Lipoprotein lipase expression exclusively in liver. A mouse model for metabolism in the neonatal period and during cachexia

Journal of Clinical Investigation

Volumn 102, Issue 5, 1998, Pages 893-901

  Merkel, Martin ^a   Weinstock, Peter H ^a   Chajek Shaul, Tova ^b   Radner, Herbert ^c   Yin, Baoyun ^d   Breslow, Jan L ^a   Goldberg, Ira J ^d  

^a ROCKEFELLER UNIVERSITY   (United States)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c UNIVERSITY OF GRAZ   (Austria)

^d New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

Energy metabolism; Fatty acids; Glucose; Ketone bodies; Triglycerides

Indexed keywords

LIPOPROTEIN LIPASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CACHEXIA; CONTROLLED STUDY; ENERGY METABOLISM; HUMAN; KNOCKOUT MOUSE; LIPID ANALYSIS; LIPID METABOLISM; LIPOPROTEIN METABOLISM; LIVER METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

EID: 0032169445     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI2912     Document Type: Article

References (33)

1. Olivecrona, G., and T. Olivecrona. 1995. Triglyceride lipases and atherosclerosis. Curr. Opin. Lipidol 6:291-305.
2. Goldberg, I.J. 1996. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J. Lipid Res. 37:693-707.
3. Chajek, T., O. Stein, and Y. Stein. 1977. Pre-and post-natal development of lipoprotein lipase and hepatic triglyceride hydrolase activity in rat tissues. Atherosclerosis. 26:549-561.
4. Bensadoun. A., and T.L. Koh. 1977. Identification of an adipose tissuelike lipoprotein lipase in perfusates of chicken liver. J. Lipid Res. 18:768-773.
5. Semenkovich, C.F., S.H. Chen, M. Wims, C.C. Luo, W.H. Li, and L. Chan. 1089. Lipoprotein lipase and hepatic lipase mRNA tissue specific expression, developmental regulation, and evolution. J. Lipid Res. 30:423-431.
6. Yacoub, L.K., T.M. Vanni, and I.J. Goldberg. 1990. Lipoprotein lipase mRNA in neonatal and adult mouse tissues: comparison of normal and combined lipase deficiency (eld) mice assessed by in situ hybridization. J Lipid Res. 31:1845-1852.
7. Tracey, K.J., and A. Cerami. 1992. Tumor necrosis factor in the malnutrition (cachexia) of infection and cancer. Am. J. Trop. Med. Hyg. 47:2-7.
8. Hardardottir, I., C. Grunfeld, and K.R. Feingold. 1994. Effects of endotoxin and cytokines on lipid metabolism. Curr. Opin. Lipidol 5:207-215.
9. Enerback, S., H. Semb, J. Tavernier, G. Bjursell, and T. Olivecrona. 1988. Tissue-specific regulation of guinea pig lipoprotein lipase; effects of nutritional state and of tumor necrosis factor on mRNA levels in adipose tissue, heart and liver. Gene. 64:97-106.
10. Chajek-Shaul, T., G. Friedman, O. Stein, E. Shiloni, J. Etienne, and Y. Stein. 1989. Mechanism of the hypertriglyceridemia induced by tumor necrosis factor administration to rats. Biochim. Biophys. Acta. 1001:316-324.
11. Chajek-Shaul, T., E. Ziv, G. Friedman, J. Etienne, and J. Adler. 1988. Regulation of lipoprotein lipase activity in the sand rat: effect of nutritional state and cAMP modulation. Metabolism. 37:1152-1158.
12. Masuno, H., T. Tsujita, H. Nakanishi, A. Yoshida, R. Fukunishi, and H. Okuda. 1984. Lipoprotein lipase-like activity in the liver of mice with Sarcoma 180. J. Lipid Res. 25:419-427.
13. Walsh, A., Y. Ito, and J.L. Breslow. 1989. High levels of human apolipoprotein A-I in transgenic mice result in increased plasma levels of small high density lipoprotein (HDL) particles comparable to human HDL3. J. Biol. Chem. 264:6488-6494.
14. Levak-Frank, S., H. Radner, A. Walsh, R. Stollberger, G. Knipping, G. Hoefler, W. Sattler, P.H. Weinstock, J.L. Breslow, and R. Zechner. 1995. Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice. J. Clin. Invest. 96:976-986.
15. Weinstock, P.H., C.L. Bisgaier, K. Aalto-Setala, H. Radner, R. Ramakrishnan, S. Levak-Frank, A.D. Essenburg, R. Zechner, and J.L. Breslow. 1995. Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. J Clin. Invest. 96:2555-2568.
16. Levak-Frank, S., P.H. Weinstock, T. Hayek, W. Hofmann, R. Verdery, J.L. Breslow, and R. Zechner. 1997. Induced mutant mice expressing lipoprotein lipase exclusively in muscle have subnormal triglycerides yet reduced HDL-cholesterol levels in plasma. J. Biol. Chem. 272:17182-17190.
17. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
18. Raisonnier, A., J. Etienne, F. Arnault, D. Brault, L. Noe, J.C. Chuat, and F. Galibert. 1995. Comparison of the cDNA and amino acid sequences of lipoprotein lipase in eight species. Comp. Biochem. Physiol. 111B:385-398.
19. Nilsson-Ehle, P., and M.C. Schotz. 1976. A stable, radioactive substrate emulsion for assay of lipoprotein lipase. J. Lipid Res. 17:536-541.
20. Goldberg, I.J., W.S. Blaner, T.M. Vanni, M. Moukides, and R. Ramakrishnan. 1990. Role of lipoprotein lipase in the regulation of high density lipoprotein apolipoprotein metabolism. Studies in normal and lipoprotein lipaseinhibited monkeys. J. Clin. Invest. 86:463-173.
21. Weinstock, P.H., S. Levak-Frank, L.C. Hudgins, H. Radner, J.M. Friedmann, R. Zechner, and J.L. Breslow. 1997. Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase. Proc. Natl. Acad. Sci. USA. 94:10261-10266.
22. Folch, J., M. Lees, and G.H. Sloane-Stanley. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226:497-509.
23. Kates, M. 1972. Techniques in lipidology. In Laboratory Techniques in Biochemistry and Molecular Biology. Vol. 3. T.S. Work and E. Work, editors. Elsevier, New York. 267-610.
24. Plump, A.S., N. Azrolan, H. Odaka, L. Wu, X. Jiang, A. Tall, S. Eisenberg, and J.L. Breslow. 1997. ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes. J. Lipid Res. 38:1033-1047.
25. Havel, R.J., H.A. Eder, and J.H. Bragdon. 1955. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest. 34:1345-1353.
26. Aalto-Setala, K., E.A. Fisher, X. Chen, T. Chajek-Shaul, T. Hayek, R. Zechner, A. Walsh, R. Ramakrishnan, H.N. Ginsberg, and J.L. Breslow. 1992. Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles. J Clin. Invest. 90:1889-1900.
27. Blanchette-Mackie. E.J., M.G. Wetzel, S.S. Chernick, J.R. Paterniti, Jr., W.V. Brown, and R.O. Scow. 1986. Effect of the combined lipase deficiency mutation (cld/cld) on ultrastructure of tissues in mice. Diaphragm, heart, brown adipose tissue, lung, and liver. Lab. Invest. 55:347-362.
28. Coleman, T., R.L. Seip, J.M. Gimble, D. Lee. N. Maeda, and C.F. Semenkovich. 1995. COOH-terminal disruption of lipoprotein lipase in mice is lethal in homozygotes, but heterozygotes have elevated triglycerides and impaired enzyme activity. J. Biol. Chem. 270:12518-12525.
29. Smart, J.L., D.N. Stephens, J. Tonkiss, N.S. Auestad, and J. Edmond. 1984. Growth and development of rats artificially reared on different milk-substitutes. Br. J. Nutr. 52:227-237.
30. Ensminger, A.H., M.E. Ensminger, E.K. James, and J.R.K. Robson. 1994. Encyclopedia of Nutrition. CRC Press, London. 1460 pp.
31. Hahn, P., and M. Novak. 1985. How important are carnitine and ketones for the newborn infant? FASEB (Fed. Am. Soc. Exp. Biol.) J. 44:2369-2373.
32. Busch, S.J., R.L. Barnhart, G.A. Martin, M.C. Fitzgerald, M.T. Yates, S.J. Mao, C.E. Thomas, and R.E. Jackson. 1994. Human hepatic triglyceride lipase expression reduces high density lipoprotein and aortic cholesterol in cholesterol-fed transgenic mice. J. Biol. Chem. 269:16376-16382.
33. Greenwood, M.R.C. 1985. The relationship of enzyme activity to feeding behavior in rats: lipoprotein lipase as the metabolic gatekeeper. Int. J. Obes. 9:67-70.