Durable donor-specific T and B cell tolerance in rhesus macaques induced with peritransplantation anti-CD3 immunotoxin and deoxyspergualin: Absence of chronic allograft nephropathy

Transplantation

Volumn 69, Issue 12, 2000, Pages 2497-2503

  Thomas, Judith M ^a,c   Eckhoff, Devin E ^a   Contreras, Juan L ^a   Lobashevsky, Andrew L ^a   Hubbard, William J ^a   Moore, Jill K ^a   Cook, William J ^a   Thomas, Francis T ^a   Neville Jr , David M ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c BDB 563 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXYSPERGUALIN; ALLOANTIBODY; CD3 ANTIGEN; IMMUNOTOXIN;

ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; CHIMERA; CONTROLLED STUDY; IMMUNOCOMPETENCE; IMMUNOLOGICAL TOLERANCE; KIDNEY ALLOGRAFT; KIDNEY ALLOGRAFT REJECTION; KIDNEY DISEASE; MALE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0034720783     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200006270-00007     Document Type: Article

References (46)

1. Cecka JM. The UNOS Scientific Renal Transplant Registry - Ten Years of Kidney Transplants. In: Cecka JM, Terasaki PI, eds. Clinical Transplants. Los Angeles, CA: UCLA Tissue Typing Laboratory, 1997: 1.
2. Halloran PF, Melk A, Barth C. Rethinking chronic allograft nephropathy: the concept of accelerated senescence. J Am Soc Nephrol 1999; 10: 167.
3. Nagano H, Tilney NL. Chronic allograft failure: the clinical problem. Am J Med Sci 1997; 313: 305.
4. Hayry P, Loubtchenkov M, Myllarniemi M, Koskinen P, Lemstrom K. Problem of chronic rejection. Graft 1999; 1: 154.
5. Paul LC. Chronic allograft nephropathy: an update. Kidney Int 1999; 56: 783.
6. Shirwan H. Chronic allograft rejection. Transplantation 1999; 68: 715.
7. Albert ML, Sauter B, Bhardwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 1998; 392: 86.
8. Hubbard WJ, Thomas JM. Cytoblation and cytoreduction strategies in transplant tolerance. Curr Opin Organ Transplant 1997; 2: 36.
9. Kawai T, Sachs DH, Cosimi AB. Tolerance to vascularized organ allografts in large-animal models. Curr Opin Immunol 1999; 11: 516.
10. Hamawy MM, Knechtle SJ. Strategies for tolerance induction in nonhuman primates. Curr Opin Immunol 1998; 10: 513.
11. Harlan DM, Kirk AD. The future of organ and tissue transplantation: can T-cell costimulatory pathway modifiers revolutionize the prevention of graft rejection? JAMA 1999; 282: 1076.
12. Rose SM, Blustein N, Rotrosen D. Recommendations of the expert panel on ethical issues in clinical trials of transplant tolerance: National Institute of Allergy and Infectious Diseases of the National Institutes of Health. Transplantation 1998; 66: 1123.
13. Sanfilippo F. Transplantation tolerance: the search continues. N Engl J Med 1998; 339: 1700.
14. Contreras JL, Wang PX, Eckhoff DE, et al. Peritransplant tolerance induction with anti-CD3-immunotoxin: a matter of proinflammatory cytokine control. Transplantation 1998; 65: 1159.
15. Thomas JM, Contreras JL, Jiang XL, et al. Peritransplant tolerance induction in macaques: early events reflecting the unique synergy between immunotoxin and deoxyspergualin. Transplantation 1999; 68: 1660.
16. Thomas JM, Neville DM, Contreras JL, et al. Preclinical studies of allograft tolerance in rhesus monkeys: a novel anti-CD3-immunotoxin given peritransplant with donor bone marrow induces operational tolerance to kidney allografts. Transplantation 1997; 64: 124.
17. Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol 1994; 12: 991.
18. Lobashevsky A, Smith JP, Kasten-Jolly J, et al. Identification of DRB alleles in rhesus monkeys using polymerase chain reaction-sequence-specific primers (PCR-SSP) amplification. Tissue Antigens 1999; 54: 254.
19. Racusen LC, Solez K, Colvin RB, et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 713.
20. Fechner JHJ, Vargo DJ, Geissler EK, et al. Split tolerance induced by immunotoxin in a rhesus kidney allograft model. Transplantation 1997; 63: 1339.
21. Harlan WR Jr, Holden KR, Williams GM, Hume DM. Proteinuria and nephrotic syndrome associated with chronic rejection of kidney transplants. N Engl J Med 1967; 277: 769.
22. Contreras JL, Eckhoff DE, Cartner S, et al. Tolerability and side effects of anti-CD3-immunotoxin in preclinical testing in kidney and pancreatic islet transplant recipients. Transplantation 1999; 68: 215.
23. Thomas J, Alqaisi M, Cunningham P, et al. The development of a posttransplant TLI treatment strategy that promotes organ allograft acceptance without chronic immunosuppression. Transplantation 1992; 53: 247.
24. Kawai T, Poncelet A, Sachs DH, et al. Long term outcome and alloantibody production in a non-myeloablative regimen for induction of renal allograft tolerance. Transplantation 1999; 68: 1767.
25. Pennock JL, Reitz BA, Bieber CP, et al. Survival of primates following orthotopic cardiac transplantation treated with total lymphoid irradiation and chemical immune suppression. Transplantation 1981; 32: 467.
26. Stevens HP, Hovius SE, Heeney JL, van Nierop PW, Jonker M. Immunologic aspects and complications of composite tissue allografting for upper extremity reconstruction: a study in the rhesus monkey. Transplant Proc 1991; 23: 623.
27. Hancock WH, Whitley WD, Tullius SG, et al. Cytokines, adhesion molecules, and the pathogenesis of chronic rejection of rat renal allografts. Transplantation 1993; 56: 643.
28. Steinmuller D. The enigma of skin allograft rejection. Transplant Rev 1998; 12: 42.
29. Nemoto K, Ogino M, Ohinata A, Hirashima K. Unique action of an immunosuppressive agent, deoxyspergualin, on hematopoiesis in mice. Exp Hematol 1997; 25: 1339.
30. Thomas JM, Carver M, Cunningham P, Sash C, Park K, Thomas F. Promotion of incompatible allograft acceptance in rhesus monkeys given posttransplant antithymocyte globulin and donor bone marrow. II. Effects of adjuvant immunosuppressive drugs [published erratum appears in Transplantation 1989 May;47(5):928]. Transplantation 1989; 47: 209.
31. Knechtle SJ, Fechner JHJ, Dong Y, et al. Primate renal transplants using immunotoxin. Surgery 1998; 124: 438.
32. Kirk AD, Burkly LC, Batty DS, et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med 1999; 5: 686.
33. Thomas JM, Verbanac KM, Smith JP, et al. The facilitating effect of one-DR antigen sharing in renal allograft tolerance induced by donor bone marrow in rhesus monkeys. Transplantation 1995; 59: 245.
34. Moseley RV, Sheil AG, Mitchell RM, Murray JE. Immunologic relationships between skin and kidney homografts in dogs on immunosuppressive therapy. Transplantation 1966; 4(6): 678.
35. Kerby JD, Luo KL, Ding Q, et al. Immunolocalization of acidic fibroblast growth factor and receptors in the tubulointerstitial compartment of chronically rejected human renal allografts. Transplantation 1997; 63: 988.
36. Matas AJ, Humar A, Payne WD, et al. Decreased acute rejection in kidney transplant recipients is associated with decreased chronic rejection. Ann Surg 1999; 230: 493.
37. Hancock WW, Buelow R, Sayegh MH, Turka LA. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes. Nat Med 1998; 4: 1392.
38. Russell PS, Chase CM, Colvin RB. Alloantibody- and T cell-mediated immunity in the pathogenesis of transplant arteriosclerosis: lack of progression to sclerotic lesions in B cell-deficient mice. Transplantation 1997; 64: 1531.
39. Vella JP, Spadafora-Ferreira M, Murphy B, et al. Indirect allorecognition of major histocompatibility complex allopeptides in human renal transplant recipients with chronic graft dysfunction. Transplantation 1997; 64: 795.
40. Opelz G. Impact of HLA compatibility on survival of kidney transplants from unrelated live donors. Transplantation 1997; 64: 1473.
41. Neville DMJ, Scharff J, Hu HZ, et al. A new reagent for the induction of T-cell depletion, anti-CD3-CRM9. J Immunother Emphasis Tumor Immunol 1996; 19: 85.
42. Mellman I, Turley SJ, Steinman RM. Antigen processing for amateurs and professionals. Trends Cell Biol 1998; 8: 231.
43. Nadler SG, Eversole AC, Tepper MA, Cleaveland JS. Elucidating the mechanism of action of the immunosuppressant 15-deoxyspergualin. Ther Drug Monit 1995; 17: 700.
44. Rescigno M, Martino M, Sutherland CL, Gold MR, RicciardiCastagnoli P. Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med 1998; 188: 2175.
45. Benichou G. Direct and indirect antigen recognition: the pathways to allograft immune rejection. Front Biosci 1999; 4: D476-80.
46. Ehl S, Aichele P, Ramseier H, et al. Antigen persistence and time of T-cell tolerization determine the efficacy of tolerization protocols for prevention of skin graft rejection. Nat Med 1998; 4: 1015.