Effects of pyrrolidine dithiocarbamate on endothelial cells: Protection against oxidative stress

Free Radical Biology and Medicine

Volumn 26, Issue 9-10, 1999, Pages 1138-1145

  Moellering, Douglas ^a   McAndrew, Joanne ^a   Jo, Hanjoong ^a   Darley Usmar, Victor M ^a  

^a Ctr Free R   (United States)

Author keywords

Glutamylcysteine synthetase; Apoptosis; Free radicals; Glutathione; Nuclear factor kappa B; Pyrrolidine dithiocarbamate

Indexed keywords

2,3 DIMETHOXY 1,4 NAPHTHOQUINONE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PYRROLIDINE DITHIOCARBAMATE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CYTOTOXICITY; ENDOTHELIUM CELL; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DNA BINDING;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CATTLE; DNA; ENDOTHELIUM, VASCULAR; GLUTATHIONE; GLUTATHIONE DISULFIDE; NAPHTHOQUINONES; NF-KAPPA B; OXIDATION-REDUCTION; OXIDATIVE STRESS; PYRROLIDINES; SUPEROXIDES; THIOCARBAMATES;

ANIMALIA; BOVINAE;

EID: 0032982324     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(98)00300-1     Document Type: Article

References (39)

1. Wever R.M., Luscher T.F., Cosentino F., Rabelink T.J. Atherosclerosis and the two faces of endothelial nitric oxide synthase. Circ. 97:1998;108-112.
2. Palmer H.J., Paulson K.E. Reactive oxygen species and antioxidants in signal transduction and gene expression. Nutrition Reviews. 55:1997;353-361.
3. Diaz M.N., Frei B., Vita J.A., Keaney J.F. Jr. Antioxidants and atherosclerotic heart disease. N. Engl. J. Med. 337:1997;408-416.
4. Feinmark S.J., Cornicelli J.A. Is there a role for 15-lipoxygenase in atherogenesis? Biochem. Pharmacol. 54:1997;953-959.
5. Heinecke J.W. Mechanisms of oxidative damage of low density lipoprotein in human atherosclerosis. Curr. Opin. Lipid. 8:1997;268-274.
6. Darley-Usmar V., Halliwell B. Blood radicals reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system . Pharm. Res. 13:1996;649-662.
7. Beckman J.S., Koppenol W.H. Nitric oxide, superoxide, and peroxynitrite the good, the bad, and ugly . Amer. J. Physiol. 271:1996;C1424-C1437.
8. Suarna C., Dean R.T., May J., Stocker R. Human atherosclerotic plaque contains both oxidized lipids and relatively large amounts of alpha-tocopherol and ascorbate. Arterioscl. Thromb. & Vasc. Biol. 15:1995;1616-1624.
9. Meister A. On the antioxidant effects of ascorbic acid and glutathione. Biochem. Pharmacol. 44:1992;1905-1915.
10. Deneke, S. M.; Fanburg, B. L. Regulation of cellular glutathione. Am J. Physiol. 257:l163-1173; 1989.
11. Radi R., Beckman J.S., Bush K.M., Freeman B.A. Peroxynitrite oxidation of sulfhydryls. J. Biol. Chem. 266:1991;4244-4250.
12. Darley-Usmar V.M., Severn A., O'Leary V.J., Rogers M. Treatment of macrophages with low density lipoprotein increases their intracellular glutathione content. Biochem. J. 278:1991;429-434.
13. Gotoh N., Graham A., Niki E., Darley-Usmar V.M. Inhibition of glutathione synthesis increases the toxicity of oxidised LDL to human monocytes and macrophages. Biochem. J. 296:1993;151-154.
14. Shi M.M., Kugelman A., Iwamoto T., Tian L., Forman H.J. Quinone induced oxidative stress elevates glutathione and induces γ-glutamylcysteine synthetase activity in rate lung epithelial L2 cells. J. Biol. Chem. 269:1994;26512-26517.
15. Kuzuya M., Naito M., Funaki C., Hayashi T., Asai K., Kuzuya F. Protective role of intracellular glutathione against oxidized LDL in cultured endothelial cells. Biochem. Biophys. Res. Comm. 163:1989;1466-1472.
16. Droge W., Schulze-Osthoff K., Mihm S., Galter D., Schenk H., Eck H.P., Roth S., Gmunder H. Functions of glutathione and glutathione disulfide in immunology and immunopathology. FASEB J. 8:1994;1131-1138.
17. Lander H.M., Ogiste J.S., Teng K.K., Novogrodsky A. p21RAS as a common signaling target of reactive free radicals and cellular redox stress. J. Biol. Chem. 270:1997;21195-21198.
18. Kawai M., Nishikomori R., Jung E.Y., Tai G., Yamanaka C., Mayumi M., Heike T. Pyrrolidine dithiocarbamate inhibits intercellular adhesion molecule-1 biosynthesis induced by cytokines in human fibroblasts. J. Immun. 154:1995;2333-2341.
19. Orthner C.L., Rodgers G.M., Fitzgerald L.A. Pyrrolidine dithiocarbamate abrogates tissue factor (TF) expression by endothelial cells evidence implicating nuclear factor-kappa B in TF induction by diverse agonists . Blood. 86:1995;436-443.
20. Nathens A.B., Bitar R., Davreux C., Bujard M., Marshall J.C., Dackiw A.P., Watson R.W., Rotstein O.D. Pyrrolidine dithiocarbamate attenuates endotoxin-induced acute lung injury. Amer. J. Resp. Cell Mol. Biol. 17:1997;608-616.
21. Pinkus R., Weiner L.M., Daniel V. Role of oxidants and antioxidants in the induction of AP-1, NF-kappaB, and glutathione S-transferase gene expression. J. Biol. Chem. 271:1996;13422-13429.
22. Munoz C., Pascual-Salcedo D., Castellanos M.C., Alfranca A., Aragones J., Vara A., Redondo M.J., de Landazuri M.O. Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators modulation of NF-kappa B and AP-1 transcription factors activity . Blood. 88:1996;3482-3490.
23. Brennan P., O'Neill L.A. 2-Mercaptoethanol restores the ability of nuclear factor kappa B (NF kappa B) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC). Biochem. J. 320:1996;975-981.
24. Nobel C., Kimland M., Lind B., Orrenius S., Slater A.F. Dithiocarbamates induce apoptosis in thymocytes by raising the intracellular level of redox-active copper. J. Biol Chem. 270:1995;26202-26208.
25. Wu H.H., Momand J. Pyrrolidine dithiocarbamate prevents p53 activation and promotes p53 cysteine residue oxidation. J. Biol. Chem. 273:1988;18898-18905.
26. Liu S.F., Ye X., Malik A.B. In vivo inhibition of nuclear factor-kappa B activation prevents inducible nitric oxide synthase expression and systemic hypotension in a rat model of septic shock. J. Immun. 159:1997;3976-3983.
27. Jo H., Dull R.O., Hollis T.M., Tarbell J.M. Endothelial albumin permeability is shear dependent, time dependent, and reversible. Am. J. Physiology. 260:1991;H1992-H1996.
28. Jones K.H., Senft J.A. An improved method to determine viability by simultaneously staining with fluorescein diacetate-propidium iodide. J. Histochem. Cytochem. 33:1985;77-79.
29. Haimovitz-Friedman A., Kan C-C, Ehleiter D., Persaud R.S., McLoughlin M., Fuks Z. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J. Exp. Med. 180:1994;525-535.
30. Turner B.M. The use of alkaline-phosphatase-conjugated second antibody for the visualization of electrophoretically separated proteins recognized by monoclonal antibodies. J. Immun. Methods. 63:1983;1-6.
31. Tietze F. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione. Anal. Biochem. 27:1969;502-522.
32. Reed D.J., Babson J.R., Beatty P.W., Brodie A.E., Ellis W.W., Potter D.W. High performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide and related thiols and disulfides. Anal. Biochem. 106:1980;55-62.
33. Hattori Y., Nakanishi N., Kasai K. Role of nuclear factor kappa B in cytokine induced nitric oxide and tetrahydrobiopterin synthesis in rat neonatal cardiac mycocytes. J. Mol. Cell. Cardiol. 29:1997;1585-1592.
34. Mulcahy R.T., Wartman M.A., Bailey H.H., Gipp J.J. Constitutive and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence. J. Biol. Chem. 272:1997;7445-7454.
35. Kaufmann S.H., Desnoyers S., Ottaviano Y., Davidson N.E., Poirier G.G. Specific proteolytic cleavage of poly (ADP-ribose); an early marker of chemotherapy-induced apoptosis. Cancer Res. 53:1993;3976-3985.
36. Wyllie A.H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature. 284:1980;555-556.
37. Chigo D., Alessio P., Foco A., Bussolino F., Costamanga C., Heller R., Garbarino G., Pescarmona G.P., Bosia A. Nitric oxide synthesis is impaired in glutathione depleted human umbilical vein endothelial cells. Am. J. Physiol. 265:1993;C728-C732.
38. Hofman H., Schmidt H.H. Thiol dependence of nitric oxide synthase. Biochemistry. 34:1995;13443-13452.
39. Buchmuller-Rouiller Y., Corrandin S.B., Smith J., Schneider P., Ransijn A., Jongeneel C.V., Mauel J. Role of glutathione in macrophage activation effect of cellular glutathione depletion on nitrite production and leishmanicidal activity . Cell. Immunol. 164:1995;73-80.