Fatty acid trafficking in the adipocyte

Seminars in Cell and Developmental Biology

Volumn 10, Issue 1, 1999, Pages 43-49

  Bernlohr, David A ^a   Coe, Natalie Ribarik ^a   LiCata, Vince J ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

Fatty acid; Lipid binding proteins; Metabolic control; Trafficking; Transporters

Indexed keywords

CARRIER PROTEIN; FATTY ACID; FATTY ACID BINDING PROTEIN; MYELIN BASIC PROTEIN; TUMOR PROTEIN;

ADIPOCYTE; ANIMAL; CELL MEMBRANE; INTRACELLULAR FLUID; METABOLISM; PHYSIOLOGY; REVIEW; TRANSPORT AT THE CELLULAR LEVEL;

ADIPOCYTES; ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL MEMBRANE; FATTY ACID-BINDING PROTEINS; FATTY ACIDS; INTRACELLULAR FLUID; MYELIN P2 PROTEIN; NEOPLASM PROTEINS;

EID: 0033069990     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1006/scdb.1998.0271     Document Type: Article

References (54)

1. Trigatti BL, Gerber GE (1995) A direct role for serum albumin in the cellular uptake of long chain fatty acids. Biochem J 308:155-159
2. Triggati BL, Gerber GE (1996) The effect of intracellular pH on long-chain fatty acid uptake in 3T3-L1 adipocytes: evidence that uptake involves the passive diffusion of protonated long-chain fatty acids across the plasma membrane. Biochem J 313:487-494
3. Kamp F, Hamilton JA (1993) Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers. Biochemistry 32:11074-11086
4. Kamp F, Zakim D, Zhang F, Noy N, Hamilton JA (1995) Fatty acid flip-flop in phospholipid bilayers is extremely fast. Biochemistry 34:11928-11937
5. Zakim D (1996) Fatty acids enter cells by simple diffusion. Proc Soc Exp Biol Med 212:5-14
6. Abumrad NA, Park JH, Park CR (1984) Permeation of long-chain fatty acid into adipocytes. J Biol Chem 259:8945-8953
7. Trigatti BL, Mangroo D, Gerber GE (1991) Photoaffinity labeling and fatty acid permeation in 3T3-L1 adipocytes. J Biol Chem 266:22621-22625
8. Schaffer JE, Lodish HF (1994) Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell 79:427-436
9. Berk PD (1996) How do long-chain free fatty acids cross cell membranes? Proc Soc Exp Biol Med 212:1-4
10. Fitscher BA, Elsing C, Riedel H-D, Gorski J, Stremmel W (1996) Protein-mediated facilitated uptake processes for fatty acids, bilirubin, and other amphipathic compounds. Proc Soc Exp Biol Med 212:15-23
11. Richieri GV, Anel A, Kleinfeld AM (1993) Interactions of long-chain fatty acids and albumin: determination of free fatty acid levels using the fluorescent probe ADIFAB. Biochemistry 32:7574-7580
12. Abumrad NA, El-Maghrabi MR, Amri E-Z, Lopez E, Grimaldi PA (1993) Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. J Biol Chem 268:17665-17668
13. Schwieterman W, Sorrentino D, Potter BJ, Rand J, Kiang C-L, Stump D, Berk PD (1988) Uptake of oleate by isolated rat adipocytes is mediated by a 40-kDa plasma membrane fatty acid binding protein closely related to that in liver and gut. Proc Natl Acad Sci USA 85:359-363
14. Isola LM, Zhou SL, Kiang CL, Stump DD, Bradbury MW, Berk PD (1995) 3T3 fibroblasts transfected with a cDNA for mitochondrial aspartate aminotransferase express plasma membrane fatty acid-binding protein and saturable fatty acid uptake. Proc Natl Acad Sci USA 92:9866-9870
15. Baillie AGS, Coburn CT, Abumrad NA (1996) Reversible binding of long-chain fatty acids to purified FAT, the adipose CD36 analog. J Membr Biol 153:75-81
16. Greenwalt DE, Lipsky RH, Ockenhouse CF, Ikeda H, Tandon NN, Jamieson GA (1992) Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine. Blood 80:1105-1115
17. Harmon CM, Luce P, Beth AH, Abumrad NA (1991) Labeling of adipocyte membranes by sulfo-N-succinimidyl derivatives of long-chain fatty acids: inhibition of fatty acid transport. J Membr Biol 121:261-268
18. Harmon CM, Abumrad NA (1993) Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins: isolation and amino-terminal sequence of an 88-kD protein implicated in the transport of long-chain fatty acids. J Membr Biol 133:43-49
19. Berk PD, Zhou SL, Kiang CL, Stump D, Bradbury M, Isola LM (1997) Uptake of long chain free fatty acids is selectively up-regulated in adipocytes of Zucker rats with genetic obesity and non-insulin-dependent diabetes mellitus. J Biol Chem 272:8830-8835
20. Zhou SL, Stump D, Sorrentino D, Potter BJ, Berk PD (1992) Adipocyte differentiation of 3T3-L1 cells involves augmented expression of a 43-kDa plasma membrane fatty acid-binding protein. J Biol Chem 267:14456-14461
21. Faergeman NJ, DiRusso CC, Elberger A, Knudsen J, Black PN (1997) Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids. J Biol Chem 272:8531-8538
22. Watkins PA, Lu J-F, Steinberg SJ, Gould SJ, Smith KD, Braiterman LT (1998) Disruption of the Saccharomyces cerevisiae FAT1 gene decreases very long-chain fatty acyl-CoA synthetase activity and elevates intracellular very long-chain fatty acid concentrations. J Biol Chem 273:18210-18219
23. Hui TY, Bernlohr DA (1997) Fatty acid transporters in animal cells. Front Biosci 2:222-231
24. Bonen A, Luiken JJFP, Lui S, Dyck DJ, Kiens B, Kristiansen S, Turcotte L, van der Vusse GJ, Glatz JFC (1998) Palmitate transport and fatty acid transporters in red and white muscles. Am J Physiol (Endocrinol Metab) 275:E471-478
25. Greenwalt DE, Scheck SH, Rhinehart-Jones T (1995) Heart CD36 expression is increased in murine models of diabetes and in mice fed a high fat diet. J Clin Invest 96:1382-1388
26. Sfeir Z, Ibrahimi A, Grimaldi P, Abumrad N (1998) Regulation of FAT/CD36 gene expression: further evidence in support of a role of the protein in fatty acid binding/transport. Prostaglandins, Leukotrienes Essent Fatty Acids 57:17-21
27. Man MZ, Hui TY, Schaffer JE, Lodish HF, Bernlohr DA (1996) Regulation of the murine adipocyte fatty acid transporter gene by insulin. Mol Endocrinol 10:1021-1028
28. Schere PE, Lisant MP, Baldini G, Sargiacomo M, Mastick CC, Lodish HF (1994) Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles. J Cell Biol 127:1233-1243
29. Coe NR, Bernlohr DA (1997) Physiological properties and functions of intracellular fatty acid-binding proteins. Biochim Biophys Acta 1391:287-306
30. Glatz JF, van der Vusse GJ (1996) Cellular fatty acid-binding proteins: their function and physiological significance. Prog Lipid Res 35:243-282
31. Spiegelman BM, Frank M, Green H (1983) Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development. J Biol Chem 258:10083-10089
32. Bernlohr DA, Doering TL, Kelly TJ, Lane MD (1985) Tissue specific expression of p422 protein, a putative lipid carrier, in mouse adipocytes. Biochem Biophys Res 132:850-855
33. Krieg P, Feil S, Fürstenberger GA, Bowden GT (1993) Tumor-specific overexpression of a novel keratinocyte lipid-binding protein. J Biol Chem 268:17362-17369
34. Banaszak L, Winter N, Xu Z, Bernlohr DA, Cowan S, Jones TA (1994) Lipid-binding proteins: a family of fatty acid and retinoid transport proteins. Adv Prot Chem 45:89-131
35. Hodson ME, Ponder JW, Cistola DP (1996) The NMR solution structure of intestinal fatty acid binding protein complexed with palmitate: application of a novel distance geometry algorithm. J Mol Biol 264:585-602
36. Hodson ME, Cistola DP (1997) Discrete backbone disorder in the nuclear magnetic resonance structure of apo intestinal fatty acid binding protein: implications for the mechanism of ligand entry. Biochemistry 36:1450-1460
37. Richieri GV, Ogata RT, Kleinfeld AM (1994) Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart and liver measured with the fluorescent probe ADIFAB. J Biol Chem 269:23918-23930
38. Simpson MA, LiCata VJ, Coe NR, Bernlohr DA (1999) Biochemical and biophysical analysis of the intracellular lipid binding proteins of adipocytes. Mol Cell Biochem in press
39. Bernlohr DA, Simpson MA, Hertzel AV, Banaszak LJ (1997) Intracellular lipid-binding proteins and their genes. Annu Rev Nutr 17:277-303
40. Hertzel AV, Bernlohr DA (1998) Cloning and characterization of the keratinocyte lipid binding protein gene. Gene 221:235-243
41. Schaap FG, van der Vusse GJ, Glatz JF (1998) Fatty acid-binding proteins in the heart. Mol Cell Biochem 180:43-51
42. Yeaman SJ (1990) Hormone-sensitive lipase: a multipurpose enzyme in lipid metabolism. Biochim Biophys Acta 1052:128-132
43. Buelt MK, Shekels LL, Jarvis BW, Bernlohr DA (1991) In vitro phosphorylation of the adipocyte lipid-binding protein (p15) by the insulin receptor. J Biol Chem 266:12266-12271
44. Hillgartner FB, Charron T (1997) Arachidonate and medium-chain fatty acids inhibit transcription of the acetyl-CoA carboxylase gene in hepatocytes in culture. J Lipid Res 38:2548-2557
45. Schoonjans K, Staels B, Auwerx J (1996) Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 37:907-92543.
46. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM (1995) 15-Deoxy-delta 12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 83:803-812
47. Motojima K, Passily P, Peters JM, Gonzalez FJ, Latruffe N (1998) Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue-and inducer-specific manner. J Biol Chem 273:16710-16714
48. Martin G, Schoonjans K, Lefebvre AM, Staels B, Auwerx J (1997) Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators. J Biol Chem 272:28210-28217
49. Rodriguez JC, Gil-Gomez G, Hegardt FG, Haro D (1994) Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. J Biol Chem 269:18767-18772
50. Garlid KD, Orosz DE, Modriansky M, Vassanelli S, Jezek P (1996) On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein. J Biol Chem 271:2615-2620
51. Jezek P, Hanus J, Semrad C, Garlid KD (1996) Photactivated azido fatty acid irreversible inhibits anion and proton transport through the mitochondrial uncoupling protein. J Biol Chem 271:6199-6205
52. + transport activity of the reconstituted uncoupling protein. J Biol Chem 269:2508-2515
53. González-Barroso MM, Fleury C, Bouillaud F, Nicholls DG, Rial E (1998) The uncoupling protein UCP1 does not increase the proton conductance of the inner mitochondrial membrane by functioning as a fatty acid anion transporter. J Biol Chem 273:15528-15532
54. Wojtczak L, Schönfeld P (1993) Effect of fatty acids on energy coupling processes in mitochondria. Biochim Biophys Acta 1183:41-57