Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus

Current Genetics

Volumn 29, Issue 6, 1996, Pages 549-555

  Yu, Jae Hyuk ^a,b   Butchko, Robert A E ^b   Fernandes, Mary ^b   Keller, Nancy P ^b   Leonard, Thomas J ^a   Adams, Thomas H ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Aflatoxin; aflR; Secondary metabolism; Zinc binuclear cluster

Indexed keywords

AFLATOXIN; MYCOTOXIN; STERIGMATOCYSTIN;

ARTICLE; ASPERGILLUS FLAVUS; ASPERGILLUS NIDULANS; CONTROLLED STUDY; FUNGAL GENETICS; GENE CLUSTER; GENE FUNCTION; GENE INDUCTION; GENE STRUCTURE; NONHUMAN; PRIORITY JOURNAL; REGULATOR GENE; TOXIN SYNTHESIS;

ASPERGILLUS FLAVUS; ASPERGILLUS PARASITICUS; EMERICELLA NIDULANS;

EID: 0029931405     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02426959     Document Type: Article

References (44)

1. Adams TH, Boylan MT, Timberlake WE (1988) brlA is necessary and sufficient to direct conidiophore development in Aspergillus nidulans. Cell 54:353-362
2. Adamson RH (1989) Induction of hepatocellular carcinoma in nonhuman primates by chemical carcinogens. Cancer Detect Prev 14:215-219
3. Aharonowitz Y, Cohen G, Martin JF (1992) Penicillin and cephalosporin biosynthetic genes: structure, organization, regulation, and evolution. Annu Rev Microbiol 46:461-495
4. 1. J S Afr Chem Inst 23:40-56
5. Barnes SE, Dola TP, Bennett JW, Bhatnagar D (1994) Synthesis of sterigmatocystin on a chemically defined medium by species of Aspergillus and Chaetomium. Mycopathologia 125:173-178
6. Bennett JW, and Papa KE (1988) The aflatoxigenic Axpergillus species. Adv Plant Pathol 6:263-280
7. Bennett JW, Bhatnagar D, Chang PK (1994) The molecular genetics of aflatoxin biosynthesis. In: Powell K A (ed) The genus Aspergillus. Plenum Press, New York, pp 51-58
8. Bhatnagar D, Ehrlich KC, Cleveland TE (1992) Oxidation-reduction reactions in biosynthesis of secondary metabolites. In: Bhatnagar D, Lillehoj EB, Arora DK (eds) Handbook of Applied Mycology. Marcel Dekker, New York, pp 255-286
9. Bressac B, Kew M, Wands J, Ozturk M (1991) Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 350:429-431
10. Brown DW, Yu J-H, Kelkar HS, Fernandes M, Nesbitt TC, Keller NP, Adams TH, Leonard TJ (1996) Twenty-five co-regulated transcripts define the sterigmatocystin gene cluster in Aspergillus nidulum. Proc Natl Acad Sci USA 93:1418-1422
11. Burger G, Strauss J, Scazzocchio C, Lang BF (1991) nirA, the pathway-specific regulatory gene of nitrate assimilation in Aspergillus nidulans, encodes a putative GAL4-type zinc finger protein and contains four introns in highly conserved regions. Mol Cell Biol 11:5746-5755
12. Chang P-K, Cary JW, Bhatnagar D, Cleveland TE, Bennett JW, Linz JE, Woloshuk CP, Payne GA (1993) Cloning of the Aspergillus parasiticus apa-2 gene associated with the regulation of aflatoxin biosynthesis. Appl Environ Microbiol 59:3273-3279
13. Chang P-K, Ehrlich KC, Yu J, Bhatnagar D, Cleveland TE (1995) Increased expression of Aspergillus parasiticus aflR, encoding a sequence-specific DNA-binding protein, relieves nitrate inhibition of aflatoxin biosynthesis. Appl Environ Microbiol 61:2372-2377
14. Church GM, Gilbert W (1984) Genomic sequencing. Proc Natl Acad Sci USA 81:1991-1995
15. Cole RJ, Cox RH (1981) Handbook of toxic fungal metabolites. Academic Press, New York, pp 67-93
16. Cove DJ (1979) Genetic studies of nitrate assimilation in Aspergillus nidulans. Biol Rev 54:291-327
17. Diener UL, Cole RJ, Sanders TH, Payne GA, Lee LS, Klich MA (1987) Epidemiology of aflatoxin formation by Aspergillus flavus. Annu Rev Phytopathol 25:249-270
18. Dutton MF (1988) Enzymes and aflatoxin biosynthesis. Microbiol Rev 52:274-295
19. Fujii K, Kurata H, Odashima S, Hatsuda Y (1976) Tumor induction by a single subcutaneous injection of sterigmatocystin in newborn mice. Cancer Res 36:1615-1618
20. Giniger E, Varaum SM, Ptashne M (1985) Specific DNA-binding of GAL4, a positive regulatory protein of yeast. Cell 40:767-774
21. Herbert RB (1989) Polyketides. In: The biosynthesis of secondary metabolites. Chapman and Hall, London, pp 31-62
22. Jelinek CF, Pohland AE, Wood GE (1989) Worldwide occurrence of mycotoxins in foods and feeds-an update. J Assoc Off Anal Chem 72:223-230
23. Johnstone IL, McCabe PC, Greaves P, Gurr SJ, Cole GE, Brow MAD, Unkles SE, Clutterbuck AJ, Kinghorn JR, Innis MA (1990) Isolation and characterization of the crnA-niiA-niaD gene cluster for nitrate assimilation in Aspergillus nidulans. Gene 90:181-192
24. Käfer E (1977) Meiotic and mitotic recombination in Aspergillus and its chromosomal aberrations. Adv Genet 19:33-131
25. Keller NP, Cleveland TE, Bhatnagar D (1992) A molecular approach towards understanding aflatoxin production. In: Bhatnagar D, Lillehoj EB, Arora DK (eds). Handbook of Applied Mycology. Marcel Dekker, Inc., New York, pp 287-310
26. Keller NP, Dischinger HCJ, Bhatnagar D, Cleveland TE, Ullah AH (1993) Purification of a 40-kilodalton methyltransferase active in the aflatoxin biosynthetic pathway. Appl Environ Microbiol 59:479-484
27. Keller NP, Kantz NJ, Adams TA (1994) Aspergillus nidulans ver A is required for production of the mycotoxin sterigmatocystin. Appl Environ Microbiol 60:1444-1450
28. Keller NP, Brown DW, Butchko RAE, Fernandes M, Kelkar H, Nesbitt C, Segner S, Bhatnagar D, Cleveland TE, Adams TH (1995) A conserved polyketide mycotoxin gene cluster in Asperdillus nidulans. In: Richard JL (ed) Molecular approaches to food safety issues involving toxic microorganisms. Alakcn Inc., Fort Coltins, pp 263-277
29. Klich MA, Pitt JI (1988) A laboratory guide to the common Aspergillus species and their teleomorphs. CSIRO Division of Food Processing, North Ryde, Australia
30. McConnell IR, Garner RC (1994) DNA adducts of aflatoxins, sterigmatocystin and other mycotoxins. IARC Scientific Publication No. 125, pp 49-55
31. Payne GA, Nystrom GJ, Bhatnagar D, Cleveland TE, Woloshuk CP (1993) Cloning of the afl-2 gene involved in aflatoxin biosynthesis from Aspergillus flavus. Appl Environ Microbiol 59:156-162
32. Proctor RH, Hohn TM, McCormick SP, Desjardins AE (1995) tri6 encodes an unusual zinc finger protein involved in regulation of trichothecene biosynthesis in Fusarium sporotrichioides. Appl Environ Microbiol 61:1923-1930
33. Samson RA (1992) Current taxonomic schemes of the genus Aspergillus and its teleomorphs. In: Bennett JW, Klich MA (eds) Aspergillus: biology and industrial applications. Butterworth-Heinemann. Boston, pp 355-390
34. Scott PM, van Walbeek W, Kennedy B, Anyeti D (1972) Mycotoxins and toxigenic fungi in grains and other agriculture. J Agric Food Chem 20:1103-1109
35. Skory CD, Chang P, Cary J, ELJ (1992) Isolation and characterization of a gene from Aspergillus parasiticus associated with the conversion of versicolorin A to sterigmatocystin in aflatoxin biosynthesis. Appl Environ Microbiol 58:3527-3537
36. Stack M, Rodricks JV (1971) Method for analysis and chemical confirmation of sterigmatocyslin. J Assoc Off Anal Chem 54:86-90
37. Trail F, Mahanti N, Rarick M, Mehigh R, Liang S-H, Zhou R, Linz JE (1995) Physical and transcriptional map of an aflatoxin gene cluster in Aspergillus parasiticus and functional disruption of a gene involved early in the aflatoxin pathway. Appl Environ Microbiol 61:2665-2673
38. Wieser J, Adams TH (1995) flbD encodes a Myb-like DNA-binding protein that regulates initiation of Aspergillus nidulans conidiophore development. Genes Dev 9:491-502
39. Woloshuk CP, Fount KR, Brewer JF, Bhatnagar D, Cleveland TE, and Payne GA (1994) Molecular characterization of aflR, a regulatory locus for aflatoxin biosynthesis. Appl Environ Microbiol 60:2408-2414
40. Yabe K, Ando Y, Hashimoto J, Hamasaki T (1989) Two distinct O-methyltransferases in aflatoxin biosynthesis. Appl Environ Microbiol 55:2172-2177
41. Yager LN, Kurtz MB, Champe SP(1982) Temperature-shift analysis of conidial development in Aspergillus nidulans. Dev Biol 93:92-103
42. Yelton MM, Hamer JE, Timberlake WE (1984) Transformation of Aspergillus nidulans by using a trpC plasmid. Proc Natl Acad Sci USA 81:1470-1474
43. Yu J, Cary JW, Bhatnagar D, Cleveland TE, Keller N P, Chu FS (1993) Cloning and characterization of a cDNA from Aspergillus parasiticus encoding an O-methyltransferase involved in aflatoxin biosynthesis. Appl Environ Microbiol 59:3564-3571
44. Yu J, Chang P-K, Cary JW, Wright M, Bhatnagar D, Cleveland TE, Payne GA, Linz JE (1995) Comparative mapping of aflatoxin pathway gene clusters in Aspergillus parasiticus and Aspergillus flavus. Appl Environ Microbiol 61:2365-2371