Immunopathology of herpetic stromal keratitis: Discordance in CD4+ T cell function between euthymic host and reconstituted SCID recipients

Journal of Immunology

Volumn 160, Issue 8, 1998, Pages 3965-3970

  Thomas, Johnson ^a   Rouse, Barry T ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; EFFECTOR CELL; FEMALE; GENOTYPE; HERPES SIMPLEX KERATITIS; HERPES SIMPLEX VIRUS; IMMUNE RESPONSE; IMMUNOPATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; T LYMPHOCYTE; VIRUS REPLICATION;

ADOPTIVE TRANSFER; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CORNEA; FEMALE; HERPESVIRUS 1, HUMAN; KERATITIS, HERPETIC; MICE; MICE, INBRED BALB C; MICE, SCID; TRANSPLANTATION, ISOGENEIC; VIRUS REPLICATION;

EID: 0032522852     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Streilein, J. W. 1996. Ocular immune privilege and the Faustian dilemma: the proctor lecture. Invest. Ophthalmol. Visual Sci. 37:1940.
2. Ferguson, T. A., and T. S. Griffith. 1997. Cell death and the immune response: a lesson from the privileged. J. Clin. Immunol. 17:1.
3. Pepose, J. S., D. A. Leib, P. M. Stuart, D. L. Easty. 1996. Herpes simplex virus diseases: anterior segment of the eye. In Ocular Infection and Immunity. J. S. Pepose, G. N. Holland, and K. R. Wilhelmus, eds. Mosby, St. Louis, MO, p. 905.
4. Metcalf, J. F., D. S. Hamilton, R. W., Reichert. 1979. Herpetic keratitis in athymic (nude) mice. Infect. Immun. 26:1164.
5. Russell, R. G., M. P. Nasisse, H. S. Larsen., and B. T. Rouse. 1984. Role of T-lymphocytes in the pathogenesis of herpetic stromal keratitis. Invest. Ophthalmol. Visual Sci. 25:938.
6. Newell, C. K., S. Martin, D. Sendele, C. M. Mercadal, and B. T. Rouse. 1989. Herpes simplex virus induced stromal keratitis: role of T lymphocyte subsets in immunopathology. J. Virol. 63:769.
7. Niemialtowski, M. G., and B. T. Rouse. 1992. Predominance of Th-1 cells in ocular tissues during herpetic stromal keratitis. J. Immunol. 149:3035.
8. Hendricks, R. L., T. M. Tumpey, and A. Finnegan. 1992. IFN-γ and IL-2 are protective in skin but pathologic in the corneas of HSV-1 infected mice. J. Immunol. 149:3023.
9. Lopez, C. 1981. Resistance to herpes simplex viras type-1 (HSV-1). Curr. Top. Microbiol. Immunol. 92:15.
10. Opremcak, E. M., P. A. Wells, P. Thompson, J. A. Daigle, B. A. Rice, J. Millin, and C. S. Foster. 1988. Immunogenetic influence of Igh-1 phenotype on experimental herpes simplex viras type-1 corneal infection. Invest. Ophthalmol. Visual Sci. 29:749.
11. Foster, C. S., Y. Tsai, J. G. Monroe, R. C. Campbell, M. Cestari, D. Knipe, and M. I. Greene. 1986. Genetic studies on murine susceptibility to herpes simplex keratitis. Clin. Immunol. Immunopathol. 40:313.
12. Babu, J. S., J. Thomas, S. Kanangat, L. A. Morrison, D. M. Knipe, and B. T. Rouse. 1996. Viral replication is required for induction of ocular immunopathology by herpes simplex virus. J. Virol. 70:101.
13. Thomas, J., and B. T. Rouse. 1997. Immunopathogenesis of herpetic ocular disease. Immunol. Res. 16:393.
14. Avery, A. C., Z. S. Zhao, A. Rodriguez., E. K. Bikoff, M. Soheilian, C. S. Foster, and H. Cantor. 1995. Resistance to herpes stromal keratitis conferred by an IgG2a derived peptide. Nature 376:431.
15. Spear, P. G., and B. Roizman. 1972. Proteins specified by herpes simplex virus. V. Purification and structural proteins of herpes virion. J. Virol. 9:431.
16. + T cells. J. Immunol. 155:259.
17. Mercadal, C. M., D. M. Bouley, D. DeStephano, and B. T. Rouse. 1993. Herpetic stromal keratitis in the reconstituted SCID mouse model. J. Virol. 67:3404.
18. + T cells in murine EAE. Science 256:1213.
19. + T-lymphocyte depletion on the induction and expression of herpes simplex stromal keratitis. Reg. Immunol. 2:366.
20. Akova, Y. A., J. Dutt, A. Rodriguez, N. Jabbur, and C. S. Foster. 1993. The role of Igh-1 disparate congenic mouse T lymphocytes in the pathogenesis of herpetic stromal keratitis. Curr. Eye Res. 12:1093.
21. + T cells induce or protect from chronic intestinal inflammation in C.B-17 SCID mice. Int. Immunol. 5:1461.
22. Powrie, F. 1995. T cells in inflammatory bowel disease: protective and pathogenic roles. Immunity 3:171.
23. Lider, O., L. M. B. Santos, C. S. Y. Lee, P. J. Higgins, and H. L. Weiner. 1989. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. J. Immunol. 142:748.
24. + cells in T cell receptor peptide-induced clonal unresponsiveness. Science 259:91.
25. Bouley, D. M. 1995. Characterization of HSV-1 induced corneal lesions and immunopathological mechanisms in reconstituted SCID and IFN-γ knockout mice. Doctoral dissertation, University of Tennessee, Knoxville, TN.
26. Kanangat, S., J. Thomas, S. Gangappa, J. S. Babu, and B. T. Rouse. 1996. Herpes simplex virus type-1 mediated upregulation IL-12 (p40) mRNA expression: implications in Immunopathogenesis and protection. J. Immunol. 156:1110.
27. Segal, B. M., D. M. Klinman, and E. M. Shevach. 1997. Microbial products induce autoimmune disease by an IL-12 dependent pathway. J. Immunol. 158: 5087.