Characterization of the diarylether sulfonylester (-)-(R)-3-(2-Hydroxymethylindanyl-4-oxy)phenyl-4,4,4-trifluoro-1-suifonate (BAY 38-7271) as a potent cannabinoid receptor agonist with neuroprotective properties

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 1, 2002, Pages 359-368

  Mauler, Frank ^a,b   Mittendorf, Joachim ^a   Horváth, Ervin ^a   De Vry, Jean ^a  

^a BAYER AG   (Germany)

^b PH R CNS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 HYDROXYMETHYLINDANYL 4 OXY)PHENYL 4,4,4 TRIFLUORO 1 SULFONATE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; BAY 387271; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; NEUROPROTECTIVE AGENT; RIMONABANT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; HYPOTHERMIA; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SUBDURAL HEMATOMA;

ANIMALS; BINDING, COMPETITIVE; BODY TEMPERATURE; BRAIN INJURIES; BRAIN ISCHEMIA; CYCLOHEXANOLS; DISCRIMINATION (PSYCHOLOGY); GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HEMATOMA, SUBDURAL; INDANS; MALE; MIDDLE CEREBRAL ARTERY; NEUROPROTECTIVE AGENTS; RATS; RATS, LONG-EVANS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB2; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; SIGNAL TRANSDUCTION; SUCCINATE DEHYDROGENASE; SULFONIC ACIDS;

EID: 0036082491     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.302.1.359     Document Type: Article

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