The monkey and human uridine diphosphate-glucuronosyltransferase UGT1A9, expressed in steroid target tissues, are estrogen-conjugating enzymes

Endocrinology

Volumn 140, Issue 7, 1999, Pages 3292-3302

  Albert, Caroline ^a   Vallée, Michel ^a   Beaudry, Guillaume ^a   Bélanger, Alain ^a,b   Hum, Dean W ^a,b  

^a Laboratory of Molecular Endocrinology   (Canada)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYESTRADIOL; 4 HYDROXYESTRADIOL; CONJUGATED ESTROGEN; ESTRADIOL; ESTRONE DERIVATIVE; GLUCURONOSYLTRANSFERASE; STEROID;

ANIMAL TISSUE; ARTICLE; ESTROGEN METABOLISM; GLUCURONIDATION; HORMONE ACTION; HORMONE RESPONSE; HUMAN; HUMAN TISSUE; MONKEY; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY;

EID: 0033304795     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.7.6853     Document Type: Article

References (58)

1. The epidemic of endometrial cancer: A commentary
2. Epidemiology of breast cancer. Findings from the nurses' health study
3. Postmenopausal hormone therapy and mortality
4. Estrogens and breast cancer
5. Functional role of estrogen metabolism in target cells: Review and perspectives
6. Catecholestrogens in the induction of tumors in the kidney of the Syrian hamster
7. New role for estrogen in cancer?
8. Dual role of estrogens as hormones and pro-carcinogens - Tumor initiation by metabolic-activation of estrogens
9. Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells: 3,4-Catechol estrogens and estriol as primary substrates
10. Two human liver cDNAs encode UDP-glucuronosyltransferases with 2 log differences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives
11. Variations in catechol O-methyltransferase activity in rodent tissues: Possible role in estrogen carcinogenicity
12. An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer
13. The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence
14. Endogenous substrates for UDP-glucuronosyltransferases
15. The UDP glucuronosyltransferase gene superfamily: Suggested nomenclature based on evolutionary divergence
16. Gene Structure at the human UGT1 locus creates diversity in isozyme structure, substrate specificity, and regulation
17. The structure and function of the UDP-glucuronosyltransferase gene family
18. The novel UGT1 gene complex links bilirubin, xenobiotics, and therapeutic drug metabolism by encoding UDP-glucuronosyltransferase isozymes with a common carboxyl terminus
19. Substrate specificities of two stably expressed human liver UDP-glucuronosyltransferases of the UGT1 gene family
20. Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation
21. Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8
22. cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3
23. The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1
24. Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein
25. Cloning and expression of human UDP-glucuronosyltransferase (UGT) 1A8
26. The uridine diphosphate glucuronosyltransferase multigene family: Function and regulation
27. Formation of glucuronides of estradiol-17β by human mammary cancer cells
28. Androgen glucuronide. Difference in its formation by human normal and benign hyperplastic prostate
29. Levels of plasma C19 steroids and 5α-reduced C19 steroid glucuronides in primates, rodents, and domestic animals
30. Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging
31. Expression and characterization of a novel UDP-glucuronosyltransferase, UGT2B9, from cynomolgus monkey
32. Codon 377 polymorphism of the human type I 3β-hydroxysteroid dehydrogenase/isomerase gene (HS5DB3)
33. Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family
34. A mutation which disrupts the hydrophobic core of the signal peptide of bilirubin UDP-glucuronosyltransferase, an endoplasmic reticulum membrane protein, causes Crigler-Najjar type II
35. Molecular basis of multiple UDP-glucuronosyltransferase isoenzyme deficiencies in the hyperbilirubinemic rat (Gunn rat)
36. Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex
37. Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p)
38. Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues
39. Regulation of steroid hormone action in target cells by specific hormone-inactivating enzyme
40. Drug-metabolizing enzymes in ligand-modulated transcription
41. Proposed role of drug-metabolizing enzymes: Regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions
42. Differential regulation of two UDP-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LnCaP cells
43. Effect of interleukins on UGT2B17 steroid uridine diphosphate-glucuronosyltransferase expression and activity in the LNCAP cell line
44. Purification and characterization of two forms of hepatic microsomal cytochrome P450 from untreated cynomolgus monkeys
45. Characterization of monkey cytochrome P450, P450 CMLd, responsible for S-mephenytoin 4-hydroxylation in hepatic microsomes of cynomolgus monkeys
46. Nucleotide and amino acid sequences of the monkey P450 2B gene subfamily
47. Purification of cytochrome P-450 from polychlorinated biphenyl-treated crab-eating monkeys: High homology to a form of human cytochrome P-450
48. Determination of ovarian cycle in Goeldi's monkey (Callimico goeldii) via the measurement of steroids and peptides in plasma and urine
49. Specificity of human UDP-glucuronosyltransferases and xenobiotic glucuronidation
50. Isolation and characterization of a simian UDP-glucuronosyltransferase UGT2B18 active on 3-hydroxyandrogens
51. 17 β-estradiol hydroxylation catalyzed by human cytochrome P450 1B1
52. Activation of chemically diverse procarcinogens by human cytochrome P450 1B1
53. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: Implications for the mechanism of uterine tumorigenesis
54. 4-Hydroxylation of estrogens as marker of human mammary tumors
55. The effects of 1-thyroxine and dexamethasone on steroid dynamics in male cynomologous monkeys
56. Urinary endocrine monitoring of the ovarian cycle and pregnancy in Goeldi's monkey (Callimico goeldii)
57. Effects of short-term hormone replacement therapies on low-density-lipoprotein metabolism in cynomolgus monkeys