Novel technologies for studying virus-host interaction and discovering new drug targets for HCV and HIV

Current Opinion in Pharmacology

Volumn 2, Issue 5, 2002, Pages 541-547

  Tang, Hengli ^a   Peng, Tao ^a   Wong Staal, Flossie ^a  

^a Immusol Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA INTERFERON; ANTIBODY; ANTIRETROVIRUS AGENT; BINDING PROTEIN; CELL PROTEIN; ENZYME INHIBITOR; GAG PROTEIN; INTERFERON; MEMBRANE COFACTOR PROTEIN; MEMBRANE PROTEIN; PROTEIN KINASE; PROTEINASE INHIBITOR; RIBAVIRIN; RIBONUCLEASE; RNA; RNA DIRECTED DNA POLYMERASE INHIBITOR; STRUCTURAL PROTEIN; VIRUS PROTEIN;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; DRUG TARGETING; GENE IDENTIFICATION; GENE TARGETING; HEPATITIS C; HEPATITIS C VIRUS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; SIDE EFFECT; VIRUS ASSEMBLY; VIRUS DNA CELL DNA INTERACTION; VIRUS GENE; VIRUS MUTATION; VIRUS PATHOGENESIS; VIRUS REPLICATION; VIRUS VIRULENCE;

EID: 0036790513     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4892(02)00201-1     Document Type: Review

References (52)

1. Y. He M.G. Katze To interfere and to anti-interfere: the interplay between hepatitis C virus and interferon Viral Immunol 15 2002 95 119
2. C. Zimmerman K.C. Klein P.K. Kiser A.R. Singh B.L. Firestein S.C. Riba J.R. Lingappa Identification of a host protein essential for assembly of immature HIV-1 capsids Nature 415 2002 88 92
3. R. Mariani B.A. Rasala G. Rutter K. Wiegers S.M. Brandt H.G. Kraeusslich N.R. Landau Mouse-human heterokaryons support efficient human immuno-deficiency virus type 1 assembly J Virol 75 2001 3141 3151
4. P. Spearman L. Ratner Human immunodeficiency virus type 1 capsid formation in reticulocyte lysates J Virol 70 1996 8187 8194
5. J.R. Lingappa R.L. Hill M.L. Wong R.S. Hegde A multistep, ATP-dependent pathway for assembly of human immunodeficiency virus capsid in a cell-free system J Cell Biol 136 1997 567 581
6. C. Martinand C. Montavon T. Salehzada M. Silhol B. Lebleu C. Bisbal RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and downregulates the 2-5A/RNase L pathway in human T cells J Virol 73 1999 290 296
7. L. VerPlank F. Bouamr T.J. LaGrassa B. Agresta A. Kikonyogo J. Leis C.A. Carter Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55Gag Proc Natl Acad Sci USA 98 2001 7724 7729
8. J.E. Garrus U.K. von Schwedler O.W. Pornillos S.G. Morham K.H. Zavitz H.E. Wang D.A. Wettstein K.M. Stray M. Cote R.L. Rich Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding Cell 107 2001 55 65 This paper reports the definitive evidence that Tsg101 is a critical co-factor for HIV budding. This may open up a new area of exciting research of HIV.
9. J. Martin-Serrano T. Zang P.D. Bieniasz HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress Nat Med 7 2001 1313 1319
10. D.G. Demirov A. Ono J.M. Orenstein E.O. Freed Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function Proc Natl Acad Sci USA 99 2002 955 960
11. J. Pflugheber B. Fredericksen R. Sumpter Jr C. Wang F. Ware D.L. Sodora M. Gale Jr Regulation of PKR and IRF-1 during hepatitis C virus RNA replication Proc Natl Acad Sci USA 99 2002 4650 4655
12. S. Crotta A. Stilla A. Wack A. D'Andrea S. Nuti U. D'Oro M. Mosca F. Filliponi R.M. Brunetto F. Bonino Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein J Exp Med 195 2002 35 41
13. C.K. Tseng G.R. Klimpel Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions J Exp Med 195 2002 43 49
14. A. Ryo Y. Suzuki K. Ichiyama T. Wakatsuki N. Kondoh A. Hada M. Yamamoto N. Yamamoto Serial analysis of gene expression in HIV-1-infected T cell lines FEBS Lett 462 1999 182 186
15. G.K. Geiss R.E. Bumgarner M.C. An M.B. Agy A.B. van't Wout E. Hammersmark V.S. Carter D. Upchurch J.I. Mullins M.G. Katze Large-scale monitoring of host cell gene expression during HIV-1 infection using cDNA microarrays Virol 266 2000 8 16
16. + T cells Genome Res 11 2001 1198 1204
17. M. Simm Z. Su E.Y. Huang Y. Chen H. Jiang D.J. Volsky P.B. Fisher Cloning of differentially expressed genes in an HIV-1 resistant T cell clone by rapid subtraction hybridization, RaSH Gene 269 2001 93 101
18. S. Shaheduzzaman V. Krishnan A. Petrovic M. Bittner P. Meltzer J. Trent S. Venkatesan S. Zeichner Effects of HIV-1 Nef on cellular gene expression profiles J Biomed Sci 9 2002 82 96
19. C.B. Bigger K.M. Brasky R.E. Lanford DNA microarray analysis of Chimpanzee liver during acute resolving hepatitis C virus infection J Virol 75 2001 7059 7066
20. P.J. Welch E.G. Marcusson Q.X. Li C. Beger M. Kruger C. Zhou M. Leavitt F. Wong-Staal J.R. Barber Identification and validation of a gene involved in anchorage-independent cell growth control using a library of randomized hairpin ribozymes Genomics 66 2000 274 283
21. Q.X. Li J.M. Robbins P.J. Welch F. Wong-Staal J.R. Barber A novel functional genomics approach identifies mTERT as a suppressor of fibroblast transformation Nucleic Acids Res 28 2000 2605 2612
22. C. Beger L.N. Pierce M. Kruger E.G. Marcusson J.M. Robbins P. Welcsh P.J. Welch K. Welte M.C. King J. Barber Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach Proc Natl Acad Sci USA 98 2001 130 135
23. M. Krüger C. Beger X.Q. Li P.J. Welch R. Tritz M. Leavitt J.R. Barber F. Wong-Staal Identification of eIF2Bγ and eIF2γ as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach Proc Natl Acad Sci USA 97 2000 8566 8571
24. M. Krüger C. Beger P.J. Welch J.R. Barber M.P. Manns F. Wong-Staal Involvement of proteasome α-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation Mol Cell Biol 21 2001 8357 8364
25. H. Tang S. He K. Kuhen J.R. Barber F. Wong-Staal Selection of hairpin ribozymes that confer HIV resistance to T cells in vitro J Human Virol 4 2001 128
26. A. Gervaix D. West L.M. Leoni D.D. Richman F. Wong-Staal J. Corbeil A new reporter cell line to monitor HIV infection and drug susceptibility in vitro Proc Natl Acad Sci USA 94 1997 4653 4658
27. S.M. Elbashir J. Harborth W. Lendeckel A. Yalcin K. Weber T. Tuschl Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature 411 2001 494 498 This paper showed for the first time that siRNA duplexes, when small enough, can induce sequence-specific gene inactivation in mammalian cells. This work is the foundation for all the subsequent RNAi work in the mammalian cell culture system.
28. T.R. Brummelkamp B. René A. Reuven A system for stable expression of short interfering RNAs in mammalian cells Science 296 2002 550 553 Description of the much-anticipated expression system for siRNA in cell culture, following the work of Elbashir et al . [27••] .
29. M. Miyagishi K. Taira U6 promoter-driven siRNA with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells Nat Biotech 20 2002 497 500
30. N.S. Lee T. Dohjima G. Bauer H. Li M. Li A. Ehsani P. Salvaterra J. Rossi Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells Nat Biotech 20 2002 500 505 A different design to express siRNA in mammalian cells. An HIV protein was chosen as the target and anti-viral effects of designed siRNA were reported. This may be the first step towards gene therapy using RNAi.
31. C.P. Paul P. Good I. Winer D.R. Engelke Effective expression of small interfering RNA in human cells Nat Biotech 20 2002 505 508
32. G. Sui C. Soohoo E.B. Affar F. Gay Y. Shi W.C. Forrester Y. Shi A DNA vector-based RNAi technology to suppress gene expression in mammalian cells Proc Natl Acad Sci USA 99 2002 5515 5520
33. J.Y. Yu S.L. DeRuiter D.L. Turner RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells Proc Natl Acad Sci USA 99 2002 6047 6052
34. P.J. Paddison A.A. Caudy E. Bernstein G. Hannon D.S. Conklin Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells Genes Dev 16 2002 948 958
35. C.M.C. de Noronha M.P. Sherman H.W. Lin M.V. Cavrois R.D. Moir R.D. Goldman W.C. Greene Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr Science 294 2001 1105 1108
36. D. McDonald M.A. Vodicka G. Lucero M. Emerman T.J. Hope HIV-1 core particles travel on microtubules to reach the nucleus of infected cells J Hum Virol 3 2000 238
37. T.J. Hope G. Lucero T. Svitkina G. Borisy D. McDonald Correlative electronmicroscopy analysis of cytoplasmic HIV reverse transcription complexes, Mol Biol Cell 11 Suppl 2000 357a
38. V. Lohmann F. Körner J.O. Koch U. Herian L. Theilmann R. Bartenschlager Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line Science 285 1999 110 113
39. K.J. Blight A.A. Kolykhalov C.M. Rice Efficient initiation of HCV RNA replication in cell culture Science 290 2000 1972 1975
40. T. Pietschmann V. Lohmann A. Kaul N. Krieger G. Rinck G. Rutter D. Strand R. Bartenschlager Persistent and transient replication of full-length hepatitis C virus genomes in cell culture J Virol 76 2002 4008 4021
41. S. Wellnitz B. Klumpp H. Barth S. Ito E. Depla J. Dubuisson H.E. Blum T.F. Baumert Binding of hepatitis C virus-like particles derived from infectious clone H77C to defined human cell lines J Virol 76 2002 1181 1193
42. S. Zhang Y. Feng O. Narayan L.J. Zhao Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein–protein interaction with a novel human cytoplasmic protein VprBP Gene 263 2001 131 140
43. R. Geleziunas W. Xu K. Takeda H. Ichijo W.C. Greene HIV-1 Nef inhibits ASK1-dependent death signaling providing a potential mechanism for protecting the infected host cell Nature 410 2001 834 838
44. D. Wolf V. Witte B. Laffert K. Blume E. Stromer S. Trapp P. d'Aloja A. Schuermann A.S. Baur HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals Nat Med 7 2001 1217 1224
45. G. Hassaine M. Courcoul G. Bessou Y. Barthalay C. Picard D. Olive Y. Collette R. Vigne E. Decroly The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral Vif protein J Biol Chem 276 2001 16885 16893
46. E. Yung M. Sorin A. Pal E. Craig A. Morozov O. Delattre J. Kappes D. Ott G.V. Kalpana Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1 Nat Med 7 2001 920 926
47. S.R. Weinberger E.A. Dalmasso E.T. Fung Current achievements using ProteinChip ##®® array technology Curr Opin Chem Biol 6 2001 86 91
48. B. Schweitzer S. Roberts B. Grimwade W. Shao M. Wang Q. Fu Q. Shu I. Laroche Z. Zhou V.T. Tchernev Multiplexed protein profiling on microarrays by rolling-circle amplification Nat Biotechnol 20 2002 359 365
49. K.B. Lee S.J. Park C.A. Mirkin J.C. Smith M. Mrksich Protein nanoarrays generated by Dip-Pen nanolithography Science 295 2002 1702 1705
50. J.J. Harrington B. Sherf S. Rundlett P.D. Jackson R. Perry S. Cain C. Leventhal M. Thornton R. Ramachandran J. Wittington Creation of genome-wide protein expression libraries using random activation of gene expression Nat Biotechnol 19 2001 440 445
51. D.S. Wilson A.D. Keefe J.W. Szostak The use of mRNA display to select high-affinity protein-binding peptides Proc Natl Acad Sci USA 98 2001 3750 3755
52. D. Koller C. Rued M. Loetscher J. Vlach S. Oehen K. Oertle M. Schirinzi E. Deneuve R. Moser M. Kopf A high-throughput alphavirus-based expression cloning system for mammalian cells Nat Biotechnol 19 2001 851 855