A high-capacity, capsid-modified hybrid adenovirus/adeno-associated virus vector for stable transduction of human hematopoietic cells

Journal of Virology

Volumn 76, Issue 3, 2002, Pages 1135-1143

  Shayakhmetov, Dmitry M ^a   Carlson, Cheryl A ^a   Stecher, Hartmut ^a   Li, Qiliang ^a   Stamatoyannopoulos, George ^a   Lieber, André ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; GREEN FLUORESCENT PROTEIN; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ADENOVIRUS; ARTICLE; CHIMERA; GENE EXPRESSION; GENE LOCUS; GENE TRANSFER; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENE; VIRUS CAPSID; VIRUS GENE;

EID: 0036149232     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.3.1135-1143.2002     Document Type: Article

References (33)

1. Effects of gamma irradiation on the transduction of dividing and nondividing cells in brain and muscle of rats by adeno-associated virus vectors
2. Efficient 3′-end formation of the human beta-globin mRNA in vivo requires sequences within the last intron but occurs independently of the splicing reaction
3. Selective growth response to Il-3 of a human leukaemic cell line with megakaryoblastic features
4. An efficient and flexible system for construction of adenovirus vectors with insertions in early regions 1 and 3
5. Rearrangements in adenoviral genomes mediated by inverted repeats: Application for vector production and tumor-specific gene expression
6. A dominant-opening activity in 5′ hypersensitive site 3 of the human beta-globin LCR
7. Stem cell gene therapy for the beta-chain hemoglobinopathies. Problems and progress
8. Position-independent, high-level expression of the human beta-globin gene in transgenic mice
9. The combination of Steel factor and GM-CSF blocks apoptosis induced by retinoic acid and upregulates AP-1 in a human growth factor-dependent cell line
10. Hybrid vector designs to control the delivery, fate and expression of transgenes
11. Position independence and proper developmental control of gamma-globin gene expression require both a 5′ locus control region and a downstream sequence element
12. Inhibition of NF-κB activation in combination with Bcl-2 expression allows for persistence of first-generation adenovirus vectors in mouse livers
13. Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo
14. Integrating adenovirus-adeno-associated virus hybrid vectors devoid of all viral genes
15. Inversion/dimerization of plasmids mediated by inverted repeats
16. HEL cells: A new human erythroleukemia cell line with spontaneous and induced globin expression
17. Viral vectors for gene therapy of hematopoietic cells
18. Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors
19. Transduction of primitive human hematopoietic cells with recombinant adenovirus vectors
20. Amelioration of retroviral vector silencing in locus control region beta-globin-transgenic mice and transduced F9 embryonic cells
21. Lentiviral vectors for enhanced gene expression in human hematopoietic cells
22. Genetic treatment of severe hemoglobinopathies: The combat against transgene variegation and transgene silencing
23. Adeno-associated virus vector integration junctions
24. Adeno-associated virus (AAV) Rep protein enhances the generation of a recombinant mini-adenovirus (Ad) utilizing an Ad/AAV hybrid virus
25. Optimization of the helper-dependent adenovirus system for production and potency in vivo
26. Efficient gene transfer into human CD34(+) cells by a retargeted adenovirus vector
27. Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells
28. Sheltering of gamma-globin expression from position effects requires both an upstream locus control region and a regulatory element 3′ to the A gamma-globin gene
29. A capsid-modified adenovirus vector devoid of all viral genes: Assessment of transduction and toxicity in human hematopoietic cells
30. Generation of adenovirus vectors devoid of all viral genes by recombination between inverted repeats
31. Tumor-specific gene expression in hepatic metastases by a replication-activated adenovirus vector
32. Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA
33. Efficient infection of primitive hematopoietic stem cells by modified adenovirus