The antiviral efficacy of the murine alpha-1 interferon transgene against ocular herpes simplex virus type 1 requires the presence of CD4+, α/β T-cell receptor-positive T lymphocytes with the capacity to produce gamma interferon

Journal of Virology

Volumn 76, Issue 18, 2002, Pages 9398-9406

  Carr, Daniel J J ^a   Noisakran, Sansanee ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA1 INTERFERON; GAMMA INTERFERON; PLASMID DNA; PLASMID VECTOR; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; GENE DISRUPTION; GENE MUTATION; HELPER CELL; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HOMOZYGOSITY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TRANSGENE; WILD TYPE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CERCOPITHECUS AETHIOPS; GENE THERAPY; HERPESVIRUS 1, HUMAN; INTERFERON TYPE II; INTERFERON-ALPHA; KERATITIS, HERPETIC; MICE; PLASMIDS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; TEARS; TRANSGENES; VERO CELLS; VIRUS REPLICATION;

EID: 0036720511     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.18.9398-9406.2002     Document Type: Article

References (83)

1. Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus protein ICP47
2. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology
3. Enhanced inhibition of herpes simplex virus type 1 growth in human corneal fibroblasts by combinations of interferon-α and -γ
4. Gene induction by interferons: Functional complementation between trans-acting factors induced by alpha interferon and gamma interferon
5. Incidence and severity of herpetic stromal keratitis: Impaired by the depletion of lymph node macrophages
6. Effect of aminoguanidine, a nitric oxide synthase inhibitor, on ocular infection with herpes simplex virus in Balb/c mice
7. Interferons α and β as immune regulators - A new look
8. Cellular responses to interferon-γ
9. Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-γ knockout mice
10. Activation of NK cells in mice following corneal infection with herpes simplex virus type-1
11. Gamma interferon (IFN-γ) receptor null-mutant mice are more susceptible to herpes simplex virus type 1 infection than IFN-γ ligand null-mutant mice
12. Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1
13. 134.5 gene if present before activation of protein kinase R by precluding its phosphorylation and that of the α subunit of eukaryotic translation initiation factor 2
14. B7 costimulatory requirements of T cells at an inflammatory site
15. Role of macrophages in restricting herpes simplex virus type 1 growth after ocular infection
16. Resistance to herpetic stromal keratitis in immunized B-cell-deficient mice
17. Production of key molecules by ocular neutrophils early after herpetic infection of the cornea
18. Specific effect of interferon on the herpes simplex virus type 1 transactivation event
19. Role of CD28/CD80-86 and CD40/CD154 costimulatory interactions in host defense to primary herpes simplex virus infection
20. Establishment of latent herpes simplex virus type 1 infection in resistant, sensitive, and immunodeficient mouse strains
21. Production of interferon-alpha/beta by murine dendritic cell lines stimulated by virus and bacteria
22. Glycoprotein C of herpes simplex virus 1 acts as a receptor for the C3b complement component in infected cells
23. Virus-induced immunoinflammatory lesions in the absence of viral antigen recognition
24. Cytokine mediated survival from lethal HSV-infection: Role of programmed cell death
25. Ectopic expression of gamma interferon in the eye protects transgenic mice from intraocular herpes simplex virus type 1 infections
26. Interferon-γ protects against herpes simplex virus type 1-mediated neuronal death
27. The role of interleukin (IL)-2 and IL-4 in herpes simplex virus type 1 ocular replication and eye disease
28. + T cell response
29. Interferons: Cell signalling, immune modulation, antiviral responses and virus countermeasures
30. Innate and acquired immunity to herpes simplex virus type 1
31. The immediate-early protein, ICP0, is essential for the resistance of herpes simplex virus to interferon-α/β
32. 134.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1 α to dephosphorylate the α subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase
33. Kinetics of cytokine production in the cornea and trigeminal ganglion of C57BL/6 mice after corneal HSV-1 infection
34. Critical role of corneal Langerhans cells in the CD4- but not CD8-mediated immunopathology in herpes simplex virus-1-infected mouse corneas
35. IFN-γ and IL-2 are protective in the skin but pathologic in the corneas of HSV-1-infected mice
36. Endogenously produced interferon α protects mice from herpes simplex virus type 1 corneal disease
37. Herpes simplex virus turns off the TAP to evade host immunity
38. Differential production of IL-12, IFN-α, and IFN-γ by mouse dendritic cell subsets
39. An important role for major histocompatibility complex class I-restricted T cells, and a limited role for gamma interferon, in protection of mice against lethal herpes simplex virus infection
40. Effect of herpes simplex virus types 1 and 2 on surface expression of class I major histocompatibility complex antigens on infected cells
41. A murine CD4-, CD8- T cell receptor-γδ T lymphocyte clone specific for herpes simplex virus glycoprotein I
42. Macrophage control of herpes simplex virus type 1 replication in the peripheral nervous system
43. Tegument-specific, virus-reactive CD4 T cells localize to the cornea in herpes simplex virus interstitial keratitis in humans
44. Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene
45. Gamma interferon impedes the establishment of herpes simplex virus type 1 latent infection but has no impact on its maintenance or reactivation in mice
46. Gamma interferon can prevent herpes simplex virus type 1 reactivation from latency in sensory neurons
47. Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection
48. - subclasses of dendritic cells direct the development of distinct T helper cells in vivo
49. + T cells
50. Type 1 interferons keep activated T cells alive
51. Interferon treatment inhibits onset of herpes simplex virus immediate-early transcription
52. Contributions of antibody and T cell subsets to protection elicited by immunization with a replication-defective mutant of herpes simplex virus type 1
53. H2 development
54. Herpes simplex virus ICP0 mutants are hypesensitive to interferon
55. In vivo immune evasion mediated by the herpes simplex virus type 1 immunoglobulin G Fc receptor
56. Sero-epidemiological and sociological patterns of herpes simplex virus infection in the world
57. Phenotypic and functional studies on ocular T cells during herpetic infections of the eye
58. Ectopic expression of DNA encoding IFN-α1 in the cornea protects mice from herpes simplex virus type 1-induced encephalitis
59. + T lymphocytes
60. Topical application of the cornea post infection with plasmid DNA encoding interferon-α1 but not recombinant interferon-αA reduces herpes simplex virus type 1-induced mortality in mice
61. IFN-γ is required for viral clearance from central nervous system oligodendroglia
62. Cell surface expression of H2 antigens on primary sensory neurons in response to acute but not latent herpes simplex virus infection in vivo
63. Upregulation of class I major histocompatibility complex gene expression in primary sensory neurons, satellite cells, and Schwann cells of mice in response to acute but not latent herpes simplex virus infection in vivo
64. T cell receptor-γδ cells protects mice from herpes simplex virus type 1-induced lethal encephalitis
65. Innate immunity to viruses: Control of vaccinia virus infection by γδ T cells
66. Immune cell infiltration and persistence in the mouse trigeminal ganglion after infection of the cornea with herpes simplex virus type 1
67. Cytokine production in the nervous system of mice during acute and latent infection with herpes simplex virus type 1
68. Anti-CD8 impairs clearance of herpes simplex virus from the nervous system: Implications for the fate of virally infected neurons
69. Cell surface expression of MHC molecules in glioma cells infected with herpes simplex virus type-1
70. How cells respond to interferons
71. Ocular avirulence of a herpes simplex virus type 1 strain is associated with heightened sensitivity to alpha/beta interferon
72. The role of natural killer cells in the development of herpes simplex virus type 1 induced stromal keratitis in mice
73. Interferon γ regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas
74. On the essential involvement of neutrophils in the immunopathologic disease: Herpetic stromal keratitis
75. + T cell function between euthymic host and reconstituted SCID recipients
76. Viral subversion of the immune system
77. Induction of bystander T cell proliferation by viruses and type I interferon in vivo
78. Anti-CD8 treatment alters interleukin-4 but not interferon-γ mRNA levels in murine sensory ganglia during herpes simplex virus infection
79. Neutrophil-mediated suppression of virus replication after herpes simplex virus type 1 infection in the murine cornea
80. Absence of macrophage inflammatory protein-1α prevents the development of blinding herpes stromal keratitis
81. Interleukin-12- and gamma interferon-dependent innate immunity are essential and sufficient for long-term survival of passively immunized mice infected with herpes simplex virus type 1
82. Herpes simplex virus type 1 suppresses the interferon signaling pathway by inhibiting phosphorylation of STATs and janus kinases during an early infection stage
83. Increased severity of HSV-1 keratitis and mortality in mice lacking the 2-5A-dependent RNase L gene