Humanized IgG1 IgG4 anti-CD4 monoclonal antibodies: Effects on lymphocytes in the blood, lymph nodes, and renal allografts in cynomolgus monkeys

Transplantation

Volumn 65, Issue 5, 1998, Pages 632-641

  Mourad, Georges J ^a,b   Preffer, Frederic I ^a   Wee, Siew Lin ^a   Powelson, John A ^a   Kawai, Tatsuo ^a   Delmonico, Francis L ^a   Knowles, Robert W ^c   Cosimi, A Benedict ^a   Colvin, Robert B ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b LAPEYRONIE HOSPITAL   (France)

^c R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; HISTOCOMPATIBILITY ANTIGEN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; INTERLEUKIN 2; LEUKOCYTE ANTIGEN; OKT 4;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FLOW CYTOMETRY; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOLOGY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT; KIDNEY TRANSPLANTATION; LYMPH NODE; MALE; MONKEY; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; CD4 LYMPHOCYTE COUNT; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; GRAFT REJECTION; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; LYMPH NODES; MACACA FASCICULARIS; MALE; RECOMBINANT FUSION PROTEINS;

EID: 0032521303     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199803150-00006     Document Type: Article

References (32)

1. Krensky AM, Weiss A, Crabtree G, Davis MM, Parham P. T-lymphocyte-antigen interaction in transplant rejection. N Engl J Med 1990; 322: 510.
2. Bishop DK, Shelby J, Eichwald EJ. Mobilization of T lymphocytes following cardiac transplantation: evidence that CD4-positive cells are required for cytotoxic T lymphocyte activation, inflammatory endothelial development, graft infiltration, and acute allograft rejection. Transplantation 1992; 53: 849.
3. Bank I, Chess L. Perturbation of the T4 molecule transmits negative signal to T cells. J Exp Med 1985; 162: 1294.
4. Tite JP, Sloan A, Janeway CAJ. The role of L3T4 in T-cell activation: L3T4 may be both an Ia-binding protein and a receptor that transduces a negative signal. J Mol Cell Immunol 1986; 2: 179.
5. Saizawa K, Rojo J, Janeway CAJ. Evidence for physical association of CD4 and the CD3:α/β T-cell receptor. Nature 1987; 328: 260.
6. Pearson TC, Darby CR, Bushell AR, West LJ, Morris PJ, Wood KJ. The assessment of transplantation tolerance induced by anti-CD4 monoclonal antibody in the murine model. Transplantation 1993; 55: 361.
7. Cobbold SP, Jayasuriya A, Nash A, Waldmann H. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 1984; 312: 548.
8. Sayegh MH, Kut JP, Milford EX. Anti-CD4 monoclonal antibody affects cellular hyporesponsiveness and prolongs renal allograft survival in the rat. Hum Immunol 1989; 26: 131.
9. Cosimi AB, Burton RC, Kung PC, et al. Evaluation in primate renal allograft recipients of monoclonal antibody to human T-cell subclasses. Blood 1981; 73: 1431.
10. Jonker M, Goldstein G, Balner H. Effects of in vivo administration of monoclonal antibodies specific for human T cell subpopulations on the immune system in a Rhesus monkey model. Transplantation 1983; 35: 521.
11. Benjamin RJ, Waldmann H. Induction of tolerance by monoclonal antibody therapy. Nature 1986; 320: 449.
12. Herbert J, Roser B. Strategies of monoclonal antibody therapy that induce permanent tolerance of organ transplants. Transplant Proc 1988; 13: 499.
13. Pearson TC, Madsen JC, Larsen CP, Morris PJ, Wood KJ. Induction of transplantation tolerance in adults using donor antigen and anti-CD4 monoclonal antibody. Transplantation 1992; 54: 475.
14. Cosimi AB, Delmonico FL, Wright JK, et al. Prolonged survival of nonhuman primate renal allograft recipients treated only with anti-CD4 monoclonal antibody. Surgery 1990; 108: 406.
15. Delmonico FL, Cosimi AB, Kawai T, et al. Non-human primate responses to murine and humanized OKT4A. Transplantation 1993; 55: 722.
16. Powelson JA, Knowles RW, Delmonico FL, et al. CDR-grafted OKT4A monoclonal antibody in cynomolgus renal allograft recipients. Transplantation 1994; 57: 788.
17. Delmonico FL, Knowles RW, Colvin RB, et al. Immunosuppression of cynomolgus renal allograft recipients with humanized OKT4A monoclonal antibodies. Transplant Proc 1993; 25: 784.
18. Sablinski T, Sayegh MH, Kut JP, Tilney NL, Milford EL. Time of antigenic challenge for induction of prolonged vascularized allograft survival. Transplantation. 1992: 53: 219.
19. Fuller TC, Trevithick JE, Fuller AA. Colvin RB, Cosimi AB, Kung PC. Antigenic polymorphism of the T4 differentiation antigen expressed on human T helper/inducer lymphocytes. Hum Immunol 1984; 9: 89.
20. Preffer FI. Flow cytometry. In: Colvin RB, Bhan AK, McCluskey RT, eds. Diagnostic immunopathology, 2nd ed. New York: Raven Press, 1995: 725.
21. Cosimi AB, Conti D, Delmonico FL, et al. In vivo effects of monoclonal antibody to ICAM-1 (CD54) in nonhuman primates with renal allografts. J Immunol 1990; 144: 4604.
22. Wong JT, Schott E, Sabga EM, Kielpinski GG, Colvin RB. Immunogenic epitopes of the p55 chain of the IL-2 receptor: relationships to high-affinity IL-2 binding and modulation of the p55 chain. Transplantation 1990; 49: 587.
23. Wee SL, Stroka DM, Preffer FI, Jolliffe LK, Colvin RB, Cosimi AB. The effects of OKT4A monoclonal antibody on cellular immunity of nonhuman primate renal allograft recipients. Transplantation 1992; 53: 501.
24. Sablinski T, Hancock WW, Tilney NL, Kupiec-Weglinsk JW. CD4 monoclonal antibodies in organ transplantation: a review of progress. Transplantation 1991; 52: 579.
25. Madsen JC, Peugh WN, Wood KJ, Morris PJ. The effect of anti L3T4 monoclonal antibody treatment on first-set rejection of murine cardiac allografts. Transplantation 1987; 44: 849.
26. Darby CR, Morris PJ, Wood KJ. Evidence that long-term cardiac allograft survival induced by anti-CD4 monoclonal antibody does not require depletion of CD4+ T cells. Transplantation 1992; 53: 483.
27. Watson CJE, Davies HS, Metcalfe SM, et al. CD4 monoclonal antibodies in the preclinical dog renal allograft model. Transplant Proc 1993; 35: 804.
28. Baldwin WMI. Alloantibody responses and B lymphocytes. In: Tilney NL, Strom TB, Paul LC, eds. Transplantation biology. Philadelphia: Lippincott, 1996: 457.
29. Wong JT, Bonventre JV, Dunn S, Colvin RB. Comparative studies of isolated CD3:CD8, CD3:CD3, and monovalent CD3 binding on CD8+ T-cell activation: model of progressive T-cell receptor aggregation synergism. Hum Immunol 1992; 35: 200.
30. Wee SL, Kawai T, Knowles T, Colvin RB, Cosimi AB. Potent CD8+ CTLs detected in anti-CD4 (OKT4A) mAb immunosuppressed cynomolgus recipients with prolonged allograft survival. Transplant Proc 1993; 25: 794.
31. Hamano K, Morris PJ, Wood KJ. Interaction between CD4 and CD8 T cells determines graft outcome in monoclonal antibody-treated mice. Transplant Proc 1993; 25: 792.
32. Pierson RN, Winn HJ, Russell PS, Auchincloss H. Xenogeneic skin graft rejection is especially dependent on CD4+ T cells. J Exp Med 1989; 170: 991.