메뉴 건너뛰기




Volumn 20, Issue 10, 2002, Pages 999-1005

Transposition from a gutless adeno-transposon vector stabilizes transgene expression in vivo

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMES; DISEASES; DNA; DRUG THERAPY; VECTORS;

EID: 0036789403     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt738     Document Type: Article
Times cited : (170)

References (49)
  • 2
    • 0028328261 scopus 로고
    • Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy
    • Yang, Y. et al. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. USA 91, 4407-4411 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4407-4411
    • Yang, Y.1
  • 3
    • 0028937785 scopus 로고
    • Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
    • Yang, Y., Li, Q., Ertl, H.C. & Wilson, J.M. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69, 2004-2015 (1995).
    • (1995) J. Virol. , vol.69 , pp. 2004-2015
    • Yang, Y.1    Li, Q.2    Ertl, H.C.3    Wilson, J.M.4
  • 4
    • 9244220682 scopus 로고    scopus 로고
    • Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo
    • Yang, Y., Jooss, K.U., Su, Q., Ertl, H.C. & Wilson, J.M. Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo. Gene Ther. 3, 137-144 (1996).
    • (1996) Gene Ther. , vol.3 , pp. 137-144
    • Yang, Y.1    Jooss, K.U.2    Su, Q.3    Ertl, H.C.4    Wilson, J.M.5
  • 5
    • 0030462599 scopus 로고    scopus 로고
    • A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal
    • Parks, R.J. et al. A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc. Natl. Acad. Sci. USA 93, 13565-13570 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13565-13570
    • Parks, R.J.1
  • 6
    • 0031916435 scopus 로고    scopus 로고
    • Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity
    • Schiedner, G. et al. Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity. Nat. Genet. 18, 180-183 (1998).
    • (1998) Nat. Genet. , vol.18 , pp. 180-183
    • Schiedner, G.1
  • 7
    • 12944317288 scopus 로고    scopus 로고
    • Sustained high-level expression of full-length human Factor VIII and restoration of clotting activity in hemophilic mice using a minimal adenovirus vector
    • Balague, C. et al. Sustained high-level expression of full-length human Factor VIII and restoration of clotting activity in hemophilic mice using a minimal adenovirus vector. Blood 95, 820-828 (2000).
    • (2000) Blood , vol.95 , pp. 820-828
    • Balague, C.1
  • 8
    • 0029857641 scopus 로고    scopus 로고
    • In vivo muscle gene transfer of full-length dystrophin with an adenoviral vector that lacks all viral genes
    • Clemens, P.R. et al. In vivo muscle gene transfer of full-length dystrophin with an adenoviral vector that lacks all viral genes. Gene Ther. 3, 965-972 (1996).
    • (1996) Gene Ther. , vol.3 , pp. 965-972
    • Clemens, P.R.1
  • 9
    • 0032506791 scopus 로고    scopus 로고
    • High doses of a helper-dependent adenoviral vector yield supraphysiological levels of α1-antitrypsin with negligible toxicity
    • Morral, N. et al. High doses of a helper-dependent adenoviral vector yield supraphysiological levels of α1-antitrypsin with negligible toxicity. Hum. Gene Ther. 9, 2709-2716 (1998).
    • (1998) Hum. Gene Ther. , vol.9 , pp. 2709-2716
    • Morral, N.1
  • 10
    • 13044304200 scopus 로고    scopus 로고
    • Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons
    • Morral, N. et al. Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons. Proc. Natl. Acad. Sci. USA 96, 12816-12821 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 12816-12821
    • Morral, N.1
  • 11
    • 0036592086 scopus 로고    scopus 로고
    • A new adenoviral helper-dependent vector results in long-term therapeutic levels of human coagulation Factor IX at low doses in vivo
    • Ehrhardt, A. & Kay, M.A. A new adenoviral helper-dependent vector results in long-term therapeutic levels of human coagulation Factor IX at low doses in vivo. Blood 99, 1-8 (2002).
    • (2002) Blood , vol.99 , pp. 1-8
    • Ehrhardt, A.1    Kay, M.A.2
  • 12
    • 0035818555 scopus 로고    scopus 로고
    • Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector
    • Kim, I.H., Jozkowicz, A., Piedra, P.A., Oka, K. & Chan, L. Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector. Proc. Natl. Acad. Sci. USA 98, 13282-13287 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 13282-13287
    • Kim, I.H.1    Jozkowicz, A.2    Piedra, P.A.3    Oka, K.4    Chan, L.5
  • 13
    • 0033056699 scopus 로고    scopus 로고
    • Frequency and stability of chromosomal integration of adenovirus vectors
    • Harui, A., Suzuki, S., Kochanek, S. & Mitani, K. Frequency and stability of chromosomal integration of adenovirus vectors. J. Virol. 73, 6141-6146 (1999).
    • (1999) J. Virol. , vol.73 , pp. 6141-6146
    • Harui, A.1    Suzuki, S.2    Kochanek, S.3    Mitani, K.4
  • 14
    • 0034812283 scopus 로고    scopus 로고
    • Chromosomal integration pattern of a helper-dependent minimal adenovirus vector with a selectable marker inserted into a 27.4-kilobase genomic stuffer
    • Hillgenberg, M., Tonnies, H. & Strauss, M. Chromosomal integration pattern of a helper-dependent minimal adenovirus vector with a selectable marker inserted into a 27.4-kilobase genomic stuffer. J. Virol. 75, 9896-9908 (2001).
    • (2001) J. Virol. , vol.75 , pp. 9896-9908
    • Hillgenberg, M.1    Tonnies, H.2    Strauss, M.3
  • 15
    • 0033179759 scopus 로고    scopus 로고
    • Resident aliens: The Tc 1/mariner superfamily of transposable elements
    • Plasterk, R.H., Izsvak, Z. & Ivics, Z. Resident aliens: the Tc 1/mariner superfamily of transposable elements. Trends Genet. 15, 326-332 (1999).
    • (1999) Trends Genet. , vol.15 , pp. 326-332
    • Plasterk, R.H.1    Izsvak, Z.2    Ivics, Z.3
  • 16
    • 0035810931 scopus 로고    scopus 로고
    • Regulated transposition of a fish transposon in the mouse germ line
    • Fischer, S.E., Wienholds, E. & Plasterk, R.H. Regulated transposition of a fish transposon in the mouse germ line. Proc. Natl. Acad. Sci. USA 98, 6759-6764 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6759-6764
    • Fischer, S.E.1    Wienholds, E.2    Plasterk, R.H.3
  • 17
    • 0030662074 scopus 로고    scopus 로고
    • Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells
    • Ivics, Z., Hackett, P.B., Plasterk, R.H. & Izsvak, Z. Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell 191, 501-510 (1997).
    • (1997) Cell , vol.191 , pp. 501-510
    • Ivics, Z.1    Hackett, P.B.2    Plasterk, R.H.3    Izsvak, Z.4
  • 18
    • 0034103009 scopus 로고    scopus 로고
    • Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system
    • Yant, S.R. et al. Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system. Nat. Genet. 25, 35-41 (2000).
    • (2000) Nat. Genet. , vol.25 , pp. 35-41
    • Yant, S.R.1
  • 19
    • 0034960344 scopus 로고    scopus 로고
    • Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo
    • Nakai, H. et al. Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo. J. Virol. 75, 6969-6976 (2001).
    • (2001) J. Virol. , vol.75 , pp. 6969-6976
    • Nakai, H.1
  • 20
    • 0029930255 scopus 로고    scopus 로고
    • Transposase is the only nematode protein required for in vitro transposition of Tc 1
    • Vos, J.C., De Baere, I. & Plasterk, R.H. Transposase is the only nematode protein required for in vitro transposition of Tc1. Genes Dev. 10, 755-761 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 755-761
    • Vos, J.C.1    De Baere, I.2    Plasterk, R.H.3
  • 21
    • 0034981674 scopus 로고    scopus 로고
    • Development of a FLP/frt system for generating helper-dependent adenoviral vectors
    • Ng, P., Beauchamp, C., Evelegh, C., Parks, R. & Graham, F.L. Development of a FLP/frt system for generating helper-dependent adenoviral vectors. Mol. Ther. 3, 809-815 (2001).
    • (2001) Mol. Ther. , vol.3 , pp. 809-815
    • Ng, P.1    Beauchamp, C.2    Evelegh, C.3    Parks, R.4    Graham, F.L.5
  • 22
    • 0034041160 scopus 로고    scopus 로고
    • High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP
    • Rodriguez, C.I. et al. High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat. Genet. 25, 139-140 (2000).
    • (2000) Nat. Genet. , vol.25 , pp. 139-140
    • Rodriguez, C.I.1
  • 23
  • 24
    • 0036478954 scopus 로고    scopus 로고
    • Chromosomal effects of adeno-associated virus vector integration
    • Miller, D.G., Rutledge, E.A. & Russell, D.W. Chromosomal effects of adeno-associated virus vector integration. Nat. Genet. 30, 147-148 (2002).
    • (2002) Nat. Genet. , vol.30 , pp. 147-148
    • Miller, D.G.1    Rutledge, E.A.2    Russell, D.W.3
  • 25
    • 0032990410 scopus 로고    scopus 로고
    • Isolation of recombinant adeno-associated virus vector-cellular DNA junctions from mouse liver
    • Nakai, H., Iwaki, Y., Kay, M.A. & Couto, L.B. Isolation of recombinant adeno-associated virus vector-cellular DNA junctions from mouse liver. J. Virol. 73, 5438-5447 (1999).
    • (1999) J. Virol. , vol.73 , pp. 5438-5447
    • Nakai, H.1    Iwaki, Y.2    Kay, M.A.3    Couto, L.B.4
  • 26
    • 0032577448 scopus 로고    scopus 로고
    • IHF modulation of Tn10 transposition: Sensory transduction of supercoiling status via a proposed protein/DNA molecular spring
    • Chalmers, R., Guhathakurta, A., Benjamin, H. & Kleckner, N. IHF modulation of Tn10 transposition: sensory transduction of supercoiling status via a proposed protein/DNA molecular spring. Cell 93, 897-908 (1998).
    • (1998) Cell , vol.93 , pp. 897-908
    • Chalmers, R.1    Guhathakurta, A.2    Benjamin, H.3    Kleckner, N.4
  • 27
    • 0035898687 scopus 로고    scopus 로고
    • Protein-DNA contacts and conformational changes in the Tn 10 transpososome during assembly and activation for cleavage
    • Crellin, P. & Chalmers, R. Protein-DNA contacts and conformational changes in the Tn10 transpososome during assembly and activation for cleavage. EMBO J. 20, 3882-3891 (2001).
    • (2001) EMBO J. , vol.20 , pp. 3882-3891
    • Crellin, P.1    Chalmers, R.2
  • 28
    • 0027979780 scopus 로고
    • Crucial role for DNA supercoiling in Mu transposition: A kinetic study
    • Wang, Z. & Harshey, R.M. Crucial role for DNA supercoiling in Mu transposition: a kinetic study. Proc. Natl. Acad. Sci. USA 91, 699-703 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 699-703
    • Wang, Z.1    Harshey, R.M.2
  • 29
    • 0034821174 scopus 로고    scopus 로고
    • Stable integration of transgenes delivered by a retrotransposon-adenovirus hybrid vector
    • Soifer, H. et al. Stable integration of transgenes delivered by a retrotransposon-adenovirus hybrid vector. Hum. Gene Ther. 12, 1417-1428 (2001).
    • (2001) Hum. Gene Ther. , vol.12 , pp. 1417-1428
    • Soifer, H.1
  • 30
    • 0032876839 scopus 로고    scopus 로고
    • Integrating adenovirusadeno-associated virus hybrid vectors devoid of all viral genes
    • Lieber, A., Steinwaerder, D.S., Carlson, C.A. & Kay, M.A. Integrating adenovirusadeno-associated virus hybrid vectors devoid of all viral genes. J. Virol. 73, 9314-9324 (1999).
    • (1999) J. Virol. , vol.73 , pp. 9314-9324
    • Lieber, A.1    Steinwaerder, D.S.2    Carlson, C.A.3    Kay, M.A.4
  • 31
    • 0033057474 scopus 로고    scopus 로고
    • Site-specific integration mediated by a hybrid adenovirus/adeno-associated virus vector
    • Recchia, A. et al. Site-specific integration mediated by a hybrid adenovirus/adeno-associated virus vector. Proc. Natl. Acad. Sci. USA 96, 2615-2620 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2615-2620
    • Recchia, A.1
  • 32
    • 0033962387 scopus 로고    scopus 로고
    • Genomic integration and gene expression by a modified adenoviral vector
    • Zheng, C., Baum, B.J., Iadarola, M.J. & O'Connell, B.C. Genomic integration and gene expression by a modified adenoviral vector. Nat. Biotechnol. 18, 176-180 (2000).
    • (2000) Nat. Biotechnol. , vol.18 , pp. 176-180
    • Zheng, C.1    Baum, B.J.2    Iadarola, M.J.3    O'Connell, B.C.4
  • 33
    • 0036210482 scopus 로고    scopus 로고
    • Novel integrating adenoviral/retroviral hybrid vector for gene therapy
    • Murphy, S.J., Chong, H., Bell, S., Diaz, R.M. & Vile, R.G. Novel integrating adenoviral/retroviral hybrid vector for gene therapy. Hum. Gene Ther. 13, 745-760 (2002).
    • (2002) Hum. Gene Ther. , vol.13 , pp. 745-760
    • Murphy, S.J.1    Chong, H.2    Bell, S.3    Diaz, R.M.4    Vile, R.G.5
  • 34
    • 0036104279 scopus 로고    scopus 로고
    • A novel, helper-dependent, adenovirus-retrovirus hybrid vector: Stable transduction by a two-stage mechanism
    • Soifer, H. et al. A novel, helper-dependent, adenovirus-retrovirus hybrid vector: stable transduction by a two-stage mechanism. Mol. Ther. 5, 599-608 (2002).
    • (2002) Mol. Ther. , vol.5 , pp. 599-608
    • Soifer, H.1
  • 35
    • 0036149232 scopus 로고    scopus 로고
    • A high-capacity, capsid-modified hybrid adenovirus/adeno-associated virus vector for stable transduction of human hematopoietic cells
    • Shayakhmetov, D.M. et al. A high-capacity, capsid-modified hybrid adenovirus/adeno-associated virus vector for stable transduction of human hematopoietic cells. J. Virol. 76, 1135-1143 (2002).
    • (2002) J. Virol. , vol.76 , pp. 1135-1143
    • Shayakhmetov, D.M.1
  • 36
    • 0030775646 scopus 로고    scopus 로고
    • Stable in vivo gene transduction via a novel adenoviral/retroviral chimeric vector
    • Feng, M. et al. Stable in vivo gene transduction via a novel adenoviral/retroviral chimeric vector. Nat. Biotechnol. 15, 866-870 (1997).
    • (1997) Nat. Biotechnol. , vol.15 , pp. 866-870
    • Feng, M.1
  • 37
    • 13144261694 scopus 로고    scopus 로고
    • Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells
    • Luo, G., Ivics, Z., Izsvak, Z. & Bradley, A. Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells. Proc. Natl. Acad. Sci. USA 95, 10769-10773 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10769-10773
    • Luo, G.1    Ivics, Z.2    Izsvak, Z.3    Bradley, A.4
  • 38
    • 0035664421 scopus 로고    scopus 로고
    • Absence of germline infection in male mice following intraventricular injection of adenovirus
    • Peters, A.H. et al. Absence of germline infection in male mice following intraventricular injection of adenovirus. Mol. Ther. 4, 603-613 (2001).
    • (2001) Mol. Ther. , vol.4 , pp. 603-613
    • Peters, A.H.1
  • 39
    • 0037022340 scopus 로고    scopus 로고
    • Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice
    • Kanatsu-Shinohara, M. et al. Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice. Proc. Natl. Acad. Sci. USA 99, 1383-1388 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 1383-1388
    • Kanatsu-Shinohara, M.1
  • 40
    • 0034945822 scopus 로고    scopus 로고
    • A mouse model for adenovirus gene delivery
    • Tallone, T. et al. A mouse model for adenovirus gene delivery. Proc. Natl. Acad. Sci. USA 98, 7910-7915 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7910-7915
    • Tallone, T.1
  • 41
    • 0034068781 scopus 로고    scopus 로고
    • Insulation from viral transcriptional regulatory elements improves inducible transgene expression from adenovirus vectors in vitro and in vivo
    • Steinwaerder, D.S. & Lieber, A. Insulation from viral transcriptional regulatory elements improves inducible transgene expression from adenovirus vectors in vitro and in vivo. Gene Ther. 7, 556-567 (2000).
    • (2000) Gene Ther. , vol.7 , pp. 556-567
    • Steinwaerder, D.S.1    Lieber, A.2
  • 42
  • 43
    • 0035008830 scopus 로고    scopus 로고
    • Site-specific genomic integration in mammalian cells mediated by phage phiC 31 integrase
    • Thyagarajan, B., Olivares, E.C., Hollis, R.P., Ginsburg, D.S. & Calos, M.P. Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase. Mol. Cell. Biol. 21, 3926-3934 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3926-3934
    • Thyagarajan, B.1    Olivares, E.C.2    Hollis, R.P.3    Ginsburg, D.S.4    Calos, M.P.5
  • 44
    • 0027318491 scopus 로고
    • Intrahepatic distribution of transforming growth factor-α (TGFα) during liver regeneration following carbon tetrachloride-induced necrosis
    • Burr, A.W., Carpenter, M.R., Hines, J.E., Gullick, W.J. & Burt, A.D. Intrahepatic distribution of transforming growth factor-α (TGFα) during liver regeneration following carbon tetrachloride-induced necrosis. J. Pathol. 170, 95-100 (1993).
    • (1993) J. Pathol. , vol.170 , pp. 95-100
    • Burr, A.W.1    Carpenter, M.R.2    Hines, J.E.3    Gullick, W.J.4    Burt, A.D.5
  • 45
    • 0032805251 scopus 로고    scopus 로고
    • Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
    • Liu, F., Song, Y. & Liu, D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther. 6, 1258-1266 (1999).
    • (1999) Gene Ther. , vol.6 , pp. 1258-1266
    • Liu, F.1    Song, Y.2    Liu, D.3
  • 46
    • 0033166561 scopus 로고    scopus 로고
    • High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA
    • Zhang, G:, Budker, V. & Wolff, J.A. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum. Gene Ther. 10, 1735-1737 (1999).
    • (1999) Hum. Gene Ther. , vol.10 , pp. 1735-1737
    • Zhang, G.1    Budker, V.2    Wolff, J.A.3
  • 47
    • 0023883716 scopus 로고
    • A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5
    • McGrory, W.J., Bautista, D.S. & Graham, F.L. A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology 163, 614-617 (1988).
    • (1988) Virology , vol.163 , pp. 614-617
    • McGrory, W.J.1    Bautista, D.S.2    Graham, F.L.3
  • 48
    • 0028899573 scopus 로고
    • Therapeutic serum concentrations of human α1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes
    • Kay, M.A., Graham, F., Leland, F. & Woo, S.L. Therapeutic serum concentrations of human α1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes. Hepatology 21, 815-819 (1995).
    • (1995) Hepatology , vol.21 , pp. 815-819
    • Kay, M.A.1    Graham, F.2    Leland, F.3    Woo, S.L.4
  • 49
    • 0034623009 scopus 로고    scopus 로고
    • Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates
    • Izsvak, Z., Ivics, Z. & Plasterk, R.H. Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates. J. Mol. Biol. 302, 93-102 (2000).
    • (2000) J. Mol. Biol. , vol.302 , pp. 93-102
    • Izsvak, Z.1    Ivics, Z.2    Plasterk, R.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.