The effect of prime-site occupancy on the hepatitis C virus NS3 protease structure

Protein Science

Volumn 11, Issue 9, 2002, Pages 2102-2112

  Casbarra, Annarita ^a   Piaz, Fabrizio Dal ^a   Ingallinella, Paolo ^b   Orrù, Stefania ^b   Pucci, Piero ^a   Pessi, Antonello ^b   Bianchi, Elisabetta ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b IRBM   (Italy)

Author keywords

Conformational changes; Hepatitis C virus NS3 serine protease; Limited proteolysis mass spectrometry; Near UV circular dichroism; Protease inhibitors

Indexed keywords

CHYMOTRYPSIN; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; NS3 PROTEIN, HEPATITIS C VIRUS; PEPTIDE; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; ENZYME INHIBITOR INTERACTION; ENZYME STABILITY; ENZYME STRUCTURE; HEPATITIS C VIRUS; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN DEGRADATION; CHEMISTRY; DRUG ANTAGONISM; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SPECTRUM ANALYSIS, MASS; SUPPORT, NON-U.S. GOV'T; VIRAL NONSTRUCTURAL PROTEINS; MASS SPECTROMETRY;

HEPATITIS C VIRUS; RNA VIRUSES;

EID: 0036720561     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.0206602     Document Type: Article

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