HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress

Nature Medicine

Volumn 7, Issue 12, 2001, Pages 1313-1319

  Martin Serrano, J ^a   Zang, T ^a   Bieniasz, P D ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; EBOLA VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; VIRION; VIRUS GENE; VIRUS PARTICLE; VIRUS REPLICATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CELL COMPARTMENTATION; CELL MEMBRANE; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; EBOLAVIRUS; ENDOSOMES; GENE PRODUCTS, GAG; HELA CELLS; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEOPROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; TRANSCRIPTION FACTORS; VIRAL CORE PROTEINS; VIRUS ASSEMBLY;

EBOLA VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0035658023     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1201-1313     Document Type: Article

References (31)

1. An assembly domain of the Rous sarcoma virus Gag protein required late in budding
2. Fine mapping and characterization of the Rous sarcoma virus Pr76gag late assembly domain
3. A proline-rich motif (PY) in the Gag polyprotein of Mason-Pfizer monkey virus plays a maturation-independent role in virion release
4. Infectivity of Moloney murine leukemia virus defective in late assembly events is restored by late assembly domains of other retroviruses
5. Equine infectious anemia virus utilizes a YXXL motif within the late assembly domain of the Gag p9 protein
6. Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release
7. Positionally independent and exchangeable late budding functions of the Rous sarcoma virus and human immunodeficiency virus Gag proteins
8. p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing protease
9. A role for ubiquitin ligase recruitment in retrovirus release
10. Equine infectious anemia virus Gag polyprotein late domain specifically recruits cellular AP-2 adapter protein complexes during virion assembly
11. Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag)
12. Proteins related to the Nedd 4 family of ubiquitin protein ligases intereact with the L domain of Rous sarcoma virus and are required for gag budding from cells
13. Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking
14. TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes
15. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I
16. A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: Implications for filovirus budding
17. A proline-rich motif within the matrix protein of vesicular stomatitis virus and rabies virus interacts with WW domains of cellular proteins: Implications for viral budding
18. Late domain function identified in the vesicular stomatitis virus M protein by use of rhabdovirus-retrovirus chimeras
19. Vesicular release of ebola virus matrix protein VP40
20. Ebola virus VP40-induced particle formation and association with the lipid bilayer
21. Efficient particle formation can occur if the matrix domain of human immunodeficiency virus type 1 Gag is substituted by a myristylation signal
22. Efficient HIV-1 replication can occur in the absence of the viral matrix protein
23. Genetic assay for multimerization of retroviral gag polyproteins
24. Mutations in the N-terminal region of human immunodeficiency virus type 1 matrix protein block intracellular transport of the Gag precursor
25. Kinetic analysis of human immunodeficiency virus type 1 assembly reveals the presence of sequential intermediates
26. Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2
27. Ubiquitin is part of the retrovirus budding machinery
28. Multiple blocks to human immunodeficiency virus type 1 replication in rodent cells
29. Genetic evidence that the Tat proteins of human immunodeficiency virus types 1 and 2 can multimerize in the eukaryotic cell nucleus
30. Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat
31. Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding