Radioprotective effects in vivo of phenolics extracted from Olea europaea L. Leaves against X-ray-induced chromosomal damage: Comparative study versus several flavonoids and sulfur-containing compounds

Journal of Medicinal Food

Volumn 5, Issue 3, 2002, Pages 125-135

  Benavente Garciia O ^a   Castillo, J ^a   Lorente, J ^a   Alcaraz, M ^b  

^a Research and Development Department   (Spain)

^b UNIVERSITY OF MURCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACTEOSIDE; ANTIOXIDANT; DIMETHYL SULFOXIDE; DIOSMIN; HYDROXYTYROSOL; LUTEOLIN; OLEA EUROPAEA EXTRACT; OLEUROPEIN; OXYGEN RADICAL; PLANT EXTRACT; POLYPHENOL DERIVATIVE; PROPYLTHIOURACIL; RUTOSIDE; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CHROMOSOME DAMAGE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; OLIVE TREE; PRIORITY JOURNAL; RADIATION INJURY; RADIATION PROTECTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X IRRADIATION;

ANIMALS; ANTIOXIDANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMOSOME ABERRATIONS; FLAVONOIDS; FLAVONOLS; MALE; MICE; OLEA; PHENOLS; PLANT EXTRACTS; PLANT LEAVES; POLYMERS; RADIATION-PROTECTIVE AGENTS; SULFUR COMPOUNDS; X-RAYS;

ANIMALIA; OLEA EUROPAEA;

EID: 0036753879     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/10966200260398152     Document Type: Article

References (45)

1. Hertog MGL, Feskens EJM, Hollman PC, Katan MB, Kromhout D: Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study. Lancet 1993;342:1007-1011.
2. Benavente-García O, Castillo J, Lorente J, Ortuño A, Del Rio JA: Antioxidant activity of phenolics extracted from Olea europaea L. leaves. Food Chem 2000;68:457-462.
3. Martínez-Domínguez E, De la Puerta R, Ruiz-Gutierrez V: Protective effects upon experimental inflammation models of a polyphenol-supplemented virgin olive oil diet. Inflamm Res 2001;50:102-106.
4. Leger CL, Kadiri-Hassani N, Descomps B: Decreased superoxide anion production in cultured human promonocyte cels (THP-1) due to polyphenol mixtures from olive oil processing wastewaters. J Agric Food Chem 2000;48:5061-5067.
5. Patrick L, Uzick M: Cardiovascular disease: C-reactive protein and the inflammatory disease paradigm. HMG-CoA reductase inhibitors, alpha-tocopherol, red yeast rice, and olive oil polyphenols: A review of the literature. Altern Med Rev 2001;6:248-271.
6. Gutierrez VR, De la Puerta R, Catala A: The effect of tyrosol, hydroxytyrosol and oleuropein on the non-enzymatic lipid peroxidation of rat liver microsomes. Mol Cell Biochem 2001;217:35-41.
7. Manna C, Galleti P, Cucciolla V, Moltedo O, Leone A, Zappia V: The protective effect of the olive oil polyphenol (3, 4-dihydroxyphenyl)-ethanol counteracts reactive oxygen metabolite-induced cytotoxicity in Caco-2-cells. J Nutr 1997;127:286-292.
8. Coni E, Di Benedetto R, Di Pasquale R, Masella R, Modesti D, Mattei R, Carlini EA: Protective effects of oleuropein, an olive oil biophenol, on low density lipoprotein oxidizability in rabbits. Lipids 2000;35:45-54.
9. Edgecombe SC, Stretch GL, Hayball PJ: Oleuropein, an antioxidant polyphenol from olive oil, is poorly absorbed from isolated perfused rat intestine. J Nutr 2000;130:2996-3002.
10. Kasai H, Crain PF, Kuchino Y, Nishimura S, Ootsuyama A, Tanooka H: Formation of 8-hydroxyguanosine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis 1986;7:1849-1851.
11. Riley PA: Free radicals in biology: Oxidative stress and the effects of ionizing radiation. Int J Radiat Biol 1994;65:27-33.
12. Komatsu K, Kator K, Mitsuda Y, Mine M, Okumura Y: Inhibitory effects of rooibos tea, Aspalathus linearis, on X-ray-induced C3H1OT1/2, cell transformation. Cancer Lett 1994;77:33-38.
13. Shimoi K, Masuda S, Shen B, Furugori M, Kinae N: Radioprotective effects of antioxidative plant flavonoids in mice. Mutat Res 1996;350:153-161.
14. Yoshikawa T, Naito Y, Oyamada H, Ueda S, Tanigawa T, Takemura T, Sugino S, Kondo M. Scavenging effects of Aspalathus linearis (rooibos tea) on active oxygen species. In: Antioxidants in Therapy and Preventive Medicine (Emerit I, ed.). Plenum Press, New York, 1990, pp. 171-174.
15. Castillo J, Benavente-García O, Lorente J, Alcaraz M, Redondo A, Ortuño A, Del Rio JA: Antioxidant activity and radioprotective effects against chromosomal damage induced in vivo by X-rays of flavan-3-ols (procyanidins) from grape seeds (Vitis vinifera): Comparative study versus other phenolic and organic compounds. J Agric Food Chem 2000;48:1738-1745.
16. Castillo J, Benavente-García O, Del Baño MJ, Lorente J, Alcaraz M, Dato MJ: Radioprotective effects against chromosomal damage induced in human lymphocytes by (-rays as a function of polymerization grade of grape seed extracts. J Med Food 2001;4:117-123.
17. Schmidt W: The micronucleus test. Mutat Res 1975;31:9-15.
18. Heddle JA, Salamone MF: Chromosomal aberrations and bone marrow toxicity. Environ Health Perspect 1981;39:23-27.
19. Almassy Z, Krepinsky AB, Bianco A, Koteles GJ: The present state and perspectives of micronucleus assay in radiation protection: A review. Appl Radiat Isot 1987;38:241-249.
20. Mavournin KH, Blakey DH, Cimino CM, Salamone MF, Heddle JA: The in vivo micronucleus assay in mammalian bone marrow and peripheral blood: A report of the U. S. Environmental Protection Agency Gene-Tox Program. Mutat Res 1990;239:29-80.
21. Krishna G, Friedler R, Theiss JC: Simultaneous evaluation of clastogenicity, aneugenicity and toxicities in the mouse micronucleus assay using immunofluorescence. Mutat Res 1992;282:159-167.
22. Mazur H. Induction of micronucleated erythrocytes by MEA, AET, WR-2721 and X-rays. Mutat Res 1995;334:317-322.
23. Pascoe W, Gatehouse D: The use of a simple haematoxylin and eosin staining procedure to demonstrate micronuclei within rodent bone marrow. Mutat Res 1986;164:237-243.
24. Sarma L, Kesavan PC: Protective effects of vitamin C and E against γ-ray-induced chromosomal damage in mouse. Int J Radiat Biol 1993;63:759-764.
25. g) quenching. J Photochem Photobiol B 1993;19:205-215.
26. Benavente-García O, Castillo J, Marin FR, Ortufio A, Del Rio JA: Uses and properties of citrus flavonoids. J Agric Food Chem 1997;45:4505-4515.
27. Diplock AT, Charleux JL, Crozier-Willi G, Kok FJ, Rice-Evans M, Roberfroid M, Stahl W, Vin a-Ribes J: Functional food science and defense against reactive oxidative species. Br J Nutr 1998;81:79-98.
28. Sáez-Tormo G, Oliva MR, Mufiiz P, Valls V, Iradi A, Ramos M, Climent J: Oxidative stress and genetic damage. In: Health and Orange. Fundación Valenciana de Estudios Avanzados, Valencia, Spain, 1994, pp. 51-60.
29. Brown DQ, Pittock JW, Rubinstein J: Early results of the screening program for radioprotectors. Int J Radiat Biol Physics 1982;5:565-570.
30. Greig WR, Smith JFB, Dugvid WP, Foster CJ, Orr JS: Assessment of rat thyroid as a radiological model: The effects of X-irradiation on cell proliferation and DNA synthesis in vivo. Int J Radiat Biol 1969;16:211-225.
31. Cillard J, Cillard P: ComposËs phÈnoliques et radicaux libres. S.T.P. Pharma 1988;4:592-596.
32. Darmon N, Ferrandiz V, Canal MT, Mitlavilla S: Activite antiradicallaire de flavonoides vis-à-vis de l'anion superoxide et du radical hydroxyle. Liaison-Groupe Polyphenols Bulletin 1990;15:158-162.
33. Murray D, VanAnkeren SC, Milas H, Meyn RE: Radioprotective action of aminothiols in vivo and in vitro: Comparison between effects on DNA damage and cell survival. Pharmacol Ther 1988;39:151-153.
34. Weiss JF, Kumar KS, Walden TH, Walden R, Landaver MR, Clarck EP: Advances in radioprotection through the use of combined agent regimens. Int J Radiat Biol 1990;57:709-722.
35. Pincemail J, Deby C, Lion Y, Braguet P, Hans P, Drien K, Goutier R: Role of flavonoids in lipoperoxidation and radical reactions. In: Flavonoids and Bioflavonoids: Proceedings of the 7th Hungarian Bioflavonoid Symposium, Szeged, Hungary. (Farkas L, Gabor M, Kallay F, eds.). Elsevier Science Publishers, New York, 1986, pp. 423-436.
36. Bors W, Hellers W, Michel C, Saran M. Flavonoids as antioxidants: Determination of radical-scavenging efficiencies. In: Methods in Enzymology, Vol. 186. (Packer L, Glazer AN, eds.). Academic Press, San Diego, CA, 1990, pp. 343-355.
37. Caruso D, Berra B, Giavarini F, Cortesi N, Fedeli E, Galli G. Effect of virgin olive oil phenolic compounds on in vitro oxidation of human low density lipoproteins. Nutr Metab Cardiovasc Dis 1999;9:102-107.
38. Budiyanto A, Ahmed NU, Wu A, Bito T, Nikaido O, Osawa T, Ueda M, Ichihashi M: Protective effects of topically applied olive oil against photocarcinogenesis following UVB exposure of mice. Carcinogenesis 2000;21:2085-2090.
39. Galati EM, Monforte MT, Kirjavainen S, Forestieri AM, Trovato A, Tripodo MM: Biological effects of hesperidin, a citrus flavonoid: Antiinflammatory and analgesic activity. Farmaco 1994;40:709-712.
40. Tordera M, Ferrandiz ML, Alcaraz MJ: Influence of antiinflammatory flavonoids on granulation and arachidonic acid release in rat neutrophils. Z Naturforsch C 1994;49:235-240.
41. Gábor M: Anti-inflammatory and anti-allergic properties of flavonoids. In: Plant Flavonoids in Biology and Medicine: Biochemical, Pharmacological, and Structure-Activity Relationships. (Cody V, Middleton E, Harborne JB, eds.). Alan R. Liss, New York, 1986, pp. 471-480.
42. Middleton E: Biochemical pharmacological structure activity relationships. In: V. Cody, E. Middleton, J. B. Harborne, (A. Beretz, Plant Flavonoids in Biology and Medicine II (Cody V, Middleton E, Harborne JB, Beretz A, eds.). Alan R. Liss, New York, 1986, pp. 493-506.
43. Visioli F, Galli C, Bornet F, Mattei A, Patelli R, Gali G, Caruso D: Olive oil phenolics are dose-dependently absorbed in humans. FEBS Lett 2000;468: 159-160.
44. Visioli F, Caruso D, Plasmati E, Patelli R, Mulinacci N, Romani A, Galli G, Galli C: Hydroxytyrosol, as a component of live mill waste water, is dose-dependently absorbed and increases the antioxidant capacity of rat plasma. Free Radic Res 2001;34:301-305.
45. Tuck KL, Freeman MP, Hayball PJ, Stretch GL, Stupans I: The in vivo fate of hydroxytyrosol and tyrosol, antioxidant phenolic constituents of olive oil, after intravenous and oral dosing of labeled compounds to rats. J Nutr 2001;131:1993-1996.