Intradermal delivery of IL-12 naked DNA induces systemic NK cell activation and Th1 response in vivo that is independent of endogenous IL-12 production

Journal of Immunology

Volumn 163, Issue 4, 1999, Pages 1943-1950

  Watanabe, Morihiro ^a   Fenton, Robert G ^a,e   Wigginton, Jon M ^c   McCormick, Kathryn L ^b   Volker, Kirk M ^a   Fogler, William E ^d   Roessler, Philip G ^a   Wiltrout, Robert H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d ENTREMED INC   (United States)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 12; PLASMID DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA TRANSFER; FEMALE; HELPER CELL; IMMUNOMODULATION; LIVER; MOUSE; NATURAL KILLER CELL; NONHUMAN; PLASMID; PRIORITY JOURNAL; SPLEEN; TRANSGENE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, MONOCLONAL; BETA-GALACTOSIDASE; CHEMOKINES, CXC; CYTOMEGALOVIRUS; CYTOTOXICITY, IMMUNOLOGIC; DNA, VIRAL; FEMALE; GENE EXPRESSION REGULATION, VIRAL; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRADERMAL; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERFERON TYPE II; INTERLEUKIN-12; KILLER CELLS, NATURAL; KINETICS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; PLASMIDS; SPLEEN; TH1 CELLS;

EID: 0033566929     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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