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0030814723
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269852 The orally active nonpeptide endothelin A-receptor antagonist A-127722 prevents and reverses hypoxia-induced pulmonary hypertension and pulmonary vascular remodelling in Sprague-Dawley rats. Chen SJ, Chen YF, Opgenorth TJ, Wessale JL, Meng QC, Durand J, DiCarlo VS, Oparil S J Cardiovasc Pharmacol 1997 29 6 713-725 A-127722 attenuated hypertension and vascular remodeling within the pulmonary system of a hypoxic rat model.
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0031951912
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Chronic oral endothelin type A receptor antagonism in experimental heart failure
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286091
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286091 Chronic oral endothelin type A receptor antagonism in experimental heart failure. Borgeson DD, Grantham JA, Wiliamson EE, Luchner A, Redfield MM, Opgenorth TJ, Burnett JC Jr Hypertension 1998 31 3 766-770
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Burnett J.C., Jr.7
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10
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0031911432
-
Coronary constriction and consequent cardiodepression in pulmonary embolism are mediated by pulmonary big endothelin and enhanced in early endothelial dysfunction
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286092
-
286092 Coronary constriction and consequent cardiodepression in pulmonary embolism are mediated by pulmonary big endothelin and enhanced in early endothelial dysfunction. Dschietzig T, Laule M, Alexiou K, Schror K, Baumann G, Stangl K Crit Care Med 1998 26 3 510-517
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11
-
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15144360873
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A antagonist (A-216546)
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296661
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Von Geldern, T.W.8
Wu-Wong, J.R.9
Chiou, W.J.10
Dixon, D.B.11
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12
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0032538495
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The effects of diminishing albumin binding to some endothelin receptor antagonists
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315739; note
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A receptor antagonist.
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0032533948
-
Arrhythmogenic effects induced by coronary conversion of pulmonary big endothelin to endothelin: Aggravation of this phenomenon in heritable hyperlipidemia
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315740
-
315740 Arrhythmogenic effects induced by coronary conversion of pulmonary big endothelin to endothelin: Aggravation of this phenomenon in heritable hyperlipidemia. Alexiou K, Dschietzig T, Simsch O, Laule M, Hundertmark J, Baumann G, Stangl K J Am Coll Cardiol 1998 32 6 1773-1778
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Baumann, G.6
Stangl, K.7
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14
-
-
0031945018
-
A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: A diffusion and perfusion MRI study
-
315741; note
-
315741 A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: A diffusion and perfusion MRI study. Tatlisumak T, Carano RA, Takano K, Opgenorth TJ, Stotak CH, Fisher M Stroke 1998 29 4 850-857 Evidence that A-127722 exhibits neuroprotectant properties that appear independent of vascular effects.
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Stotak, C.H.5
Fisher, M.6
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15
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0004331947
-
American Chemical Society 217th National Meeting (Part III) Division of Medicinal Chemistry - Endothelins, Anaheim, CA, USA
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319405
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319405 American Chemical Society 217th National Meeting (Part III) Division of Medicinal Chemistry - Endothelins, Anaheim, CA, USA. IDDB Meeting Report 1999 March 22
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IDDB Meeting Report 1999 March 22
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Agathangelou, P.1
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16
-
-
0032948745
-
Early-onset but not late-onset endothelin-A-receptor blockade can modulate hypertension, cerebral edema, and proteinuria in stroke-prone hypertensive rats
-
319549; note
-
319549 Early-onset but not late-onset endothelin-A-receptor blockade can modulate hypertension, cerebral edema, and proteinuria in stroke-prone hypertensive rats. Blezer EL, Nicolay K, Goldschmeding R, Jansen GH, Koomans HA, Rabelink TJ, Joles JA Hypertension 1999 33 1 137-144 A-127722 prevented, but failed to reverse cerebral and renal injury in stroke-prone, spontaneously hypertensive rats.
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Koomans, H.A.5
Rabelink, T.J.6
Joles, J.A.7
-
17
-
-
0004336919
-
American Society of Clinical Oncology - 35th Annual Meeting (Part IV), Atlanta, GA, USA
-
326268
-
326268 American Society of Clinical Oncology - 35th Annual Meeting (Part IV), Atlanta, GA, USA. McKinnon C IDDB Meeting Report 1999 May 15-18
-
IDDB Meeting Report 1999 May 15-18
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McKinnon, C.1
-
18
-
-
0000375702
-
ABT-627, an endothelin-receptor antagonist for refractory adenocarcinomas: Phase I and pharmacologic evaluation
-
326599; Abs 625
-
326599 ABT-627, an endothelin-receptor antagonist for refractory adenocarcinoma: Phase I and pharmacologic evaluation. Carducci M, Bowling M, Rogers T, Leahy T, Moyse D, Janus T, Padley R, Nelson J Proc Am Soc Clin Oncol 1999 18 Abs 625
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-
Carducci, M.1
Bowling, M.2
Rogers, T.3
Leahy, T.4
Moyse, D.5
Janus, T.6
Padley, R.7
Nelson, J.8
-
19
-
-
0003348268
-
Results of an initial phase I dose-escalation study of the endothelin-A receptor antagonist ABT-627 in patients with hormone refractory prostate cancer
-
326601; Abs 626
-
326601 Results of an initial phase I dose-escalation study of the endothelin-A receptor antagonist ABT-627 in patients with hormone refractory prostate cancer. Zonnenberg BA, Anbaum B, Kronemeier R, Yang F, Samra E, Janus TJ, Padley RI, Grahn A, Groenewegen G Proc Am Soc Clin Oncol 1999 18 Abs 626
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Zonnenberg, B.A.1
Anbaum, B.2
Kronemeier, R.3
Yang, F.4
Samra, E.5
Janus, T.J.6
Padley, R.I.7
Grahn, A.8
Groenewegen, G.9
-
20
-
-
0033528717
-
Chronic endothelin receptor antagonism preserves coronary endothelial function in experimental hypercholesterolemia
-
333071
-
333071 Chronic endothelin receptor antagonism preserves coronary endothelial function in experimental hypercholesterolemia. Best PJ, McKenna CJ, Hasdai D, Holmes DR Jr, Lerman A Circulation 1999 99 13 1747-1752
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Best, P.J.1
McKenna, C.J.2
Hasdai, D.3
Holmes D.R., Jr.4
Lerman, A.5
-
21
-
-
0033539145
-
B selectivity
-
342237
-
B selectivity. Von Geldurn TW, Tasker AS, Sorensen BK, Winn M, Sczcepankiewicz BG, Dixon DB, Chiou WJ, Wang L, Wessale JL, Adler A, Marsh KC, Nguyen B J Med Chem 1999 42 18 3668-3678
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Von Geldurn, T.W.1
Tasker, A.S.2
Sorensen, B.K.3
Winn, M.4
Sczcepankiewicz, B.G.5
Dixon, D.B.6
Chiou, W.J.7
Wang, L.8
Wessale, J.L.9
Adler, A.10
Marsh, K.C.11
Nguyen, B.12
-
22
-
-
0033539053
-
B antagonists containing a diphenylmethylamine acetamide side chain
-
342252
-
B antagonists containing a diphenylmethylamine acetamide side chain. Liu G, Kozmina NS, Winn M, Von Geldern TW, Dixon DB, Nguyen B, Marsh KC, Opgenorth YJ J Med Chem 1999 42 18 3679-4689
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Liu, G.1
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Winn, M.3
Von Geldern, T.W.4
Dixon, D.B.5
Nguyen, B.6
Marsh, K.C.7
Opgenorth, Y.J.8
-
23
-
-
0033967648
-
A receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain
-
360432
-
A receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain. Jarvis MF, Wessale JL, Zhu CZ, Lynch III JJ, Dayton BD, Calzadilla SV, Padley RJ, Opgenorth TJ, Kowaluk EA Eur J Pharmacol 2000 388 1 29-35
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Jarvis, M.F.1
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Lynch J.J. III4
Dayton, B.D.5
Calzadilla, S.V.6
Padley, R.J.7
Opgenorth, T.J.8
Kowaluk, E.A.9
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24
-
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0033215464
-
Preparation of endothelin antagonist ABT-627
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360437
-
360437 Preparation of endothelin antagonist ABT-627. Wittenberger SJ, McLaughlin MA Tetrahedrob Lett 1999 40 40 7175-7178
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Wittenberger, S.J.1
McLaughlin, M.A.2
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25
-
-
0001569259
-
Inhibition of tumor growth and angiogenesis by ABT-627 an endothelin receptor A antagonist in ovarian carcinoma xenografts
-
362442; Abs 2075
-
362442 Inhibition of tumor growth and angiogenesis by ABT-627 an endothelin receptor A antagonist in ovarian carcinoma xenografts. Rosano L, Salani D, Di Castro V, Nicotra MR, Varmi M, Padley RJ, Natali P, Bagnato A Proc Annu Meet Am Assoc Cancer Res 2000 41 Abs 2075
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Rosano, L.1
Salani, D.2
Di Castro, V.3
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Varmi, M.5
Padley, R.J.6
Natali, P.7
Bagnato, A.8
-
26
-
-
0013410707
-
Endothelin-1 promotes survival in prostate and renal carcinoma cell lines by inhibition of apoptosis involving the AKT pathway
-
363137; Abs 5241
-
363137 Endothelin-1 promotes survival in prostate and renal carcinoma cell lines by inhibition of apoptosis involving the AKT pathway. Pflug BR, Udan M S, Nelson J B Proc Annu Meet Am Assoc Cancer Res 20001 41 Abs 5241
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Pflug, B.R.1
Udan, M.S.2
Nelson, J.B.3
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27
-
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0034107746
-
B receptor activation
-
368124
-
B receptor activation. Piovezan AP, D'Orleans-Juste P, Souza GE, Rae GA Br J Pharmacol 2000 129 5 961-968
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Piovezan, A.P.1
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Rae, G.A.4
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28
-
-
0013403264
-
A placebo (pbo) controlled phase Ii dose-ranging evaluation of an endothelin-a receptor antagonist for men with hormone refractory prostate cancer (hrpca) and disease-related pain
-
370262; Abs 12151
-
370262 A placebo (pbo) controlled phase Ii dose-ranging evaluation of an endothelin-a receptor antagonist for men with hormone refractory prostate cancer (hrpca) and disease-related pain. Carducci MA, Vogelzang NJ, Daliani D, Dawson M, Hippensteel R, Padley RJ, Janus TJ Proc Am Soc Clin Oncol 2000 19 Abs 12151
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-
Carducci, M.A.1
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Padley, R.J.6
Janus, T.J.7
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29
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0034076139
-
A selective endothelin antagonist, in humans
-
375392
-
A selective endothelin antagonist, in humans. Verhaar MC, Grahn AY, Van Weerdt AWM, Honing MLH, Morrison PJ, Yang YP, Padley RJ, Rabelink TJ Br J Clin Pharmacol 2000 49 6 562-573
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-
Verhaar, M.C.1
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Honing, M.L.H.4
Morrison, P.J.5
Yang, Y.P.6
Padley, R.J.7
Rabelink, T.J.8
-
30
-
-
0001075906
-
Preliminary phase II results using ABT-627, an endothelin-A selective receptor antagonist, in men with symptomatic hormone refractory prostate cancer
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375418
-
375418 Preliminary phase II results using ABT-627, an endothelin-A selective receptor antagonist, in men with symptomatic hormone refractory prostate cancer. Nelson JB, Carducci MA, Dawson M, Hippensteel RL, Padley RJ, Janus TJ, ABT 627 Clinical Study Group J Urol 2000 163 4 Suppl 159
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Nelson, J.B.1
Carducci, M.A.2
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Padley, R.J.5
Janus, T.J.6
-
31
-
-
0003352176
-
Atrasentan supresses tumor induced bone remodeling in men with hormone refractory prostate cancer (HRPCa)
-
404786; Abs 764
-
404786 Atrasentan supresses tumor induced bone remodeling in men with hormone refractory prostate cancer (HRPCa). Zonnenberg B, Janus TJ, Venetucci M, Hippensteel R, Padley RJ Proc Annu Meet Am Assoc Cancer Res 2001 42 Abs 764
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Proc Annu Meet Am Assoc Cancer Res
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Zonnenberg, B.1
Janus, T.J.2
Venetucci, M.3
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Padley, R.J.5
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32
-
-
0003366375
-
ABT 627: An endothelin A receptor antagonist as new antitumor agent in HPV-associated cervical carcinoma
-
405176; Abs 4146
-
405176 ABT 627: An endothelin A receptor antagonist as new antitumor agent in HPV-associated cervical carcinoma. Venuti A, Rosanch L, Marcante ML, Padley R, Bagnato A Proc Annu Meet Am Assoc Cancer Res 2001 42 Abs 4146
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-
Venuti, A.1
Rosanch, L.2
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Padley, R.4
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33
-
-
0013361478
-
Drug development pipeline - ABT-627, Kaletra, MC-4 receptor antagonists, Abbott, and Ancrod
-
407049; April 25
-
407049 Drug development pipeline - ABT-627, Kaletra, MC-4 receptor antagonists, Abbott, and Ancrod. Abbott Laboratories Company Communication 2001 April 25
-
(2001)
Abbott Laboratories Company Communication
-
-
-
34
-
-
0003265457
-
The endothelin-A receptor antagonist atrasentan (ABT-627) reduces skeletal remodeling activity in men with advanced, hormone refractory prostate cancer
-
409615; Abs 12
-
409615 The endothelin-A receptor antagonist atrasentan (ABT-627) reduces skeletal remodeling activity in men with advanced, hormone refractory prostate cancer Nelson JB, Carducci MA, Padley RJ, Janus T, Humerickhouse R, Hippensteel R Proc Am Clin Oncol 2001 20 1 Abs 12
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Nelson, J.B.1
Carducci, M.A.2
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Hippensteel, R.6
-
35
-
-
0002943523
-
Endothelin A receptor blockade inhibits osteoblastic metastases
-
409892; Abs 331
-
409892 Endothelin A receptor blockade inhibits osteoblastic metastases Guise T, Grubbs B, Cui Y, Wu-Wong J, Wessale J, Padley R, Janus T, Yin J Proc Am Assoc Clin Oncol 2001 20 1 Abs 331
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Proc Am Assoc Clin Oncol
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-
Guise, T.1
Grubbs, B.2
Cui, Y.3
Wu-Wong, J.4
Wessale, J.5
Padley, R.6
Janus, T.7
Yin, J.8
-
36
-
-
0003222738
-
The selective endothelin-A receptor antagonist atrasentan improves quality of life adjusted time to progression (QATTP) in hormone refractory prostate cancer patients
-
410596; Abs 1567
-
410596 The selective endothelin-A receptor antagonist atrasentan improves quality of life adjusted time to progression (QATTP) in hormone refractory prostate cancer patients. Singh A, Padley RJ, Ashraf T Proc Am Soc Clin Oncol 2001 20 1 Abs 1567
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, vol.20
, pp. 1
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-
Singh, A.1
Padley, R.J.2
Ashraf, T.3
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37
-
-
0003265455
-
The endothelin-A receptor antagonist atrasentan (ABT-627) delays clinical progression in hormone refractory prostate cancer: A multinational, randomized, double-blind, placebo controlled trial
-
410415; Abs 694
-
410415 The endothelin-A receptor antagonist atrasentan (ABT-627) delays clinical progression in hormone refractory prostate cancer: A multinational, randomized, double-blind, placebo controlled trial Carducci MA, Nelson JB, Padley RJ, Janus T, Hippensteel R Proc Am Assoc Clin Oncol 2001 20 1 Abs 694
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Carducci, M.A.1
Nelson, J.B.2
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Janus, T.4
Hippensteel, R.5
-
38
-
-
0013413219
-
Abbott will continue to study prostate cancer drug atrasentan for early-stage/prevention
-
414666
-
414666 Abbott will continue to study prostate cancer drug atrasentan for early-stage/prevention. FDC Reports Pink Sheet 2001 63 27 22-23
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FDC Reports Pink Sheet
, vol.63
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-
-
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39
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0035829441
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A antagonists
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431060
-
A antagonists. Jae HS, Winn M, Von Geldern TW, Sorensen BK, Chiou WJ, Nguyen B, Marsh KC, Opgenorth TJ J Med Chem 2001 44 23 3978-3984
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