Genomic integration and gene expression by a modified adenoviral vector

Nature Biotechnology

Volumn 18, Issue 2, 2000, Pages 176-180

  Zheng, Changyu ^a   Baum, Bruce J ^a   Iadarola, Michael J ^a   O'Connell, Brian C ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Adeno retrovirus vector; Gene therapy

Indexed keywords

VIRUS VECTOR;

ADENOVIRUS; ARTICLE; ENZYME ACTIVITY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; GENOME IMPRINTING; HUMAN; HUMAN CELL; LONG TERMINAL REPEAT; MOLONEY LEUKEMIA ONCOVIRUS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRUS REPLICATION;

ADENOVIRIDAE; ANIMALS; BRAIN; GENE EXPRESSION; GENES, REPORTER; GENETIC VECTORS; HIPPOCAMPUS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKOCYTES, MONONUCLEAR; LUCIFERASES; MACROPHAGES; MOLONEY MURINE LEUKEMIA VIRUS; NEURONS; RATS; SUBMANDIBULAR GLAND; TERMINAL REPEAT SEQUENCES; VIRUS INTEGRATION;

ADENOVIRIDAE; ANIMALIA; DNA VIRUSES; MOLONEY MURINE LEUKEMIA VIRUS; MURINAE; ONCOVIRINAE; UNIDENTIFIED RETROVIRUS;

EID: 0033962387     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/72628     Document Type: Article

References (48)

1. Blaese, R.M. et al. T lymphocyte-directed gene therapy for ADA-SCID: initial trial results after 4 years. Science 270, 475-480 (1995).
2. Anderson, W.F. Human gene therapy. Nature 392, 25-30 (1998).
3. Crystal, R.G. Transfer of genes to humans: Early lessons and obstacles to success. Science 270, 404-410 (1995).
4. Verma, I.M. & Somia, N. Gene therapy - promises, problems and prospects. Nature 389, 239-242 (1997).
5. Nabel, G.J. Development of optimized vectors for gene therapy. Proc. Natl. Acad. Sci. USA 96, 324-326 (1999).
6. Springett, G.M., Moen, R.C., Anderson, S., Blaese, R.M. & Anderson, W.F. Infection efficiency of T lymphocytes with amphotropic retroviral vectors is cell cycle dependent. J. Virol. 63, 3865-3869 (1989).
7. Miller, D.G., Adam, M.A. & Miller, A.D. Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol. Cell. Biol. 10, 4239-4242 (1990).
8. Harel, J., Rassart, E. & Jolicoeur, P. Cell cycle dependence of synthesis of unintegrated viral DNA in mouse cells newly infected with murine leukemia virus. Virology 110, 202-207 (1981).
9. Dales, S. & Chardonnet, Y. Early events in the interaction of adenoviruses with HeLa cells. IV. Association with microtubules and the nuclear pore complex during vectorial movement of the inoculum. Virology 56, 465-483 (1973).
10. Greber, U.F. et al. The role of the nuclear pore complex in adenovirus DNA entry. EMBO J. 16, 5998-6007 (1997).
11. Greber, U.F., Webster, P., Weber, J. & Helenius, A. The role of the adenovirus protease on virus entry into cells. EMBO J. 15, 1766-1777 (1996).
12. Schaack, J., Ho, W.Y., Freimuth, P. & Shenk, T. Adenovirus terminal protein mediates both nuclear matrix association and efficient transcription of adenovirus DNA. Genes Dev. 4, 1197-1208 (1990).
13. Harui, A., Suzuki, S., Kochanek, S. & Mitani, K. Frequency and stability of chromosomal integration of adenovirus vectors. J. Virol. 73, 6141-6146 (1999).
14. Feng, M. et al. Stable in vivo gene transduction via a novel adenoviral/retroviral chimeric vector. Nat. Biotechnol. 15, 866-870 (1997).
15. Caplen, N.J. et al. Adeno-retroviral chimeric viruses as in vivo transducing agents. Gene Ther. 6, 454-459 (1999).
16. Ramsey, W.J. et al. Adenovirus vectors as transcomplementing templates for the production of replication defective retroviral vectors. Biochem. Biophys. Res. Commun. 246, 912-919 (1998).
17. st annual meeting of the American Society of Gene Therapy, Seattle, WA, May 28, 1998.
18. Vile, R.G. et al. abstract #521 presented at the 1st annual meeting of the American Society of Gene Therapy, Seattle, WA, May 28, 1998.
19. Hodgson, C.P. in Medical intelligence unit: retro-vectors for human gene therapy. (ed. Hodgson, C.P.) 1-51 (R.G. Landes, Austin, TX; 1996).
20. Bajocchi, G., Feldman, S.H., Crystal, R.G. & Mastrangeli, A. Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors. Nat. Genet. 3, 229-234 (1993).
21. Mannes, A.J., Caudle, R.M., O'Connell, B.C. & Iadarola, M.J. Adenoviral gene transfer to spinal cord neurons: intrathecal versus intraparenchymal administration. Brain Res. 793, 1-6 (1998).
22. Suzuki, M. et al. Similarity of strain- and route-dependent murine responses to an adenovirus vector using the homologous thrombopoietin cDNA as the reporter genes. Human Gene Ther. 9, 1223-1231 (1998).
23. Chen, L.M., Chao, L. & Chao, J. Adenovirus-mediated delivery of human kallistatin gene reduces blood pressure of spontaneously hypertensive rats. Human Gene Ther. 8, 341-347 (1997).
24. Gilgenkrantz, H. et al. Transient expression of genes transferred in vivo into heart using first-generation adenoviral vectors: role of the immune response. Human Gene Ther. 6, 1265-1274 (1995).
25. Dong, J.Y. et al. Systematic analysis of repeated gene delivery into animal lungs with a recombinant adenovirus vector. Human Gene Ther. 7, 319-331 (1996).
26. Yang, Y., Trinchieri, G. & Wilson, J.M. Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. Nat. Med. 9, 890-893 (1995).
27. Adesanya, M.R., Redman, R.S., Baum, B.J. & O'Connell, B.C. Immediate inflammatory responses to adenovirus-mediated gene transfer in rat salivary glands. Human Gene Ther. 7: 1085-1093 (1996).
28. Brown, P.O. in Retroviruses. (eds Coffin, J.M., Hughes, S.H. & Varmus, H.E.) 161-203 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY; 1997).
29. Colicelli, J. & Goff, S.P. Mutants and pseudorevertants of Moloney murine leukemia virus with alterations at the integration site. Cell 42, 573-580 (1985).
30. Panganiban, A.T. & Temin, H.M. The terminal nucleotides of retrovirus DNA are required for integration but not virus production. Nature 306, 155-160 (1983).
31. Goff, S.P. Genetics of retroviral integration. Annu. Rev. Genet. 26, 527-544 (1992).
32. Roth, M.J., Schwartzberg, P.L. & S. P. Goff, S.P. Structure of the termini of DNA intermediates in the integration of retroviral DNA: dependence on IN function and terminal DNA sequence. Cell 58, 47-54 (1989).
33. Asante-Appiah, E & Skalka, A.M. Molecular mechanisms in retrovirus DNA integration. Antiviral Res. 36, 139-156 (1997).
34. Panganiban, A.T. & Temin, H.M. The retrovirus pol gene encodes a product required for DNA integration: identification of a retrovirus int locus. Proc. Natl. Acad. Sci. USA B1, 7885-7889 (1984).
35. Donehower, L. & Varmus, H.E. A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration. Proc. Natl. Acad. Sci. USA B1, 6461-6465 (1984).
36. Schwartzberg, P., Colicelli, J. & Goff, S.P. Construction and analysis of deletion mutations in the pol gene of Moloney murine leukemia virus: a new viral function required for productive infection. Cell 37, 1043-1052 (1984).
37. Hagino-Yamagishi, K., Donehower, L.A. & Varmus, H.E. Retroviral DNA integrated during infection by an integration-deficient mutant of murine leukemia virus is oligomeric. J. Virol. 61, 1964-1971 (1987).
38. Murphy, J.E. & Goff, S.P. A mutation at one end of Moloney murine leukemia virus DNA blocks cleavage of both ends by the viral integrase in vivo. J. Virol. 66, 5092-5095 (1992).
39. Daniel, R., Katz, R.A. & Skalka, A.M. A role for DNA-PK in retroviral DNA integration. Science 284, 644-647 (1999).
40. Roe, T., Chow, S.A. & Brown, P.O. 3′-End processing and kinetics of 5′-end joining during retroviral integration in vivo. J. Virol. 71, 1334-1340 (1997).
41. Lee, M.S. & Craigie, R. Protection of retroviral DNA from autointegration: Involvement of a cellular factor. Proc. Natl. Acad. Sci. USA 91, 9823-9827 (1994).
42. Muller, H.-P. & Varmus, H.E. DNA bending creates favored sites for retroviral integration: an explanation for preferred insertion sites in nucleosomes. EMBO J. 66, 5092-5095 (1992).
43. Boulter, C.A. & Wagner, E.F. A universal retroviral vector for efficient constitutive expression of exogenous genes. Nucleic Acids Res. 15, 7194 (1987).
44. Becker, T.C. et al. Use of recombinant adenovirus for metabolic engineering of mammalian cells. Methods Cell Biol. A 43, 161-189 (1994).
45. Yanagawa, T. et al. Generation of cells with phenotypes of both intercalated ducttype and myoethelial cells in human parotid gland adenocarcinoma clonal cells grown in athymic nude mice. Virchows Arch. B 51, 1871-1885 (1986).
46. Brown, A.M., Rusnock, E.J., Sciubba, J.J. & Baum, B.J. Establishment and characterization of an epithelial cell line from the rat submandibular gland. J. Oral Pathol. Med. 18, 206-213 (1989).
47. Shirasuna, K., Sato, M., & Wiyasaki, T. A neoplastic epithelial duct cell line established from an irradiated human salivary gland. Cancer 48, 745-752 (1981).
48. Heng, H.H., Squire, J. & Tsui, L.C. High-resolution mapping of mammalian genes by in situ hybridization to free chromatin. Proc. Natl. Acad. Sci. USA 89, 9509-9513 (1992).