Bone marrow CD34+ cells and megakaryoblasts secrete β-chemokines that block infection of hematopoietic cells by M-tropic R5 HIV

Journal of Clinical Investigation

Volumn 104, Issue 12, 1999, Pages 1739-1749

  Majka, Marcin ^a   Rozmyslowicz, Tomasz ^a   Lee, Benhur ^a   Murphy, Samuel L ^a   Pietrzkowski, Zbigniew ^b   Gaulton, Glen N ^a   Silberstein, Leslie ^a   Ratajczak, Mariusz Z ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Valeant Pharmaceuticals International   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CHEMOKINE; CD34 ANTIGEN; GAMMA INTERFERON; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; RANTES;

ARTICLE; BONE MARROW CELL; CELL MATURATION; CELL PROTECTION; CONTROLLED STUDY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION SENSITIVITY; INTERNALIZATION; MEGAKARYOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN SYNTHESIS; T LYMPHOCYTE;

EID: 0033369975     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI7779     Document Type: Article

References (43)

1. Fauci, A.S. 1996. Host factors and the pathogenesis of HIV-induced disease. Nature. 384:529-534.
2. Hoxie, J.A. 1995. Hematologic manifestations of AIDS. In Hematology: basic principles and practice. R. Hoffman et al., editors. Churchill Livingstone, New York. 2171-2200.
3. Moses, A., Nelson, J., and Bagby, G.C. 1998. The influence of human immunodeficiency virus-1 on hematopoiesis. Blood. 91:1479-1495.
4. Lee, B., Doranz, B.J., Ratajczak, M.Z., and Doms, R.W. 1998. An intricate web: chemokine receptors, HIV-1 and hematopoiesis. Stem Cells. 16:79-88.
5. Cairns, J.S., and D'Souza, M.P. 1998. Chemokines and HIV-1 second receptors: the therapeutic connection. Nat. Med. 4:563-568.
6. Oliva, A., et al. 1998. Natural killer cells from human immunodeficiency virus (HIV)-infected individuals are an important source of CC-chemokines and suppress HIV-1 entry and replication in vitro. J Clin. Invest. 102:223-231.
7. Fehniger, T.A., et al. 1998. Natural killer cells from HIV-1+ patients produce CC-chemokines and inhibit HIV-1 infection. Blood. 92 (Suppl. 1):544a.
8. Rollins, B.J. 1997. Chemokines. Blood. 90:909-928.
9. Lee, B., Racajczak, J., Doms, R.W., Gewirtz, A.M., and Ratajczak, M.Z. 1999. Coreceptor/chemokine receptor expression on human hematopoietic cells: biological implications for HIV-1 infection. Blood. 93:1145-1156.
10. Shen, H., et al. 1999. Intrinsic human immunodeficiency virus type 1 resistance of hematopoietic stem cells despite corecepror expression. J. Virol. 73:728-737.
11. Dutt, P., Wang, J.R., and Groopman, J.E. 1998. Stromal cell-derived factor-1α and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: a potential mechanism for cooperative induction of chemotaxis. J. Immunol. 161:3652-3658.
12. Cardoso, A.A., et al. 1993. Release from quiescence of CD34+ CD38 human umbilical cord blood cells reveals their potentiality to engraft adults. Proc. Natl. Acad. Sci. USA. 90:8707-8711.
13. + marrow cells. Blood. 86:2161-2167.
14. Watari, K., Lansdorp, P.M., Dragowska, W., Mayani, H., and Schrader, J.W. 1994. Expression of interleukin-1β gene in candidate human hematopoietic stem cells. Blood. 84:36-42.
15. + haematopoietic progenitor cells: detection in single cells Br. J. Haematol. 97:9-14.
16. low phenotype identifies a marrow cell population highly enriched for human hematopoietic stem cells. Leukemia. 12:942-950.
17. Ratajczak, M.Z., Ratajczak, J., Machalinski, B., Mick, R., and Gewirtz, A.M. 1998. In vitro and in vivo evidence that ex vivo cytokine priming of donor marrow cells may ameliorate post-transplant thrombocytopenia. Blood. 91:353-359.
18. + cells. Folia Histochem. Cytobiol 36:55-60.
19. Ratajczak, J., et al. 1998. The role of insulin (INS) and insulin-like growth factor-I (IGF-I) in regulating human erythropoiesis. Studies in vitro under serum-free conditions - comparison to other cytokines and growth factors. Leukemia. 12:371-381.
20. Majka, M., et al. 1998. Expression and function of HIV-1 co-receptor on human hematopoietic cell lines. Blood. 92 (Suppl. 1):166a.
21. Vodicka, M.A., et al. 1997. Indicator cell lines for detection of primary strains of human and simian immunodeficiency viruses. Virology. 233:193-198.
22. Shen, H., et al. 1999. Intrinsic human immunodeficiency virus type 1 resistance of hematopoietic stem cells despite coreceptor expression. J. Virol. 73:728-737.
23. Kowalska, M.A., et al. 1999. Megakaryocyte precursors, megakaryocytes and platelets express the HIV co-receptor CXCR4 on their surface: determination of response to stromal-derived factor-1 by megakaryocytes and platelets. Br. J. Haematol. 104:220-229.
24. + progenitor cells: CXC chemokine receptor 4 and CC chemokine receptor 5 expression and infection by HIV. J. Immunol. 161:4169-4176.
25. Wagner, L., et al. 1998. β-chemokines are released from HIV-1 specific cytolytic T-cell granules complexed to proteoglycans. Nature. 391:908-911.
26. Majka, M., et al. 1999. The stromal derived factor-1 (SDF-1) receptor -CXCR4 is expressed on the human erythroid progenitors and SDF-1 is an important chemotactic factor for early human erythroid cells. Comparison to other chemokine receptor - chemokines axes. Blood. 92 (Suppl. 1):366a.
27. + patients produce C-C chemokines and inhibit HIV-1 infection. J. Immunol. 161:6433-6438.
28. + T-cell-derived soluble factor(s), but not β-chemokines RANTES, MIP-1α, and MIP-1β, suppress HIV-1 replication in monacyte/macrophages. Proc. Natl. Acad. Sci. USA. 93:15341-15345.
29. Farzan, M., et al. 1999. Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry. Cell. 96:667-676.
30. Lapham, C.K., Zaitseva, M.B., Lee, S., Romantseva, T., and Golding, H. 1999. Fusion of monocytes and macrophages with HIV-1 correlates with biochemical properties of CXCR4 and CCR5. Nat. Med. 5:303-308.
31. Lefkowitz, P.J. 1998. G protein-coupled receptors. III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization. J. Biol. Chem. 273:18677-18680.
32. Gutkind, J.S. 1998. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J. Biol. Chem. 273:1839-1842.
33. Hariharan, D., et al. 1999. Interferon-γ upregulates CCR5 expression in cord and adult blood mononuclear phagocytes. Blood. 93:1137-1144.
34. Broxmeyer, H.E., et al. 1993. Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. J. Immunol. 150:3448-3458.
35. Mantel, C., Kim, Y.J., Cooper, S., Kwon, B., and Broxmeyer, H.E. 1993. Polymerization of murine macrophage inflammarory protein 1α inactivates its myelosuppressive effects in vitro: the active form is monomer. Proc. Natl. Acad. Sci. USA. 90:2232-2236.
36. Su, S., et al. 1997. Inhibition of immature erythroid progenitor cell proliferation by macrophage inflammatory protein-1α by interacting mainly with a C-C chemokine receptor. CCR1. Blood. 90:605-611.
37. Cashman, J.D., Eaves, C.J., Sarris, A.H., and Eaves, A.C. 1998. MCP-1, not MIP-1α, is the endogenous chemokine that cooperates with TGF-β to inhibit the cycling of primitive normal bur not leukemic (CML) progenitors in long-term human marrow cultures. Blood. 92:2338-2344.
38. Cook, D.N., et al. 1995. Requirement of MIP-1α for an inflammatory response to viral infection. Science. 269:1583-1585.
39. Patel, V.P., et al. 1997. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. J. Exp. Med. 185:1163-1172.
40. +/Lin /DR cells in stroma-derived soluble factors, interleukin-3, and macrophage inflammatory protein-1 α maintains not only myeloid but also lymphoid progenitors in a novel switch culture assay. Blood. 91:4516-4522.
41. + progenitors to peripheral blood. J. Exp. Med. 185:111-120.
42. + hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1. Blood. 91:4523-4530.
43. Majka, M , Ratajczak, J., Kowalska, M.A., and Ratajczak, M.Z. 2000. Binding of stromal derived factor-1a (SDF-1a) to CXCR4 chemokine receptor in normal human megakaryoblasts but not in platelets induces phosphorylation of mitogen-activated protein kinase p42/44 (MAPK), ELK-1 transcription factor and serine/threonine kinase AKT. Eur. J. Haematol. In press.