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Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 3, 2001, Pages 359-362

Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity

(12) Tamamura, Hirokazu a Sugioka, Makiko b Odagaki, Yoshihiko b Omagari, Akane a Kan, Yukiko c Oishi, Shinya a Nakashima, Hideki d Yamamoto, Naoki e Peiper, Stephen C f Hamanaka, Nobuyuki b Otaka, Akira a Fujii, Nobutaka a

a KYOTO UNIVERSITY (Japan)

b ONO PHARMACEUTICAL CO (Japan)

c SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH (Japan)

d KAGOSHIMA UNIVERSITY (Japan)

e TOKYO MEDICAL AND DENTAL UNIVERSITY (Japan)

f UNIVERSITY OF LOUISVILLE (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 NAPHTHYL)ALANINE; ALANINE DERIVATIVE; AMINO ACID; ARGININE; CHEMOKINE RECEPTOR CXCR4; PEPTIDE DERIVATIVE; RECEPTOR BLOCKING AGENT; T 140; TYROSINE; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; BETA SHEET; DRUG CONFORMATION; DRUG STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHARMACOPHORE; RECEPTOR BLOCKING; T LYMPHOCYTE; VIRUS STRAIN;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; COMPUTER SIMULATION; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGOPEPTIDES; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, CXCR4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035847678 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/S0960-894X(00)00664-8 Document Type: Article

Times cited : (56)

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