The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells

Stem Cells

Volumn 19, Issue 5, 2001, Pages 453-466

  Kijowski, Jacek ^a   Baj Krzyworzeka, Monika ^a   Majka, Marcin ^a   Reca, Ryan ^a   Marquez, Leah A ^b   Christofidou Solomidou, Melpo ^a   Janowska Wieczorek, Anna ^b,c   Ratajczak, Mariusz Z ^a,d,e  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CANADIAN BLOOD SERVICES   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

^d UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Apoptosis; Cellular proliferation; Chemokines; Lymphocytes; Protein kinases

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CYTOKINE; FIBRONECTIN; INTEGRIN; MACROPHAGE INFLAMMATORY PROTEIN 1; MATRIX METALLOPROTEINASE; STAT PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; VASCULOTROPIN;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL ADHESION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE RELEASE; HEMATOPOIESIS; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0034807055     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.19-5-453     Document Type: Article

References (53)

1. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
2. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
3. Chemokines
4. Host factors and the pathogenesis of HIV-induced disease
5. The influence of human immunodeficiency virus-1 on hematopoiesis
6. Chemokines and HIV-1 second receptors: The therapeutic connection
7. Coreceptor/chemokine receptor expression on human hematopoietic cells: Biological implications for HIV-1 infection
8. + hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1
9. + progenitors to peripheral blood
10. Stromal cell-derived factor-1α and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: A potential mechanism for cooperative induction of chemotaxis
11. Stromal derived factor-1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis
12. The role of HIV related chemokine receptors and chemokines in human erythropoiesis in vitro
13. The alpha-chemokine, stromal cell-derived factor-1α, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways
14. + cells on vascular endothelium under shear flow
15. Stromal cell-derived factor-1α stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: Roles of phosphoinositide-3 kinase and protein kinase C
16. The β-chemokine receptor CXCR4 is expressed on the megakaryocytic lineage from progenitor to platelets and modulates migration and adhesion
17. Stromal cell-derived factor-1 (SDF-1) acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells (CFU-MK)
18. + cell proliferation in synergy with cytokines: Possible role in progenitor survival
19. Biological significance of the expression of HIV related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines
20. Guidelines for the characterization and publication of human malignant hematopoietic cell lines
21. Neutrophil platelet endothelial cell adhesion molecule-1 participates in neutrophil recruitment at inflammatory sites and is down-regulated after leukocyte extravasation
22. Anti-ICAM-1 monoclonal antibody R6.5 (Enlimomab) promotes activation of neutrophils in whole blood
23. Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells
24. A monoclonal antibody to a membrane glycoprotein binds only to activated platelets
25. A colorimetric method for the measurement of platelet adhesion in microtiter plates
26. + cells in a lymphocyte expression system
27. Expression of matrix metalloproteinases (MMP-2 and -9) and tissue inhibitors of metalloproteinases (TIMP-1 and -2) in acute myelogenous leukaemia blasts: Comparison with normal bone marrow cells
28. + cells and their transmigration through reconstituted basement membrane
29. Binding of stromal derived factor-1α (SDF-1α) to CXCR4 chemokine receptor in normal human megakaryoblasts but not in platelets induces phosphorylation of mitogen-activated protein kinase p42/44 (MAPK), ELK-1 transcription factor and serine/threonine kinase AKT
30. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades
31. Thrombopoietin induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: Role in endomitosis
32. Akt is more than just bad kinase
33. Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B
34. Interleukin-3 dependent survival by the Akt protein kinase
35. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
36. NF-κB and rel proteins: Evolutionarily conserved mediators of immune response
37. Requirement of phosphatidylinositol 3-kinase activity for bradykinin stimulation of NF-kb activation in cultured human epithelial cells
38. + cells in response to chemokines
39. Transendothelial migration of megakaryocytes in response to stromal cell-derived factor-1 (SDF-1) enhances platelet formation
40. + cells (long-term culture-initiating cells) through endothelial cells is mediated by E-selectin
41. Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1
42. Stroma-derived factor 1 alpha induces a selective inhibition of human erythroid development via the functional upregulation of Fas/CD95 ligand
43. Phenotypic and functional evidence for the expression of CXCR4 receptor during megakaryocytopoiesis
44. Activation of HIV-1 coreceptor (CXCR4) mediates myelosuppression
45. Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: Possible sites for intervention with anti-neoplastic drugs
46. Thrombopoietin signal transduction requires functional JAK2 not TYK2
47. Constitutive activation of JAK2/STAT5 signal transduction pathway correlates with growth factor independence of megakaryocytic leukemic cell lines
48. Bcr/abl activates transcription of the Bcl-X gene through STAT5
49. Cytokine response profiles of human myeloid factor-dependent leukemia cell lines
50. Matrix metalloproteinases in immunity
51. Interleukin-6 regulation of matrix metalloproteinase (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) expression in malignant non-Hodgkin's lymphomas
52. Selective CXCR4 antagonism by Tat: Implications for in vivo expansion of coreceptor use by HIV-1
53. Anchorage dependence, integrins and apoptosis