Strategies for preclinical evaluation of dendritic cell subsets for promotion of transplant tolerance in the nonhuman primate

Human Immunology

Volumn 63, Issue 10, 2002, Pages 955-965

  Coates, P Toby H ^a   Barratt Boyes, Simon M ^b   Donnenberg, Albert D ^c   Morelli, Adrian E ^a   Murphey Corb, Michael ^b   Thomson, Angus W ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Dendritic cells; Nonhuman primates; Tolerance; Transplantation

Indexed keywords

CD123 ANTIGEN; GLYCOPROTEIN P 15095; HLA DR ANTIGEN;

ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; CELL LINEAGE; CELL SUBPOPULATION; CONTROLLED STUDY; DENDRITIC CELL; GRAFT SURVIVAL; HUMAN; HUMAN CELL; IMMUNITY; IMMUNOLOGICAL TOLERANCE; LYMPHOID TISSUE; NONHUMAN; PRIMATE; PRIORITY JOURNAL;

ANIMALS; CELL MOVEMENT; DENDRITIC CELLS; HEMATOPOIETIC STEM CELLS; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNE TOLERANCE; MACACA MULATTA; MICE; SPECIES SPECIFICITY; T-LYMPHOCYTES; TRANSPLANTATION IMMUNOLOGY;

EID: 0036775351     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(02)00457-3     Document Type: Article

References (72)

1. Rastellini C, Lu L, Ricordi C, Starzl TE, Rao AS, Thomson AW: Granulocyte/macrophage colony-stimulating factor-stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival. Transplantation 60:1366, 1995.
2. -) prolong cardiac allograft survival in nonimmunosuppressed recipients. Transplantation 62:659, 1996.
3. Hayamizu K, Huie P, Sibley RK, Strober S: Monocyte-derived dendritic cell precursors facilitate tolerance to heart allografts after total lymphoid irradiation. Transplantation 66:1285, 1998.
4. Gao J-X, Madrenas J, Zeng W, Cameron M, Zhang Z, Wang J-J, Zhong R: CD-40 deficient dendritic cells producing interleukin-10, but not interleukin-12, induce T-cell hyporesponsiveness in vitro and prevent acute allograft rejection. Immunology 98:159, 1999.
5. Lutz MB, Suri RM, Niimi M, Ogilvie AL, Kukutsch NA, Rossner S, Schuler G, Austyn JM: Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur J Immunol 30:1813, 2000.
6. Lu L, Bonham CA, Liang X, Chen Z, Li W, Wang L, Watkins SC, Nalesnik MA, Schlissel MS, Demetris AJ, Fung JJ, Qian S: Liver-derived DEC205+B220+CD19-dendritic cells regulate T cell responses. J Immunol 166:7042, 2001.
7. O'Connell PJ, Li W, Wang Z, Specht S, Logar AJ, Thomson AW: Immature and mature CD8 alpha(+) dendritic cells prolong the survival of vascularized heart allografts. J Immunol 168:143, 2002.
8. Lu L, Li W, Fu F, Chambers FG, Qian S, Fung JJ, Thomson AW: Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival. Transplantation 64:1808, 1997.
9. Thomas J, Contreras J, Jiang X, Eckhoff D, Wang P, Hubbard W, Lobashevsky A, Wang W, Asiedu C, Stavrou S, Cook W, Robbin M, Thomas F, Neville DJ: Peritransplant tolerance induction in macaques: Early events reflecting the unique synergy between immunotoxin and deoxyspergualin. Transplantation 68:1660, 1999.
10. Coates PTH, Thomson AW: Dendritic cells and tolerance induction. Am J Transplant 2:299, 2002.
11. Morelli AE, Hackstein H, Thomson AW: Potential of tolerogenic dendritic cells for transplantation. Semin Immunol 13:323, 2001.
12. Steinman RM, Turley S, Mellman I, Inaba K: The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med 191:411, 2000.
13. Kuwana M, Kaburaki J, Wright TM, Kawakami Y, Ikeda Y: Induction of antigen-specific human CD4+T cell anergy by peripheral blood DC2 precursors. Eur J Immunol 31:2547, 2001.
14. Arpinati M, Green CL, Heimfeld S, Heuser JE, Anasetti C: Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells. Blood 95:2484, 2000.
15. Maraskovsky E, Daro E, Rous E, Teepe M, Maliszewski CR, Hoek J, Caron D, Lebsack ME, McKenna H: In vivo generation of human dendritic cell subsets by Flt3 ligand. Blood 96:878, 2000.
16. Pulendran B, Banchereau J, Burkeholder S, Kraus E, Guinet E, Chalouni C, Caron D, Maliszewski C, Davoust J, Fay J, Palucka K: Flt3 -Ligand and Granulocyte Colony-Stimulating Factor mobilize distinct human dendritic cell subsets in vivo. J Immunol 165:566, 2000.
17. Steptoe RJ, Thomson AW: Dendritic cells and tolerance induction. Clin Exp Immunol 105:397, 1996.
18. Thomson AW, Lu L: Are dendritic cells the key to liver transplant tolerance? Immunol Today 20:27, 1999.
19. Morelli AE, Thomson AW: Role of dendritic cells in the immune response against allografts. Curr Opin Nephrol Hypertens 9:640, 2000.
20. Lotze MT, Thomson AW (eds.): Dendritic Cells: Biology and Clinical Applications 2nd Ed. San Diego, CA: Academic Press, 2001.
21. Wells A, Li X, Walsh M, Zheng X, Wu Z, Nunez G, Tang A, Sayegh M, Hancock W: Requirement for T-cell apoptosis in the induction of peripheral tolerance. Nat Med 5:1304, 1999.
22. Vendetti S, Chai J-C, Dyson J, Simpson E, Lombardi G, Lechler R: Anergic T cells inhibit the antigen-presenting function of dendritic cells. J Immunol 165:1175, 2000.
23. Chang C, Ciubotariu R, Manavalan J, Yuan J, Colovani A, Piazza F, Lederman S, Colonna M, Cortesini R, Dalla-Favera R, Suciu-Foca N: Tolerization of dendritic cells by TS cells: The crucial roles of ILT3 and ILT4. Nat Immunol 3:237, 2002.
24. Lu L, Qian S, Hershberger PA, Rudert WA, Lynch DH, Thomson AW: Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation. J Immunol 158:5676, 1997.
25. Fanger N, Maliszewski C, Schooley K, Griffith T: Human dendritic cells mediate cellular apoptosis via tumor-necrosis factor related apoptosis-inducing ligand (TRAIL). J Exp Med 190:1155, 1999.
26. Khoury S, Gallon L, Verburg R, Chandraker A, Peach R, Linsley P, Turka L, Hancock W, Sayegh M: ex vivo treatment of antigen presenting cells with CTLA4Ig and enchepalitogenic peptide prevents experimental autoimmune encephalomyelitis in Lewis rats. J Immunol 157:3700, 1996.
27. Gorczynski RM, Cohen Z, Fu XM, Hua Z, Sun Y, Chen Z: Interleukin-13, in combination with anti-interleukin-12, increases graft prolongation after portal venous immunization with cultured allogeneic bone marrow-derived dendritic cells. Transplantation 62:1592, 1996.
28. Jonuleit L, Schmitt E, Schuler G, Knop J, Enk AH: Induction of interleukin 10-producing, nonproliferating CD4+ T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 192:1213, 2000.
29. Dhodapkar MV, Steinman RM, Krasovsky J, Munz C, Bhardwaj N: Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med 193:233, 2001.
30. Menges M, Rossner S, Voigtlander C, Schindler H, Kukutsch N, Bogdan C, Erb K, Schuler G, Lutz M: Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection from autoimmunity. J Exp Med 195:15, 2002.
31. Josien R, Heslan M, Brouard S, Soulillou J-P, Cuturi M-C: Critical requirement for graft passenger leukocytes in allograft tolerance induced by donor blood transfusion. Blood 92:4539, 1998.
32. Gagne K, Brouard S, Guillet M, Cuturi M, Souilillou JP: TGF-betal and donor dendritic cells are common key components in donor-specific blood transfusion and anti-class II heart graft enhancement, whereas tolerance induction also required inflammatory cytokines down-regulation. Eur J Immunol 31:3111, 2001.
33. -) induce allo-antigen specific hyporesponsiveness in murine T lymphocytes. Transplantation 60:1539, 1995.
34. Demetris AJ, Murase N, Ye Q, Galvao F, Richert C, Saad R, Pham S, Duquesnoy R, Zeevi A, Fung JJ, Starzl TE: Analysis of chronic rejection and obliterative arteriolopathy. Possible contributions of donor antigen presenting cells and lymphatic disruption. Am J Path 150:563, 1997.
35. Starzl TE, Demetris AJ, Murase N, Trucco M, Thomson AW, Rao AS: The lost chord: Microchimerism and allograft survival. Immunol Today 17:577, 1996.
36. Wood K, Sachs D: Chimerism and transplant tolerance: Cause and effect. Immunol Today 17:584, 1996.
37. Kirk A: Transplantation Tolerance: A look at the nonhuman primate literature in the light of modern tolerance theories. Crit Rev Immunol 19:349, 1999.
38. Myburgh J, Smit J, Browde S, Hill R: Transplantation tolerance in primates following total lymphoid irradiation and allogeneic bone marrow injection: Orthotopic liver allografts. Transplantation 29:401, 1980.
39. Kawai T, Abrahamian G, Sogawa S, Wee S, Boskovic S, Andrew D, Nadazdin O, Mauiyyedi D, Weymouth D, Ko D, Colvin D, Sachs D, Cosimi A: Co-srimulation blockade for the induction of mixed chimerism and renal allograft tolerance in nonhuman primates. Transplant Proc 33:221, 2001.
40. Gozzo A, Wood M, Monaco A: Use of allogeneic, homozygous bone marrow cells for the induction of specific immune tolerance in mice treated with antilymphocyte serum. Surg Forum 21:281, 1970.
41. Thomas F, Carver F, Foil M, Pryor W, Larkin E, Hall W, Haisch C, Thomas J: Long-term incompatible kidney survival in outbred higher primates without chronic immunosuppression. Ann Surg 198:370, 1983.
42. Thomas J, Carver F, Kasten-Jolly J, Haisch C, Rebellato L, Gross U, Vore S, Thomas F: Further studies of veto activity in rhesus monkey bone marrow in relation to allograft tolerance and chimerism. Transplantation 57:101, 1994.
43. Thomas J, Carver F, Haisch C, Fahrenbusch G, Deepe R, Thomas F: Suppressor cells in rhesus monkeys treated with antilymphocyte globulin. Transplantation 34:83, 1982.
44. Mourad G, Preffer F, Wee S, Powelson J, Kawai T, Delmonico F, Knowles L, Cosimi A, Colvin R: Humanized IgG1 and IgG4 anti-CD4 monoclonal antibodies: Effects on lymphocytes in the blood, lymph nodes, and renal allografts in cynomologous monkeys. Transplantation 65:632, 1998.
45. Kirk A, Harlan D, Armstrong N, Davis T, Dong Y, Gray G, Hong X, Thomas D, Fechner S, Knechtle S: CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci 94:8789, 1997.
46. Adams AB, Shirasugi N, Durham MM, Strobert E, Anderson D, Rees P, Cowan S, Xu H, Blinder Y, Cheung M, Hollenbaugh D, Kenyon NS, Pearson TC, Larsen CP: Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates. Diabetes 51:51, 2002.
47. Contreras J, Xang P, Eckhoff D, Lobashevsky A, Asiedu C, Frenette L, Robbin M, Hubbard W, Cartner S, Nadler S, Cook W, Sharff J, Shiloach J, Thomas F, Neville D, Thomas J: Peritransplant tolerance induction with anti-CD3-immunotoxin. Transplantation 65:1159, 1998.
48. Thomas J, Contreras J, Smyth C, Lobashevsky A, Hubbard W, Moore J, Cook W, Thomas F, Neville D: Durable donor-specific T and B cell tolerance in rhesus macaques induced with peritransplantation anti-CD3 immunotoxin and deoxyspergualin. Transplantation 69:2479, 2000.
49. Thomas J, Contreras J, Smyth A, Lobashevsky A, Jenkins S, Hubbard W, Eckhoff D, Stavrou S, Neville D, Thomas F: Successful reversal of streptozotocin-induced diabetes with stable allogeneic islet function in a preclinical model of type-1 diabetes. Diabetes 50:1227, 2001.
50. Kawai T, Cosimi A, Colvin R, Powelson J, Eason J, Kozlowski T, Sykes M, Monroy R, Tanaka M, Sachs D: Mixed allogeneic chimerism and renal allograft tolerance in cynomologous monkeys. Transplantation 59:256, 1995.
51. Kawai T, Poncelet A, Sachs D, Mauiyyedi A, Boskovic S, Wee S, Ko D, Bartholomew A, Kimikawa M, Hong H, Abrahamian G, Colvin R, Cosimi A: Long term outcome and allo-antibody production in a nonmyeloablative regimen for induction of renal allogtaft tolerance. Transplantation 68:1767, 1999.
52. Pinchuk L, Grouard-Vogel G, Magaletti D, Doty R, Andrews R, Clark E: Isolation and characterization of macaque dendritic cells from CD34+ bone marrow progenitors. Cell Immunol 196:34, 1999.
53. O'Doherty U, Ignatius R, Bhardwaj N, Pope M: Generation of monocyte-derived dendritic cells from precursors in rhesus macaques. J Immunol Methods 207:185, 1997.
54. Barratt-Boyes SM, Watkins S, Finn O: In vivo migration of dendritic cells differentiated in vitro. J Immunol 158:4543, 1997.
55. Barratt-Boyes SM, Zimmer M, Harshyne L, Meyer E, Watkins S, Capuamo S, Murphey-Corb M, Falo L, Donnenberg AD: Maturation and trafficking of monocyte-derived dendritic cells in monkeys: Implications for dendritic cell based vaccines. J Immunol 164:2487, 2000.
56. Pichyangkul S, Saengkrai P, Yongvanitchit K, Limsomwong C, Gettayacamin M, Walsh D, Stewart V, Ballou W, Heppner D: Isolation and characterization of rhesus blood dendritic cells using flow cytometry. J Immunol Methods 252:15, 2001.
57. Koopman G, Dalgleisch A, Bhogal B, Haakma A, Heeney J: Changes in dendritic cell subsets in the lymph nodes of rhesus macaques after application of glucocorticoids. Human Immunol 62:208, 2001.
58. + lymphoid-related dendritic cells. J Immunol 165:795, 2000.
59. - and CD8α+)dendritic cells. Transplantation 69:2647, 2000.
60. Donnenberg VS, O'Connell PJ, Logar AJ, Zeevi A, Thomson AW, Donnenberg AD: Rare event analysis of circulating human DC subsets and their presumptive mouse counterparts. Transplantation 72:1946, 2001.
61. Steptoe RJ, Fu F, Li W, Drakes ML, Lu L, Demetris AJ, Qian S, McKenna HJ, Thomson AW: Augmentation of dendritic cells in murine organ donors by Flt3 ligand alters the balance between transplant tolerance and immunity. J Immunol 159:5483, 1997.
62. Thomson AW, Lu L, Murase N, Demetris AJ, Rao AS, Starzl TE: Microchimerism, dendritic cell progenitors and transplantation tolerance. Stem Cells 13:622, 1995.
63. Thomson AW, Lu L, Wan Y, Qian S, Larsen CP, Starzl TE: Identification of donor-derived dendritic cell progenitors in bone marrow of spontaneously tolerant liver allograft recipients. Transplantation 60:1555, 1995.
64. Sonderlund J, Nilsson C, Ekman M, Walther L, Gaines H, Biberfeld G, Biberfeld P: Recruitment of monocyte derived dendritic cells ex vivo from SIV infected and noninfected cynomologous monkeys. Scan J Immunol 51:186, 2000.
65. Tary-Lehmann M, Hricik D, Justice A, Potter N, Heeger P: Enzyme-linked immunosorbent assay spot detection of interferon-gamma and interleukin-5 producing cells as a predictive marker of allograft failure. Transplantation 66:219, 1998.
66. Heeger P, Greenspan N, Kuhlenschmidt S, Dejelo C, Hricik D, Schulak J, Tary-Lehman M: Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with risk of post-transplant rejection episodes. J Immunol 163:2267, 1999.
67. VanBuskirk A, Burlingham W, Jankowska-Gan E, Chin T, Kusaka S, Geissler F, Pelletier R, Orosz C: Human allograft acceptance is associated with immune regulation. J Clin Invest 106:145, 2000.
68. Murray AG, Petzelbauer P, Hughes CC, Costa J, Askenase P, Pober JS: Human T-cell-mediated destruction of allogeneic dermal microvessels in a severe combined immunodeficient mouse. Proc Natl Acad Sci USA 91:9146, 1994.
69. Coates PTH, Krishnan R, Kireta S, Johnston J, Russ GR: Human myeloid dendritic cells transduced with an adenoviral interleukin 10 gene construct inhibit human skin graft rejection in humanized NOD-scid chimeric mice. Gene Therapy 8:1224, 2001.
70. Lu L, Li W, Zhong C, Qian S, Fung JJ, Thomson AW, Starzl TE: Increased apoptosis of immunoreactive host cells and augmented donor leukocyte chimerism, not sustained inhibition of B7 molecule expression are associated with prolonged cardiac allograft survival in mice preconditioned with immature donor dendritic cells plus anti-CD40L mAb. Transplantation 68:747, 1999.
71. Zhong R, Donnenberg AD, Zhang HF, Watkins S, Zhou JH, Ball ED: Human blood dendritic cell-like B cells isolated by the 5G9 monoclonal antibody reactive with a novel 220-kDa antigen. J Immunol 163:1354, 1999.
72. +, and mature interdigitating dendritic cells. J Clin Invest 107:835, 2001.