse , vol.44 , pp. 23-35
    • Lastres-becker, I.1    Hansen, H.H.2    Berrendero, F.3
  • 89
    • 0036141160 scopus 로고    scopus 로고
    • Neuroprotection is unlikely to be effective in humans using current trial designs
    • GROTTA J: Neuroprotection is unlikely to be effective in humans using current trial designs. Stroke (2002) 33:306-307.
    • (2002) Stroke , vol.33 , pp. 306-307
    • Grotta, J.1
  • 90
    • 0036142768 scopus 로고    scopus 로고
    • Neuroprotection is unlikely to be effective in humans using current trial designs: An opposing view
    • LEES KR: Neuroprotection is unlikely to be effective in humans using current trial designs: an opposing view. Stroke (2002) 33:308-309.
    • (2002) Stroke , vol.33 , pp. 308-309
    • Lees, K.R.1
  • 92
    • 0024316874 scopus 로고
    • Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker
    • FEIGENBAUM JJ, BERGMANN F, RICHMOND SA et al.: Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker. Proc. Natl. Acad. Sci. USA (1989) 86:9584-9587.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 9584-9587
    • Feigenbaum, J.J.1    Bergmann, F.2    Richmond, S.A.3
  • 93
    • 0030827712 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of escalating i.v. doses of dexanabinol (HU-211), a neuroprotectant agent, in normal volunteers
    • BREWSTER ME, POP E, FOLTZ RL et al: Clinical pharmacokinetics of escalating i.v. doses of dexanabinol (HU-211), a neuroprotectant agent, in normal volunteers. Int. J. Clin. Pharmacol. Ther. (1997) 35:361-365.
    • (1997) Int. J. Clin. Pharmacol. Ther , vol.35 , pp. 361-365
    • Brewster, M.E.1    Pop, E.2    Foltz, R.L.3
  • 94
    • 4243345400 scopus 로고    scopus 로고
    • Pharmos corporation reports 2002 first quarter results
    • PHARMOS CORP (2 May ):Press Release
    • PHARMOS CORP: Pharmos corporation reports 2002 first quarter results (2 May 2002):Press Release.
    • (2002)
  • 95
    • 0011035835 scopus 로고    scopus 로고
    • Pharmos reports significant brain recovery in stroke models using dexanabinol - New dexanabinol analogs seen as powerful neuroprotectants
    • PHARMOS CORP (7 July ):Press release
    • PHARMOS CORP: Pharmos reports significant brain recovery in stroke models using dexanabinol - new dexanabinol analogs seen as powerful neuroprotectants (7 July 2000):Press release.
    • (2000)
  • 96
    • 0010957859 scopus 로고    scopus 로고
    • GW PHARMACEUTICALS PLC Annual report and accounts for the year ended 30 September 2001 (30 September ): Annual report
    • GW PHARMACEUTICALS PLC: Annual report and accounts for the year ended 30 September 2001 (30 September 2001): Annual report.
    • (2001)
  • 97
    • 0010963229 scopus 로고    scopus 로고
    • Drug development pipeline: New projects in development at Bayer
    • (1 February ):Company communication
    • BAYER AG: Drug development pipeline: New projects in development at Bayer (1 February 2002):Company communication.
    • (2002)
    • Bayer, A.G.1
  • 98
    • 0003921985 scopus 로고    scopus 로고
    • Rat microglial cells express the peripheral type cannabinoid receptor (CB2) which is negatively coupled to adenylate cyclase
    • International Cannabinoid Research Society Abstract
    • KEARN CS, HILLARD CJ: Rat microglial cells express the peripheral type cannabinoid receptor (CB2) which is negatively coupled to adenylate cyclase. International Cannabinoid Research Society (1997):Abstract.
    • (1997)
    • Kearn, C.S.1    Hillard, C.J.2
  • 99
    • 0034948614 scopus 로고    scopus 로고
    • Evidence for a new G protein-coupled cannabinoid receptor in mouse brain
    • BREIVOGEL CS, GRIFFIN G, DI MARZO V, MARTIN BR. Evidence for a new G protein-coupled cannabinoid receptor in mouse brain. Mol. Pharmacol. (2001) 60:155-163.
    • (2001) Mol. Pharmacol , vol.60 , pp. 155-163
    • Breivogel, C.S.1    Griffin, G.2    Di Marzo, V.3    Martin, B.R.4
  • 100
    • 0038845604 scopus 로고    scopus 로고
    • Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
    • JARAI Z, WAGNER JA, VARGA K et al.: Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc. Natl. Acad. Sci. USA (1999) 96:14136-14141.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 14136-14141
    • Jarai, Z.1    Wagner, J.A.2    Varga, K.3
  • 101
    • 0035801320 scopus 로고    scopus 로고
    • Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus
    • HAJOS N, LEDENT C, FREUND TF: Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus. Neuroscience (2001) 106:1-4.
    • (2001) Neuroscience , vol.106 , pp. 1-4
    • Hajos, N.1    Ledent, C.2    Freund, T.F.3


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