Cell-surface heparan sulfate is involved in the repulsive guidance activities of Slit2 protein

Nature Neuroscience

Volumn 4, Issue 7, 2001, Pages 695-701

  Hu, H ^a  

^a METROHEALTH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARAN SULFATE;

ARTICLE; BRAIN DEVELOPMENT; CELL MIGRATION; CELL SURFACE; HUMAN; HUMAN CELL; NERVE CELL; NERVE FIBER GROWTH; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ANIMALS; AXONS; CELL LINE; CELL MOVEMENT; FLUORESCENT ANTIBODY TECHNIQUE; HEPARAN SULFATE PROTEOGLYCANS; HEPARITIN SULFATE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERNEURONS; MICE; NERVE TISSUE PROTEINS; OLFACTORY BULB; RATS; RECEPTORS, IMMUNOLOGIC;

EID: 0034960507     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/89482     Document Type: Article

References (50)

1. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord
2. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system
3. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6
4. Collapsin: A protein in brain that induces the collapse and paralysis of neuronal growth cones
5. The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules
6. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance
7. Slit is the midline repellent for the robo receptor in Drosophila
8. Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons
9. Slit2-mediated chemorepulsion and collapse of developing forebrain axons
10. Slit: An extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains
11. Roundabout controls axon crossing of the CNS midline and defines a novel subfamily o f evolutionarily conserved guidance receptors
12. The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans
13. Crossing the midline: Roles and regulation of Robo receptors
14. Selecting a longitudinal pathway: Robo receptors specify the lateral position of axons in the Drosophila CNS
15. Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance
16. Short-range and long-range guidance by Slit and its Robo receptors: A combinatorial code of Robo receptors controls lateral position
17. Axon repulsion from the midline of the Drosophila CNS requires slit function
18. Chimeric axon guidance receptors: The cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion
19. Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening
20. Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis
21. Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system
22. Retinal ganglion cell axon guidance in the mouse optic chiasm: Expression and function of Robos and Slits
23. Slit inhibition of retinal axon growth and its role in retinal axon pathfinding and innervation patterns in the diencephalon
24. Slit2 is a repellent for retinal ganglion cell axons
25. Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching
26. Directional guidance of neuronal migration in the olfactory system by the protein Slit
27. Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex
28. Chemorepulsion of neuronal migration by Slit2 in the developing mammalian forebrain
29. The N-terminal leucine-rich regions in Slit are sufficient to repel olfactory bulb axons and subventricular zone neurons
30. Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain
31. Kinetics of basic fibroblast growth factor binding to its receptor and heparan sulfate proteoglycan: A mechanism for cooperactivity
32. A septum-derived chemorepulsive factor for migrating olfactory interneuron precursors
33. Chemorepulsion of axons in the developing mammalian central nervous system
34. Functions of cell surface heparan sulfate proteoglycans
35. Genetic evidence that heparin-like glycosaminoglycans are involved in wingless signaling
36. Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development
37. Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling
38. The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis
39. Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila
40. Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan
41. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
42. Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase
43. Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface
44. Heparan sulphate and HB-GAM (heparin-binding growth-associated molecule) in the development of the thalamocortical pathway of rat brain
45. N-syndecan and HB-GAM (heparin-binding growth-associated molecule) associate with early axonal tracts in the rat brain
46. Immunocytochemical and in situ hybridization studies of the heparan sulfate proteoglycan, glypican, in nervous tissue
47. Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain
48. Expression of the heparan sulfate proteoglycan glypican-1 in the developing rodent
49. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
50. Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation