Proliferative and apoptotic differences between alveolar rhabdomyosarcoma subtypes: A comparative study of tumors containing PAX-3-FKHR or PAX-7-FKHR gene fusions

Medical and Pediatric Oncology

Volumn 37, Issue 2, 2001, Pages 83-89

  Collins, Margaret H ^a,c   Zhao, Huaqing ^a   Womer, Richard B ^a   Barr, Frederic G ^b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Alveolar rhabdomyosarcoma; Apoptosis; MIB1; Mitoses; PAX3 FKHR; PAX7 FKHR

Indexed keywords

APOPTOSIS; ARTICLE; CANCER SURVIVAL; CELL CYCLE; CELL PROLIFERATION; CHROMOSOME TRANSLOCATION; COMPARATIVE STUDY; CONTROLLED STUDY; GENE EXPRESSION; GENE FUSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NICK END LABELING; PRIORITY JOURNAL; PROGNOSIS; RHABDOMYOSARCOMA;

APOPTOSIS; ARTIFICIAL GENE FUSION; CELL CYCLE; CELL DIVISION; CHILD; CHILD, PRESCHOOL; DISEASE-FREE SURVIVAL; DNA, NEOPLASM; DNA-BINDING PROTEINS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; PAIRED BOX TRANSCRIPTION FACTORS; PAX7 TRANSCRIPTION FACTOR; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA, ALVEOLAR; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 0034899529     PISSN: 00981532     EISSN: None     Source Type: Journal    
DOI: 10.1002/mpo.1174     Document Type: Article

References (33)

1. Classification of rhabdomyosarcoma and related sarcomas
2. Fusion of a forkhead domain gene to PAX3 in the solid tumor alveolar rhabdomyosarcoma
3. Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma
4. Common and variant gene fusions predict distinct clinical phenotypes in rhabdomyosarcoma
5. A consensus polymerase chain reaction-oligonucleotide hybridization approach for the detection of chromosomal translocations in pediatric bone and soft tissue sarcomas
6. Detection of gene fusions in rhabdomyosarcoma by reverse transcriptase-polymerase chain reaction assay of archival samples
7. Immunohistochemical study of rhabdomyosarcoma: Unexpected staining with S100 protein and cytokeratin
8. O13 (CD99) positivity in hematologic proliferations correlates with TdT positivity
9. The clinicopathologic spectrum of putative extrarenal rhabdoid tumor. An analysis of 42 cases studied with immunohistochemistry or electron microscopy
10. Extrarenal rhabdoid tumors of soft tissue: A clinicopathologic and immunohistochemical study of 18 cases
11. CD99 reactivity in mesenchymal chondrosarcoma
12. Desmoplastic small round cell tumor: II: An ultrastructural and immunohistochemical study with emphasis on new immunohistochemical markers
13. Synovial sarcoma
14. CD99, keratin, and vimentin staining of sex cord-stromal tumors, normal ovary, and testis
15. Utility of cytokeratin subsets for distinguishing poorly differentiated synovial sarcoma from peripheral primitive neuroectodermal tumor
16. Histopathologic prognostic factors in neuroblastic tumors: Definition of subtypes of ganglioneuroblastoma and an age-linked classification of neuroblastomas
17. Evaluation of newer prognostic markers for adult soft tissue sarcomas
18. Synovial sarcoma. Evaluation of prognosis with emphasis on the study of DNA ploidy and proliferation (PCNA and Ki-67) markers
19. An inherited disorder of lymphocyte apoptosis: The autoimmune lymphoproliferative syndrome
20. Immunohistochemical detection of bcl-2 and p53 proteins and apoptosis in soft tissue sarcoma: Their correlations with prognosis
21. Changes in mitotic rate and cell cycle fractions caused by delayed fixation
22. Does delay in fixation affect the number of mitotic figures in processed tissue?
23. Is the grading of breast carcinomas affected by a delay in fixation?
24. The influence of fixation delay on mitotic activity and flow cytometric cell cycle variables
25. Determination of cell proliferation
26. Correlation of Ki-67 antigen expression with mitotic figure index and tumor grade in breast carcinomas using the novel "paraffin"-reactive MIB1 antibody
27. Nuclear morphometry and the MIB-1 index in rhabdomyosarcoma
28. Proliferative activity and apoptosis of Langerhans histiocytes in eosinophilic granulomas as evaluated by MIB-1 and TUNEL methods
29. Hyperthermic isolated limb perfusion with tumor necrosis factor-a and melphalan in patients with locally advanced soft tissue sarcomas: Treatment response and clinical outcome related to changes in proliferation and apoptosis
30. Gene alterations and apoptosis in rhabdomyosarcoma
31. Clinical relevance of DNA ploidy and proliferative activity in childhood rhabdomyosarcoma: A retrospective analysis of patients enrolled into the Italian Cooperative Rhabdomyosarcoma Study RMS88
32. Analysis of cyclin-dependent kinase inhibitor genes (CDKN2A, CDKN2B, and CDKN2C) in childhood rhabdomyosarcoma
33. Molecular genetics and pathogenesis of rhabdomyosarcoma