Binding of stromal derived factor-1α (SDF-1α) to CXCR4 chemokine receptor in normal human megakaryoblasts but not in platelets induces phosphorylation of mitogen-activated protein kinase p42/44 (MAPK), ELK-1 transcription factor and serine/threonine kinase AKT

European Journal of Haematology

Volumn 64, Issue 3, 2000, Pages 164-172

  Majka, Marcin ^a   Ratajczak, Janina ^a   Kowalska, M Anna ^b   Ratajczak, Mariusz Z ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

AKT; CXCR4; ELK 1; MAPK; Megakaryopoiesis; Platelets; SDF 1

Indexed keywords

BIOLOGICAL FACTOR; CHEMOKINE RECEPTOR CXCR4; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; SERINE THREONINE KINASE AKT; STROMAL CELL DERIVED FACTOR 1ALPHA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MEGAKARYOBLAST; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

BLOOD PLATELETS; CALCIUM; CHEMOKINES, CXC; CHEMOTAXIS, LEUKOCYTE; DNA-BINDING PROTEINS; ETS-DOMAIN PROTEIN ELK-1; HEMATOPOIETIC STEM CELLS; HUMANS; JURKAT CELLS; LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED; MEGAKARYOCYTES; MITOGEN-ACTIVATED PROTEIN KINASE 1; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0034016785     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0609.2000.90112.x     Document Type: Article

References (31)

1. 1. JI TH, GROSSMANN M, JI J. G protein-coupled receptors. J Biol Chem 1998;273:17299-17302.
2. 2. LEFKOWITZ PJ. G protein-coupled receptors. III. New roles for receptor kinase and β-arrestins in receptor signaling and desensitization. J Biol Chem 1998;273: 18677-18680.
3. 3. ROLLINS BJ. Chemokines. Blood 1997;90:909-928.
4. 4. FAUCI AS. Host factors and the pathogenesis of HIV-induced disease. Nature 1996;384:529-534.
5. 5. CAIRNS JS, D'SOUZA MP. Chemokines and HIV-1 second receptors: the therapeutic connection. Nature Med 1998;4: 563-568.
6. 6. LEE B, DORANZ BJ, RATAJCZAK MZ, DOMS RW. An intricate web: chemokine receptors, HIV-1 and hematopoiesis. Stem Cells 1998;16:79-88.
7. 7. MOSES A, NELSON J, BAGBY GC. The influence of human immunodeficiency virus-1 on hematopoiesis. Blood 1998;91: 1479-1495.
8. + progenitors to peripheral blood. J Exp Med 1997;185:111-120.
9. 9. DUTT P, WANG JF, GROOPMAN JE. Stromal cell-derived factor-1α and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: a potential mechanism for cooperative induction of chemotaxis. J Immunol 1998;161:3652-3658.
10. + hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1. Blood 1998;91:4523-4530.
11. 11. NAGASAWA T, HIROTA S, TACHIBANA K, et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 1996;382: 635-638.
12. 12. ZOU Y, KOTTMANN AH, KURODA M, TANIUCHI I, LITTMAN DR. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 1998;393: 595-599.
13. 13. MAJKA M, LEE B, HONCZARENKO M, et al. The stromal derived factor-1 (SDF-1) receptor CXCR4 is expressed on the human erythroid progenitors and SDF-1 is an important chemotactic factor for early human erythroid cells. Comparison to other chemokine receptor chemokines axes. J Immunol 1999 (submitted).
14. 14. KOWALSKA MA, RATAJCZAK J, HOXIE J, et al. Platelet and megakaryocytes express the HIV co-receptor CXCR4 on their surface but do not respond to stromal derived factor (SDF) - 1. Br J Haematol 1999;104:220-229.
15. 15. RATAJCZAK MZ, RATAJCZAK J, MACHALINSKI B, MICK R, GEWIRTZ AM. In vitro and in vivo evidence that ex vivo cytokine priming of donor marrow cells may ameliorate post-transplant thrombocytopenia. Blood 1998;91: 353-359.
16. 16. RATAJCZAK J, ZHANG Q, PERTUSINI E, WOJCZYK B, WASIK M, RATAJCZAK MZ. The role of insulin (INS) and insulin like growth factor-I (IGF-I) in regulating human erythropoiesis. Studies in vitro under serum-free conditions: comparison to other cytokines and growth factors. Leukemia 1998;12: 371-381.
17. 17. RATAJCZAK J, MACHALINSKI B, SAMUEL A, et al. A novel serum free system for cloning human megakaryocytic progenitors (CFU-Meg): the role of thrombopoietin and other cytokines on bone marrow and cord blood CFU-Meg growth under serum free conditions. Folia Histochem Cytobiol 1998;36:55-60.
18. 18. LEE B, RATAJCZAK J, DOMS RW, GEWIRTZ AM, RATAJCZAK MZ. Coreceptor/chemokine receptor expression on human hematopoietic cells: Biological implications for HIV-1 infection. Blood 1999;93:1145-1156.
19. 19. GUTKIND JS. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J Biol Chem 1998;273: 1839-1842.
20. 20. WANG JF, LIU ZY, GROOPMAN JE. The α-chemokine receptor CXCR4 is expressed on the megakaryocytic lineage from progenitor to platelets and modulates migration and adhesion. Blood 1998;92:756-764.
21. 21. RIVIERE C, SUBRA F, COHEN-SOLAL K, et al. Phenotypic and functional evidence for the expression of CXCR4 receptor during megakaryocytopoiesis. Blood 1999;93:1511-1523.
22. 22. MURGAT C, LAGUINGE L, WETZKER R, CUADRADO A, GUTKIND JS. Activation of Akt/protein kinase B by G protein-coupled receptors. J Biol Chem 1998;273:19080-19085.
23. 23. PAPKOFF J, CHEN RH, BLENIS J, FORSMAN J. p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation. Mol Cell Biol. 1994;14:463-472.
24. 24. BANFIC H, DOWNES CP, RITTENHOUSE SE. Biphasic activation of PKBα/AKT in platelets. Evidence for stimulation both by phosphatydiloinositol 3,4-biphosphate, produced via a novel pathway, and by posphatidyloinositol 3,4,5-triphosphate. J Biol Chem 1998;271:11630-11637.
25. 25. PTASZNIK A, TRAYNOR-KAPLAN A, BOKOCH GM. G protein-coupled chemoattractant receptors regulate lyn tyrosine kinase - shc adapter protein signaling complexes. J Biol Chem 1995;270:19969-19973.
26. 26. GANJU RK, BRUBAKER SA, MEYER J, et al. The α-chemokine, stromal cell-derived factor-1α, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J Biol Chem 1998;273:23169-23175.
27. 27. SONGYANG Z, BALTIMORE D, CANTLEYLC, KAPLAN DR, FRANKE TF. Interleukin-3 dependent survival by the Akt protein kinase. Proc Natl Acad Sci USA 1997;94:11345-11350.
28. 28. PAN ZK, CHRISTIANSEN SC, PTASZNIK A, ZURAW BL. Requirement of phosphatidylinositol 3 - kinase activity for bradykinin stimulation of NF-kb activation in cultured human epithelial cells. J Biol Chem 1999;274:9918-9922.
29. 29. DATTA SR, DUDEK H, TAO X, et al. Akt phosphorylation of BAD couples survival signals to the cell intrinsic death machinery. Cell 1997;91:231-241.
30. 30. DOHLMAN HG, THORNER J. RGS proteins and signaling by heterotrimeric G proteins. J Biol Chem 1997;272:3871-3874.
31. 31. MICHAEL NL, MOORE JP. HIV-1 entry inhibitors: evading the issue. Nature Med 1999;5:740-742.