Kinetic basis for selective inhibition of cyclo-oxygenases

Biochemical Journal

Volumn 339, Issue 3, 1999, Pages 607-614

  Gierse, James K ^a   Koboldt, Carol M ^a   Walker, Mark C ^a   Seibert, Karen ^a   Isakson, Peter C ^a  

^a PFIZER INC   (United States)

Author keywords

Celecoxib; Inhibitors; Prostaglandin synthase

Indexed keywords

ACETYLSALICYLIC ACID; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ETODOLAC; IBUPROFEN; INDOMETACIN; MECLOFENAMIC ACID; MEFENAMIC ACID; MELOXICAM; NABUMETONE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; OXICAM DERIVATIVE; PIROXICAM;

ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENZYME INHIBITION; INHIBITION KINETICS; MALE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BINDING, COMPETITIVE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; HUMANS; IBUPROFEN; INDOMETHACIN; INHIBITORY CONCENTRATION 50; ISOENZYMES; KINETICS; MALE; MEMBRANE PROTEINS; MICE; NAPROXEN; OXYGEN; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; SHEEP; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TETRAMETHYLPHENYLENEDIAMINE; THERMODYNAMICS;

ANIMALIA;

EID: 0033136768     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3390607     Document Type: Article

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